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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Non-Traditional Roles of Protein Ubiquitination in Cellular Processes and Health

edited by

Chuanjin Wu

submission deadline 15 Oct 2025 | 2 articles | Viewed by 3846 | Submission Open

Keywords: Protein Ubiquitination; ; Ubiquitin chain; ; k63-linked ubiquitination; ; linear ubiquitination; ; ubiquitin-binding proteins; ; deubiquitinases; ; NF-kB; ; autophagy; ; inflammation; ; immunodeficiency; ; neurodegenerative diseases.

(This special issue belongs to the Section Cellular Pathology)

Ras Family of Genes and Proteins: Structure, Function and Regulation

edited by

Eugenio Santos

Alberto Fernández-Medarde

and Rosula Garcia-Navas

submission deadline 15 Oct 2025 | 2 articles | Viewed by 2979 | Submission Open

Keywords: HRAS; NRAS; KRAS; RAS-driven tumors; rasopathies; RAS signaling; RAS inhibitors; GAP; GEF; SOS; GRF

Regulation of the Subcellular Compartmentalization of Signaling Pathways by Post-Translational Modifications

edited by Jürgen Fritsch

submission deadline 15 Oct 2025 | 1 articles | Viewed by 1221 | Submission Open

Keywords: phosphorylation; ubiquitination; acetylation; acylation; methylation; sumoylation; glycosylation; neddylation; ribosylation; oxidation; proteolysis

Advances in Understanding Inflammation in Atherosclerosis: From Mechanisms to Therapeutic Targets

edited by Yaw Asare and Michael Lacy

submission deadline 15 Oct 2025 | Viewed by 725 | Submission Open

Keywords: atherosclerosis; inflammatory pathways; monocytes/macrophages; endothelial cells; innate immunity; inflammasome; IL-1β ; cytokines and chemokines; neutrophils; epigenetic mechanisms; adaptive immunity; small-molecule inhibitors; T cells; B cells

(This special issue belongs to the Section Cellular Pathology)

LPS-Induced Inflammatory Diseases

edited by

Lin-Hua Jiang

and

Pankaj Kumar

submission deadline 15 Oct 2025 | Viewed by 427 | Submission Open

Keywords: lipopolysaccharide (LPS); endotoxemia; inflammation; LPS signaling; acute lung injury; inflammatory cytokines; therapeutic targets

(This special issue belongs to the Section Cellular Pathology)

Molecular and Cellular Mechanisms of Type 1 Diabetes (T1D)

edited by Robert Sharp and

Itamar Raz

submission deadline 15 Oct 2025 | Viewed by 353 | Submission Open

Keywords: T1D; autoimmunity; type 1 diabetes; single-nucleotide polymorphisms (SNPs); viral/bacterial pathogens; T-cell biology; inflammation; pancreatic beta cells; immunoregulatory; molecular biology; cellular biology

(This special issue belongs to the Section Cellular Pathology)

Advances in Adipocyte Biology Research and Their Relevance to Metabolic Health

edited by

Aaron C. Brown

submission deadline 15 Oct 2025 | Viewed by 219 | Submission Open

Keywords: adipose tissue; obesity; inflammation; thermogenesis; adipokines

AI, CRISPR, and Molecular Mechanisms in Precision Medicine

edited by Karim Daliri

submission deadline 15 Oct 2025 | Viewed by 200 | Submission Open

Keywords: CRISPR; gene therapy; precision medicine

(This special issue belongs to the Section Cell Methods)

Extracellular Vesicles and Exosomes: Novel Insight and Therapeutic Applications in Cancer

edited by Giusi Alberti and

Celeste Caruso Bavisotto

submission deadline 16 Oct 2025 | Viewed by 308 | Submission Open

Keywords: extracellular vesicles (EVs); exosomes (Exos); proteins and miRNA; 2D-EVs and Exos; 3D-EVs and Exos; precision therapy; molecular mechanism; cancer physiology; oncology research

Molecular Mechanisms of Autism Spectrum Disorder

edited by Tanya Gandhi and

Charles Lee

submission deadline 20 Oct 2025 | 8 articles | Viewed by 23540 | Submission Open

Keywords: autism spectrum disorder; neurodevelopmental disorders; molecular mechanisms; cellular-molecular mechanisms; neurobiological mechanisms; neural mechanisms; intervention approaches; treatment strategies

