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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Regulation of Trophoblast Invasion in Placental Function and Pregnancy Disorders

edited by Mirjana Nacka-Aleksić and

Nihar R. Nayak

submission deadline 25 Jul 2026 | Viewed by 27 | Submission Open

Keywords: trophoblast invasion; preeclampsia; placenta accreta; human trophoblast stem cells

(This special issue belongs to the Section Reproductive Cells and Development)

Toxicology in Cells: Cellular Mechanisms, Molecular Responses, and Modern Models

edited by Maria Jurczuk and

Patrice X. Petit

submission deadline 30 Jul 2026 | Viewed by 143 | Submission Open

Keywords: cellular toxicology; oxidative stress; apoptosis; autophagy; biomarkers; nanotoxicology; organ-on-chip; toxicogenomics; epigenetic regulation; mitochondrial dysfunction

New Advances in Immunomodulation Using Biomaterials

edited by

Gundula Schulze-Tanzil

and Vaishali Inamdar

submission deadline 30 Jul 2026 | Viewed by 95 | Submission Open

Keywords: immunomodulation; biomaterials; cell– material interactions; biocompatibility; immune system

Mitochondria in Cancer Immune Evasion and Immunotherapy

edited by Loredana Moro and

Flora Guerra

submission deadline 30 Jul 2026 | Viewed by 88 | Submission Open

Keywords: mitochondria; mtDNA; immunity; cancer immune evasion; tumor microenvironment; immune tolerance; lymphocytes; inflammation; immune response

(This special issue belongs to the Section Cellular Immunology)

Cancer Cytopathology: Structural Features and Intracellular Events in Malignancy

edited by

Toshimichi Onuma

and

Jianjun Wei

submission deadline 30 Jul 2026 | Viewed by 51 | Submission Open

Keywords: cancer cells; cytopathology; tumor microenvironment; cell culture; biopsies

(This special issue belongs to the Section Cellular Pathology)

Targeted Therapy and Immunotherapy in Breast Cancer: Molecular Mechanisms and Translational Advances

edited by Saranya Chumsri, Hatem H. Soliman and

Aixa Elena Soyano

submission deadline 30 Jul 2026 | Viewed by 41 | Submission Open

Keywords: breast cancer; targeted therapy; immunotherapy; biomarkers of response; therapeutic resistance

(This special issue belongs to the Section Cellular Immunology)

Cellular Mechanisms of Anti-Cancer Therapies

edited by Ilgen Mender and

Kazuyuki Kitatani

submission deadline 31 Jul 2026 | 8 articles | Viewed by 21315 | Submission Open

Keywords: anti-cancer therapies; innovative treatment strategies; cellular mechanisms; drug resistance; personalized medicine

(This special issue belongs to the Section Cellular Pathology)

How Can We Optimise Cancer Therapy? Tumour Microenvironment and Immune Evasion Strategies

edited by

Agnieszka Bojarska-Junak

and

Michal Zarobkiewicz

submission deadline 31 Jul 2026 | 6 articles | Viewed by 11454 | Submission Open

Keywords: immunosurveillance; immune evasion in cancer; tumour microenvironment; immune suppression; immunotherapy; immune checkpoints; cancer immunity; drug intervention

(This special issue belongs to the Section Cell Microenvironment)

Advances in the Discovery of Retinal Degeneration

edited by

Ram Prasad

and

Yvonne Adu-Rutledge

submission deadline 31 Jul 2026 | 5 articles | Viewed by 7560 | Submission Open

Keywords: retinal cell biology; photoreceptors; oxidative stress; inflammation; blood– retinal barriers; diabetic retinopathy; clinical eye research; inherited retinal diseases; ocular immunology

(This special issue belongs to the Section Cellular Pathology)

Cellular and Molecular Mechanisms of Vascular-Related Diseases

edited by

Bingmei Fu

and

Ye Zeng

submission deadline 31 Jul 2026 | 7 articles | Viewed by 7034 | Submission Open

Keywords: cellular and molecular mechanisms; cardiovascular disease; cerebrovascular disease; vascular signaling; vascular dysfunctions in cns disorders; vascular dysfunctions in diabetes; vascular dysfunction in chronic kidney disease; tumor metastasis via vascular system

(This special issue belongs to the Section Cellular Pathology)

