mRNA Regulation in Endoplasmic Reticulum Stress and Protein Homeostasis
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell and Gene Therapy".
Deadline for manuscript submissions: 30 September 2026
Special Issue Editors
Interests: pancreatic cancer; endoplasmic reticulum stress; unfolded protein response; protein homeostasis
Interests: autophagy; unfolded protein response; apoptosis; lung cancer; glioblastoma; rhabdomyosarcoma; cell phenotype; drug development; cell fate
Special Issues, Collections and Topics in MDPI journals
Interests: ER quality control; ERAD; glycoprotein misfolding; ER stress; UPR; protein aggregation; huntington disease; neurodegenerative diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Protein translation is a tightly coordinated and highly conserved cellular process that plays a crucial role in gene expression. Translational control is essential for maintaining homeostasis in the cell and other cellular functions, including proliferation, growth, and development. While inhibiting one or more components of translation induces global translational regulation, specific regulation involves the cis elements of mRNA, trans-acting proteins, and microRNAs. During endoplasmic reticulum stress (ER stress), a cell evokes a network of adaptive signaling pathways collectively referred to as the unfolded protein response (UPR), which induces global translation inhibition and enhances mRNA-specific translation to maintain protein homeostasis in the cell. Defective UPR is associated with many neurological diseases, metabolic diseases, and even cancer.
Even though a lot of research has focused on this area for the last two decades, there is still a knowledge gap in this complex network of cellular processes. Finding out novel factors, unraveling molecular mechanisms, and crosstalk interactions with other signaling pathways are necessary for a better understanding of these stress-induced cellular conditions.
This Special Issue aims to provide novel insights into the molecular mechanisms of translational regulation of ER stress and protein homeostasis pathways. We welcome comprehensive reviews and original research articles in this field, including, but not limited to, the following topics:
- Stress-induced mRNAs;
- Regulatory mechanisms of unique mRNAs;
- Molecular Targets and Biomarkers;
- Methods to detect complex mRNA regulation;
- RNA degradation pathway;
- MRNAs implicated in cancer and other diseases;
- Novel factors involved in ER stress and UPR;
- Other non-canonical pathways of UPR;
- Crosstalk interactions between UPR and other signaling pathways.
Dr. Jagadeesh Uppala
Dr. Saeid Ghavami
Prof. Dr. Gerardo Z. Lederkremer
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- mRNA
- secondary structures of mRNA
- upstream open reading frames (uORFs)
- biomarkers
- endoplasmic reticulum stress
- unfolded protein response
- protein homeostasis
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