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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Crosstalk Between Autophagy, Apoptosis and Inflammation

edited by

Maurizio Sorice

and

Tina Garofalo

submission deadline 31 Oct 2026 | Viewed by 169 | Submission Open

Keywords: autophagy; apoptosis; inflammation; signal transduction; lipid messengers; rheumatic disorders; cancer; neurodegenerative diseases

(This special issue belongs to the Section Autophagy)

Advances in Alcohol-Associated Liver Disease

edited by

Sheetalnath Babasaheb Rooge

submission deadline 31 Oct 2026 | Viewed by 169 | Submission Open

Keywords: alcohol-associated liver disease (ALD); metabolic and alcohol associated liver disease (MetALD); alcohol-associated hepatitis (AH)；steatosis; fibrosis; cirrhosis; portal hypertension; hepatic inflammation; hepatocytes; macrophages; neutrophils; stellate cells

(This special issue belongs to the Section Cellular Pathology)

Ion Transporters and Channels in Cellular Homeostasis and Disease

edited by Guanxiao Qi and Raul E. Guzman

submission deadline 31 Oct 2026 | Viewed by 149 | Submission Open

Keywords: patch-clamp recording; ligand-gated channels; ion channel modulators; channel-specific ligands; channelopathies; epilepsy; neurodegenerative disease

Cellular and Molecular Mechanisms of Oocyte Maturation and the Fertilization Process

edited by

Luigia Santella

, Jong Tai Chun,

Evelyn Telfer

and Bart M. Gadella

submission deadline 31 Oct 2026 | Viewed by 136 | Submission Open

Keywords: oocyte growth; meiotic maturation; sperm capacitation; acrosome reaction; actin; calcium; cortical/zona reaction; polyspermy; cleavage; implantation

(This special issue belongs to the Section Reproductive Cells and Development)

The Role of Immune Checkpoint Inhibitors Combined with Cancer Vaccines in the Neoadjuvant Setting of Solid Tumors

edited by Yasser Mostafa Kamel and Mahmoud Abdelsalam

submission deadline 31 Oct 2026 | Viewed by 131 | Submission Open

Keywords: neoadjuvant therapy; immune checkpoint inhibitors (ICIs); therapeutic cancer vaccines; early-stage solid tumors; pathologic complete response (pCR); major pathologic response (MPR)

(This special issue belongs to the Section Cellular Immunology)

Allergy and Immunity

edited by Anish R. Maskey and

Jan Geliebter

submission deadline 31 Oct 2026 | Viewed by 118 | Submission Open

Keywords: allergy; immune regulation; inflammation; epithelial barrier; biomarker; alternate therapy

(This special issue belongs to the Section Cellular Immunology)

Integrating CRISPR-Based Functional Genomics and Multi-Omics to Identify Therapeutic Targets

edited by

Farimah Ghorbani

and David J. Elliott

submission deadline 31 Oct 2026 | Viewed by 113 | Submission Open

Keywords: CRISPR-technology; functional genomics screening; Perturb-seq; multi-omics; disease mechanisms; drug target discovery

(This special issue belongs to the Section Cell Methods)

Cellular and Molecular Mechanisms Behind Liver Inherited Metabolic Diseases and Novel Therapeutic Strategies

edited by Sonam Gurung

submission deadline 31 Oct 2026 | Viewed by 112 | Submission Open

Keywords: inherited metabolic liver diseases; urea cycle disorders; hepatic metabolic homeostasis; molecular mechanisms of disease; disease-modifying therapies; monogenic disorders; systems biology approaches; rare diseases

(This special issue belongs to the Section Cellular Pathology)

Autophagy, Mitochondria, and Cell Death in Cancer

edited by Yuchen Lei and

Kazuyuki Kitatani

submission deadline 31 Oct 2026 | Viewed by 106 | Submission Open

Keywords: autophagy; cancer; cell death; metabolism; mitochondria

(This special issue belongs to the Section Autophagy)

Microscopy in Decoding Complex Cellular Structures

edited by

Marcus Frank

submission deadline 31 Oct 2026 | Viewed by 105 | Submission Open

Keywords: correlative microscopy; super resolution microscopy; electron microscopy; 3D reconstruction; cell– cell contact; cell– matrix contact; cell surface; cell signaling; cell microenvironment; cell adhesion; cell junction; cell organelle; organelle maturation; mitochondria; Golgi apparatus; phagosomes; cilia; synapse formation; barrier function; blood– brain barrier; multimodal microscopy; fluorescence microscopy; expansion microscopy; organelle shaping; migrasomes; protozoan; organoid; spheroid

(This special issue belongs to the Section Cell Methods)

MicroRNAs in Atherosclerosis: Mechanisms, Biomarkers, and Therapeutic Opportunities

edited by Genesio Karere

submission deadline 31 Oct 2026 | Viewed by 83 | Submission Open

Keywords: microRNAs (miRNAs); atherosclerosis and vascular inflammation; endothelial dysfunction; circulating biomarkers; RNA-based therapeutics

(This special issue belongs to the Section Cell and Gene Therapy)

