Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Adipose-Derived Stem Cells: Current Applications and Future Directions
edited by
submission deadline 20 Jan 2026 | 4 articles | Viewed by 4748 | Submission Open
Keywords: cell therapy; regenerative medicine; adipose-derived stem cells (ADSCs); exosome; cytokine
(This special issue belongs to the Section Stem Cells)
Pathophysiology of Signal Transduction in Cardiovascular and Pulmonary Disease II
edited by and
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1572 | Submission Open
Keywords: cardiac arrhythmia; atrium; ventricle; pulmonary; vascular; signal transduction
(This special issue belongs to the Section Cellular Pathology)
Mitochondria at the Crossroad of Health and Disease—Second Edition submission deadline 20 Jan 2026 | 1 articles | Viewed by 1272 | Submission Open
Keywords: mitochondria; oxidative phosphorylation; mitochondrial ion transport; permeability transition pore; mitochondrial ROS generation; mitochondrial quality control; mitochondrial traffic; mitochondrial morphology; mitochondrial dynamics; mitophagy
(This special issue belongs to the Section Cellular Aging)
Neurotoxicity and Neurodegenerative Diseases: The Potential of Regenerative Medicine
edited by Elisabetta Mormone, Paola Crociani and
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1023 | Submission Open
Keywords: inflammation; iPSCs; MSCs; neural stem cells niche; neurodegeneration; regenerative medicine; ROS; PRP
(This special issue belongs to the Section Cellular Aging)
Role of Cell Organelles in Normal Aging, Senescence, and Cancer
edited by and Christopher Albanese
submission deadline 20 Jan 2026 | Viewed by 456 | Submission Open
Keywords: aging; accumulated damage; ROS-induced damage; protein aggregation; senescence; cancer; senescence escape; cell organelles; mitochondria; lysosomes; SASP; inflammation; IL1-beta/IL-6/IL-8
(This special issue belongs to the Section Cellular Aging)
Study on Human Mesenchymal Stem Cells—2nd Edition
edited by
submission deadline 20 Jan 2026 | Viewed by 283 | Submission Open
Keywords: mesenchymal stem cells; disease; cardiac; therapy
(This special issue belongs to the Section Stem Cells)
Cellular Origin of Glioma: From Triggers to Treatments
edited by Katherine Karakoula
submission deadline 20 Jan 2026 | Viewed by 217 | Submission Open
Keywords: glioblastoma; brain tumour; tumour heterogeneity; targeted therapy; glioma stem cells
Applications of Proteomics in Human Diseases and Treatments submission deadline 20 Jan 2026 | Viewed by 203 | Submission Open
Keywords: biomarkers; clinical proteomics; single-cell proteomics; next-generation proteomics; biofluids; high-throughput proteomics
(This special issue belongs to the Section Cell Methods)
Intestinal Stem Cells submission deadline 20 Jan 2026 | Viewed by 116 | Submission Open
Keywords: stem cells; self-renewal; enterocytes; intestinal organoid; villus; crypt
(This special issue belongs to the Section Stem Cells)
The Evolving Landscape of Cell and Gene Therapy—Opportunities, Challenges and the Road Ahead submission deadline 20 Jan 2026 | Viewed by 66 | Submission Open
Keywords: cell therapy; gene therapy/gene editing; micro RNAs; rare diseases; metabolic disease; cancer; diabetes; proatherogenic lipoproteins; drug discovery; ASO
Gliomas: Molecular Insights, Next-Generation Therapies, and Precision Targeting
edited by
submission deadline 20 Jan 2026 | Viewed by 60 | Submission Open
Keywords: gliomas; molecular targets; precision oncology; immunotherapy; gene editing; tumor microenvironment
Molecular Basis of Gynecological Disorders and Associated Infertility submission deadline 20 Jan 2026 | Viewed by 58 | Submission Open
Keywords: gynecological disorders; endometriosis; polycystic ovary syndrome (PCOS); cervical cancer; ovarian cancer; uterine and vaginal pathologies
(This special issue belongs to the Section Cellular Pathology)
Fibrosis in Chronic Inflammatory Diseases submission deadline 25 Jan 2026 | 7 articles | Viewed by 13266 | Submission Open
Keywords: fibrosis; fibroblasts; myofibroblasts; inflammation; molecular pathways; pathogenetic mechanisms; therapeutic targets
(This special issue belongs to the Section Cellular Pathology)
Targeting Hallmarks of Cancer submission deadline 25 Jan 2026 | 3 articles | Viewed by 4966 | Submission Open