(This special issue belongs to the Section Cells of the Nervous System)

Understanding Spinal Cord Injury and Repair: From Molecules to Neurocircuits and Multimodal Prostheses

edited by

Yang D. Teng

submission deadline 20 Oct 2025 | 9 articles | Viewed by 23032 | Submission Open

(This special issue belongs to the Section Cells of the Nervous System)

Therapeutic Targets in Glioblastoma

edited by Candice Mazewski and

Frank Eckerdt

submission deadline 20 Oct 2025 | 5 articles | Viewed by 13971 | Submission Open

Keywords: glioblastoma; signaling targets; blood-brain-barrier; complementary and alternative medicine; combination therapy; glioma stem cells; progression; resistance; nutrient-sensing

(This special issue belongs to the Section Cells of the Nervous System)

New Trends and Advances in Diagnosis and Prognosis of Head and Neck Cancer from Carcinogenesis to Future Molecular Targeted Therapies: 2nd Edition

edited by

Piotr Cierpikowski

and

Julia Bar

submission deadline 20 Oct 2025 | 5 articles | Viewed by 8006 | Submission Open

Keywords: head and neck cancer; oral cancer; biomarker; prognosis; carcinogenesis; oral premalignant lesions; cancer stem cells; signaling pathways; molecular targeted therapy

(This special issue belongs to the Section Cellular Pathology)

Experimental Systems to Model Aging Processes

edited by

Natascia Tiso

Giovanni Risato

and Ralf Dahm

submission deadline 20 Oct 2025 | 4 articles | Viewed by 6111 | Submission Open

Keywords: aging; ageing; age-related; longevity; model; animal; signalling pathway; mechanism; in vitro; in vivo; cell culture; marker

(This special issue belongs to the Section Cellular Aging)

Mechanism of Cell Signaling During Eye Development and Diseases—Second Edition

edited by

Mehrnoosh Saghizadeh Ghiam

and

Vivien Coulson-Thomas

submission deadline 20 Oct 2025 | 6 articles | Viewed by 5716 | Submission Open

Keywords: cell signaling; ocular; eye disorders; Wnt signaling; TGF-β

(This special issue belongs to the Section Cell Signaling)

Sperm Biology and Reproductive Health—Second Edition

edited by

Yi-Xun Liu

and

Shou-Long Deng

submission deadline 20 Oct 2025 | 2 articles | Viewed by 3812 | Submission Open

Keywords: spermatogenesis; differentiation of spermatogonial stem cells in vitro; mitosis; meiosis; sperm formation

New Advances in Anticancer Therapy

edited by

Dooil Jeoung

submission deadline 20 Oct 2025 | 1 articles | Viewed by 1725 | Submission Open

Keywords: antibody-based immunotherapy; cell therapy; personalized anticancer therapy; RNA vaccines; nanotechnology

(This special issue belongs to the Section Cellular Pathology)

Unraveling Protein–Protein Interactions for Innovative Therapeutics and Nanodelivery

edited by Roberta Montanari and

Alberto Vitali

submission deadline 20 Oct 2025 | 1 articles | Viewed by 1139 | Submission Open

Keywords: protein– protein interactions; PPI modulators; nanodelivery; molecular mechanisms

(This special issue belongs to the Section Cellular Biophysics)

Immune Response in HIV Infection, Pathogenesis and Persistence

edited by Suvadip Mallick

submission deadline 20 Oct 2025 | 1 articles | Viewed by 1062 | Submission Open

Keywords: HIV infection; immune response; chronic inflammation; immune activation; antiretroviral therapy (ART); immune reconstitution; immune checkpoints

(This special issue belongs to the Section Cellular Immunology)

Cell Therapy for Retinal Diseases

edited by

Girish Kumar Srivastava

and

Yogeswaran Lokanathan

submission deadline 20 Oct 2025 | Viewed by 361 | Submission Open

Keywords: retinal diseases; cell therapy; stem cells; retinal regeneration; cell transplantation; gene editing in retinal therapy; tissue engineering; retinal organoids; vision restoration; clinical translation of cell therapy; future directions in retinal regeneration

(This special issue belongs to the Section Tissues and Organs)

