Advances in Aging-Related Hyperphosphatemia
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Aging".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 104
Special Issue Editors
Interests: skeletal muscle aging; cellular senescence; hyperphosphatemia; kidney disease
Special Issue Information
Dear Colleagues,
Phosphate is essential in cellular physiology, participating in energy metabolism, nucleic acid synthesis, and intracellular signaling. Accumulating evidence suggests that dysregulated phosphate homeostasis—particularly elevations in systemic phosphate levels or hyperphosphatemia—may act as an underrecognized driver of aging-related pathology. Age-associated alterations to the bone–kidney endocrine axis, including fibroblast growth factor 23 (FGF23), Klotho, parathyroid hormone, and vitamin D, contribute to this systemic phosphate imbalance. Hyperphosphatemia directly affects cellular function by promoting oxidative stress, mitochondrial dysfunction, inflammation, and cellular senescence and has been associated with cardiovascular injury, muscle dysfunction, and bone fragility, among other issues. Despite growing interest in this field, the key molecular mechanisms linking phosphate toxicity to cellular dysfunction remain incompletely understood.
This Special Issue will highlight recent advances in the cellular and molecular basis of age-related hyperphosphatemia, its contribution to age-related diseases, the underlying mechanisms of action involved, the regulation of miRNAs, and their potential use as disease biomarkers.
Dr. Elena Alcalde-Estévez
Dr. Susana López-Ongil
Guest Editors
Manuscript Submission Information
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Keywords
- hyperphosphatemia
- age-related diseases
- cellular senescence
- biomarkers
- sarcopenia
- endothelial dysfunction
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