Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Role of Macrophages and Neutrophils in Chronic Inflammation-Related Disorders submission deadline 10 May 2025 | 5 articles | Viewed by 11030 | Submission Open
Keywords: chronic inflammation; neutrophils; macrophages; Alzheimer’ s disease; aging; cardiovascular diseases; obesity; cancer; fibrosis; tissue injury and repair
(This special issue belongs to the Section Cellular Immunology)
Molecular Signaling Pathways Associated with Neurotoxicity submission deadline 10 May 2025 | 2 articles | Viewed by 7306 | Submission Open
Keywords: neurotoxicity; signal transduction; heavy metals; environmental toxicants; neurodegeneration
(This special issue belongs to the Section Cells of the Nervous System)
Understanding the Interplay Between Autophagy and Neurodegeneration submission deadline 10 May 2025 | 2 articles | Viewed by 4474 | Submission Open
Keywords: autophagy; neurodegeneration; ATG; protein aggregates; misfolded proteins; toxic stimuli
(This special issue belongs to the Section Autophagy)
Molecular and Genetic Pathogenesis of Hematological Disorders
edited by
submission deadline 10 May 2025 | 1 articles | Viewed by 1542 | Submission Open
Keywords: hematological disorders; molecular and genetic mechanisms; signal transduction pathways; microenvironment; gene editing technologies; targeted therapies; novel biomarkers; mechanisms of treatment resistance; innovative therapeutic strategies
(This special issue belongs to the Section Cellular Pathology)
New Advances in Neuroinflammation
edited by and Michael Breckwoldt
submission deadline 15 May 2025 | 14 articles | Viewed by 41122 | Submission Open
Keywords: neuroinflammation; biomarkers; neurodegeneration; microglia; astrocytes; oligodendrocytes; neurological diseases; blood-brain barrier; imaging
(This special issue belongs to the Section Cells of the Nervous System)
Novel Therapeutic Targets and Approaches, Genetic Markers and Signaling Pathways in Neoplasms submission deadline 15 May 2025 | 10 articles | Viewed by 21958 | Submission Open
Keywords: cancer; neoplasms; personalized medicine; genetic markers; next-generation sequencing (NGS); whole-genome sequencing; signaling pathways in cancer; novel therapeutic targets; drug development
(This special issue belongs to the Section Cell and Gene Therapy)
Oral Tissue Stem Cells in Regenerative Dentistry submission deadline 15 May 2025 | 5 articles | Viewed by 12330 | Submission Open
Keywords: oral tissue stem cells; oral tissue regeneration; dental materials; stem cell-derived exosomes; stem cell engineering
(This special issue belongs to the Section Stem Cells)
New Insights into Therapeutic Targets for Cardiovascular Diseases submission deadline 15 May 2025 | 2 articles | Viewed by 4940 | Submission Open
Keywords: cardiovascular disease prevention and treatment; ischemic cardiomyopathies; endothelium injury/damage; cardiac remuscularization and repair; cardiovascular/angiogenic targets and biomarkers; targeted delivery platforms/systems/formulations; precision nanomedicine; targeted nano-theranostic applications; localized and systemic administration; safety and efficacy
(This special issue belongs to the Section Cells of the Cardiovascular System)
The Pathogenetic Triad of Chronic Airway Diseases—Inflammation, Tissue Destruction, and Airway Remodeling
edited by and Michael Wegmann
submission deadline 15 May 2025 | 2 articles | Viewed by 3945 | Submission Open
Keywords: chronic lung disease; inflammation; signaling pathway; disease models; tissue destruction; airway remodeling; epigenetics
(This special issue belongs to the Section Cellular Immunology)
Retinal Disorders: Cellular Mechanisms and Targeted Therapies
edited by
submission deadline 15 May 2025 | 2 articles | Viewed by 3654 | Submission Open
Keywords: inherited eye diseases; genome; omics; gene editing; iPS cells; animal models; single cell analysis; AI; epigenetics
(This special issue belongs to the Section Cellular Pathology)
Understanding the Extracellular Vesicles (EVs)-Mediated Horizontal Transfer of Non-coding RNAs submission deadline 15 May 2025 | 1 articles | Viewed by 3181 | Submission Open
Keywords: extracellular vesicles; non-coding RNA  ; horizontal transfer; RNA loading; RNA binding proteins
Caenorhabditis elegans: Model Organism, Endless Possibilities—Volume II
edited by
submission deadline 15 May 2025 | 2 articles | Viewed by 2419 | Submission Open
Keywords: Caenorhabditis elegans; C. elegans; model organism