Cell Death and Its Clearance in Health and Disease

edited by

Turan Tufan

submission deadline 20 Oct 2025 | Viewed by 276 | Submission Open

Keywords: cell death; phagocytosis; immune homeostasis; inflammation

(This special issue belongs to the Section Cellular Pathology)

Autophagy in Neurological Disorders

edited by

Natalia Jimenez-Moreno

and

Ciro Isidoro

submission deadline 20 Oct 2025 | Viewed by 213 | Submission Open

Keywords: autophagy; selective autophagy; neurodegeneration; proteostasis; lysosomes; aging; oxidative stress; aging; biomarkers; pharmacological agents

(This special issue belongs to the Section Cells of the Nervous System)

New Molecular Insights into Hepatitis and Hepatic Cancer

edited by

Mark A. Feitelson

submission deadline 20 Oct 2025 | Viewed by 186 | Submission Open

Keywords: hepatitis; alcoholic and non-alcoholic steatohepatitis; HBV and HCV; hepatic Cancer; hepatocellular carcinoma; chronic liver disease; cellular and molecular basis; signaling pathways; antiviral therapies; immunotherapy; therapeutic advances

(This special issue belongs to the Section Cellular Pathology)

The Cellular and Molecular Mechanisms of Immunity to Infectious Viruses

edited by

Dimitrios Vlachakis

Tassos Georgakopoulos

and

Marios Agelopoulos

submission deadline 20 Oct 2025 | Viewed by 155 | Submission Open

Keywords: viral infections; immune cell biology; gene expression programs; epigenetics; chromatin architecture; cis-regulatory elements; functional genomics; computational biology applications

(This special issue belongs to the Section Cellular Pathology)

Recent Advances in Regenerative Dentistry—Second Edition

edited by

Li Xiao

submission deadline 25 Oct 2025 | 6 articles | Viewed by 18854 | Submission Open

Keywords: oral stem cells; oral tissue regeneration; bioengineering; dental materials; stem cell banking

(This special issue belongs to the Section Tissues and Organs)

3D Cultures and Organ-on-a-Chip in Cell and Tissue Cultures

edited by

Annunziata Mauro

Barbara Barboni

and

Giovanna Della Porta

submission deadline 25 Oct 2025 | 3 articles | Viewed by 7766 | Submission Open

Keywords: three-dimensional cell culture; organ-on-a-chip; tissue engineering; regenerative medicine; drug testing; microfluidics; in vitro models; personalized medicine; cellular interaction; disease modeling

(This special issue belongs to the Section Cell Methods)

Adult Stem Cells in Human Disease

edited by Esther Wolfs, Tim Vangansewinkel and

Annelies Bronckaers

submission deadline 25 Oct 2025 | 2 articles | Viewed by 5479 | Submission Open

Keywords: dental pulp stem cells; disease; regenerative medicine; disease modeling

(This special issue belongs to the Section Stem Cells)

Beyond Bystanders: The Emerging Roles of Glia in Brain Health and Disease

edited by

Ruqayya Afridi

submission deadline 25 Oct 2025 | Viewed by 256 | Submission Open

Keywords: astrocytes; microglia; oligodendrocytes; neuroinflammation; neuroimmunology; synaptic plasticity; blood– brain barrier; neuropsychiatric disorders

(This special issue belongs to the Section Cells of the Nervous System)

Molecular Anatomy and Function of Sensory Organs and Sensory Tissues

edited by

Frank Schmitz

submission deadline 25 Oct 2025 | Viewed by 209 | Submission Open

Keywords: sensory organ; sensory tissue; vision; hearing; skin; sensory structures of internal organs

(This special issue belongs to the Section Tissues and Organs)

Regenerating Poorly Vascularized Tissues

edited by Simone Pacini

submission deadline 25 Oct 2025 | Viewed by 205 | Submission Open

Keywords: regenerative medicine; avascular tissue; angiogenesis; vasculogenesis; cell-based medicinal products; bioengineered materials; cell transplantation

(This special issue belongs to the Section Tissues and Organs)

Immunoregulatory Functions of Mesenchymal Stem Cells (MSCs)

edited by

Joni H. Ylostalo

submission deadline 30 Oct 2025 | 2 articles | Viewed by 3511 | Submission Open

Keywords: mesenchymal stem cells; MSCs; immunoregulation; immunosuppression

(This special issue belongs to the Section Stem Cells)

