Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Advances in Prenatal Exposure to Environmental Toxicants submission deadline 20 May 2026 | 4 articles | Viewed by 18142 | Submission Open
Keywords: prenatal exposures; toxicogenomics; epigenomics; placenta; perinatal outcomes; neurodevelopmental outcomes; respiratory outcomes
Mechanism of Cell Signaling During Eye Development and Diseases—Second Edition submission deadline 20 May 2026 | 8 articles | Viewed by 17734 | Submission Open
Keywords: cell signaling; ocular; eye disorders; Wnt signaling; TGF-β
(This special issue belongs to the Section Cell Signaling)
The Cellular and Molecular Mechanisms of Immunity to Infectious Viruses submission deadline 20 May 2026 | 3 articles | Viewed by 7471 | Submission Open
Keywords: viral infections; immune cell biology; gene expression programs; epigenetics; chromatin architecture; cis-regulatory elements; functional genomics; computational biology applications
(This special issue belongs to the Section Cellular Pathology)
Unraveling Protein–Protein Interactions for Innovative Therapeutics and Nanodelivery
edited by Roberta Montanari and
submission deadline 20 May 2026 | 1 articles | Viewed by 6187 | Submission Open
Keywords: protein– protein interactions; PPI modulators; nanodelivery; molecular mechanisms
(This special issue belongs to the Section Cellular Biophysics)
Heparanase and Heparanase-2: Function, Regulation, Signaling, and Disease submission deadline 20 May 2026 | 1 articles | Viewed by 2642 | Submission Open
Keywords: heparanase (Hpa1); heparanase-2 (Hpa2); tumor microenvironment; extracellular matrix; tumor progression; tumor suppression; metastatic niche; glycocalyx; immune cells; inflammation
(This special issue belongs to the Section Cell Signaling)
The Placental Matrix: Trophoblasts, Decidualization, and Embryo Implantation
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 2504 | Submission Open
Keywords: trophoblast; decidualization; embryo implantation; uterus; infection; cancer; reproductive immunology; reproductive toxicology; cellular differentiation
(This special issue belongs to the Section Tissues and Organs)
Regulation of Iron Homeostasis
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 1425 | Submission Open
Keywords: iron homeostasis; iron transport; iron storage; iron-containing proteins
Molecular Pathogenesis of Ovarian Cancer and Therapeutic Strategies
edited by Jayakumar R. Nair
submission deadline 20 May 2026 | 1 articles | Viewed by 1184 | Submission Open
Keywords: ovarian cancer; pathogenic mutations; target therapy; genetic heterogeneity                                 
(This special issue belongs to the Section Cellular Pathology)
Stem Cell Secretome: Therapeutic Potential in Regenerative Medicine
edited by Emanuela Mari
submission deadline 20 May 2026 | 1 articles | Viewed by 1090 | Submission Open
Keywords: paracrine factors and tissue regeneration; secretome conditioned by microenvironment or stimuli; extracellularvesicles vs. soluble fraction; formulations and delivery of the therapeutic secretome
(This special issue belongs to the Section Stem Cells)
Targeting Tumor Metabolism and Epigenetics: Mechanisms and Therapeutic Strategies
edited by , and Íñigo Casafont
submission deadline 20 May 2026 | Viewed by 523 | Submission Open
Keywords: tumor metabolism; epigenetics; metabolic reprogramming; DNA methylation; histone modification; warburg effect; glycolysis inhibitors; fatty acid synthesis; chromatin remodeling; cancer therapy
(This special issue belongs to the Section Cellular Metabolism)
New Advances in Cancer Cell Biology: Biomarkers and Therapeutic Targets
edited by
submission deadline 20 May 2026 | Viewed by 448 | Submission Open
Keywords: cancer; biomarkers; therapeutic targets
(This special issue belongs to the Section Cellular Immunology)
State-of-the-Art Insights into the Cell Microenvironment
edited by
submission deadline 20 May 2026 | Viewed by 334 | Submission Open
Keywords: cell microenvironment; stem cells; organoid and 3D culture models
(This special issue belongs to the Section Cell Microenvironment)
Pathology and Therapies in Brain Tumor
edited by Bachuchu Lal
submission deadline 20 May 2026 | Viewed by 294 | Submission Open
Keywords: brain tumor; gliomas; target treatment; pathogenesis; animal models
(This special issue belongs to the Section Cellular Pathology)
Cellular and Molecular Basis of Sjögren’s Syndrome
