Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Chronic Obstructive Pulmonary Disease (COPD): From Molecular and Cellular Mechanisms to Therapeutic Opportunities
edited by , Bradley W. Richmond and
submission deadline 20 Mar 2026 | Viewed by 4 | Submission Open
Keywords: chronic obstructive pulmonary disease (COPD); small airway disease; vascular remodeling; emphysema
(This special issue belongs to the Section Cellular Immunology)
Gene Editing Therapies for Hereditary Diseases submission deadline 25 Mar 2026 | Viewed by 201 | Submission Open
Keywords: gene therapy; base editing; prime editing; genome editing; hereditary diseases
(This special issue belongs to the Section Cell and Gene Therapy)
Ischemic Heart Disease: From Cellular Level to Clinical Approaches submission deadline 25 Mar 2026 | Viewed by 49 | Submission Open
Keywords: ischemic heart disease; myocardial ischemia; reperfusion injury; oxidative stress; mitochondrial dysfunction; cardiomyocyte death; endothelial dysfunction; inflammation; fibrosis; epigenetics; non-coding RNAs; immunometabolism; single-cell transcriptomics; angiogenesis; ischemic preconditioning; nanomedicine; molecular cardiology; targeted therapy
Cell and Molecular Mechanisms of Bacterial Meningitis submission deadline 25 Mar 2026 | Viewed by 34 | Submission Open
Keywords: bacterial meningitis; innate immunity; inflammation; immune response; central nervous system; neuron; microglia; astrocytes; granulocytes; blood– brain barrier
Breaking the Balance: Cellular Stress, Proteostasis, Aggregates and Neurodegeneration
edited by
submission deadline 25 Mar 2026 | Viewed by 26 | Submission Open
Keywords: proteostasis; cellular stress; protein aggregation; neurodegeneration; autophagy; unfolded protein response; oxidative stress; aging; molecular chaperones; protein quality control
Mitochondria: Multifaceted Regulators of Cell Death
edited by Rasa Banienė and Sonata Trumbeckaite
submission deadline 25 Mar 2026 | Viewed by 24 | Submission Open
Keywords: mitochondria; cell death; multifaceted regulators; reactive oxygen species (ROS); cell metabolism; mitochondrial transfer
Molecular Mechanisms of Trophoblast Differentiation
edited by Milica Jovanivić Krivokuća and
submission deadline 25 Mar 2026 | Viewed by 16 | Submission Open
Keywords: trophoblast differentiation; cytotrophoblast; syncytiotrophoblast; extravillous trophoblast; trophoblast stem cells; molecular mechanisms; signaling pathways; epigenetic regulation
Cancer Stem Cells in Triple-Negative Breast Cancer submission deadline 25 Mar 2026 | Viewed by 15 | Submission Open
Keywords: cancer stem cells; TNBC; signal pathways; epithelial– mesenchymal transition; tumor microenvironment; targeted therapy; biomarkers
From Signals to Shape: Molecular Control of Cellular Plasticity Through Epigenetic, Transcriptomic, and Immune Mechanisms submission deadline 25 Mar 2026 | Viewed by 14 | Submission Open
Keywords: cellular plasticity; epigenetics; transcriptomics; mechanotransduction; immune signaling; cell fate regulation; RNA methylation; biomaterials interaction; molecular cytology; cell adaptation
Neuroimaging of Cerebrovascular Diseases
edited by Dragan Stojanov
submission deadline 30 Mar 2026 | Viewed by 85 | Submission Open
Keywords: neuroimaging; cerebrovascular diseases; stroke; intracerebral hemorrhage; SAHA neurysms; AVM; small vessels diseases; CT; MRI; advance MRI techniques; DSA; AI
Novel Insights into Molecular and Cellular Mechanisms Underlying Chronic Pain submission deadline 30 Mar 2026 | Viewed by 60 | Submission Open
Keywords: pain; pain management; sexual dimorphism; neurons; non-neuronal factors
(This special issue belongs to the Section Cellular Pathology)
Cellular and Molecular Mechanisms of Cardiomyopathy submission deadline 30 Mar 2026 | Viewed by 59 | Submission Open