Molecular Mechanisms and Therapeutic Targets of Autoimmune Diseases submission deadline 15 May 2025 | 1 articles | Viewed by 1294 | Submission Open
Keywords: systemic autoimmune diseases; inflammation; cytokines; proteomics; transcriptomics; metabolomics; flow cytometry; autoantibodies; molecular mechanisms; novel therapeutic approaches
(This special issue belongs to the Section Cellular Immunology)
Novel Mechanisms of Gene Regulation in Cardiac Development and Congenital Heart Defects
edited by
submission deadline 15 May 2025 | Viewed by 478 | Submission Open
Keywords: long noncoding RNA; epigenetic regulation; whole-genome sequencing; cardiomyocyte signaling; cardiovascular development  ; congenital heart defects
(This special issue belongs to the Section Cells of the Cardiovascular System)
New Trends and Advances in Diagnosis and Prognosis of Head and Neck Cancer from Carcinogenesis to Future Molecular Targeted Therapies: 2nd Edition submission deadline 20 May 2025 | 3 articles | Viewed by 4164 | Submission Open
Keywords: head and neck cancer; oral cancer; biomarker; prognosis; carcinogenesis; oral premalignant lesions; cancer stem cells; signaling pathways; molecular targeted therapy
(This special issue belongs to the Section Cellular Pathology)
Ion Channel Involvement in Neurological and Neuromuscular Disorders submission deadline 20 May 2025 | 1 articles | Viewed by 1961 | Submission Open
Keywords: ion channels; neurological diseases; neuromuscular diseases; personalized therapy
(This special issue belongs to the Section Cells of the Nervous System)
Ovarian Cancer and Endometriosis
edited by and
submission deadline 20 May 2025 | 1 articles | Viewed by 1092 | Submission Open
Keywords: ovarian cancer; endometriosis; microenvironment; cell-cell interaction; drug resistance; natural product
(This special issue belongs to the Section Cellular Pathology)
Metabolic Hallmarks in Cancer
edited by , Ubaldo Martinez-Outshoorn and Marta Mauro-Lizcano
submission deadline 20 May 2025 | Viewed by 337 | Submission Open
Keywords: cancer; metabolic reprogramming; metabolic adaptation; cancer energy metabolism; glycolysis; the Warburg effect; the reverse Warburg effect; glutamine addiction; the pentose phosphate pathway; cellular and molecular mechanisms; tumor microenvironment; novel therapeutic interventions
(This special issue belongs to the Section Cellular Metabolism)
Microglial Functions in Neurodegenerative Diseases: In Search of Potential Therapeutic Targets
edited by and María Martín Estebané
submission deadline 20 May 2025 | Viewed by 212 | Submission Open
Keywords: microglia; inflammation; neural damage; mitochondria; potential targets
(This special issue belongs to the Section Cellular Aging)
New Advances in Pluripotent Stem Cells
edited by Zack Wang
submission deadline 20 May 2025 | Viewed by 108 | Submission Open
Keywords: pluripotent stem cell; PSCs; disease modeling; 3D organoid models; gene; regenerative medicine; drug discovery
(This special issue belongs to the Section Stem Cells)
Targeting Tumor Metabolism and Epigenetics: Mechanisms and Therapeutic Strategies
edited by , and Íñigo Casafont
submission deadline 22 May 2025 | Viewed by 139 | Submission Open
Keywords: tumor metabolism; epigenetics; metabolic reprogramming; DNA methylation; histone modification; warburg effect; glycolysis inhibitors; fatty acid synthesis; chromatin remodeling; cancer therapy
(This special issue belongs to the Section Cellular Metabolism)
Novel Signaling Mechanisms of G Protein-Coupled Receptors
edited by
submission deadline 25 May 2025 | Viewed by 255 | Submission Open
Keywords: G protein-coupled receptor (GPCR); signal transduction; biased agonism; functional selectivity; arrestin; receptor cross-talk; receptor dimerization
Advances in the Cellular and Molecular Mechanisms of Cardiovascular Diseases
edited by and Katie S. Wraith
submission deadline 25 May 2025 | Viewed by 162 | Submission Open
Keywords: thrombosis; smooth muscle; endothelium; atherosclerosis; inflammation
(This special issue belongs to the Section Cells of the Cardiovascular System)
Neurobiology of Chronicity of Pain submission deadline 30 May 2025 | 1 articles | Viewed by 1920 | Submission Open
Keywords: pain; chronicity; synapses; receptors; brain circuits; depression; comorbidities
(This special issue belongs to the Section Cells of the Nervous System)
Current Research on Immunotherapy for Glioblastoma
edited by Markella Zannikou
submission deadline 30 May 2025 | Viewed by 125 | Submission Open