Osteoblasts, Osteoclasts and Bone Diseases: Cellular Crosstalk and Therapeutic Opportunities

edited by

Thomas Nicholson

submission deadline 31 Jul 2026 | 3 articles | Viewed by 5519 | Submission Open

Keywords: osteoblasts; osteoclasts; bone remodelling; osteoporosis; skeletal diseases; bone homeostasis; bone interactions; bone crosstalk; targeted therapies

(This special issue belongs to the Section Cellular Pathology)

Advances in the Cellular and Molecular Mechanisms of Cardiovascular Diseases

edited by

Timothy Martin Palmer

and Katie S. Wraith

submission deadline 31 Jul 2026 | 6 articles | Viewed by 5336 | Submission Open

Keywords: thrombosis; smooth muscle; endothelium; atherosclerosis; inflammation

(This special issue belongs to the Section Cells of the Cardiovascular System)

Mechanisms of Lung Growth and Regeneration

edited by

Saverio Bellusci

and

Yuanlin Song

submission deadline 31 Jul 2026 | 3 articles | Viewed by 5228 | Submission Open

Keywords: stem cells; niche; aging; growth factors; extracellular matrix; organoids; fibrosis; single-cell RNAseq

(This special issue belongs to the Section Cell Microenvironment)

Cellular and Molecular Mechanisms in Neuropsychiatric and Neurological Disorders

edited by Irina Balan

submission deadline 31 Jul 2026 | 3 articles | Viewed by 3902 | Submission Open

Keywords: cellular mechanisms; molecular mechanisms; neuropsychiatric disorders; neurological disorders; neuroinflammation; neuronal signaling; gene expression; synaptic function; glial cells; peripheral factors

(This special issue belongs to the Section Cellular Pathology)

Genetic Mechanisms in Cellular Genomics and Therapeutics

edited by Elaine T. Lim and Yingleong Chan

submission deadline 31 Jul 2026 | 1 articles | Viewed by 3142 | Submission Open

Keywords: genetics of human diseases; functional genomics; cellular mechanisms; genomics or stem cell technologies; therapeutics research and development for human diseases

Integrated Approaches Between Metabolomics and Cellular Aging

edited by Maria Nikolaou and

Nikolaos Theodorakis

submission deadline 31 Jul 2026 | 2 articles | Viewed by 2597 | Submission Open

Keywords: metabolomics; cellular aging; senescence; mitochondrial dysfunction; DNA damage; biomarkers; metabolism

(This special issue belongs to the Section Cellular Aging)

Standardization and Metrological Advancements in Cellular and Genomic Diagnostics for Cancer

edited by

Jessica Petiti

and Marika Fava

submission deadline 31 Jul 2026 | 1 articles | Viewed by 2215 | Submission Open

Keywords: cancer diagnostics; cellular analysis; genomic profiling; precision medicine; metrology in diagnostics; next generation sequencing (NGS); reference measurement systems (RMSs); quality assurance (QA); IVDR compliance; SI-traceable standards

Cellular and Molecular Mechanisms of Heart Diseases

edited by

Sumita Mishra

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1872 | Submission Open

Keywords: heart failure; HFrEF; HFpEF; molecular signaling; therapeutic interventions; ejection fraction; fibrosis; metabolism; mitochondrial dysfunction; cardiovascular therapies

(This special issue belongs to the Section Cellular Pathology)

Cellular and Molecular Mechanisms in Immune Regulation—Second Edition

edited by Fábio Rinaldo Santori and Natalia B. Ivanova

submission deadline 31 Jul 2026 | 3 articles | Viewed by 1784 | Submission Open

Keywords: innate immunity; dendritic cells; macrophages; T cells; B cells; cytokines; immunotherapy

(This special issue belongs to the Section Cellular Pathology)

Biochemical Mechanisms and Physiological Implication of Stem Cell Differentiation

edited by

Giuliana Mannino

and

Floriana D'Angeli

submission deadline 31 Jul 2026 | 1 articles | Viewed by 781 | Submission Open

Keywords: stem cells; differentiation; 3D cultures; co-cultures; biochemistry; physiology; epigenetics

(This special issue belongs to the Section Stem Cells)

