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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Cellular and Molecular Treatment of Autoimmune Diseases—Second Edition

edited by

Panagiotis Athanassiou

Dimitrios P. Bogdanos

and

Ifigenia Kostoglou-Athanassiou

submission deadline 30 Oct 2025 | Viewed by 167 | Submission Open

Keywords: autoimmune diseases; disease activity; TNFa inhibitors; tocilizumab; infliximab; golimumab; etanercept; JAK inhibitors; cellular targets; molecular targets

(This special issue belongs to the Section Cellular Immunology)

New Advances in Cancer Cell Biology: Biomarkers and Therapeutic Targets

edited by

Verena Damiani

submission deadline 30 Oct 2025 | Viewed by 66 | Submission Open

Keywords: cancer; biomarkers; therapeutic targets

(This special issue belongs to the Section Cellular Immunology)

Molecular Cell Biology of T Cells in Cancer and Infectious Diseases

edited by

Gustavo P. Amarante-Mendes

and João Viola

submission deadline 30 Oct 2025 | Viewed by 57 | Submission Open

Keywords: T cells; cancer; infectious diseases; genomics; proteomics; metabolomics; metabolism

(This special issue belongs to the Section Cellular Immunology)

Thirty plus Years’ Journey—Painting the Molecular Picture of E-C Coupling

edited by Jianjie Ma, Long-Sheng Song,

Jingsong Zhou

and

Hua Zhu

submission deadline 30 Oct 2025 | Viewed by 54 | Submission Open

Keywords: E-C coupling; calcium signaling; muscle physiology; cardiovascular disease

Emerging Topics in Smooth Muscle Cell Fate and Plasticity in Atherosclerosis

edited by

Mandy Grootaert

and

Julián Albarrán-Juárez

submission deadline 30 Oct 2025 | Viewed by 50 | Submission Open

Keywords: vascular smooth muscle cells; lineage tracing; fate mapping; VSMC plasticity; (single cell) (spatial) omics; vascular heterogeneity; atherosclerosis

Perinatal Brain Injury—from Pathophysiology to Therapy

edited by Cora H.A. Nijboer,

Bobbi Fleiss

and

Ivo Bendix

submission deadline 31 Oct 2025 | 5 articles | Viewed by 8734 | Submission Open

Keywords: preterm birth; perinatal brain injury; infection; inflammation; hypoxia; ischemia; hyperoxia; malnutrition; regenerative therapies; pharmacological intervention; stem cells

(This special issue belongs to the Section Cells of the Nervous System)

Gastrointestinal Disease: From Cellular Mechanisms to Targeted Therapy

edited by

Grazia Serino

and

Amilcare Barca

submission deadline 31 Oct 2025 | 3 articles | Viewed by 7456 | Submission Open

Keywords: gastrointestinal cancer; gastric cancer; colorectal cancer; esophageal cancer; liver cancer; pancreatic cancer; inflammatory bowel disease; miRNAs; in vitro and in vivo models; molecular networks; molecular pathways; translational medicine; epithelial barrier functions/processes

(This special issue belongs to the Section Cellular Pathology)

Small Molecular Therapeutics Promoting Neuronal Plasticity, Hippocampal Learning, and Memory

edited by

Avik Roy

submission deadline 31 Oct 2025 | 2 articles | Viewed by 3319 | Submission Open

Keywords: synaptic transmission; dendritic spines; metabotropic calcium influx; dendritic morphogenesis; small molecular therapeutics promoting neuronal plasticity

(This special issue belongs to the Section Cells of the Nervous System)

Immune Cell Effect on the Endothelium

edited by

Constantinos Mikelis

and Margarita Lamprou

submission deadline 31 Oct 2025 | 1 articles | Viewed by 3314 | Submission Open

Keywords: immune cells; endothelial cells; cytokines; extracellular vesicles; angiogenesis; vascular permeability

(This special issue belongs to the Section Cellular Immunology)