Emerging Topics in Smooth Muscle Cell Fate and Plasticity in Atherosclerosis

edited by

Mandy Grootaert

and

Julián Albarrán-Juárez

submission deadline 30 Oct 2025 | 2 articles | Viewed by 2014 | Submission Open

Keywords: vascular smooth muscle cells; lineage tracing; fate mapping; VSMC plasticity; (single cell) (spatial) omics; vascular heterogeneity; atherosclerosis

(This special issue belongs to the Section Cellular Pathology)

Thirty plus Years’ Journey—Painting the Molecular Picture of E-C Coupling

edited by Jianjie Ma, Long-Sheng Song,

Jingsong Zhou

and

Hua Zhu

submission deadline 30 Oct 2025 | 2 articles | Viewed by 1369 | Submission Open

Keywords: E-C coupling; calcium signaling; muscle physiology; cardiovascular disease

Advances in Cellular and Molecular Treatment of Autoimmune Diseases—Second Edition

edited by

Panagiotis Athanassiou

Dimitrios P. Bogdanos

and

Ifigenia Kostoglou-Athanassiou

submission deadline 30 Oct 2025 | 1 articles | Viewed by 607 | Submission Open

Keywords: autoimmune diseases; disease activity; TNFa inhibitors; tocilizumab; infliximab; golimumab; etanercept; JAK inhibitors; cellular targets; molecular targets

(This special issue belongs to the Section Cellular Immunology)

New Advances in Cancer Cell Biology: Biomarkers and Therapeutic Targets

edited by

Verena Damiani

submission deadline 30 Oct 2025 | Viewed by 178 | Submission Open

Keywords: cancer; biomarkers; therapeutic targets

(This special issue belongs to the Section Cellular Immunology)

Perinatal Brain Injury—from Pathophysiology to Therapy

edited by Cora H.A. Nijboer,

Bobbi Fleiss

and

Ivo Bendix

submission deadline 31 Oct 2025 | 6 articles | Viewed by 15939 | Submission Open

Keywords: preterm birth; perinatal brain injury; infection; inflammation; hypoxia; ischemia; hyperoxia; malnutrition; regenerative therapies; pharmacological intervention; stem cells

(This special issue belongs to the Section Cells of the Nervous System)

Gastrointestinal Disease: From Cellular Mechanisms to Targeted Therapy

edited by

Grazia Serino

and

Amilcare Barca

submission deadline 31 Oct 2025 | 5 articles | Viewed by 11577 | Submission Open

Keywords: gastrointestinal cancer; gastric cancer; colorectal cancer; esophageal cancer; liver cancer; pancreatic cancer; inflammatory bowel disease; miRNAs; in vitro and in vivo models; molecular networks; molecular pathways; translational medicine; epithelial barrier functions/processes

(This special issue belongs to the Section Cellular Pathology)

Advances in Cell-Based Studies and Therapeutic Approaches for Tissue Regeneration

edited by

Anişoara Cîmpean

and

Andreea-Mariana Negrescu

submission deadline 31 Oct 2025 | 6 articles | Viewed by 8277 | Submission Open

Keywords: soft/hard tissue regeneration; therapeutical approaches; cell culture studies; inflammation-based diseases; degenerative diseases

(This special issue belongs to the Section Tissues and Organs)

The Role of Cilia in Health and Diseases—2nd Edition

edited by Rim Hjeij

submission deadline 31 Oct 2025 | 5 articles | Viewed by 7226 | Submission Open

Keywords: motile cilia; motile ciliopathy; Primary Ciliary Dyskinesia; genetic screening; bronchiectasis; hydrocephalus; laterality defects; infertility; gene therapy

Non-Coding and Coding RNAs in Targeted Cancer Therapy

edited by

César López-Camarillo

and

Macrina B. Silva-Cázares

submission deadline 31 Oct 2025 | 4 articles | Viewed by 6516 | Submission Open

Keywords: gene expression; non-coding RNAs; lncRNAs; microRNAs; piwi-associated RNA; circular RNAs; therapeutic targets

(This special issue belongs to the Section Cell and Gene Therapy)