Keywords: epigenetic regulators; organotypic culture models; anticancer drugs; hallmarks of cancer
Soluble Interleukin-6 Receptor (sIL-6R): Role in Health and Disease submission deadline 25 Jan 2026 | Viewed by 226 | Submission Open
Keywords: sIL-6R; IL-6 signalling; IL-6ST; genetic polymorphism; health; disease; exercise physiology; therapeutics; mental health
(This special issue belongs to the Section Cell Signaling)
Induced Pluripotent Stem Cells (iPSCs): Molecular and Cellular Mechanisms
edited by Masmoudi-Kouki Olfa and
submission deadline 25 Jan 2026 | Viewed by 81 | Submission Open
Keywords: iPSCs; gene regulation; epigenetic reprogramming; cellular signaling; disease modeling
(This special issue belongs to the Section Stem Cells)
Decoding the Tumor-Immune Intersection: Opportunities for Breakthroughs in Cancer Therapies
edited by
submission deadline 25 Jan 2026 | Viewed by 71 | Submission Open
Keywords: immuno-oncology; tumor-immune interface; tumor microenvironment; cancer immunotherapy; targeted therapy; immunometabolism; oncometabolism; epigenetics; combination strategies
(This special issue belongs to the Section Cellular Immunology)
Targeting Immune Dysfunction in Aging and Age-Related Diseases
edited by and
submission deadline 25 Jan 2026 | Viewed by 63 | Submission Open
Keywords: immunosenescence; inflammaging; immune dysfunction; aging; age-related diseases (ARDs); immune– metabolic interactions; immunomodulators; immunoceuticals; senotherapeutics; lifestyle interventions
Plant Stress and Acclimation Responses During Global Warming submission deadline 25 Jan 2026 | Viewed by 62 | Submission Open
Keywords: acclimatory responses in plants; chloroplast retrograde and nuclear anterograde signaling; excess light and heat shock responses; global warming and regulation of gene expression; energy dissipation as heat and cell death regulation; photosynthesis; stomatal conductance and transpiration regulation during heat waves
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Metabolic Flexibility in Cancer: How Tumor Cells Adapt Their Metabolism to Growth and Spread
edited by Erica Pranzini
submission deadline 25 Jan 2026 | Viewed by 61 | Submission Open
Keywords: cancer metabolism; metabolic plasticity; tumor microenvironment; oncometabolites; targeting cancer metabolism
Immune Cell Signaling Networks in Tumor and Regenerative Stem Cell Niches
edited by
submission deadline 25 Jan 2026 | Viewed by 40 | Submission Open
Keywords: tumor microenvironment; stem cell niche; macrophage polarization; T-cell activation; immune checkpoints; targetable signaling pathways; engineered biomaterials; immune signaling in 3D culture; organ-on-chip models; single-cell omics
(This special issue belongs to the Section Stem Cells)
The Developments and Applications of Vibrational Spectroscopy in Cellular Research
edited by
submission deadline 25 Jan 2026 | Viewed by 34 | Submission Open
Keywords: vibrational spectroscopy; FT-IR spectroscopy; Raman spectroscopy; biomedical diagnostics; cancer research; Alzheimer’ s disease; neurodegeneration; tissue engineering; spectroscopic biomarkers; label-free imaging
(This special issue belongs to the Section Cell Methods)
Neuronal Development and Disease: From Molecular Bases to Neurological Disorders
edited by Ramiro Almeida
submission deadline 30 Jan 2026 | 3 articles | Viewed by 3303 | Submission Open
Keywords: neuronal development; neurological disorders; neurogenesis; neuroinflammation; synaptic plasticity
(This special issue belongs to the Section Cells of the Nervous System)
Mechanisms Underlying Cardiovascular Aging
edited by Soheil Saeedi
submission deadline 30 Jan 2026 | 2 articles | Viewed by 2043 | Submission Open
Keywords: cardiovascular aging; cellular senescence; epigenetic clock; endothelial cells; perivascular adipose tissue (PVAT); premature aging; senolytics; rejuvenating strategies
(This special issue belongs to the Section Cells of the Cardiovascular System)
Tumor Immune Responsiveness in the Era of T Cell Immunotherapy
edited by and
submission deadline 30 Jan 2026 | Viewed by 113 | Submission Open
Keywords: T cell-mediated immunity; cancer immune responsiveness; cytokine modulation
Ubiquitin Ligases in Health and Diseases
edited by Haitao Luan
submission deadline 30 Jan 2026 | Viewed by 39 | Submission Open