edited by Muhammad Shahnawaz Soyfoo
submission deadline 20 May 2026 | Viewed by 208 | Submission Open
Keywords: Sjö gren disease; epithelial dysfunction; immune tolerance; autoimmunity
Non-Coding and Coding RNAs in Targeted Cancer Therapy submission deadline 25 May 2026 | 4 articles | Viewed by 11273 | Submission Open
Keywords: gene expression; non-coding RNAs; lncRNAs; microRNAs; piwi-associated RNA; circular RNAs; therapeutic targets
(This special issue belongs to the Section Cell and Gene Therapy)
Small Molecular Therapeutics Promoting Neuronal Plasticity, Hippocampal Learning, and Memory
edited by
submission deadline 25 May 2026 | 2 articles | Viewed by 6584 | Submission Open
Keywords: synaptic transmission; dendritic spines; metabotropic calcium influx; dendritic morphogenesis; small molecular therapeutics promoting neuronal plasticity
(This special issue belongs to the Section Cellular Neuroscience)
Advances in Musculoskeletal Tissue Regeneration Using Mesenchymal Stromal/Stem Cells, Biomaterials, and Signaling Molecules: Second Edition submission deadline 25 May 2026 | 2 articles | Viewed by 4757 | Submission Open
Keywords: mesenchymal stromal/stem cells; extracellular vesicles; biomaterials; signalling molecules; microphysiological systems; musculoskeletal regeneration; immunomodulation; cell therapy; tissue engineering
(This special issue belongs to the Section Stem Cells)
Brain Function and Structure: Mapping Complexity in Neuronal Cells submission deadline 25 May 2026 | 1 articles | Viewed by 1795 | Submission Open
Keywords: optogenetics; lab-on-chip platforms and brain organoids; neuronal and glial networks; neuromechanobiology; system neuroscience
Basic Mechanisms and Emerging Therapeutic Strategies for Spinal Cord Injury
edited by and Angela R. Filous
submission deadline 25 May 2026 | 1 articles | Viewed by 1262 | Submission Open
Keywords: spinal cord injury; neuroinflammation; neural regeneration; axon growth; neurons; glial cells; oligodendrocytes; myelin; astrocytes; microglia
Recent Advances in Astrocyte Neuron Communication submission deadline 25 May 2026 | Viewed by 1187 | Submission Open
Keywords: astrocytes; calcium signaling; ion channels; gliotransmitters; brain circuits; reactive astrogliosis; astrocyte heterogeneity; astrocyte– neuron networks; synaptic plasticity
(This special issue belongs to the Section Cellular Neuroscience)
Cell Signaling in Neurodegenerative Disease
edited by , Yasuhiro Funahashi, Akira Sobue, and Md-nadim Hossain
submission deadline 25 May 2026 | 1 articles | Viewed by 990 | Submission Open
Keywords: neurodegeneration; cell signaling; biomarkers; synaptic dysfunction; neuroinflammation; protein aggregation; IPSC and animal models; mitochondrial dysfunction; therapeutic targets; translational neuroscience
(This special issue belongs to the Section Cellular Neuroscience)
Cell Therapy for Retinal Diseases submission deadline 25 May 2026 | Viewed by 539 | Submission Open
Keywords: retinal diseases; cell therapy; stem cells; retinal regeneration; cell transplantation; gene editing in retinal therapy; tissue engineering; retinal organoids; vision restoration; clinical translation of cell therapy; future directions in retinal regeneration
(This special issue belongs to the Section Tissues and Organs)
Cellular and Molecular Insights into Female Reproductive Biology
edited by
submission deadline 25 May 2026 | Viewed by 305 | Submission Open
Keywords: female reproductive biology; cellular mechanisms; reproductive aging; microfluidics; fertility preservation; stem cells; uterine endocrinology; infertility; reproductive health; gametogenesis
(This special issue belongs to the Section Reproductive Cells and Development)
Human DNA Replication/Repair Factors submission deadline 25 May 2026 | Viewed by 289 | Submission Open
Keywords: DNA replication; replisome; DNA polymerase; helicase; replication fork; DNA repair; replication stress; DNA damage response; homologous recombination; replication-coupled DNA repair
Resistance of Hematological Malignancies and Solid Tumors to CAR T Cell Therapy
edited by
submission deadline 25 May 2026 | Viewed by 225 | Submission Open
Keywords: solid tumors; hematological malignancies; CAR T cell; immunotherapy; resistance; apoptosis
From Fat to Flame: Targeting Adipose Tissue in Chronic Inflammation and Exploring Therapeutic Strategies submission deadline 29 May 2026 | 1 articles | Viewed by 1250 | Submission Open