Cellular and Molecular Mechanisms in Mammalian Reproduction

edited by

Kirsten E.S. Scoggin

Carleigh Elizabeth Fedorka

and

Hossam El Sheikh Ali

submission deadline 31 Oct 2026 | Viewed by 81 | Submission Open

Keywords: cell physiology; intra- and extracellular signaling; cell growth and differentiation; cellular immunology; stem cells; autophagy; apoptosis; omics; aging/senescence; cell techniques

(This special issue belongs to the Section Reproductive Cells and Development)

Emerging Trends in Liquid Biopsy: Recent Advances and Challenges

edited by

Nurmaa Dashzeveg

submission deadline 31 Oct 2026 | Viewed by 75 | Submission Open

Keywords: liquid biopsy; circulating DNA (ctDNA); circulating tumor cells (CTC); blood; biofluid

(This special issue belongs to the Section Cell Methods)

Cellular and Molecular Responses to Abiotic and Biotic Stress in Plants

edited by

Akhilesh Yadav

submission deadline 31 Oct 2026 | Viewed by 74 | Submission Open

Keywords: abiotic stress; biotic stress; plants; stress signaling; plant immunity; gene regulation; plant– microbe interactions; stress physiology; genomics

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Cellular and Molecular Mechanisms of Sperm Capacitation

edited by Patricio J. Morales,

Héctor Zapata-Carmona

and Milene Kong

submission deadline 31 Oct 2026 | Viewed by 67 | Submission Open

Keywords: sperm capacitation; acrosome reaction; protein phosphorylation; calcium signaling; signal transduction; post-translational modifications

(This special issue belongs to the Section Reproductive Cells and Development)

Advanced Review Papers in ‘Tissue and Organs’

edited by

Chao Xie

submission deadline 31 Oct 2026 | Viewed by 60 | Submission Open

Keywords: tissue biology; organ development and morphogenesis; tissue architecture and organization; stem cells and progenitor cells; tissue regeneration and repair; extracellular matrix; cell– cell communication; cellular microenvironment; tissue remodeling; 3D tissue models and bioengineering

(This special issue belongs to the Section Tissues and Organs)

Epigenetic Regulation of Cellular Plasticity in Brain Tumors

edited by

Sree Deepthi Muthukrishnan

and Erina Vlashi

submission deadline 31 Oct 2026 | Viewed by 53 | Submission Open

Keywords: brain tumors; epigenetic modifiers; tumor plasticity; epigenetic heterogeneity; microenvironment-epigenetic interactions; therapy resistance

(This special issue belongs to the Section Cell and Gene Therapy)

Molecular Genetics of Cystic Kidney Disease

edited by

John Sayer

and Juliana Galvis

submission deadline 31 Oct 2026 | Viewed by 47 | Submission Open

Keywords: cystic kidney disease; polycystic kidney disease; cilia; PKD1; PKD2; autosomal dominant; renal epithelium; animal models; disease mechanisms; organoids

(This special issue belongs to the Section Cell and Gene Therapy)

Glycolysis in Tumorigenesis: Mechanisms and Therapeutic Implications

edited by

Fabrizio Marcucci

, Shibo Wei and

Marco Cordani

submission deadline 1 Nov 2026 | 2 articles | Viewed by 1704 | Submission Open

Keywords: glycolysis; tumorigenesis; moonlighting functions; Warburg effect; metabolic reprogramming; tumor microenvironment; therapeutic targets; cancer metabolism

Role of Inflammasomes in Neurological Disorders

edited by

Juan Pablo de Rivero Vaccari

submission deadline 1 Nov 2026 | Viewed by 225 | Submission Open

Keywords: inflammasome; pyroptosis; caspase-1; ASC specks; IL-1beta; PANoptosis; CNS injury; neurodegenerative diseases; biomarkers; Alzheimer’ s disease; Parkinson’ s disease; multiple sclerosis; amyotrophic lateral sclerosis

(This special issue belongs to the Section Cellular Neuroscience)

Plasticity of Skeletal, Cardiac and Smooth Muscles in COPD: Repair and Remodeling

edited by

Joaquim Gea Guiral

submission deadline 5 Nov 2026 | 3 articles | Viewed by 6257 | Submission Open

Keywords: injury; repair; adaptation; aerobic metabolism; muscle mass; limb muscles; respiratory muscles; proteolysis

Cancer Stem Cells in Triple-Negative Breast Cancer

edited by

Antonella Zannetti

and

Maria Grazia Caprio

submission deadline 5 Nov 2026 | Viewed by 406 | Submission Open

Keywords: cancer stem cells; TNBC; signal pathways; epithelial– mesenchymal transition; tumor microenvironment; targeted therapy; biomarkers

Advancements in Research on hiPSC-Derived Cells

edited by Akhilesh Kumar

submission deadline 10 Nov 2026 | 2 articles | Viewed by 7291 | Submission Open

Keywords: hiPSCs; hematopoietic progenitors; T cells; NK cells; cardiac cells; B cells; macrophages; neutrophiles; CRISPR/Cas9 technology; genetic engineering