Cilia-Based New Discoveries: Ciliogenesis, Function, and Human Diseases

edited by

Lisbeth Birk Møller

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2905 | Submission Open

Keywords: primary cilium; human disease; cell signaling; mTOR; Hedgehog; WNT; PDGFRalpha

Advances in Cell-Based Studies and Therapeutic Approaches for Tissue Regeneration

edited by

Anişoara Cîmpean

and

Andreea-Mariana Negrescu

submission deadline 31 Oct 2025 | 3 articles | Viewed by 2047 | Submission Open

Keywords: soft/hard tissue regeneration; therapeutical approaches; cell culture studies; inflammation-based diseases; degenerative diseases

(This special issue belongs to the Section Tissues and Organs)

Natural Killer (NK) Cells in Immunity: Limitations and Potential

edited by Rehan Mujeeb Faridi

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1232 | Submission Open

Keywords: natural killer cells; adaptive NK cells; infection

(This special issue belongs to the Section Cellular Immunology)

How Can We Optimise Cancer Therapy? Tumour Microenvironment and Immune Evasion Strategies

edited by

Agnieszka Bojarska-Junak

and

Michal Zarobkiewicz

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1074 | Submission Open

Keywords: immunosurveillance; immune evasion in cancer; tumour microenvironment; immune suppression; immunotherapy; immune checkpoints; cancer immunity; drug intervention

(This special issue belongs to the Section Cell Microenvironment)

Galectins in Cancer, Fibrosis and Immune Modulation: Mechanisms, Therapeutic Strategies and Translational Advances

edited by Tsung-Chieh Shih

submission deadline 31 Oct 2025 | 1 articles | Viewed by 877 | Submission Open

Keywords: Galectin; tumor microenvironment; immunosuppression; fibrosis; epithelial– mesenchymal transition (EMT); cancer metastasis; immune evasion; therapy resistance; myeloid-derived suppressor cells (MDSCs); tumor-associated macrophages (TAMs); extracellular matrix remodeling; Galectin-targeted therapy; combination immunotherapy; fibroblast activation; chronic inflammation; tumor– stroma interactions; novel inhibitors of Galectins

(This special issue belongs to the Section Cellular Immunology)

Glial Cells: Physiological and Pathological Perspective

edited by

Qing Richard Lu

submission deadline 31 Oct 2025 | 1 articles | Viewed by 805 | Submission Open

Keywords: neurodegeneration; oligodendrocytes; astrocytes; microglia; neuroinflammation; demyelination neuron– glial interactions; homeostasis; glia-targeted therapies

(This special issue belongs to the Section Cells of the Nervous System)

Recent Advances in Astrocyte Neuron Communication

edited by

Stefano Ferroni

and

Francesco Formaggio

submission deadline 31 Oct 2025 | Viewed by 756 | Submission Open

Keywords: astrocytes; calcium signaling; ion channels; gliotransmitters; brain circuits; reactive astrogliosis; astrocyte heterogeneity; astrocyte– neuron networks; synaptic plasticity

(This special issue belongs to the Section Cells of the Nervous System)

Molecular Research of Cardiomyopathy

edited by

Luigi Sansone

and

Manuel Belli

submission deadline 31 Oct 2025 | Viewed by 367 | Submission Open

Keywords: cardiomyopathy; heart failure; hypertrophic cardiomyopathy; cellular and molecular rehabilitation

(This special issue belongs to the Section Cells of the Cardiovascular System)

Updates and Perspectives on Prion-Like Tau Pathology Propagation

edited by Kunie Ando, Jean-Pierre Brion and Siranjeevi Nagaraj

submission deadline 31 Oct 2025 | Viewed by 285 | Submission Open

Keywords: tau; amyloid beta; prion-like; propagation; Alzheimer’ s disease; neurodegenerative diseases; protein-protein interactions; synaptic dysfunction; aggregation; protein misfolding; risk factors; post-translational modifications