Keywords: obesity; inflammasomes; immune system; microbiota
(This special issue belongs to the Section Tissues and Organs)
Advanced Research in Neurogenesis and Neuroinflammation
edited by
submission deadline 30 May 2026 | 6 articles | Viewed by 10128 | Submission Open
Keywords: neurogenesis; neuroinflammation; neurodegeneration; neurodegenerative diseases; cognitive functions
(This special issue belongs to the Section Cellular Neuroscience)
Autophagy in Stress Responses: From Molecular Mechanisms to Disease Relevance
edited by and Kleiton Silva
submission deadline 30 May 2026 | Viewed by 356 | Submission Open
Keywords: autophagy; stress response; proteostasis; mitophagy; neurodegeneration; aging; stress granules; mTOR signaling; selective autophagy; disease models; exercise; muscle disorders
(This special issue belongs to the Section Autophagy)
Protein–Protein Interaction in Health and Disease submission deadline 30 May 2026 | Viewed by 256 | Submission Open
Keywords: protein– protein interactions; mass spectrometry; cross-linking; disease mechanisms; structural biology; proteomics; therapeutic targets; protein complexes
(This special issue belongs to the Section Cell Signaling)
Therapeutic Targeting of Myeloid Cells in Tumor
edited by Mirko Farina and
submission deadline 30 May 2026 | Viewed by 218 | Submission Open
Keywords: myeloid cells; therapeutic targeting; tumor microenvironment; leukemia; myelodysplastic syndromes; tumor development
Perinatal Brain Injury—from Pathophysiology to Therapy
edited by Cora H.A. Nijboer, and
submission deadline 31 May 2026 | 11 articles | Viewed by 31926 | Submission Open
Keywords: preterm birth; perinatal brain injury; infection; inflammation; hypoxia; ischemia; hyperoxia; malnutrition; regenerative therapies; pharmacological intervention; stem cells
(This special issue belongs to the Section Cellular Neuroscience)
3D Cultures and Organ-on-a-Chip in Cell and Tissue Cultures submission deadline 31 May 2026 | 9 articles | Viewed by 26732 | Submission Open
Keywords: three-dimensional cell culture; organ-on-a-chip; tissue engineering; regenerative medicine; drug testing; microfluidics; in vitro models; personalized medicine; cellular interaction; disease modeling
(This special issue belongs to the Section Cell Methods)
Proteomic Applications in Ageing and Neurodegenerative Conditions submission deadline 31 May 2026 | 5 articles | Viewed by 22544 | Submission Open
(This special issue belongs to the Section Cell Methods)
Stem Cells and Beyond: Innovations in Tissue Repair and Regeneration
edited by Aurora Almadori
submission deadline 31 May 2026 | 7 articles | Viewed by 19387 | Submission Open
Keywords: adipose-derived stem cells; mesenchymal stem cells; induced pluripotent stem cells; stromal vascular fraction; platelet-rich plasma; exosomes; polynucleotides; cytokines; growth factors; extracellular matrix; cell signaling; wound healing; ageing; immune response; inflammation; scarring
(This special issue belongs to the Section Stem Cells)
Intervertebral Disc Degeneration and Regeneration: New Molecular Mechanisms and Therapeutics—Second Edition
edited by
submission deadline 31 May 2026 | 4 articles | Viewed by 17918 | Submission Open
Keywords: spine; intervertebral disc; biomaterial; stem cell; gene therapy
(This special issue belongs to the Section Cellular Pathology)
Immunoregulatory Functions of Mesenchymal Stem Cells (MSCs)
edited by
submission deadline 31 May 2026 | 5 articles | Viewed by 11720 | Submission Open
Keywords: mesenchymal stem cells; MSCs; immunoregulation; immunosuppression
(This special issue belongs to the Section Stem Cells)
Cellular and Molecular Mechanisms of Liver Diseases
edited by Jieyun Jiang
submission deadline 31 May 2026 | 4 articles | Viewed by 10298 | Submission Open
Keywords: liver; alcoholic liver disease (ALD); viral hepatitis; metabolic associated steatotic liver disease (MASLD); autoimmune hepatitis; drug-induced liver injury; liver fibrosis and cirrhosis; liver cancer; cellular and molecular mechanisms
(This special issue belongs to the Section Cellular Pathology)
Adipose-Derived Stem Cells for Tissue Regeneration submission deadline 31 May 2026 | 2 articles | Viewed by 8449 | Submission Open
Keywords: adipose stem cells (ASCs); stromal vascular fraction (SVF); cell enriched lipotransfer (CELT and CELT-PLUS); extracellular vesicles (EVs); tissue processing; basic biology; mechanisms of action; regenerative medicine; cell-bases therapies