Keywords: genetic cardiomyopathies; acquired cardiomyopathies; cardiac arrhythmias; disease mechanisms; disease cause; pathogenesis
(This special issue belongs to the Section Tissues and Organs)
Nanoparticle-Mediated Immunotherapy: Reshaping the Tumor Microenvironment for Enhanced Cancer Treatment
edited by
submission deadline 30 Mar 2026 | Viewed by 55 | Submission Open
Keywords: tumor microenvironment; drug delivery; nanoparticle
(This special issue belongs to the Section Cell Methods)
Novel Insights into Cancer Immune Responsiveness submission deadline 30 Mar 2026 | Viewed by 20 | Submission Open
Keywords: cancers; tumors; immune cells; tumor immunology; cancer immunology; onco-immunology; immunotherapies; resistance; immunotherapy resistance; immune checkpoint; CAR; antibody; cancer vaccines
Flow Cytometry in Immunology Research
edited by and Ekaterina Kopitman
submission deadline 31 Mar 2026 | 2 articles | Viewed by 9415 | Submission Open
Keywords: multi-parametric analysis; full-spectrum flow cytometry; imaging flow cytometry; immuno-phenotyping; immune synapse; cytokines; activation markers; cancer immunology; host-pathogen interactions; functional immune assays
(This special issue belongs to the Section Cell Methods)
Cellular and Molecular Insights into Allergies and Allergic Diseases
edited by
submission deadline 31 Mar 2026 | Viewed by 246 | Submission Open
Keywords: allergy; immune regulation; mast cells; Th2 responses; epithelial barrier; IgE; inflammation; cellular signaling; molecular mechanisms
(This special issue belongs to the Section Cellular Immunology)
Current Research on Immunotherapy for Glioblastoma
edited by Markella Zannikou
submission deadline 31 Mar 2026 | Viewed by 185 | Submission Open
Keywords: GBM; tumor microenvironment; cancer vaccines; TIL (tumor-infiltrating lymphocytes) therapy; combination therapy; BiTEs; immune checkpoint therapy; CAR T-cell therapy; peptide/dendritic vaccines; tumor-associated antigens; oncolytic virotherapy
(This special issue belongs to the Section Cellular Immunology)
Therapeutic Targeting of MicroRNAs in Human Cancer
edited by
submission deadline 31 Mar 2026 | Viewed by 126 | Submission Open
Keywords: microRNAs; nanoparticle platforms; spatial miRNomics; combination therapeutic strategies
(This special issue belongs to the Section Cell and Gene Therapy)
The Challenges and Opportunities of Mesenchymal Stromal Cells in Regenerative Medicine
edited by
submission deadline 31 Mar 2026 | Viewed by 93 | Submission Open
Keywords: mesenchymal stromal cells; mesenchymal stem cells; medicinal signaling cells; multipotent stem cells; paracrine secretion; angiogenesis; immunomodulation; cell therapy; cell-free cell-based therapy; stem cell differentiation; tissue engineering
Advances in CAR Cell Therapies and Manufacturing
edited by William J. Kelly and Madhuresh C. Sumit
submission deadline 31 Mar 2026 | Viewed by 76 | Submission Open
Keywords: CAR cells; autologous; allogeneic; crispr; lentivirus; expansion; cryopreservation; isolation; biomarker; cytokines
Neurodevelopmental Factors of Autism Spectrum Disorder: Etiology to Therapy
edited by
submission deadline 31 Mar 2026 | Viewed by 69 | Submission Open
Keywords: autism spectrum disorder; developmental factors; genetic contributions; environmental influences; gene– environment interactions; developing therapies
Neurodegenerative Diseases and Related Proteins
edited by Tian Liu
submission deadline 31 Mar 2026 | Viewed by 65 | Submission Open
Keywords: protein misfolding and aggregation; proteostasis and quality control; neuroinflammation; autophagy and mitophagy; molecular chaperones; Amyloid-β and tau; α -synuclein and TDP-43; multi-omics biomarkers; structural biology; therapeutic targets; mitochondrial– ER crosstalk; genetic and epigenetic regulation