Keywords: GBM; tumor microenvironment; cancer vaccines; TIL (tumor-infiltrating lymphocytes) therapy; combination therapy; BiTEs; immune checkpoint therapy; CAR T-cell therapy; peptide/dendritic vaccines; tumor-associated antigens; oncolytic virotherapy
(This special issue belongs to the Section Cellular Immunology)
Modeling Developmental Processes and Disorders in Zebrafish submission deadline 31 May 2025 | 12 articles | Viewed by 38833 | Submission Open
(This special issue belongs to the Section Cellular Biophysics)
Advances in Scanning Probe Microscopy in Cell Biology submission deadline 31 May 2025 | 14 articles | Viewed by 32687 | Submission Open
Cellular and Molecular Basis in Chronic Kidney Disease submission deadline 31 May 2025 | 6 articles | Viewed by 12953 | Submission Open
Keywords: CKD; renal inflammation; renal fibrosis; RAAS; aldosterone; TGF-B1; uremic toxins; hypertension; GFR; albuminuria
(This special issue belongs to the Section Cellular Pathology)
The Current Applications and Potential of Stem Cell-Derived Organoids submission deadline 31 May 2025 | 3 articles | Viewed by 10125 | Submission Open
Keywords: organoids; stem cell-derived organoids; stem cells; pluripotent stem cells; iPSCs; organ-on-a-chip; disease modelling; cellular therapeutics; regenerative medicine
(This special issue belongs to the Section Stem Cells)
Cell-to-Cell Crosstalk as a Target of Therapies submission deadline 31 May 2025 | 2 articles | Viewed by 4261 | Submission Open
Keywords: cell-to-cell crosstalk; cellular communication; microenvironment; extracellular vesicles; diagnostic tools; membrane nanotubes; pathogenesis; therapy; cell metabolism; homeostasis
Metabolic Regulation of Hematopoietic Stem Cells
edited by
submission deadline 31 May 2025 | 1 articles | Viewed by 3752 | Submission Open
Keywords: hematopoietic stem cells; metabolic regulation; mitochondrial function; self-renewal and differentiation; quiescence; energy metabolism; HSC exhaustion; aging; bm niche; leukemia stem cells (LSCs)
(This special issue belongs to the Section Stem Cells)
Extracellular Vesicles as Biomarkers for Human Disease
edited by
submission deadline 31 May 2025 | 3 articles | Viewed by 3751 | Submission Open
Keywords: extracellular vesicles; exosomes; biomarkers; human diseases; diagnostic applications; prognostic indicators; EV subtypes; isolation techniques
(This special issue belongs to the Section Intracellular and Plasma Membranes)
Mechanisms of Respiratory Diseases submission deadline 31 May 2025 | 1 articles | Viewed by 3548 | Submission Open
Keywords: cell death/stress; DNA/RNA sensor; cGAS/STING; inflammasome; microbiome; FMT or transfer of bacteria; metabolite; viral infection; emphysema; progressive fibrosis; innate immune response; defined inhibitors
(This special issue belongs to the Section Cellular Pathology)
Recent Advances in Metabolism and Oxidative Stress in Human Diseases 2.0
edited by and Vanessa Cossu
submission deadline 31 May 2025 | 2 articles | Viewed by 3166 | Submission Open
Keywords: antioxidant responses; redox balance; ROS; hematologic oncology; solid tumors; immune response; ATP; cancer cells; mitochondria-ER interactions; endoplasmic reticulum; glucose metabolism; inflammation; mitochondria; mitochondrial dynamics; autophagy; mitophagy; metabolic plasticity; metabolism
(This special issue belongs to the Section Cellular Metabolism)
Extracellular Vesicle-Based Therapeutics: Current Advances and Future Perspectives
edited by Heather Branscome
submission deadline 31 May 2025 | 2 articles | Viewed by 2919 | Submission Open
Keywords: extracellular vesicles (EVs); stem cells; mesenchymal stem cells; in vitro cellular repair models; animal models for repair and or/tissue regeneration; cell-free therapy
Cellular Glycosphingolipids in Human Disease submission deadline 31 May 2025 | 1 articles | Viewed by 2766 | Submission Open
Keywords: glycosphingolipid; cancer; sphingolipid; signal transduction; epithelial to mesenchymal; ceramide; microdomain; chemoresistance; glucosylceramide; ganglioside; globoside; lactoside; neolactoside; sulfatide; GSL
(This special issue belongs to the Section Cellular Pathology)
Advances in Muscle Research in Health and Disease—2nd Edition
edited by
submission deadline 31 May 2025 | 2 articles | Viewed by 2615 | Submission Open
Keywords: skeletal muscle; cardiac muscle; smooth muscle; myocyte; vascular smooth muscle cell; stem cell; development; homeostasis; regeneration; biomarker; therapeutic target
(This special issue belongs to the Section Tissues and Organs)
Cellular and Molecular Mechanisms in Oxidative Stress-Related Chronic Diseases
edited by Sara Spinelli, and
