Applications of Organ-on-a-Chip Model in Vascular Disease
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Cardiovascular System".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 162
Special Issue Editors
Interests: organs-on-chips; vascular biology; metabolomics; immunology; infectious diseases; women’s health
Interests: microphysiological systems; vascular biomechanics and hemodynamics; thrombosis and thromboinflammation; vascular-targeted therapeutics; drug delivery under flow; cardiovascular and inflammatory diseases
Special Issue Information
Dear Colleagues,
Organ-on-a-chip technologies have emerged as powerful platforms to recapitulate key structural, mechanical and biochemical features of human vascular tissues at the cellular and microenvironmental levels in vitro. By integrating living vascular cells within perfusable microfluidic architectures, these systems enable precise control of hemodynamic forces, oxygen and nutrient gradients, extracellular matrix properties and inflammatory or thrombotic cues, thereby providing unique opportunities to interrogate cellular behaviors, signal transduction pathways and dynamic cell–cell and cell–matrix interactions in vascular biology. This Special Issue, “Applications of Organ-on-a-Chip Model in Vascular Disease,” aims to highlight cutting-edge advances that leverage these platforms to dissect the cellular and molecular mechanisms underlying vascular pathologies and support the development and evaluation of experimental vascular models.
We welcome original research articles, reviews and perspectives spanning the full spectrum of vascular disease, including atherosclerosis, aneurysm, thrombosis, microvascular dysfunction, pulmonary and systemic hypertension and rare vascular and blood disorders. Contributions may address mechanism-driven model development and validation, the incorporation of patient-derived or stem-cell–derived vascular cells, the analysis of flow-dependent signaling, mechanotransduction, and endothelial dysfunction, multi-organ and immune–vascular interactions as well as applications in drug screening and toxicity testing from a mechanistic and cellular perspective. By bringing together engineers, biologists and clinician-scientists, this Special Issue seeks to define the current state of the art in vascular organ-on-a-chip research and outline future directions for using microphysiological systems to advance fundamental vascular cell biology and disease mechanisms.
Dr. Abidemi Junaid
Dr. Netanel Korin
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- organ‑on‑a‑chip
- microfluidics
- vascular disease
- endothelial dysfunction
- hemodynamics and shear stress
- thrombosis and inflammation
- drug screening
- precision medicine
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