GABAA Receptor Dynamics: From Cellular Quality Control to Disease Mechanisms
edited by Tingwei Mu and Yajuan Wang
submission deadline 31 Mar 2026 | Viewed by 63 | Submission Open
Keywords: GABAA receptors; trafficking; biogenesis; proteostasis; structure and function; gating; neurotransmission; neurological diseases; disease mechanisms
Multi-Omics Technologies in Immunity Within Tumors submission deadline 31 Mar 2026 | Viewed by 60 | Submission Open
Keywords: multi-omics; proteomics; metabolomics; lipidomics; genomics and epigenomics; synergistic combinations for cancer; AI applications in multi-omics integrations; tumor microenvironment (TME); cancer immunotherapy; immuno-oncology; integrative analysis of multi-omics; biomarkers; precision medicine; tumor heterogeneity
Cellular and Molecular Mechanisms of Alcohol-Induced Cellular/Organ Injury and Regeneration
edited by Mukund Srinivasan
submission deadline 31 Mar 2026 | Viewed by 52 | Submission Open
Keywords: alcohol use disorder; ethanol; liver; lung; pancreas; gut; brain; cellular toxicity; alcohol metabolism; alcohol metabolites; oxidative stress; mitochondrial stress; ER stress
Hepatoblastoma: Molecular Mechanisms and Therapeutic Strategies submission deadline 31 Mar 2026 | Viewed by 49 | Submission Open
Keywords: hepatoblastoma; APC; ARID1; β -catenin; hepatocellular carcinoma; hippo; YAP; pathogenesis; therapeutic strategies; molecular mechanisms
PI3K/AKT/mTOR Signaling Network in Human Health and Diseases 3.0 submission deadline 31 Mar 2026 | Viewed by 40 | Submission Open
Keywords: acne; ageing; Akt; Alzheimer’ s disease; autophagy; autoimmunity; PI3K; mTOR; cancer; cardiovascular diseases; diabetes; growth; hamartoma; hypertrophy; inflammation; neurologic; tuberous sclerosis; systemic sclerosis; obesity; Parkinson’ s disease; psoriasis; atopic dermatitis; burns/wound healing; targeted therapy; natural products; biologics
Cellular and Molecular Insights into Gynecologic Tumors
edited by and
submission deadline 31 Mar 2026 | Viewed by 23 | Submission Open
Keywords: gynecologic cancers; cervical cancer; endometrial cancer; ovarian tumors; tumor microenvironment; molecular biomarkers; genetic mutations; targeted therapies
Cellular Mechanisms in Pregnancy and Foetal Development submission deadline 31 Mar 2026 | Viewed by 17 | Submission Open
Keywords: pregnancy; fetus; reproduction; placenta; maternal; fertility; preeclampsia; fetal growth restriction; gestational diabetes; stillbirth
From Liver Transplantation to Gene Therapy: A Therapeutic Revolution in Argininosuccinic Aciduria
edited by Sonam Gurung
submission deadline 31 Mar 2026 | Viewed by 14 | Submission Open
Keywords: urea cycle disorder; argininosuccinic aciduria; gene therapies; mRNA therapies; liver transplantation; arginosuccinate lyase (ASL)
Next-Generation CAR-T Cell Therapy: From Bench to Bedside
edited by
submission deadline 31 Mar 2026 | Viewed by 5 | Submission Open
Keywords: chimeric antigen receptor T cells; cytokine release syndrome; immune effector cell-associated neurotoxicity syndrome (ICANS); immunotoxicity; T cell exhaustion; antigen discovery; CAR engineering; mouse models
(This special issue belongs to the Section Cellular Immunology)
Molecular Mechanisms and Cellular Pathways in Parkinson's Disease
edited by and
submission deadline 31 Mar 2026 | Viewed by 3 | Submission Open
Keywords: Parkinson’ s disease; neurodegeneration; mitochondrial dysfunction; α -synuclein aggregation; neurotoxicity; neuroinflammation; oxidative stress; environmental factors; gene– environment interactions; cell death
(This special issue belongs to the Section Cells of the Nervous System)
Cellular and Molecular Mechanisms in Aging
edited by Michel Satya Naslavsky and Mateus Vidigal
