Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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From Energy Metabolism to Disease: The Multifaceted Roles of Mitochondria
edited by Amy H. Attaway and Saurabh Mishra
submission deadline 20 Oct 2026 | 2 articles | Viewed by 3199 | Submission Open
Keywords: mitochondrial oxidation; ROS; aging; disease
Vascular Biology: From Molecular Mechanisms to Precision Therapies
edited by Payaningal R. Somanath
submission deadline 20 Oct 2026 | 2 articles | Viewed by 1356 | Submission Open
Keywords: angiogenesis; endothelium; vascular permeability; blood– tissue barrier; organ injury
PI3K/AKT/mTOR Signaling Network in Human Health and Diseases, 3rd Edition submission deadline 20 Oct 2026 | 1 articles | Viewed by 923 | Submission Open
Keywords: acne; ageing; Akt; Alzheimer’ s disease; autophagy; autoimmunity; PI3K; mTOR; cancer; cardiovascular diseases; diabetes; growth; hamartoma; hypertrophy; inflammation; neurologic; tuberous sclerosis; systemic sclerosis; obesity; Parkinson’ s disease; psoriasis; atopic dermatitis; burns/wound healing; targeted therapy; natural products; biologics
Exclusive Review Papers in 'Cellular Biophysics'
edited by
submission deadline 20 Oct 2026 | Viewed by 189 | Submission Open
Keywords: cellular biophysics; membrane biophysics; cytoskeletal dynamics; cellular mechanics; mechanotransduction; phase separation; molecular motors; bioelectricity; single-molecule techniques; computational biophysics; mechanobiology; active matter
(This special issue belongs to the Section Cellular Biophysics)
Cellular Pathophysiology of Intensive Care Unit-Acquired Muscle Dysfunction
edited by Lars Larsson
submission deadline 20 Oct 2026 | Viewed by 142 | Submission Open
Keywords: intensive care unit-acquired weakness; ventilator-induced diaphragm dysfunction; skeletal muscle atrophy; protein degradation; mitochondrial dysfunction; JAK-STAT signaling; oxidative stress; critical illness myopathy; autophagy; muscle proteostasis
(This special issue belongs to the Section Cellular Pathology)
New Advances and Perspectives in the Molecular Mechanisms of Aging and Skin Cancer: Potential Options for Prevention and Treatment
edited by and Ewelina Musielak
submission deadline 20 Oct 2026 | Viewed by 79 | Submission Open
Keywords: skin cancer; malignancy; melanoma; non-melanoma; prevention; skin aging; skin photo-aging; skin inflammation; treatment; inflammaging; immune dysfunction; senescent cell
(This special issue belongs to the Section Cellular Aging)
Polyadenylation-Mediated Regulation of Pulmonary Diseases submission deadline 20 Oct 2026 | Viewed by 64 | Submission Open
Keywords: polyadenylation; lung remodeling; pulmonary fibrosis; epitranscriptomics; alveolar epithelial cells
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
Regulatory Factors and Signaling Pathways of Anti-Tumor Immune Responses
edited by
submission deadline 22 Oct 2026 | Viewed by 245 | Submission Open
Keywords: anti-tumor immunity; immunotherapy; immune checkpoint blockade; immune receptor and ligand; immune evasion; tumor immune microenvironment; inflammation; T-cell activation and inhibition; myeloid-derived suppressor cell; macrophage; dendritic cell
(This special issue belongs to the Section Cellular Immunology)
The Dual Role of Extracellular Vesicles in Neurodegeneration: Disease Biomarkers and Drug Delivery Platforms Within the Matrix Microenvironment submission deadline 25 Oct 2026 | 1 articles | Viewed by 464 | Submission Open
Keywords: extracellular vesicles; neurodegenerative diseases; extracellular matrix; biomarkers; therapeutic applications; drug delivery
(This special issue belongs to the Section Intracellular and Plasma Membranes)
Caveolae Function in Cell Membrane Dynamics and Signal Transduction submission deadline 25 Oct 2026 | Viewed by 295 | Submission Open