Immune Cell Effect on the Endothelium

edited by

Constantinos Mikelis

and Margarita Lamprou

submission deadline 31 Oct 2025 | 1 articles | Viewed by 5306 | Submission Open

Keywords: immune cells; endothelial cells; cytokines; extracellular vesicles; angiogenesis; vascular permeability

(This special issue belongs to the Section Cellular Immunology)

Cilia-Based New Discoveries: Ciliogenesis, Function, and Human Diseases

edited by

Lisbeth Birk Møller

submission deadline 31 Oct 2025 | 2 articles | Viewed by 4732 | Submission Open

Keywords: primary cilium; human disease; cell signaling; mTOR; Hedgehog; WNT; PDGFRalpha

Small Molecular Therapeutics Promoting Neuronal Plasticity, Hippocampal Learning, and Memory

edited by

Avik Roy

submission deadline 31 Oct 2025 | 2 articles | Viewed by 4689 | Submission Open

Keywords: synaptic transmission; dendritic spines; metabotropic calcium influx; dendritic morphogenesis; small molecular therapeutics promoting neuronal plasticity

(This special issue belongs to the Section Cells of the Nervous System)

How Can We Optimise Cancer Therapy? Tumour Microenvironment and Immune Evasion Strategies

edited by

Agnieszka Bojarska-Junak

and

Michal Zarobkiewicz

submission deadline 31 Oct 2025 | 3 articles | Viewed by 3966 | Submission Open

Keywords: immunosurveillance; immune evasion in cancer; tumour microenvironment; immune suppression; immunotherapy; immune checkpoints; cancer immunity; drug intervention

(This special issue belongs to the Section Cell Microenvironment)

The Role of Oxidative Stress in Cardiovascular Diseases—2nd Edition

edited by

Liya Yin

and

Chuanxi Cai

submission deadline 31 Oct 2025 | 1 articles | Viewed by 3124 | Submission Open

Keywords: oxidative stress; antioxidants; apoptosis; atherosclerosis; blood vessel; heart failure; hypertension; inflammation; mitochondria; microcirculation; reactive oxygen species

(This special issue belongs to the Section Cells of the Cardiovascular System)

Galectins in Cancer, Fibrosis and Immune Modulation: Mechanisms, Therapeutic Strategies and Translational Advances

edited by Tsung-Chieh Shih

submission deadline 31 Oct 2025 | 3 articles | Viewed by 2921 | Submission Open

Keywords: Galectin; tumor microenvironment; immunosuppression; fibrosis; epithelial– mesenchymal transition (EMT); cancer metastasis; immune evasion; therapy resistance; myeloid-derived suppressor cells (MDSCs); tumor-associated macrophages (TAMs); extracellular matrix remodeling; Galectin-targeted therapy; combination immunotherapy; fibroblast activation; chronic inflammation; tumor– stroma interactions; novel inhibitors of Galectins

(This special issue belongs to the Section Cellular Immunology)

Glial Cells: Physiological and Pathological Perspective

edited by

Qing Richard Lu

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2852 | Submission Open

Keywords: neurodegeneration; oligodendrocytes; astrocytes; microglia; neuroinflammation; demyelination neuron– glial interactions; homeostasis; glia-targeted therapies

(This special issue belongs to the Section Cells of the Nervous System)

Natural Killer (NK) Cells in Immunity: Limitations and Potential

edited by Rehan Mujeeb Faridi

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2672 | Submission Open

Keywords: natural killer cells; adaptive NK cells; infection

(This special issue belongs to the Section Cellular Immunology)

New Discoveries in Calcium Signaling-Related Neurological Disorders

edited by Matheus De Castro Fonseca

submission deadline 31 Oct 2025 | 1 articles | Viewed by 2667 | Submission Open

Keywords: Ca2+ signaling; neurons; neurological disorders; intracellular signaling; synaptic dysfunction

(This special issue belongs to the Section Cells of the Nervous System)

Cellular Pathways on Brain Control of Energy Metabolism

edited by Liangyou Rui

submission deadline 31 Oct 2025 | 1 articles | Viewed by 2347 | Submission Open

Keywords: energy balance neurocircuit; molecular pathways governing energy balance neurocircuits; gut– brain axis in obesity; neuroinflammation in obesity and metabolic disease; neural sensing of metabolites and hormones

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