Human Brain Development: Insights from Experimental and Stem Cell-Based Models
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Neuroscience".
Deadline for manuscript submissions: 1 October 2026 | Viewed by 114
Special Issue Editor
2. Department of Physiology, Karl Landsteiner Private University, Krems, Austria
Interests: developmental neuroscience; epigenetics; neuro-oncology; iPSC; cerebral organoids
Special Issue Information
Dear Colleagues,
Human brain development is one of the most fascinating parts of human life, as the brain is the organ with the highest degree of cell-type diversity and enormous regional and functional heterogeneity. Optimal brain function relies on the faithful progression of stem cells through the necessary lineages to produce the correct cell types in the correct ratios and establish functional neural circuit formation. As compared to other mammals, humans have a protracted time span of brain development, thus increasing the sensitive time window for errors to occur. As a result, malformations or disease, such as cancer and neurodevelopmental disorders, may occur and challenge brain function.
In the recent decade, novel molecular profiling methods, as well as the establishment of cerebral organoid models, have greatly advanced our knowledge about how the human brain is generated and have provided new insights into the neuropathological underpinnings of developmental malformations. This Special Issue will provide a collection of new discoveries on the cellular and molecular mechanisms guiding human brain development in health and disease.
Dr. Nicole Amberg
Guest Editor
Manuscript Submission Information
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Keywords
- progenitor cells
- neurons
- glia
- regional identity
- neurodevelopmental disorders
- cerebral organoids
- iPSCs
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