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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cellular and Molecular Mechanisms in Gynecological Disorders

edited by

Qiwei Yang

submission deadline 30 Jun 2025 | 15 articles | Viewed by 24138

Keywords: uterus; ovary; breast; cervix; cancer; endometriosis; leiomyoma; adenomyosis; polycystic ovary syndrome; female infertility; pathways; cell atlas; transcriptome; epigenome

(This special issue belongs to the Section Reproductive Cells and Development)

Highlights in Red Blood Cell Research

edited by

Anna Bogdanova

and

Lars Kaestner

submission deadline 30 Jun 2025 | 3 articles | Viewed by 15547

Keywords: red blood cells; anemia; transfusion; erythropoiesis; signaling

Insight into Cardiomyopathy

edited by Sobuj Mia

submission deadline 30 Jun 2025 | 1 articles | Viewed by 15518

Keywords: heart failure; ventricular dysfunction; hypertrophic cardiomyopathy; dilated cardiomyopathy; cardiac fibrosis; cardiac hypertrophy; biomarkers

(This special issue belongs to the Section Cells of the Cardiovascular System)

Cellular and Molecular Mechanisms in Immune Regulation

edited by Fábio Rinaldo Santori and Natalia B. Ivanova

submission deadline 30 Jun 2025 | 9 articles | Viewed by 14129

Keywords: innate immunity; dendritic cells; macrophages; T cells; B cells; cytokines; immunotherapy

(This special issue belongs to the Section Cellular Immunology)

Natural Products in Neurodegenerative Diseases: Current Trends and Future Perspectives

edited by

Anthony Tsarbopoulos

and Nikolaos Kokras

submission deadline 30 Jun 2025 | 4 articles | Viewed by 9843

Keywords: bioactive compounds; protein aggregation processes in AD; cognitive; anxiolytic and antidepressant effects

(This special issue belongs to the Section Cells of the Nervous System)

Radiation-Induced Brain Injury: Molecular Mechanisms and Therapeutic Strategies

edited by

Feng Ru Tang

submission deadline 30 Jun 2025 | 3 articles | Viewed by 9590

Keywords: radiation injury; brain; neurological and neuropsychiatric disorders; molecular mechanisms; novel therapeutic approaches

(This special issue belongs to the Section Cells of the Nervous System)

Charming Micro-Insights into Health and Diseases

edited by

Alexander E. Kalyuzhny

submission deadline 30 Jun 2025 | 4 articles | Viewed by 9059

Keywords: cellular pathology of cancers neural cell biology cellular antivirus immune responses cell therapies cellular signaling cell research in animal models cellular metabolism protein quality control proteasomal degradation and autophagy

Heat Shock Proteins and Human Cancers

edited by

Alexander E. Kabakov

submission deadline 30 Jun 2025 | 6 articles | Viewed by 8951

Keywords: heat shock protein; glucose-regulated protein; cancer; tumorigenesis; theranostics; anticancer vaccine

Male Infertility Update: Current Knowledge on Etiology, Comorbidities, Diagnosis and Treatment: Preclinical Topics

edited by

Francesco Lotti

and

Mario Maggi

submission deadline 30 Jun 2025 | 4 articles | Viewed by 8187

Keywords: male infertility; diagnosis; treatment; etiology; pre-testicular/testicular/post-testicular causes; genetic causes; seminal parameters; hormonal parameters; ultrasound; general health; azoospermia

(This special issue belongs to the Section Reproductive Cells and Development)

Astrocyte Reprogramming and Brain Homeostasis

edited by Dimitra Thomaidou and Elsa Papadimitriou

submission deadline 30 Jun 2025 | 2 articles | Viewed by 4986

Keywords: in vitro astrocytic reprogramming; in vivo astrocytic reprogramming; induced neurons; transcription factors; miRNAs; small molecules; direct reprogramming mechanisms; scRNA-seq; gene regulatory networks; astrocytic metabolism; metabolic reprogramming

(This special issue belongs to the Section Cells of the Nervous System)

