Aging, Oxidative Stress, and Inflammation in Ocular Diseases
A Special Issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 30 September 2026 | Viewed by 1111
Editor
Interests: cellular senescence; translational research; gene therapy; senotherapies; epigenome analysis; age related cataract (ARC) and glaucoma
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The global burden of age-related ocular diseases continues to rise as populations worldwide live longer. Conditions such as age-related macular degeneration, glaucoma, diabetic retinopathy, and cataracts remain leading causes of visual impairment and blindness, profoundly impacting quality of life and healthcare systems. While the clinical manifestations of these diseases are diverse, they share common underlying mechanisms that converge on three interconnected processes: aging, oxidative stress, and inflammation.
Aging represents the primary risk factor for most ocular pathologies, yet the molecular and cellular pathways through which chronological age translates into tissue dysfunction remain incompletely understood. Within the eye, post-mitotic tissues accumulate oxidative damage over decades, leading to mitochondrial dysfunction, protein aggregation, and chronic low-grade inflammation—a phenomenon increasingly recognized as inflammaging. The delicate balance between pro-inflammatory and anti-inflammatory signals determines whether the ocular microenvironment maintains homeostasis or progresses toward degeneration.
This Special Issue aims to bring together cutting-edge research exploring the complex interplay between aging, oxidative stress, and inflammation in the pathogenesis of ocular diseases. We welcome original research articles, reviews, and perspective pieces that investigate molecular mechanisms, identify novel biomarkers, or evaluate therapeutic interventions targeting these pathways. By deepening our understanding of how these fundamental processes drive ocular pathology, we hope to illuminate new strategies for prevention, early detection, and treatment that will preserve vision for aging populations worldwide.
Dr. Bhavana Chhunchha
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- aging
- oxidative stress
- inflammation
- ocular diseases
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