submission deadline 31 May 2025 | 1 articles | Viewed by 2350 | Submission Open
Keywords: aging; age-related diseases; redox system; cellular and molecular mechanisms; oxidative stress biomarkers; synthetic and natural antioxidant molecules
(This special issue belongs to the Section Cellular Pathology)
Insight into Lipid Droplets
edited by
submission deadline 31 May 2025 | 1 articles | Viewed by 2047 | Submission Open
Keywords: lipid droplet; lipid droplet protein; lipid droplet biogenesis; lipid droplet growth; lipid droplet degradation; lipid droplet– organelle interaction; lipid metabolism; lipid-metabolism-related diseases
(This special issue belongs to the Section Cellular Biophysics)
Non-Coding and Coding RNAs in Targeted Cancer Therapy submission deadline 31 May 2025 | 3 articles | Viewed by 1790 | Submission Open
Keywords: gene expression; non-coding RNAs; lncRNAs; microRNAs; piwi-associated RNA; circular RNAs; therapeutic targets
(This special issue belongs to the Section Cell and Gene Therapy)
Cellular Mechanisms in Mitochondrial Function and Calcium Signaling
edited by Sergio De la Fuente and Jaime Santo-Domingo
submission deadline 31 May 2025 | 1 articles | Viewed by 1650 | Submission Open
Keywords: mitochondria; calcium; MCU; uniporter; NCLX; energy metabolism; disease; MAMs; signaling
(This special issue belongs to the Section Cellular Metabolism)
Emerging Insights into Natural Killer Cell Immunity in Infection and Cancer
edited by Sumit Sen Santara, , Weshely Kujur and Sachin Mulik
submission deadline 31 May 2025 | 1 articles | Viewed by 915 | Submission Open
Keywords: CAR NK cells; cancer immunotherapy; cell therapy; viral infection; memory NK cells; NK cell targeted therapies; NK-immune cell crosstalk; exosomes
(This special issue belongs to the Section Cellular Immunology)
The Role of Stem Cells and Circadian Clock in Cancer Immunotherapy
edited by Yool Lee
submission deadline 31 May 2025 | 1 articles | Viewed by 908 | Submission Open
Keywords: circadian clock; circadian disruption; neural stem cells; cancer stem cells; tumor– immune microenvironment; cancer chronotherapy
(This special issue belongs to the Section Stem Cells)
The Role of T-Cells in Lymphomas and Leukemias
edited by
submission deadline 31 May 2025 | 1 articles | Viewed by 701 | Submission Open
Keywords: T cells; regulatory T cells; leukemia; lymphoma; hematological malignancies; chimeric antigen receptor; CAR T cells; tumor microenvironment; tumor-infiltrating T cells; TCR; adoptive T cell therapy; TCR-engineered T cells
(This special issue belongs to the Section Cellular Immunology)
Genetic and Cellular Basis of Autoimmune Diseases
edited by
submission deadline 31 May 2025 | 1 articles | Viewed by 667 | Submission Open
Keywords: autoimmune disease; break of tolerance; effector cells; immunodysregulation; risk genes
(This special issue belongs to the Section Cellular Immunology)
G Protein-Coupled Receptors and Diseases
edited by
submission deadline 31 May 2025 | Viewed by 389 | Submission Open
Keywords: G protein-coupled receptor; taste receptor; microbiome; cancer; aging; neurodegenerative disease; cardiovascular disease; pulmonary hypertension; cell survival; cell death; apoptosis; autophagy; necroptosis; ferroptosis; proliferation
Development of PET Radiotracers for Imaging Alpha-Synuclein
edited by and Jamie Eberling
submission deadline 31 May 2025 | Viewed by 370 | Submission Open
Keywords: alpha-synuclein; Parkinson’ s disease; multiple system atrophy; positron emission tomography
(This special issue belongs to the Section Cellular Aging)
Role of Calpains in Health and Diseases
edited by and Peter A. Greer
submission deadline 31 May 2025 | Viewed by 317 | Submission Open
Keywords: calpain; physiology; biochemistry; disease; mutation; target; inhibitor
(This special issue belongs to the Section Cellular Pathology)
New Insight into Tumor–Tumor Microenvironment Crosstalk submission deadline 31 May 2025 | Viewed by 265 | Submission Open
Keywords: tumor– microenvironment interaction; cancer therapy; signaling; extracellular matrix; immune cells; cell networks; tumorigenesis; cancer metabolism; tumor cell plasticity
(This special issue belongs to the Section Cell Microenvironment)
Immunity to Infections—Respiratory
edited by
submission deadline 31 May 2025 | Viewed by 231 | Submission Open
Keywords: immune responses; infections; neutrophils; macrophages; lymphocytes; respiratory pathogens
(This special issue belongs to the Section Cellular Immunology)
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