Keywords: ubiquitination; E3 ubiquitin ligase; Proteasome; protein degradation; cell cycle regulation; immune response; neurodegeneration; cancer; autoimmune disorders; therapeutic targeting
(This special issue belongs to the Section Cell Signaling)
Advanced Technology for Cellular Imaging
edited by Alessandro Grinzato, and
submission deadline 31 Jan 2026 | 8 articles | Viewed by 17694 | Submission Open
Keywords: electron tomography; fluorescence microscopy; live cell imaging; multimodal imaging; super resolution microscopy; cell– cell interaction
(This special issue belongs to the Section Cell Methods)
Molecular and Cellular Mechanisms of Cardiovascular and Metabolic Diseases
edited by
submission deadline 31 Jan 2026 | 6 articles | Viewed by 15079 | Submission Open
Keywords: mitochondrial dysfunction; endoplasmic reticulum (ER) stress; oxidative/nitrosative stress; diabetes; obesity; diet; atherosclerosis; hypertension; metabolomics; cell death; nutraceuticals/functional foods
(This special issue belongs to the Section Cells of the Cardiovascular System)
Cancer-Associated Fibroblasts: Challenges and Directions submission deadline 31 Jan 2026 | 4 articles | Viewed by 12194 | Submission Open
Keywords: cancer-associated fibroblast (CAFs); tumor microenvironment (TME); fibroblast activation protein alpha (FAPα ); immunotherapy; cytokines; angiogenesis; metastasis; FAP inhibitors; radioligands; imaging agents
(This special issue belongs to the Section Cell Microenvironment)
Imaging Methods in Cell Biology submission deadline 31 Jan 2026 | 5 articles | Viewed by 9072 | Submission Open
Keywords: cellular organelles; molecular function; molecular interaction; disease- and drug-related subcellular phenomena; single-molecule imaging; light microscopy; electron microscopy; fluorescence microscopy; fluorescence correlation methods; fluorescence lifetime imaging microscopy (FLIM); Raman microscopy; spatial biology
(This special issue belongs to the Section Cell Methods)
Neuroinflammation in Brain Health and Diseases
edited by Debashis Dutta and Nemil Bhatt
submission deadline 31 Jan 2026 | 6 articles | Viewed by 7148 | Submission Open
Keywords: neuroinflammation; gliosis; inflammasome; neurodegeneration; neurotherapeutics
(This special issue belongs to the Section Cells of the Nervous System)
Emerging Targets and Therapeutic Potential Drugs in Tumor Progression and Therapeutic Resistance
edited by , and Yuancheng Li
submission deadline 31 Jan 2026 | 2 articles | Viewed by 4916 | Submission Open
Keywords: cancer; tumor progression; therapeutic resistance; molecular targets; tumor microenvironment; innovative therapies; targeted drug delivery; natural product
(This special issue belongs to the Section Cell Microenvironment)
Renewing Reasons to Believe in Gene Therapies for Epilepsy
edited by Casper Gøtzsche
submission deadline 31 Jan 2026 | 2 articles | Viewed by 4407 | Submission Open
Keywords: epilepsy; seizure; gene therapy; gene editing; disease modification; transformative; unmet need
(This special issue belongs to the Section Cells of the Nervous System)
Novel Therapeutic Strategies to Improve Mitochondrial Function in Neurodegenerative Diseases
edited by Patricia Morcillo
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1160 | Submission Open
Keywords: mitochondria; cellular signaling; neurodegenerative diseases; mitochondrial dynamics; organelles; neurological diseases; therapies; biomarkers
(This special issue belongs to the Section Cellular Aging)
Cell Behavior Under Blood Flow
edited by Alexander Gural, Ivana Pajic-Lijakovic and
submission deadline 31 Jan 2026 | 1 articles | Viewed by 580 | Submission Open
Keywords: blood flow; shear stress; red blood cells; white blood cells; platelets; endothelial cells; cell stimulation; mechanical stress
The Role of Macrophages in Leishmaniasis: Current Perspective
edited by Devki Nandan
submission deadline 31 Jan 2026 | 1 articles | Viewed by 521 | Submission Open
Keywords: Leishmania; leishmaniasis; macrophage biology; host– pathogen interactions
Neuro-Oncological Advances in Stem Cell Research: A New Era in Brain Tumor Therapy submission deadline 31 Jan 2026 | Viewed by 250 | Submission Open
Keywords: brain tumor genetics and epigenetics; brain tumor stem cells; stem cell therapy against brain tumors; mesenchymal stem cells; iPSC; resistance to therapy
(This special issue belongs to the Section Stem Cells)