Synaptic Plasticity in Brain and Nerves: New Vistas in Health and Diseases (2nd Edition)

edited by

Jean-Marie Billard

submission deadline 30 Jun 2025 | 2 articles | Viewed by 4974

Keywords: cellular networks; synaptic strength; Hebbian plasticity; homeostatic plasticity; neuron– glia interactions; brain disorders; cognitive functions

(This special issue belongs to the Section Cells of the Nervous System)

Cellular Signaling and Therapeutic Approaches of Pulmonary Fibrosis

edited by Jennifer Speth

submission deadline 30 Jun 2025 | 1 articles | Viewed by 3818

Keywords: pulmonary fibrosis; resolution; cellular interactions

(This special issue belongs to the Section Tissues and Organs)

The Role of Hypoxia-Inducible Factors (HIFs) in Human Diseases

edited by

Efrosyni Paraskeva

and

George Simos

submission deadline 30 Jun 2025 | 2 articles | Viewed by 3789

Keywords: oxygen; hypoxia; HIF; transcription; cancer; anemia; ischemia; cardiovascular disorders; erythrocytosis; pulmonary hypertension

(This special issue belongs to the Section Cellular Pathology)

Advances in Melanoma Immunotherapy

edited by Jeffrey D. McBride

submission deadline 30 Jun 2025 | 1 articles | Viewed by 3709

Keywords: melanoma immunotherapy; therapeutic targets; immune modulation; oncolytic viruses; checkpoint inhibitors; cancer vaccines; tumor biomarkers; tumor microenvironment; treatment strategies

(This special issue belongs to the Section Cellular Immunology)

Sepsis: Pathogenesis, Pathophysiology, Molecular and Cellular Mechanisms and Immunity

edited by

Guozheng Wang

and

Simon Abrams

submission deadline 30 Jun 2025 | 3 articles | Viewed by 3416

Keywords: sepsis; bacterial infection; PAMPs; DAMPs; TLRs; small RNAs; RNA splicing; DNA recombination; signaling pathways; cell death; NET/NETosis; coagulopathy; DIC; toxins; complements

(This special issue belongs to the Section Cellular Immunology)

Advancements in Cellular Immunotherapies in the Immune Checkpoint Inhibitor Era for Cancer Treatment

edited by

Andrés Tittarelli

and

Flavio Salazar-Onfray

submission deadline 30 Jun 2025 | 1 articles | Viewed by 3403

Keywords: CAR-T cells; NK-cell immunotherapy; adoptive T-cell transfer; dendritic cell cancer vaccines; whole-tumor-cell vaccines

(This special issue belongs to the Section Cellular Immunology)

Recent Developments in the Role of Enteroendocrine Cells in Gastrointestinal and Non-gastrointestinal Disorders

edited by

Tarek Mazzawi

and Trygve Hausken

submission deadline 30 Jun 2025 | 1 articles | Viewed by 3062

Keywords: enteroendocrine; stem cells; quantification; transcriptome; immunohistochemistry; gut hormones; obesity; Parkinson’ s disease; diabetes; IBD

The Role of Inflammation in AMD (Multifactorial Age-Related Macular Degeneration)—Volume II

edited by Kai Kaarniranta,

Anu Kauppinen

and

Heping Xu

submission deadline 30 Jun 2025 | 2 articles | Viewed by 3009

Keywords: aging; autophagy; degeneration; inflammation; macula; oxidative stress; retina

(This special issue belongs to the Section Cellular Immunology)

Axonal Transport: Mechanisms, Disorders, and Therapeutic Approaches

edited by Yuxiang Xie and Jingqi Yan

submission deadline 30 Jun 2025 | 1 articles | Viewed by 2903

Keywords: axonal transport; motor proteins; autophagy– lysosome pathway; neurodegenerative diseases; therapeutic strategies

(This special issue belongs to the Section Cells of the Nervous System)

Research on the Amyloid in Alzheimer’s Disease

edited by Archna Sharma

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1776

Keywords: amyloid; Alzheimer’ s disease; amyloid biomarkers; brain network; anti-amyloid immunotherapy; inducible pluripotent stem cells; neuron and non-neuron differentiation; brain organoids; amyloidopathy animal models

(This special issue belongs to the Section Cellular Aging)