Keywords: caveolae; caveolin and cavin proteins; plasma membrane organization; endocytosis and vesicular trafficking; mechanotransduction; lipid rafts and cholesterol metabolism; signal transduction; vascular biology and angiogenesis; cancer cell biology; membrane remodeling in disease
Nuclear Receptors, Drug Discovery, Nutraceuticals, and Neurodegenerative Diseases
edited by Rajesh Haresh Amin, and Meenakshi Singh
submission deadline 25 Oct 2026 | Viewed by 93 | Submission Open
Keywords: nuclear receptors; neurodegenerative diseases; metabolic dysfunction; inflammation; drug design
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
Tumor Microenvironment and Immune Regulation
edited by
submission deadline 25 Oct 2026 | Viewed by 90 | Submission Open
Keywords: cellular immunology; tumor microenvironment; intra- and extracellular signaling; immunometabolism; experimental cytology; tumor-infiltrating lymphocytes; spatial transcriptomics
(This special issue belongs to the Section Cell Microenvironment)
Vascular Microenvironment and Atherosclerosis submission deadline 25 Oct 2026 | Viewed by 79 | Submission Open
Keywords: vascular microenvironment; atherosclerosis; vascular inflammation; endothelial cells; smooth muscle cells; vascular– immune cell interactions; extracellular matrix; vascular remodeling; mechanotransduction; vascular biology
(This special issue belongs to the Section Cells of the Cardiovascular System)
Advances in Annexin Biology
edited by , and Nunzia Novizio
submission deadline 28 Oct 2026 | 1 articles | Viewed by 1050 | Submission Open
Keywords: annexin family; calcium-dependent membrane binding; cell signaling; inflammation and immune response; membrane repair; cancer biology; cell motility; cell differentiation; tumor microenvironment; diagnostic/prognostic biomarkers; therapeutic targets
Role of Thyroid Hormone in Neurodegenerative and Neurodevelopmental Disorders
edited by Janaína Sena de Souza
submission deadline 30 Oct 2026 | 5 articles | Viewed by 15697 | Submission Open
Keywords: thyroid hormones; neurodevelopmental and neurodegenerative disorders; central nervous system
(This special issue belongs to the Section Cellular Neuroscience)
Advances in Reproductive Biology: Cellular and Molecular Mechanisms
edited by and Clara González-Marín
submission deadline 30 Oct 2026 | 6 articles | Viewed by 9312 | Submission Open
Keywords: gametogenesis; fertilization; embryo implantation; reproductive genetics; epigenetics in reproduction; hormonal signaling; stem cells and reproduction; assisted reproductive technologies (ARTs); molecular fertility regulation; reproductive health innovations
(This special issue belongs to the Section Reproductive Cells and Development)
Identifying Functional Genomics and Pathways in Cancer Pathogenesis and Therapy Resistance
edited by and Ramkrishna Mitra
submission deadline 30 Oct 2026 | 3 articles | Viewed by 6807 | Submission Open
Keywords: functional genomics; cancer signaling pathways; targeted therapy; drug resistance; tumor microenvironment; oncogenomics; acquired resistance; tumor mutations
(This special issue belongs to the Section Cellular Pathology)
Translational Aspects of Cell Signaling
edited by
submission deadline 30 Oct 2026 | 4 articles | Viewed by 5121 | Submission Open
Keywords: cell signaling; drug development; prognostic markers; bioinformatics; translational research
Mechanisms and Therapies of Cell Death Pathways
edited by and Deniz Gulfem Ozturk
submission deadline 30 Oct 2026 | 1 articles | Viewed by 1759 | Submission Open
Keywords: cell death; mitochondrial regulation; BCL-2 family; non-apoptotic cell death; cell death pathways interactions; small molecules; therapeutic strategy; therapy resistance
(This special issue belongs to the Section Cellular Pathology)