Cellular Pathways on Brain Control of Energy Metabolism

edited by Liangyou Rui

submission deadline 31 Oct 2025 | Viewed by 224 | Submission Open

Keywords: energy balance neurocircuit; molecular pathways governing energy balance neurocircuits; gut– brain axis in obesity; neuroinflammation in obesity and metabolic disease; neural sensing of metabolites and hormones

Autophagy in Cancer Regulation

edited by Tejinder Pal Khaket

submission deadline 31 Oct 2025 | Viewed by 201 | Submission Open

Keywords: autophagy; drug resistance; immune response: cancer stemness

(This special issue belongs to the Section Autophagy)

Advances in Bacterial Cell Biophysics: Metabolic Engineering and Host Interactions

edited by Shahid Khan

submission deadline 31 Oct 2025 | Viewed by 198 | Submission Open

Keywords: bacterial cell biophysics; mechanical properties; biophysical techniques; host interactions; metabolic engineering

Cell and Tissue Engineering for Functional Analysis (2nd Edition)

edited by

Masamichi Kamihira

submission deadline 31 Oct 2025 | Viewed by 166 | Submission Open

Keywords: animal cell engineering; tissue engineering; genome engineering; stem cell technology; synthetic biology

(This special issue belongs to the Section Tissues and Organs)

Potential Therapeutic Biomarkers for Prostate Cancer

edited by Benyi Li

submission deadline 31 Oct 2025 | Viewed by 124 | Submission Open

Keywords: prostate cancer; novel biomarkers; treatment

(This special issue belongs to the Section Cellular Pathology)

Kidney and Lung Disorders: The Role of Tubular and Alveolar Epithelia in Health, Disease, Infection, and Organ Crosstalk

edited by Aparna Renigunta and

Poornima Mahavadi

submission deadline 31 Oct 2025 | Viewed by 89 | Submission Open

Keywords: renal tubular disorders; alveolar lung diseases; transport mechanism; intracellular signaling; viral infection; crosstalk; dialysis; ventilation

From Bench to Bedside: Animal Models and Molecular Mechanisms in Cancer Therapeutics

edited by Sijana H. Dzinic

submission deadline 31 Oct 2025 | Viewed by 75 | Submission Open

Keywords: animal models in cancer research; cancer therapeutics; preclinical research; drug development; efficacy testing of novel anticancer agents; translational research

Cellular and Molecular Mechanisms in Peritoneal Malignancies: Insights into Pathogenesis and Therapeutic Advances

edited by

Tarkan Jäger

, Ibrahim Büdeyri and Jan Philipp Ramspott

submission deadline 31 Oct 2025 | Viewed by 62 | Submission Open

Keywords: peritoneal metastasis; cytoreductive surgery; HIPEC; PIPAC; biomarker; tumor microenvironment; epigenetics; precision oncology; tumor metabolism; immunotherapy

(This special issue belongs to the Section Cellular Pathology)

Mechanisms Underlying Cell Growth and Development

edited by

Rustem E. Uzbekov

submission deadline 31 Oct 2025 | Viewed by 59 | Submission Open

Keywords: cell growth; cell development; cell differentiation; cell cycle; mitosis; meiosis; molecular rearrangements; chromosomes; gene expression

Plasticity of Skeletal, Cardiac and Smooth Muscles in COPD: Repair and Remodeling

edited by Joaquim Gea Guiral

submission deadline 31 Oct 2025 | Viewed by 50 | Submission Open

Keywords: injury; repair; adaptation; aerobic metabolism; muscle mass; limb muscles; respiratory muscles; proteolysis

Functional Differences in Periostin Splicing Isoforms in Cancer and Inflammatory Disorders

edited by

Yoshiaki Taniyama

and Nobutaka Koibuchi

submission deadline 31 Oct 2025 | Viewed by 33 | Submission Open

Keywords: periostin; splicing variant; treatment-resistant cancer; diagnostics; periostin suppression therapy