New Advances in Tissue Engineering and Regeneration submission deadline 31 Jan 2026 | Viewed by 236 | Submission Open
Keywords: tissue regeneration; tissue engineering; regenerative medicine; musculoskeletal tissues; biomaterials; stem cells; 3D bioprinting; scaffold design; cell therapy; organoids; translational research
(This special issue belongs to the Section Tissues and Organs)
Mechanisms That Link Olfactory Perception with Aging in Drosophila
edited by , Anindya Ganguly and Jordan A. Munroe
submission deadline 31 Jan 2026 | Viewed by 232 | Submission Open
Keywords: olfaction; aging; neuroscience
(This special issue belongs to the Section Cellular Aging)
Single-Molecule Tracking for Live Cells
edited by
submission deadline 31 Jan 2026 | Viewed by 221 | Submission Open
Keywords: single-molecule level; many-molecule level; biological cell; diluted liquids; single-molecule localization microscopy; nanoscopy; modeling; diffusion; theory
Diagnostic and Therapeutic Application of Extracellular Vesicles (EV) submission deadline 31 Jan 2026 | Viewed by 206 | Submission Open
Keywords: extracellular vesicles (EVs); diseases biomarkers; therapeutic targets; drugs delivery; engineered extracellular vesicles; EVs therapeutic applications
Autophagy and Neurodegeneration: Unveiling Cellular Pathways in ALS and Beyond
edited by Valeria Gerbino
submission deadline 31 Jan 2026 | Viewed by 162 | Submission Open
Keywords: autophagy; neurodegeneration; amyotrophic lateral sclerosis (ALS); protein aggregation; cellular homeostasis; lysosomal dysfunction; neuronal health; therapeutic targets; molecular pathways; neuroprotective strategies
(This special issue belongs to the Section Cells of the Nervous System)
Human Organoids: A New Frontier in Disease Modeling
edited by and Umesh Kumar
submission deadline 31 Jan 2026 | Viewed by 93 | Submission Open
Keywords: 3D organ culture; embryonic stem cells; induced pluripotent stem cells; 3D bioprinting; personalized medicine; regenerative medicine
(This special issue belongs to the Section Tissues and Organs)
Function of Stress Granules in Normal Cells and in Alzheimer’s Disease
edited by and Benjamin Wolozin
submission deadline 31 Jan 2026 | Viewed by 90 | Submission Open
Keywords: stress granules; Alzheimer's disease; neurodegenerative diseases
(This special issue belongs to the Section Cellular Aging)
New Trends and Advances in Molecular Targeted Therapy for Cancers
edited by Dhivya Sridaran and
submission deadline 31 Jan 2026 | Viewed by 77 | Submission Open
Keywords: cancer targeted therapy; antibodies; small-molecule inhibitors; antibody– drug conjugates; combination therapies
(This special issue belongs to the Section Cell and Gene Therapy)
Cellular and Molecular Mechanisms in Immune Regulation—Second Edition
edited by Fábio Rinaldo Santori and Natalia B. Ivanova
submission deadline 31 Jan 2026 | Viewed by 69 | Submission Open
Keywords: innate immunity; dendritic cells; macrophages; T cells; B cells; cytokines; immunotherapy
(This special issue belongs to the Section Cellular Pathology)
Acute Myeloid Leukemia: Unraveling Molecular Drivers, Cellular Plasticity, and Therapeutic Vulnerabilities
edited by Fabio Guolo
submission deadline 31 Jan 2026 | Viewed by 67 | Submission Open
Keywords: acute myeloid leukemia (AML); hematologic malignancy; AML classification; myeloid precursors; hematopoiesis; high-risk AML; biomarkers
(This special issue belongs to the Section Cellular Immunology)
Gastrointestinal Disorders: Immunity and Inflammation
edited by Faizan Ahmed and
submission deadline 31 Jan 2026 | Viewed by 66 | Submission Open
Keywords: gastrointestinal disorders; immunity; inflammation; immune system; microbiota; gastroenterology; biomarkers; pathways
Genetics and Gene Regulation
edited by and
submission deadline 31 Jan 2026 | Viewed by 65 | Submission Open
Keywords: genetics; gene regulation; human diseases
The Language of Neural Cells: Decoding Molecular Signaling in Neurodevelopmental and Neuro-Oncological Disorders
edited by Marilena Briglia, and Adriana C. E. Graziano
submission deadline 31 Jan 2026 | Viewed by 62 | Submission Open
Keywords: neural cells; molecular signaling; neurodevelopmental disorders; neuro-oncological disorders; transcriptional dysregulation
(This special issue belongs to the Section Cells of the Nervous System)
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