New Therapeutic Approaches to Cardiac Repair
edited by Dinakar Iyer
submission deadline 30 Oct 2026 | 1 articles | Viewed by 713 | Submission Open
Keywords: cardiac regeneration; CRISPR/base editing; mRNA therapeutics; circular RNA (circRNA); lipid nanoparticles (LNPs); engineered exosomes/extracellular vesicles; direct cardiac reprogramming; engineered heart muscle/3D cardiac patches; myocardial infarction repair; translational cardiology
Extracellular Vesicles in Chronic Obstructive Pulmonary Disease: A 2025 Update
edited by and
submission deadline 30 Oct 2026 | Viewed by 334 | Submission Open
Keywords: extracellular vesicles (EVs); chronic obstructive pulmonary disease (COPD); inflammation; epithelial barrier; cellular senescence; tissue remodeling; biomarkers; exacerbations; microbiota; therapeutic targets
Mechanism of Endocrine Therapy Resistance in Breast Cancer
edited by and Clodia Osipo
submission deadline 30 Oct 2026 | Viewed by 311 | Submission Open
Keywords: estrogen receptor; endocrine resistance; mechanism of action; predictive biomarkers; signal transduction; novel therapeutics; drug sequencing; drug targets; pathological findings
(This special issue belongs to the Section Cellular Pathology)
Cellular and Molecular Basis in Chronic Kidney Disease—2nd Edition
edited by and Dulat Bekbolsynov
submission deadline 30 Oct 2026 | Viewed by 141 | Submission Open
Keywords: CKD; renal inflammation; renal fibrosis; RAAS; aldosterone; TGF-B1; uremic toxins; hypertension; GFR; albuminuria
(This special issue belongs to the Section Cellular Pathology)
Gut Microbiota as a Regulator and Target in Cancer Immunology
edited by and Pazhanichamy Kalailingam
submission deadline 30 Oct 2026 | Viewed by 109 | Submission Open
Keywords: gut microbiota; cancer immunology; tumor microenvironment; immune checkpoint inhibitors; cellular immunotherapy; tumor infiltrating lymphocytes; dysbiosis; microbiota targeted therapy; microbiome biomarkers; immunotherapy resistance
(This special issue belongs to the Section Cellular Immunology)
Decoding Melanoma: Molecular and Cellular Mechanisms and Therapeutic Opportunities submission deadline 30 Oct 2026 | Viewed by 70 | Submission Open
Keywords: translational oncology; tumor biology; melanoma-targeted therapy; precision medicine; biomarker discovery
(This special issue belongs to the Section Cellular Pathology)
Cellular and Molecular Mechanisms of Leukemia
edited by Xiangguo Shi
submission deadline 30 Oct 2026 | Viewed by 62 | Submission Open
Keywords: leukemia; genomics; epigenetics; therapeutic resistance; metabolic reprogramming; clonal evolution; immunotherapy
(This special issue belongs to the Section Cellular Pathology)
Cellular and Molecular Mechanisms in Bone and Cartilage Damage and Regeneration
edited by
submission deadline 31 Oct 2026 | 7 articles | Viewed by 17497 | Submission Open
Keywords: bone morphogenic proteins (BMPs); bone union with cell therapy; advances in stem cell therapies for fracture non-union and cartilage regeneration; novel cell-based therapies for cartilage repair; functional of collagen/PLA scaffolds in cartilage regeneration; regeneration and revascularization of bone osteonecrosis; evaluation of osteonecrosis regeneration with MRI and histology; and arteriography; identification and validation of new cartilage biomarkers; diaphyseal regeneration with callostasis; union with the membrane technique
(This special issue belongs to the Section Cellular Pathology)
Gene Expression in Adipocytes During Obesity: Understanding Challenges and Future Prospects
edited by
submission deadline 31 Oct 2026 | 1 articles | Viewed by 4181 | Submission Open
Keywords: adipocytes; adipose tissue; obesity; hypoxia; transcription factor; metabolism; epigenetics
Immunoregulation in Cardiovascular Disease
edited by
