Applications of Organ-on-a-Chip Model in Vascular Disease

Dear Colleagues,

Organ-on-a-chip technologies have emerged as powerful platforms to recapitulate key structural, mechanical and biochemical features of human vascular tissues at the cellular and microenvironmental levels in vitro. By integrating living vascular cells within perfusable microfluidic architectures, these systems enable precise control of hemodynamic forces, oxygen and nutrient gradients, extracellular matrix properties and inflammatory or thrombotic cues, thereby providing unique opportunities to interrogate cellular behaviors, signal transduction pathways and dynamic cell–cell and cell–matrix interactions in vascular biology. This Special Issue, “Applications of Organ-on-a-Chip Model in Vascular Disease,” aims to highlight cutting-edge advances that leverage these platforms to dissect the cellular and molecular mechanisms underlying vascular pathologies and support the development and evaluation of experimental vascular models.

We welcome original research articles, reviews and perspectives spanning the full spectrum of vascular disease, including atherosclerosis, aneurysm, thrombosis, microvascular dysfunction, pulmonary and systemic hypertension and rare vascular and blood disorders. Contributions may address mechanism-driven model development and validation, the incorporation of patient-derived or stem-cell–derived vascular cells, the analysis of flow-dependent signaling, mechanotransduction, and endothelial dysfunction, multi-organ and immune–vascular interactions as well as applications in drug screening and toxicity testing from a mechanistic and cellular perspective. By bringing together engineers, biologists and clinician-scientists, this Special Issue seeks to define the current state of the art in vascular organ-on-a-chip research and outline future directions for using microphysiological systems to advance fundamental vascular cell biology and disease mechanisms.

Dr. Abidemi Junaid
Dr. Netanel Korin
Guest Editors

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