submission deadline 1 Apr 2026 | 1 articles | Viewed by 860 | Submission Open
Keywords: cellular senescence; aging models; DNA repair; neurodegeneration; elderly
(This special issue belongs to the Section Cellular Aging)
Novel and Experimental Strategies for the Treatment of Neurodegenerative Diseases
edited by and Justyna Okarmus
submission deadline 10 Apr 2026 | 2 articles | Viewed by 4198 | Submission Open
Keywords: neurodegenerative diseases; experimental treatments; stem cell transplantation; immunotherapy; gene therapy; focused ultrasound; neuroprotective agents; Parkinson's disease; Alzheimer's disease; Huntington’ s disease; amyotrophic lateral sclerosis
(This special issue belongs to the Section Cells of the Nervous System)
Role of Thyroid Hormone in Neurodegenerative and Neurodevelopmental Disorders
edited by Janaína Sena de Souza
submission deadline 15 Apr 2026 | 4 articles | Viewed by 6444 | Submission Open
Keywords: thyroid hormones; neurodevelopmental and neurodegenerative disorders; central nervous system
(This special issue belongs to the Section Cells of the Nervous System)
Stem Cells and Beyond: Innovations in Tissue Repair and Regeneration
edited by Aurora Almadori
submission deadline 15 Apr 2026 | 4 articles | Viewed by 5066 | Submission Open
Keywords: adipose-derived stem cells; mesenchymal stem cells; induced pluripotent stem cells; stromal vascular fraction; platelet-rich plasma; exosomes; polynucleotides; cytokines; growth factors; extracellular matrix; cell signaling; wound healing; ageing; immune response; inflammation; scarring
(This special issue belongs to the Section Stem Cells)
Advances in Zebrafish Disease Models submission deadline 15 Apr 2026 | 2 articles | Viewed by 3682 | Submission Open
Keywords: zebrafish; human disease models; experimental disease models; novel drugs and therapies; organic diseases; functional disorders
Mast Cells in Health and Disease: Current Insights and Future Perspectives on Development, Activation, Functional Roles, and Therapeutic Strategies
edited by
submission deadline 15 Apr 2026 | 1 articles | Viewed by 1281 | Submission Open
Keywords: mast cell granules; mast cell mediators; mast cell development; mast cell survival; mast cell activation; mast cell activating and inhibitory receptors; receptor signaling; allergic and non-allergic pathologies; immunity and host defense; mast cell-directed therapeutic approaches
(This special issue belongs to the Section Cellular Immunology)
Molecular Mechanisms and Pathophysiology of Diabetic Retinopathy
edited by , Stephanie L. Grillo and
submission deadline 15 Apr 2026 | Viewed by 522 | Submission Open
Keywords: diabetic retinopathy; retina; retinal neurodegeneration; diabetic macular edema; pathophysiology of diabetic retinopathy; proliferative and non-proliferative diabetic retinopathy; molecular mediators of diabetic retinopathy; cell-based therapies for diabetic retinopathy
(This special issue belongs to the Section Cellular Pathology)
Gut Dysbiosis in Inflammatory Diseases
edited by Weiwei Liu
submission deadline 15 Apr 2026 | Viewed by 369 | Submission Open
Keywords: gut microbiota; innate and adaptive immunity; dysbiosis; metabolism; inflammatory bowel diseases; autoimmune diseases; metabolic disorders; fecal microbiota transplantation
(This special issue belongs to the Section Cellular Pathology)
Decoding Cancer Metabolism: Recent Insights and Future Directions
edited by Parash Prasad and Snehasis R. Mishra
submission deadline 15 Apr 2026 | Viewed by 316 | Submission Open
Keywords: glutamine metabolism; Warburg effect; anaplerosis; fatty acid metabolism; ferroptosis; oncometabolites; hypoxia; mitochondrial dynamics; reactive oxygen species; glutathione synthesis; nutrient sensing
Cell Biology of the Eye: Development, Disorders, and Repair submission deadline 15 Apr 2026 | Viewed by 55 | Submission Open