Role of Zinc in Brain Homeostasis and Neurological Disorders

edited by Richard Dyck

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1688

Keywords: zinc; neurotransmitter; neuromodulator; homeostasis; zinc transporters; ZnTs; Slc30; ZIPs; Slc39

(This special issue belongs to the Section Cells of the Nervous System)

Novel Insights into Molecular Mechanisms of Renal Fibrosis

edited by

Yanlin Wang

submission deadline 30 Jun 2025 | Viewed by 775

Keywords: renal fibrosis; chronic kidney disease; fibroblasts; extracellualr matrix; inflammation; cell signaling

(This special issue belongs to the Section Cellular Pathology)

Mitochondria Meets Oxidative Stress

edited by

Fernanda M. Ferreira

and

Francisco Peixoto

submission deadline 30 Jun 2025 | 1 articles | Viewed by 635

Keywords: mitochondria; oxidative stress; reactive oxygen species (ROS); cellular respiration; antioxidant defense; ageing

(This special issue belongs to the Section Mitochondria)

Cellular and Molecular Alterations in the Down Syndrome Brain: A Starting Point for the Design of Therapeutic Approaches

edited by

Sandra Guidi

Fiorenza Stagni

and

Marco Emili

submission deadline 30 Jun 2025 | Viewed by 534

Keywords: down syndrome; cellular defects; deranged molecular pathways; altered neurodevelopment; neurodegeneration; effects of therapies

(This special issue belongs to the Section Cellular Pathology)

Immunotherapeutic Challenges and Treatment Resistance in Glioma

edited by Kristen A. Batich

submission deadline 30 Jun 2025 | Viewed by 474

Keywords: antigen presentation; innate immunity; cellular immunotherapy; treatment resistance

(This special issue belongs to the Section Cells of the Nervous System)

Unlocking the Gates: Multidrug Resistance Proteins—Mechanisms and Therapeutic Strategies

edited by

Brindusa Tiperciuc

, Angela Cozma and Cezar Login

submission deadline 30 Jun 2025 | Viewed by 434

Keywords: multidrug resistance; ABC transporters; therapeutic resistance; drug efflux mechanisms; chemotherapy challenges; targeted therapy strategies

(This special issue belongs to the Section Cellular Pathology)

Focus on Inflammation and Atherosclerotic Diseases

edited by

Qianman Peng

and Jianzhong Shen

submission deadline 30 Jun 2025 | Viewed by 280

Keywords: inflammation in atherosclerosis; atherothrombosis; cell signaling ; atheroma progression and regression; endothelial– mesenchymal transition in atherosclerosis; vascular cells; immune cells; new therapeutics for atherosclerosis; metabolic regulation of inflammation; non-coding RNAs; in vitro and in vivo models

(This special issue belongs to the Section Cells of the Cardiovascular System)

Decoding Signaling Pathways in Liver Disease: From Mechanisms to Therapeutic Strategies

edited by Junyan Tao

submission deadline 30 Jun 2025 | Viewed by 128

Keywords: liver regeneration and repair; liver fibrosis; cirrhosis; HCC; ICC; NASH; MASLD; liver disease model; AI and deep machine learning; cell communication; single-cell RNA seq; spatial transcriptomics

(This special issue belongs to the Section Cellular Pathology)

Molecular and Biochemical Mechanisms Elucidating Growth and Cellular Stress Responses of Microalgae

edited by

Krishna Mohan Poluri

and Damar Lizbeth López-Arredondo

submission deadline 1 Jul 2025 | 2 articles | Viewed by 6481 | Submission Open

Keywords: microalgal physiology; cellular stress; organic pollutants; inorganic pollutants; nano & micro plastics; nutrient limitations; growth promotors; carbon fixation; carbon flux channelization; bioenergy and bioproducts; biorefinery; molecular mechanisms; omics technologies

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Molecular Mechanisms and Pathophysiology of Diabetic Retinopathy

edited by

Siddharth Sunilkumar

, Stephanie L. Grillo and

Sandeep M. Subrahmanian

submission deadline 1 Jul 2025 | Viewed by 450 | Submission Open

Keywords: diabetic retinopathy; retina; retinal neurodegeneration; diabetic macular edema; pathophysiology of diabetic retinopathy; proliferative and non-proliferative diabetic retinopathy; molecular mediators of diabetic retinopathy; cell-based therapies for diabetic retinopathy