submission deadline 31 Oct 2026 | 1 articles | Viewed by 3496 | Submission Open
Keywords: cardiovascular disease (CVD); immunoregulation; inflammation; immune cells; immune mediators; immunomodulatory therapies; biomarkers; epigenetics; microbiome; cellular methods/technologies
Spatial Biology: Decoding Cellular Complexity in Tissues submission deadline 31 Oct 2026 | 2 articles | Viewed by 2742 | Submission Open
Keywords: spatial biology; spatial tissue profiling; proteomics; transcriptomics; cell and tissue
(This special issue belongs to the Section Tissues and Organs)
Advances in Liquid Biopsy for Early Detection and Monitoring of Cancer
edited by Nicola Normanno, and
submission deadline 31 Oct 2026 | 3 articles | Viewed by 2033 | Submission Open
Keywords: ctDNA; circulating tumor cells; microRNAs; exosomes; methylation; fragmentomics; early detection; minimal residual disease; artificial intelligence
Novel Immunotherapies for Diffuse Large B-Cell Lymphoma
edited by
submission deadline 31 Oct 2026 | 2 articles | Viewed by 1973 | Submission Open
Keywords: diffuse large B-cell lymphoma; immunotherapy; CAR-T cells; bispecific antibodies; immune checkpoint inhibitors; antibody– drug conjugates; tumor microenvironment; biomarkers; translational research
Signalling Mechanisms Regulating Cardiac Fibroblast Function
edited by Haofei Wang and
submission deadline 31 Oct 2026 | 1 articles | Viewed by 1781 | Submission Open
Keywords: cardiac fibroblasts; myofibroblast activation; extracellular matrix remodeling; fibrosis; intercellular communication; mechanotransduction; single-cell and spatial insights; regeneration; therapeutic targeting
Mechanisms and Dynamics in Cellular Adhesion in Development and Disease
edited by
submission deadline 31 Oct 2026 | 1 articles | Viewed by 1332 | Submission Open
Keywords: actin; integrin; cell adhesion; signalling; mechanotransduction
Cellular and Molecular Mechanisms of Cardiomyopathy submission deadline 31 Oct 2026 | 2 articles | Viewed by 1256 | Submission Open
Keywords: genetic cardiomyopathies; acquired cardiomyopathies; cardiac arrhythmias; disease mechanisms; disease cause; pathogenesis
(This special issue belongs to the Section Tissues and Organs)
Molecular Signaling and Mechanism on Vascular Remodeling
edited by and Yitao Huang
submission deadline 31 Oct 2026 | 1 articles | Viewed by 1055 | Submission Open
Keywords: vascular diseases; atherosclerosis; aneurysm; intimal hyperplasia; vascular remodeling; cellular mechanisms; cellular signaling
Novel Biomarkers and Dose-Response Modifiers in Radiation Oncology and Nuclear Medicine: Molecular Insights for Personalized Therapy and Precision Medicine
edited by and Andrea Wittig
submission deadline 31 Oct 2026 | Viewed by 362 | Submission Open
Keywords: targeted therapies; predictive essays; radiosensitizers; radioprotectors; theranostics; BNCT; alpha-immunotherapy; biological response modifiers; biomarkers
Targeting of Cancer Cells with Small Molecule Drugs
edited by
submission deadline 31 Oct 2026 | 1 articles | Viewed by 357 | Submission Open
Keywords: small molecule drugs; cancer cell targeting; targeted cancer therapy; drug delivery systems; precision oncology
(This special issue belongs to the Section Cellular Pathology)
GABAA Receptor Dynamics: From Cellular Quality Control to Disease Mechanisms
edited by Tingwei Mu and Yajuan Wang
submission deadline 31 Oct 2026 | Viewed by 321 | Submission Open
Keywords: GABAA receptors; trafficking; biogenesis; proteostasis; structure and function; gating; neurotransmission; neurological diseases; disease mechanisms
Cellular and Molecular Mechanisms of Idiopathic Pulmonary Fibrosis
edited by and
submission deadline 31 Oct 2026 | Viewed by 300 | Submission Open
Keywords: idiopathic pulmonary fibrosis; fibroblast activation; epithelial– mesenchymal interaction; extracellular matrix remodeling; inflammation; signaling pathways; biomarkers; molecular targets; autophagy; senescence
