Integrating Advanced Cellular Models in Radiation Biology: From Electromagnetic Fields to Photons and Emerging Particle Modalities

A Special Issue of Cells (ISSN 2073-4409) belonging to the section "Cellular Biophysics".

Deadline for manuscript submissions: 10 October 2026 | Viewed by 756

Editors


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Guest Editor
Department of Life and Environmental Physics, Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering, 077125 Magurele, Romania
Interests: radiobiology; neurobiology; neuro-oncology; cellular biology; DNA damage and repair

Special Issue Information

Dear Colleagues,

Radiation research represents a multidisciplinary field in which physics and nuclear engineering intersect with biochemistry and molecular biology to advance medical innovation. The radiation spectrum encompasses a wide range of modalities, from non-ionizing electromagnetic fields (microwaves, radiofrequency, and infrared) and ultraviolet (UV) radiation to ionizing photons (X-ray and gamma rays) and particle radiation (protons, carbon ions, and other heavy ions), each possessing distinct physical characteristics.

Consequently, biological responses to radiation vary widely depending on both the radiation quality and the specific cellular and tissue context. Understanding these interactions at the molecular, cellular, and tissue level is critical for improving radiation-based applications. While simplified in vitro models provide important mechanistic insights and experimental advantages, more complex preclinical models are often required to capture physiologically relevant responses, both in therapeutic settings and in radioprotection research.

This Special Issue welcomes contributions that explore cellular and molecular radiation responses across diverse biological models and radiation types. We particularly encourage the submission of papers addressing novel experimental approaches, advanced biological models, and innovative radiation delivery techniques.

Dr. Mihaela Temelie
Dr. Diana Savu
Guest Editors

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Keywords

  • ionizing radiation
  • particle radiation
  • electromagnetic
  • radiation biology
  • cell cultures
  • preclinical models

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Published Papers (1 paper)

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Research

27 pages, 6112 KB  
Article
3.75 THz Repetitive Radiation Regulates Collagen Metabolism in Human Fetal Scleral Fibroblasts
by Wenxia Wang, Liu Sun, Lei Wang, Jinwu Zhao, Pandeng Hou and Mingxia He
Cells 2026, 15(14), 1285; https://doi.org/10.3390/cells15141285 - 17 Jul 2026
Viewed by 411
Abstract
The sclera constitutes a critical structural element of the eyeball, as its biomechanical properties and structural integrity are primarily governed by collagen metabolism. Using a controlled in vitro experimental system, the present study explored the quantitative relationship between exposure duration to terahertz radiation [...] Read more.
The sclera constitutes a critical structural element of the eyeball, as its biomechanical properties and structural integrity are primarily governed by collagen metabolism. Using a controlled in vitro experimental system, the present study explored the quantitative relationship between exposure duration to terahertz radiation of distinct frequencies (3.10 THz and 3.75 THz) and the transcriptional expression of collagen metabolism-associated genes in human fetal scleral fibroblasts (HFSFs). During the 120 min terahertz irradiation exposure, neither of the two frequencies produced significant regulatory effects on collagen metabolism-associated genes in normal and hypoxia-induced HFSFs. However, 3.75 THz radiation had markedly raised the expression level of the COL1A1 gene in HFSFs 12 h after the terahertz radiation stopped. Proteomic analysis was conducted on scleral fibroblasts exposed to repeated radiation at 3.75 THz. Proteomic analysis identified a total of 213 differentially expressed proteins (DEPs), comprising 172 downregulated proteins and 41 upregulated proteins. These DEPs were predominantly enriched in ribosome-associated proteins and mitochondrial function-related proteins, suggesting a potential regulatory role in intracellular protein synthesis and ATP production. Furthermore, the study demonstrated that expression levels of fourteen proteins associated with the collagen-rich extracellular matrix exhibited a marked enrichment trend, indicating that repeated exposure to 3.75 THz radiation induces remodeling changes in the scleral extracellular matrix (ECM). This study demonstrates the impacts of terahertz radiation on collagen metabolism of HFSFs and provides preliminary molecular evidence, yet direct functional effects remain unconfirmed. These findings provide theoretical and experimental bases for studying the regulation of scleral collagen metabolism by terahertz radiation. Full article
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