(This special issue belongs to the Section Cellular Pathology)

Microscopy in Structural Biology Research

edited by

Chandran R. Sabanayagam

submission deadline 1 Jul 2025 | Viewed by 152 | Submission Open

Keywords: cryo-electron microscopy (Cryo-EM); super-resolution microscopy; X-ray crystallography; structural biology; cellular architecture; biomolecular interactions; high-resolution structural analysis; integrative structural biology

(This special issue belongs to the Section Cell Methods)

Primary and Continued Cell Cultures

edited by

Xuefeng Liu

submission deadline 8 Jul 2025 | 5 articles | Viewed by 36788 | Submission Open

Keywords: primary normal cells; primary tumor cells; patient-derived cells; CRC (conditionally reprogrammed cells); organoids; circulating tumor cells; human diseases; toxicity; cancer models; drug discovery

(This special issue belongs to the Section Cell Methods)

Sickle Cell Disease: Pathogenesis, Diagnosis and Treatment

edited by Vivien Sheehan and Ben Kopp

submission deadline 10 Jul 2025 | 1 articles | Viewed by 1645 | Submission Open

Keywords: sickle cell disease; vaso-occlusive events; acute chest syndrome; omics; gene therapy; red cell rheology; microfluidics

(This special issue belongs to the Section Cellular Pathology)

Novel Insights into Molecular Mechanisms and Therapy of Asthma

edited by

Marco Caminati

submission deadline 15 Jul 2025 | 6 articles | Viewed by 28232 | Submission Open

(This special issue belongs to the Section Cellular Pathology)

Inflammation in Target Organs

edited by

Itamar Raz

and Roni Weinberg Sibony

submission deadline 15 Jul 2025 | 8 articles | Viewed by 17333 | Submission Open

Keywords: inflammation; fibrosis; cardio-renal; vascular; liver; brain

(This special issue belongs to the Section Cellular Immunology)

Advances in the Biogenesis, Biology, and Functions of Noncoding RNAs

edited by Xinguo Chen

submission deadline 15 Jul 2025 | 4 articles | Viewed by 8219 | Submission Open

Keywords: noncoding RNA biogenesis; long noncoding RNA (lncRNAs); circular RNA (circRNAs); enhancer RNA (eRNAs); microRNA (miRNAs); PIWI-interacting RNAs (pi-RNAs); tRNA-derived fragments (tRFs)

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

Stem Cells and Beyond: Innovations in Tissue Repair and Regeneration

edited by Aurora Almadori

submission deadline 15 Jul 2025 | 3 articles | Viewed by 2342 | Submission Open

Keywords: adipose-derived stem cells; mesenchymal stem cells; induced pluripotent stem cells; stromal vascular fraction; platelet-rich plasma; exosomes; polynucleotides; cytokines; growth factors; extracellular matrix; cell signaling; wound healing; ageing; immune response; inflammation; scarring

(This special issue belongs to the Section Stem Cells)

Gut Dysbiosis in Inflammatory Diseases

edited by Weiwei Liu

submission deadline 15 Jul 2025 | Viewed by 300 | Submission Open

Keywords: gut microbiota; innate and adaptive immunity; dysbiosis; metabolism; inflammatory bowel diseases; autoimmune diseases; metabolic disorders; fecal microbiota transplantation

(This special issue belongs to the Section Cellular Pathology)

Decoding Cancer Metabolism: Recent Insights and Future Directions

edited by Parash Prasad and Snehasis R. Mishra

submission deadline 15 Jul 2025 | Viewed by 194 | Submission Open

Keywords: glutamine metabolism; Warburg effect; anaplerosis; fatty acid metabolism; ferroptosis; oncometabolites; hypoxia; mitochondrial dynamics; reactive oxygen species; glutathione synthesis; nutrient sensing