Interactions Between Gut Microbiota and Epigenetic Markers in Health and Disease
edited by
submission deadline 31 Oct 2026 | Viewed by 287 | Submission Open
Keywords: gut microbiome; epigenetic marks; cancer; metabolic diseases; neuropsychiatric disorders; inflammatory diseases; infectious diseases; cardiovascular diseases; probiotics; prebiotics
(This special issue belongs to the Section Cell and Gene Therapy)
Mechanobiological Regulation of Fibroblast-to-Myofibroblast Phenotype Transition
edited by Mirko D’urso and
submission deadline 31 Oct 2026 | Viewed by 264 | Submission Open
Keywords: fibroblasts; myofibroblasts; mechanotransduction; extracellular matrix; fibrosis; tissue remodeling; mechanobiology
(This special issue belongs to the Section Cell Microenvironment)
Neurotoxicity: Focusing on Molecular and Cellular Mechanisms
edited by , Manuel José Morales and
submission deadline 31 Oct 2026 | Viewed by 257 | Submission Open
Keywords: neurotoxicity; neuroinflammation; neurodegeneration; chemotherapy-induced neuropathy; neuroprotection; neuronal injury
Ovarian Tumors—Molecular Mechanisms, Cellular Dynamics, and Therapeutic Advances
edited by David Schweer, Joel Cardenas and
submission deadline 31 Oct 2026 | Viewed by 217 | Submission Open
Keywords: ovarian tumor biology; cellular signaling networks; genetic and epigenetic regulation; tumor microenvironment; cellular heterogeneity; single-cell and spatial omics; functional genomics; mechanisms of therapeutic resistance
(This special issue belongs to the Section Cellular Pathology)
Nucleic Acids and Their Binding Partners: Structural and Mechanistic Insights
edited by
submission deadline 31 Oct 2026 | Viewed by 204 | Submission Open
Keywords: cryo-EM; NMR; AFM; molecular dynamics; nucleic acids; nucleic acid-protein complexes
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
Colorectal Cancer: Genetics and Molecular Mechanisms submission deadline 31 Oct 2026 | Viewed by 198 | Submission Open
Keywords: colorectal cancer; metastasis  ; generation alterations; epigenetic regulation; signal transduction pathways; biomarkers; therapeutic resistance; in vitro and in vivo models; translational research
(This special issue belongs to the Section Tissues and Organs)
Dictyostelium as a Model in Cell Dynamics and Disease
edited by
submission deadline 31 Oct 2026 | Viewed by 184 | Submission Open
Keywords: dictyostelium; disease; cell migration; chemotaxis; cytoskeleton; cell mechanics; actin; host-bacteria interaction; cell division
(This special issue belongs to the Section Cellular Pathology)
Advances in Alcohol-Associated Liver Disease submission deadline 31 Oct 2026 | Viewed by 172 | Submission Open
Keywords: alcohol-associated liver disease (ALD); metabolic and alcohol associated liver disease (MetALD); alcohol-associated hepatitis (AH);steatosis; fibrosis; cirrhosis; portal hypertension; hepatic inflammation; hepatocytes; macrophages; neutrophils; stellate cells
(This special issue belongs to the Section Cellular Pathology)
Crosstalk Between Autophagy, Apoptosis and Inflammation submission deadline 31 Oct 2026 | Viewed by 170 | Submission Open
Keywords: autophagy; apoptosis; inflammation; signal transduction; lipid messengers; rheumatic disorders; cancer; neurodegenerative diseases
(This special issue belongs to the Section Autophagy)
Ion Transporters and Channels in Cellular Homeostasis and Disease
edited by Guanxiao Qi and Raul E. Guzman
submission deadline 31 Oct 2026 | Viewed by 150 | Submission Open
Keywords: patch-clamp recording; ligand-gated channels; ion channel modulators; channel-specific ligands; channelopathies; epilepsy; neurodegenerative disease
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