Advances in Adipocyte Biology Research and Their Relevance to Metabolic Health

edited by

Aaron C. Brown

submission deadline 31 Jul 2026 | 1 articles | Viewed by 583 | Submission Open

Keywords: adipose tissue; obesity; inflammation; thermogenesis; adipokines

Rho Family Small GTPases in Health and Diseases

edited by

Katalin Szászi

submission deadline 31 Jul 2026 | Viewed by 324 | Submission Open

Keywords: Rho signalling; Rho guanine nucleotide exchange factor; Rho GTPase-activating protein; Rho effector; dysregulation of Rho GTPases; Rho pathway inhibitors

(This special issue belongs to the Section Cell Signaling)

Molecular Research in Osteoporosis

edited by

Virginia Visconti

Annalisa Botta

and

Umberto Tarantino

submission deadline 31 Jul 2026 | Viewed by 290 | Submission Open

Keywords: osteoporosis; osteosarcopenia; bone– muscle crosstalk; genetics; epigenetics; transcriptomics; biomarkers; therapeutic strategy

(This special issue belongs to the Section Cellular Pathology)

Is Gene Therapy the Answer to Overcoming Diabetes?

edited by

Ann Simpson

and

Najah Therese Nassif

submission deadline 31 Jul 2026 | Viewed by 250 | Submission Open

Keywords: gene therapy; type 1 diabetes; type 2 diabetes; glycemic control; beta-cell transcription factors; insulin granules; viral vectors

Advances in Toxoplasma gondii Treatment, Immunology and Host–Parasite Interaction

edited by Namrata Anand

submission deadline 31 Jul 2026 | Viewed by 237 | Submission Open

Keywords: T. gondii; treatment strategies; secretory proteins; immune response; exosomes; nanoparticle; congenital infection; host– parasite interaction

(This special issue belongs to the Section Cellular Immunology)

Immunometabolic Reprogramming in Diabetic Kidney Disease: The Interplay of Innate Immunity, Oxidative Stress, and Cellular Metabolism

edited by

Nela Kelam

, Sandra Kostić and Anita Racetin

submission deadline 31 Jul 2026 | Viewed by 216 | Submission Open

Keywords: diabetic kidney disease; immunometabolism; innate immunity; oxidative stress; metabolic reprogramming; inflammasome; renal fibrosis; mitochondrial dysfunction; non-coding RNAs; multi-omics integration

Kinin System in Health and Disease: Cellular and Molecular Perspectives

edited by Marcos Gregnani and Leonardo Martins

submission deadline 31 Jul 2026 | Viewed by 198 | Submission Open

Keywords: kallikrein– kinin system; bradykinin receptors; inflammation; cardiovascular disease; molecular pathways

(This special issue belongs to the Section Cellular Pathology)

Aquaporins at the Crossroads of Human Health and Disease

edited by

Anna Patrizia Gena

submission deadline 31 Jul 2026 | Viewed by 187 | Submission Open

Keywords: aquaporins; membrane molecular transport; channels proteins in health and disease; novel drug targets; cellular biophysics

ALK Signaling Pathways in NSCLC: From Cell Biology to Therapeutic Insights

edited by

Edyta Maria Urbanska

and

Eric Santoni-Rugiu

submission deadline 31 Jul 2026 | Viewed by 147 | Submission Open

Keywords: anaplastic lymphoma kinase (ALK); non-small-cell lung cancer (NSCLC); ALK tyrosine kinase inhibitors (ALK-TKIs); drug resistance; signal transduction and oncogenic pathways; molecular diagnostics (IHC; FISH; NGS); targeted therapy

Extracellular Vesicles: Drivers, Biomarkers and Therapeutics in Cardiovascular Disease

edited by

Prabhu Mathiyalagan

submission deadline 31 Jul 2026 | Viewed by 103 | Submission Open

Keywords: cardiovascular disease; extracellular vesicles; biomarkers; therapeutics; drug delivery; RNA therapeutics; fibrosis; atherosclerosis; liquid biopsy

Recent Advances in Vitamin D and K in Cancer

edited by

Alexandra M. Crǎciun

Ciprian N. Silaghi

and

Andreea Crintea

submission deadline 31 Jul 2026 | Viewed by 81 | Submission Open

Keywords: vitamin D; vitamin K; VDR signaling; tumor microenvironment; cancer prevention; molecular pathways; apoptosis and proliferation; oxidative stress; immunomodulation; therapeutic resistance