Molecular and Cellular Mechanisms of Browning of Adipocytes in Metabolic Health and Disease

edited by You Lee Son and Yuko Okamatsu-Ogura

submission deadline 15 Jul 2025 | Viewed by 189 | Submission Open

Keywords: brown and white adipose tissue; BAT; and WAT; brown; beige; and white adipocyte; browning of white adipocyte; adipocyte differentiation; adipose tissue remodeling; adipose hyperplasia and hypertrophy; metabolic disorders; obesity; aging; inflammation

(This special issue belongs to the Section Cellular Pathology)

Molecular Mechanisms of Neuropathic Pain

edited by

Hiroshi Ueda

and

Norimitsu Morioka

submission deadline 20 Jul 2025 | 8 articles | Viewed by 11781 | Submission Open

Keywords: neuropathic pain; nociplastic pain; fibromyalgia; brain-immune connection; sexual dimorphism; glial cells; lysophosphatidic acid

(This special issue belongs to the Section Cells of the Nervous System)

Signaling Pathways in Endometrial Cancer Cells

edited by

Tomohiko Fukuda

submission deadline 20 Jul 2025 | 2 articles | Viewed by 4347 | Submission Open

Keywords: endometrial cancer; cellular signaling; cell metabolism; DNA damage repair pathway; the PI3K/AKT/mTOR pathway; the RAS/MAPK pathway; molecular classification

(This special issue belongs to the Section Cell Signaling)

Environmental Exposure and Cell Damage

edited by

Paola Piomboni

Alice Luddi

and

Melvin K. S. Leow

submission deadline 20 Jul 2025 | 1 articles | Viewed by 3879 | Submission Open

Keywords: cellular and molecular damage; oxidative stress; environmental effects; endocrine disruptors; lifestyle factors

(This special issue belongs to the Section Cellular Immunology)

The Role of Cilia in Health and Diseases—2nd Edition

edited by Rim Hjeij

submission deadline 20 Jul 2025 | 4 articles | Viewed by 3425 | Submission Open

Keywords: motile cilia; motile ciliopathy; Primary Ciliary Dyskinesia; genetic screening; bronchiectasis; hydrocephalus; laterality defects; infertility; gene therapy

Adipose-Derived Stem Cells: Current Applications and Future Directions

edited by

Yasuhito Ishigaki

submission deadline 20 Jul 2025 | 3 articles | Viewed by 3410 | Submission Open

Keywords: cell therapy; regenerative medicine; adipose-derived stem cells (ADSCs); exosome; cytokine

(This special issue belongs to the Section Stem Cells)

Advances in Intestinal Epithelial Plasticity and Regeneration

edited by

Aiguo Tian

submission deadline 20 Jul 2025 | 1 articles | Viewed by 2429 | Submission Open

Keywords: intestinal epithelium; epithelial plasticity; stem cells; tissue repair; self-renewal; regeneration

Role of Autophagy in Plant Cells

edited by

Alessio Papini

submission deadline 20 Jul 2025 | 1 articles | Viewed by 2134 | Submission Open

Keywords: autophagy; endoplasmic reticulum; TOR; vacuoles; lysosomes; mitochondria; plastids

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Protein Misfolding and Aggregation: From Molecular Mechanisms to Human Diseases

edited by Xinrui Gui and Jinjun Wu

submission deadline 20 Jul 2025 | 1 articles | Viewed by 908 | Submission Open

Keywords: protein aggregation; amyloid fibrils; protein quality control; neurodegenerative diseases

(This special issue belongs to the Section Cellular Biophysics)

Host–Microbial Interactions: Second Edition

edited by

Hung-Jen Liu

Brent L. Nielsen

and

Muhammad Munir

submission deadline 20 Jul 2025 | Viewed by 784 | Submission Open

Keywords: virus– host interactions; signaling pathway; virus entry; life cycle

(This special issue belongs to the Section Cellular Immunology)

Neurotoxicity and Neurodegenerative Diseases: The Potential of Regenerative Medicine

edited by Elisabetta Mormone, Paola Crociani and

Gianluigi Ubaldo Mazzoccoli

submission deadline 20 Jul 2025 | 1 articles | Viewed by 684 | Submission Open

Keywords: inflammation; iPSCs; MSCs; neural stem cells niche; neurodegeneration; regenerative medicine; ROS; PRP

(This special issue belongs to the Section Cellular Aging)

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