Keywords: eye development; ocular homeostasis; degenerative eye disorders; stem cells; Regenerative medicine; ocular imaging; disease modeling; cellular senescence; gene therapy; ophthalmology therapeutics  
Extracellular Vesicles in Chronic Obstructive Pulmonary Disease: A 2025 Update
edited by and
submission deadline 15 Apr 2026 | Viewed by 33 | Submission Open
Keywords: extracellular vesicles (EVs); chronic obstructive pulmonary disease (COPD); inflammation; epithelial barrier; cellular senescence; tissue remodeling; biomarkers; exacerbations; microbiota; therapeutic targets
Cellular and Molecular Mechanisms of Cell Death in Neurodegenerative Diseases
edited by and Emmanouil Metzakopian
submission deadline 15 Apr 2026 | Viewed by 31 | Submission Open
Keywords: cell death; neurodegenerative diseases; molecular biology; genomics; neuroinflammation; protein aggregation; neurobiology; mitochondria dysfunction
Advance in Annexin Biology
edited by , and Nunzia Novizio
submission deadline 15 Apr 2026 | Viewed by 16 | Submission Open
Keywords: annexin family; calcium-dependent membrane binding; cell signaling; inflammation and immune response; membrane repair; cancer biology; cell motility; cell differentiation; tumor microenvironment; diagnostic/prognostic biomarkers; therapeutic targets
Novel Therapeutic Targets and Approaches, Genetic Markers and Signaling Pathways in Neoplasms submission deadline 20 Apr 2026 | 11 articles | Viewed by 28131 | Submission Open
Keywords: cancer; neoplasms; personalized medicine; genetic markers; next-generation sequencing (NGS); whole-genome sequencing; signaling pathways in cancer; novel therapeutic targets; drug development
(This special issue belongs to the Section Cell and Gene Therapy)
Chromosomal Instability in Health and Disease
edited by Anna V. Roschke
submission deadline 20 Apr 2026 | 3 articles | Viewed by 4827 | Submission Open
Keywords: chromosomal instability; aneuploidy; polyploidy; cancer evolution; chromosomal instability and aneuploidy in embryonic development; chromosomal instability and polyploidy in evolutionary process; somatic aneuploidy in senescence and ageing
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
Recent Advances in Novel Cell and Gene Therapies for the Treatment of Immune Diseases
edited by Qingdong Guan
submission deadline 20 Apr 2026 | 2 articles | Viewed by 3622 | Submission Open
Keywords: cell therapy; gene therapy; chimeric antigen receptor T cells; T cell receptor-engineered T cells; tumor-infiltrating lymphocytes; hematopoietic stem cells; chimeric antigen receptor NK cells; induced pluripotent stem cells; mesenchymal stem/stromal cells; immune regulatory cells
(This special issue belongs to the Section Cellular Immunology)
pH Sensing, Signaling, and Regulation in Cellular Processes
edited by Maike Glitsch
submission deadline 20 Apr 2026 | 1 articles | Viewed by 830 | Submission Open
Keywords: extra- and intracellular pH; pH sensing; signaling; and regulation; pH-dependent receptors; proton signaling; ion channels; G-protein-coupled receptors; cell biology and function; physiological and pathological processes; aging; cancer; inflammation; and so on; novel therapeutic strategies and targets
(This special issue belongs to the Section Cell Signaling)
Pathogenesis and Novel Therapies in Epithelial Cancers
edited by Jung Wook Park and Sanjeevram Dhandapani
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1554 | Submission Open
Keywords: transformation; malignant; oncogene; tumor suppressor; molecular mechanisms; epigenetic; metabolic; immune; biomarkers; personalized medicine; primary cells; small-molecule inhibitor
(This special issue belongs to the Section Cellular Pathology)
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