Molecular Mechanisms to Treatment Progress of Ovarian Cancer

edited by Amal M. El-Naggar

submission deadline 31 Jul 2026 | Viewed by 73 | Submission Open

Keywords: ovarian cancer; molecular mechanisms; therapeutic targets; drug resistance; biomarkers; preclinical models; targeted therapy; immunotherapy; tumor microenvironment; translational research

(This special issue belongs to the Section Reproductive Cells and Development)

Molecular Signatures and Cellular Pathways of Immune Dysfunction in HIV and Tuberculosis

edited by

Sandeep Rai Kaushik

, Pradeep Kumar Sheokand,

Nejat Düzgüneş

, Ekta Saini and Prashant Bajpai

submission deadline 31 Jul 2026 | Viewed by 70 | Submission Open

Keywords: immune cell dysfunction; immune persistence; T cell exhaustion; chronic infection; host– pathogen interactions; cellular immunity; molecular immune signaling; single-cell immunology; immune cell plasticity; infection-induced immune remodeling

(This special issue belongs to the Section Cellular Immunology)

Emerging Insights into Natural Killer Cell Immunity in Infection and Cancer—2nd Edition

edited by Sachin Mulik, Weshely Kujur,

Engin Berber

and Sumit Sen Santara

submission deadline 31 Jul 2026 | Viewed by 68 | Submission Open

Keywords: CAR NK cells; cancer immunotherapy; cell therapy; viral infection; memory NK cells; NK cell targeted therapies; NK-immune cell crosstalk; exosomes

(This special issue belongs to the Section Cellular Immunology)

Histological Classification of Lung Cells Across Animal Models and Life Stages

edited by

Roberta Ciccimarra

submission deadline 31 Jul 2026 | Viewed by 67 | Submission Open

Keywords: lung parenchyma; histological classification; normal lung anatomy; spatial organization; animal models; non-rodent models; comparative lung anatomy; lung ageing

(This special issue belongs to the Section Tissues and Organs)

Sex Differences in Molecular Mechanisms Linking Neuronal Stress and Inflammation

edited by John R. Bethea and Kayla Lee Nguyen

submission deadline 31 Jul 2026 | Viewed by 65 | Submission Open

Keywords: ER stress; intracellular signaling; neuronal stress; immune activation; sex differences; neuro-immune interactions

(This special issue belongs to the Section Cellular Neuroscience)

Signaling Dynamics in Cancer

edited by Claudia Voena, Riccardo Taulli and Francesca Bersani

submission deadline 31 Jul 2026 | Viewed by 58 | Submission Open

Keywords: cancer signaling; cancer biology; tumor microenvironment; tumor progression; biomarkers; therapeutics

(This special issue belongs to the Section Cell Signaling)

Advances in the Gut–Liver–Brain Axis in Human Health and Disease

edited by

Pradeep K. Shukla

submission deadline 31 Jul 2026 | Viewed by 56 | Submission Open

Keywords: gut– liver– brain axis; microbiota; liver metabolism; neuroinflammation; metabolic disease; neurodegeneration; gut– brain communication

Uncovering Placental Inflammatory Pathways Affecting the Developing Brain

edited by

Guillaume Sébire

and

Math Chevin

submission deadline 31 Jul 2026 | Viewed by 45 | Submission Open

Keywords: neuroplacentology; neuroinflammation; hypoxia– ischemia; developing brain; ASD; CP; ADHD; learning disabilities; preclinical model; cell culture

(This special issue belongs to the Section Reproductive Cells and Development)

Recent Insights into the Role of Metal Ions in the Nervous System

edited by Richard H. Dyck

submission deadline 31 Jul 2026 | Viewed by 41 | Submission Open

Keywords: metal ions; neurobiology; zinc signalling; copper homeostasis; iron metabolism; calcium signalling; magnesium; lithium; metallomics; synaptic transmission; neuromodulation; ion transporters; metal-binding proteins; oxidateive stress; mitochondrial function; neurodevelopment; synaptic plasticity; neuroinflammation; neurodegeneration; neuropsychiatric disorders; autism spectrum disorder; schizophrenia; Alzheimer disease; Parkinson disease; imaging of metal ions; metal ion dysregulation