(This special issue belongs to the Section Tissues and Organs)
Glial Cells: Physiological and Pathological Perspective
edited by
submission deadline 31 May 2026 | 4 articles | Viewed by 8045 | Submission Open
Keywords: neurodegeneration; oligodendrocytes; astrocytes; microglia; neuroinflammation; demyelination neuron– glial interactions; homeostasis; glia-targeted therapies
(This special issue belongs to the Section Cellular Neuroscience)
Cilia-Based New Discoveries: Ciliogenesis, Function, and Human Diseases submission deadline 31 May 2026 | 3 articles | Viewed by 7550 | Submission Open
Keywords: primary cilium; human disease; cell signaling; mTOR; Hedgehog; WNT; PDGFRalpha
Natural Killer (NK) Cells in Immunity: Limitations and Potential
edited by Rehan Mujeeb Faridi
submission deadline 31 May 2026 | 3 articles | Viewed by 5378 | Submission Open
Keywords: natural killer cells; adaptive NK cells; infection
(This special issue belongs to the Section Cellular Immunology)
Emerging Advances in Neurodegeneration: Innovations in Stem Cell and Organoid Research
edited by
submission deadline 31 May 2026 | 1 articles | Viewed by 5147 | Submission Open
Keywords: neurodegeneration; stem cells; induced pluripotent stem cells (iPSCs); brain organoids; disease modeling; therapeutic strategies; personalized medicine
(This special issue belongs to the Section Stem Cells)
G Protein-Coupled Receptors and Diseases
edited by
submission deadline 31 May 2026 | 2 articles | Viewed by 3346 | Submission Open
Keywords: G protein-coupled receptor; taste receptor; microbiome; cancer; aging; neurodegenerative disease; cardiovascular disease; pulmonary hypertension; cell survival; cell death; apoptosis; autophagy; necroptosis; ferroptosis; proliferation
Non-Coding RNAs as Regulators of Cellular Function and Disease
edited by
submission deadline 31 May 2026 | 2 articles | Viewed by 2950 | Submission Open
Keywords: non-coding RNAs; gene regulation; disease mechanisms; therapeutic targets; molecular mechanisms
The Multifaceted Role of Molecular Chaperones in Cancer: Pro-Tumoral or Therapeutic Function
edited by and Federica Scalia
submission deadline 31 May 2026 | 1 articles | Viewed by 2794 | Submission Open
Keywords: molecular chaperones; cancer biology; carcinogenesis; tumor progression; diagnostic/prognostic biomarkers; anti-tumor therapeutic strategies; in vitro/in vivo experimental approaches; in silico computational approaches
Exploring the Structural and Functional Diversity of Proteins: Foundations of Life and Biological Complexity
edited by Jiabei Lin
submission deadline 31 May 2026 | 1 articles | Viewed by 2509 | Submission Open
Keywords: AAA+ protein; RNA-binding protein; protein kinase; PTMs; protein structure; function; and diseases; protein and RNA homeostasis; neurodegeneration; cancer
Sex Differences in Cardiovascular Structure and Function—from Mechanisms to Therapeutics submission deadline 31 May 2026 | 1 articles | Viewed by 1887 | Submission Open
Keywords: cardiovascular diseases; sex hormones; sex differences; vascular and cell signaling; therapeutic targets
Circadian Rhythms in Action: Cellular and Molecular Mechanisms Revealed by Model Organisms submission deadline 31 May 2026 | 1 articles | Viewed by 1814 | Submission Open
Keywords: circadian rhythm; molecular regulation; cellular mechanisms; model organisms; time-restricted feeding; metabolism; aging; neurodegeneration
Molecular and Cellular Mechanisms of Type 1 Diabetes (T1D)
edited by Robert Sharp and
submission deadline 31 May 2026 | 1 articles | Viewed by 1749 | Submission Open
Keywords: T1D; autoimmunity; type 1 diabetes; single-nucleotide polymorphisms (SNPs); viral/bacterial pathogens; T-cell biology; inflammation; pancreatic beta cells; immunoregulatory; molecular biology; cellular biology
(This special issue belongs to the Section Cellular Pathology)
Molecular Bases Underlying Early Embryonic Development in Mammals
edited by , Julio Ávila Marrero and Angela Palumbo
submission deadline 31 May 2026 | 1 articles | Viewed by 633 | Submission Open
Keywords: embryonic development; early embryogenesis; gene expression; miRNA profile; reproductive physiology; cell signalling; embryo quality; developmental competence; in vitro embryo culture
(This special issue belongs to the Section Reproductive Cells and Development)
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