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5.1
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Cells
Special Issues
Advances in Zebrafish Disease Models
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Advances in Zebrafish Disease Models

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: 1 June 2025 | Viewed by 2579

Special Issue Editors

Dr. Natalia Kasica

E-Mail Website
Guest Editor
Department of Animal Anatomy, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland
Interests: zebrafish; human disease models; experimental disease models; novel drugs and therapies; natural products; neurotransmitters; innate immune response
Dr. Jaroslaw Widelski

E-Mail Website
Guest Editor
Department of Pharmacognosy with Medicinal Plant Unit, Medical University of Lublin, Chodzki, 120-093 Lublin, Poland
Interests: natural products; zebrafish
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Modeling human diseases to comprehend their etiology and pathogenesis, along with developing new therapies, is still a big challenge for researchers around the world. On the one hand, we still struggle with understanding the detailed mechanisms behind already described disorders aiming at discovering more effective drugs, and on the other hand, the need of the hour is to cope with absolutely novel diseases arising from human factors, ecological changes, and microorganisms evolution and adaptation. Hence, the effective living or simulated model is of paramount interest. Within the last few decades, the zebrafish became an excellent scientific tool for investigating various diseases ranging from cancer to metabolic, behavioral to developmental, infectious to those related to toxicology as well as age-related ones. Valuable biological characteristics and considerable human genome homology make the zebrafish an excellent animal research model, partially replacing the mammalian models. The growth of its use in medical translation research is the greatest proof for its utility in this field. Therefore, this Special Issue aims to present original papers revealing the vast advances on zebrafish disease models. We strongly encourage you to share your research presenting new approaches and insights into molecular, cellular, and functional disease modeling using zebrafish.

Dr. Natalia Kasica
Dr. Jaroslaw Widelski
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • zebrafish
  • human disease models
  • experimental disease models
  • novel drugs and therapies
  • organic diseases
  • functional disorders

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Published Papers (2 papers)

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15 pages, 5336 KiB  
Article
Trehalose Ameliorates Zebrafish Emotional and Social Deficits Caused by CLN8 Dysfunction
by Rosario Licitra, Stefania Della Vecchia, Lorenzo Santucci, Rachele Vivarelli, Sara Bernardi, Filippo M. Santorelli and Maria Marchese
Cells 2025, 14(1), 55; https://doi.org/10.3390/cells14010055 - 5 Jan 2025
Viewed by 1139
Abstract
CLN8 and other neuronal ceroid lipofuscinoses (NCLs) often lead to cognitive decline, emotional disturbances, and social deficits, worsening with disease progression. Disrupted lysosomal pH, impaired autophagy, and defective dendritic arborization contribute to these symptoms. Using a cln8−/− zebrafish model, we identified significant [...] Read more.
CLN8 and other neuronal ceroid lipofuscinoses (NCLs) often lead to cognitive decline, emotional disturbances, and social deficits, worsening with disease progression. Disrupted lysosomal pH, impaired autophagy, and defective dendritic arborization contribute to these symptoms. Using a cln8−/− zebrafish model, we identified significant impairments in locomotion, anxiety, and aggression, along with subtle deficits in social interactions, positioning zebrafish as a useful model for therapeutic studies in NCL. Our findings show that trehalose, an autophagy enhancer, ameliorates anxiety, and modestly improves social behavior and predator avoidance in mutant zebrafish. This finding aligns animal models with clinical reports suggestive of behavioral improvements in NCL patients. Trehalose holds promise as a therapeutic agent for CLN8, warranting further research into its neuroprotective mechanisms and clinical applications. Full article
(This article belongs to the Special Issue Advances in Zebrafish Disease Models)
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22 pages, 2087 KiB  
Systematic Review
Valproate-Induced Model of Autism in Adult Zebrafish: A Systematic Review
by Diletta Camussi, Maria Marchese, Ferdinando Nicoletti, Filippo Maria Santorelli and Asahi Ogi
Cells 2025, 14(2), 109; https://doi.org/10.3390/cells14020109 - 13 Jan 2025
Viewed by 1087
Abstract
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social skills and the presence of repetitive and restricted behaviors and interests. The social behavior of the zebrafish (Danio rerio) makes this organism a valuable tool for modeling ASD in order [...] Read more.
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social skills and the presence of repetitive and restricted behaviors and interests. The social behavior of the zebrafish (Danio rerio) makes this organism a valuable tool for modeling ASD in order to explore the social impairment typical of this disorder. In addition to transgenic models, exposure of zebrafish embryos to valproic acid (VPA) has been found to produce ASD-like symptoms. This review first sets out to examine the existing literature on adult social behavior in the zebrafish VPA-induced model of autism, and the authors also aim to identify the ideal VPA dosage able to induce a persistent and long-lasting ASD-like phenotype while minimizing the suffering and distress of research animals in compliance with the principles of replacement, refinement, and reduction (3Rs). Full article
(This article belongs to the Special Issue Advances in Zebrafish Disease Models)
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