Exploring Mitochondrial Dysfunction and Neuroinflammation in Neurodegeneration for New Therapeutic Advances

edited by Hanhan Liu

submission deadline 31 Oct 2025 | Viewed by 28 | Submission Open

Keywords: mitochondria; neuroinflammation; neurodegeneration; neuroprotective therapy; innate immunity

Macrophages in Cancer: Immunosuppression, Immunoregulation, and Immunotherapy

edited by Abdullah Saeed

submission deadline 5 Nov 2025 | Viewed by 381 | Submission Open

Keywords: macrophage; immunosuppression; immunoregulation; immunotherapy; tumor immune microenvironment

(This special issue belongs to the Section Cellular Immunology)

Stem Cells in Cancer

edited by

Ajit Kumar Sharma

submission deadline 10 Nov 2025 | 2 articles | Viewed by 2156 | Submission Open

Keywords: cancer stem cells; heterogeneity; metastasis; plasticity; self-renewal

(This special issue belongs to the Section Stem Cells)

Synaptic Plasticity and the Neurobiology of Learning and Memory

edited by Erica Berretta, Laura Petrosini and Anna Panuccio

submission deadline 10 Nov 2025 | Viewed by 638 | Submission Open

Keywords: learning and memory; neuronal and glial cells; long-term potentiation and long-term depression; molecular mechanisms

Recent Advances in the Molecular Mechanisms of Neurodegenerative Diseases: Current Progress and Future Directions for Disease-Modifying Therapies

edited by

Rengasamy Balakrishnan

and

Balamuralikrishnan Balasubramanian

submission deadline 10 Nov 2025 | Viewed by 99 | Submission Open

Keywords: neuroprotection; new drug development; natural products; blood– brain barrier; molecular mechanisms; neuronal signaling; neuroinflammation; microglial cells; neurotoxicity; neurodegenerative diseases

(This special issue belongs to the Section Cellular Aging)

Biomarkers in Breast Cancer

edited by Julie Decock and Sana A. Bentebbal

submission deadline 10 Nov 2025 | Viewed by 56 | Submission Open

Keywords: breast cancer biomarkers; AI in oncology; multi-omics; exosomes; tumor immune microenvironment; liquid biopsy; precision oncology; personalized medicine

(This special issue belongs to the Section Cellular Pathology)

Immunoregulation in Cardiovascular Disease

edited by

Hong Wang

submission deadline 10 Nov 2025 | Viewed by 55 | Submission Open

Keywords: cardiovascular disease (CVD); immunoregulation; inflammation; immune cells; immune mediators; immunomodulatory therapies; biomarkers; epigenetics; microbiome; cellular methods/technologies

Innate-Like T Cells: The Variegated Roles of Semi-Invariant TCRs in Health and Disease

edited by

Ethan Shevach

and Akshat Sharma

submission deadline 15 Nov 2025 | Viewed by 871 | Submission Open

Keywords: innate-like T cells; cancer; autoimmunity; cytokines; immune mechanisms

Novel Therapies and Biomarkers for Rare Diseases

edited by Reena Kartha

submission deadline 15 Nov 2025 | Viewed by 97 | Submission Open

Keywords: rare diseases; translational research; novel therapies; biomarker discovery; precision medicine

Lipids and Lipidomics in Neurodegenerative Diseases

edited by

Nathalie Bernoud-Hubac

and Catherine Malaplate

submission deadline 20 Nov 2025 | 1 articles | Viewed by 5711 | Submission Open

Keywords: lipids; lipidomics; neurodegenerative disease diagnosis; prevention; or treatment; cellular and molecular mechanisms

(This special issue belongs to the Section Cells of the Nervous System)