(This special issue belongs to the Section Cellular Neuroscience)

Endothelial Phenotype Transition and Vascular Calcification Mechanisms

edited by

Yin Tintut

and Jeffrey J. Hsu

submission deadline 31 Jul 2026 | Viewed by 28 | Submission Open

Keywords: endothelial cell; vascular calcification; cell plasticity; endothelial-to-mesenchymal transition (EndMT); vascular biology

Molecular Drivers of Oncogenesis and Tumor Evolution: Mechanisms and Cellular Pathways

edited by

Ioana Berindan-Neagoe

and

Alexandru Tirpe

submission deadline 31 Jul 2026 | Viewed by 15 | Submission Open

Keywords: oncogenesis; cancer progression; cancer biology; tumor immunology; tumor microenvironment; metastasis; angiogenesis; metabolic reprogramming; therapy resistance

AI and Multi-Modal Data Integration in Neurobiology and Neurological Diseases

edited by Jeon Lee

submission deadline 31 Jul 2026 | Viewed by 5 | Submission Open

Keywords: artificial intelligence; multi-modal integration; multi-omics; neurobiology; neurological disease; molecular characterization; neuronal biomarker; cellular pathway

(This special issue belongs to the Section Cellular Neuroscience)

NF-κB Signaling in Inflammation: Molecular Mechanisms and Therapeutic Targets

edited by Gaetano Spinelli and

Francesco Di Blasi

submission deadline 1 Aug 2026 | Viewed by 101 | Submission Open

Keywords: NF-κ B signaling; inflammation; canonical and non-canonical pathways; immune regulation; post-translational modifications; signal transduction; inflammatory diseases; autoimmune disorders; cancer; tumor microenvironment; oncogenesis; metabolic diseases; neuroinflammation; therapeutic targets; drug development

Stem Cells in Congenital Heart Disease: Novel Approaches and Regenerative Strategies

edited by

Aaron D. Argall

Mingtao Zhao

and Wei Shi

submission deadline 1 Aug 2026 | Viewed by 29 | Submission Open

Keywords: stem cell; congenital heart defect; iPSC; maturation; regeneration; cardiac arrhythmia; heart failure

(This special issue belongs to the Section Stem Cells)

Inflammation at the Nexus of Neurodegeneration: Cellular Mechanisms, Biomarkers and Therapeutic Targets

edited by Kirstan A. Vessey

submission deadline 1 Aug 2026 | Viewed by 21 | Submission Open

Keywords: neuroinflammation; microglia; astrocytes; neurovascular unit; inflammasome; cytokine signaling; cell death pathways; biomarkers; retinal degeneration; neurodegenerative disease

(This special issue belongs to the Section Cellular Neuroscience)

Intestinal Stem Cells

edited by

Natalia Soshnikova

and

Arunkumar Jagadeesan

submission deadline 5 Aug 2026 | Viewed by 246 | Submission Open

Keywords: stem cells; self-renewal; enterocytes; intestinal organoid; villus; crypt

(This special issue belongs to the Section Stem Cells)

Focus on Machinery of Cell Death

edited by

Subhadip Mukhopadhyay

, Prashanta Kumar Panda and

Suprabhat Mukherjee

submission deadline 10 Aug 2026 | 8 articles | Viewed by 21674 | Submission Open

Keywords: cell death; autophagy; apoptosis; necrosis; ferroptosis; metabolism; stem cell biology; infection; aging; development; Alzheimer’ s; neurodegeneration; therapy

(This special issue belongs to the Section Cellular Pathology)

Cell Therapies in Cancer Treatment

edited by

Giovanni Amabile

submission deadline 10 Aug 2026 | 1 articles | Viewed by 2825 | Submission Open

Keywords: cellular therapies; cancer; immune

The Role of Stem Cells in Retinal Conditions

edited by

Georgios Panos

, Theo Empeslidis and Lorenzo Motta

submission deadline 10 Aug 2026 | Viewed by 601 | Submission Open

Keywords: stem cells; retinal conditions; regenerative medicine; age-related macular degeneration (AMD); retinitis pigmentosa; diabetic retinopathy; induced pluripotent stem cells (iPSCs); cell differentiation; vision restoration; clinical trials

(This special issue belongs to the Section Stem Cells)

Displaying special issue 551-600 on page 12 of 14.

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