Second Edition of Advances in Adipose Tissue Biology

edited by

Melvin K. S. Leow

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2554 | Submission Open

Keywords: adipocyte differentiation; progenitors; and stem cells; adipokines; myokines; hepatokines; cytokines; cellular signaling; and molecular crosstalk; white adipose tissue (WAT) and brown adipose tissue (BAT); beige fat and browning of WAT; research techniques and methodologies; diagnostics and therapeutics; genomics; metabolomics; other ‘ omics’ technologies; metabolic syndrome; obesity; insulin resistance; cancer

(This special issue belongs to the Section Tissues and Organs)

Aging and Metabolic Diseases

edited by

Carlos Guillen

submission deadline 20 Nov 2025 | Viewed by 386 | Submission Open

Keywords: aging; insulin resistance; diabetes; obesity; mitochondrial dysfunction; beta-galactosidase; senescent-associated secretory phenotype; pancreatic beta cells

(This special issue belongs to the Section Cellular Aging)

Ripening and Degradation Mechanisms of Neutrophil Extracellular Traps

edited by

Martin Herrmann

and Maximilian Dölling

submission deadline 20 Nov 2025 | Viewed by 365 | Submission Open

Keywords: neutrophil extracellular traps; degradation of NETs; ripening of NETs

(This special issue belongs to the Section Cellular Immunology)

Tumor Stroma Interaction

edited by

Vladimir Jurisic

submission deadline 20 Nov 2025 | Viewed by 273 | Submission Open

Keywords: cells; cancer; inflammation; exocytosis; immune system; tumor stroma

Extracellular Vesicles Based Drug Delivery

edited by

Giovanni Camussi

and

Cristina Grange

submission deadline 20 Nov 2025 | Viewed by 245 | Submission Open

Keywords: EV engineering; targeting; therapy; natural carrier; exosomes

Recent Advances in the Study of Tau Protein

edited by

Santosh Jadhav

submission deadline 20 Nov 2025 | Viewed by 106 | Submission Open

Keywords: tau protein; post-translational modification; tauopathy filaments; neuro-immune interactions

(This special issue belongs to the Section Cells of the Nervous System)

Decoding the Complexity of Angiogenesis: Insights into Vascular Formation and Disease

edited by

Kay-Dietrich Wagner

submission deadline 20 Nov 2025 | Viewed by 95 | Submission Open

Keywords: angiogenesis; vasculogenesis; development; physiological angiogenesis; pathophysiology; cell– cell communication; cell signaling

(This special issue belongs to the Section Cells of the Cardiovascular System)

Acute Liver Failure: Molecular Actors in Liver–Adipose Tissue Interplay

edited by Marika Crescenzi

submission deadline 20 Nov 2025 | Viewed by 63 | Submission Open

Keywords: inflammasome; adipose tissue; acute liver injury; adipokines; liver macrophages; hepatic stellate cells; liver sinusoidal endothelial cells

(This special issue belongs to the Section Tissues and Organs)

Methane Biosynthesis

edited by

Divya Prakash

, James Ferry and

Shikha Singh Chauhan

submission deadline 20 Nov 2025 | Viewed by 44 | Submission Open

Keywords: methane; methanogenesis; methanogens; carbon cycle; gut microbiota; energy conservation; human diseases

New Insights into Astrocytes in Health and Disease

edited by

Tao Tao

submission deadline 20 Nov 2025 | Viewed by 29 | Submission Open

Keywords: astrocytes heterogeneity; blood-brain barrier (BBB); synaptic modulation; metabolic support; neuroinflammation; ageing; neurodegenerative disorders; neurodevelopmental disorders; stress response

(This special issue belongs to the Section Cells of the Nervous System)

Transient Receptor Potential (TRP) Channels and Health and Disease

edited by Hiroki Kittaka and Makoto Tominaga

submission deadline 20 Nov 2025 | Viewed by 16 | Submission Open

Keywords: Transient Receptor Potential (TRP) channels; cell signaling; cell physiology

Displaying special issue 351-400 on page 8 of 11.

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