(This special issue belongs to the Section Stem Cells)

Hematologic Diseases: From Cellular and Molecular Mechanisms to Therapies

edited by

Wei Du

and

Pier Paolo Piccaluga

submission deadline 10 Nov 2026 | 2 articles | Viewed by 3340 | Submission Open

Keywords: hematologic diseases; mechanisms; therapies

Cellular Senescence and Transformation: Unraveling the Biological Links Between Aging and Cancer

edited by

Yongye Huang

, Lin Yuan and Yang Yu

submission deadline 10 Nov 2026 | 2 articles | Viewed by 1455 | Submission Open

Keywords: aging; cancer; stem cells; gene editing; oncogene; apoptosis; targeted therapy; epigenetics

Molecular and Cellular Mechanisms of Heart Regeneration

edited by Mira Pronobis and

Dinender K. Singla

submission deadline 10 Nov 2026 | 1 articles | Viewed by 648 | Submission Open

Keywords: cardiac regeneration; cardiomyocyte proliferation; tissue remodeling; cardiovascular repair; regenerative therapy; cellular plasticity; myocardial infarction; heart failure

(This special issue belongs to the Section Cells of the Cardiovascular System)

Methane Biosynthesis

edited by

Divya Prakash

, James Ferry and

Shikha Singh Chauhan

submission deadline 10 Nov 2026 | Viewed by 406 | Submission Open

Keywords: methane; methanogenesis; methanogens; carbon cycle; gut microbiota; energy conservation; human diseases

New Insights into Platelet Physiology and Dysfunction

edited by Serena Valsami and

Sotiris Fortis

submission deadline 10 Nov 2026 | Viewed by 64 | Submission Open

Keywords: platelets; platelet function; platelet physiology; platelet dysfunction; platelet disorders; platelet biology; pathophysiology; platelet transfusion; hereditary platelet disorders; acquired platelet disorders

(This special issue belongs to the Section Cells of the Cardiovascular System)

Recent Advances in Novel Cell and Gene Therapies for the Treatment of Immune Diseases

edited by Qingdong Guan

submission deadline 15 Nov 2026 | 5 articles | Viewed by 14938 | Submission Open

Keywords: cell therapy; gene therapy; chimeric antigen receptor T cells; T cell receptor-engineered T cells; tumor-infiltrating lymphocytes; hematopoietic stem cells; chimeric antigen receptor NK cells; induced pluripotent stem cells; mesenchymal stem/stromal cells; immune regulatory cells

(This special issue belongs to the Section Cellular Immunology)

Mast Cells in Health and Disease: Current Insights and Future Perspectives on Development, Activation, Functional Roles, and Therapeutic Strategies

edited by

Aida Paivandy

submission deadline 15 Nov 2026 | 7 articles | Viewed by 8285 | Submission Open

Keywords: mast cell granules; mast cell mediators; mast cell development; mast cell survival; mast cell activation; mast cell activating and inhibitory receptors; receptor signaling; allergic and non-allergic pathologies; immunity and host defense; mast cell-directed therapeutic approaches

(This special issue belongs to the Section Cellular Immunology)

Host–Pathogen Interactions and Immune Responses

edited by Harish Chandra

submission deadline 15 Nov 2026 | 4 articles | Viewed by 4648 | Submission Open

Keywords: multidrug-resistant bacteria; environmental mycobacteria; exosomes; oxidative stress; catalases; antimicrobial resistance; polycyclic aromatic hydrocarbons (PAHs); cellular signaling

(This special issue belongs to the Section Cellular Immunology)

Mechanisms and Therapies in Chronic Pain

edited by Nikesh Kunder and June Bryan I. de la Peña

submission deadline 15 Nov 2026 | 1 articles | Viewed by 2364 | Submission Open

Keywords: chronic pain; pain mechanisms; pain targets; opioid alternatives; neurobiology; pre-clinical; translational research; pathophysiology; pain management

(This special issue belongs to the Section Cellular Pathology)

Molecular Basis of Gynecological Disorders and Associated Infertility

edited by

Ahmad Albaghdadi

and

Nihar R. Nayak

submission deadline 15 Nov 2026 | 1 articles | Viewed by 963 | Submission Open

Keywords: gynecological disorders; endometriosis; polycystic ovary syndrome (PCOS); cervical cancer; ovarian cancer; uterine and vaginal pathologies

(This special issue belongs to the Section Cellular Pathology)

Metabolic Regulation of Cell Behavior and Implications for Aging

edited by

Eloy Bejarano

and José Antonio Rodríguez Navarro

submission deadline 15 Nov 2026 | Viewed by 345 | Submission Open

Keywords: metabolism; cellular aging; senescence; proteostasis; oxidative stress; glycation; autophagy

Cancer and Vessels: Insights at the Cellular and Molecular Levels

edited by Francesco Pezzella and Tom Donnem

submission deadline 15 Nov 2026 | Viewed by 322 | Submission Open

Keywords: angiogenesis; vessel co-option; tumor microenvironment; tumor blood vessels; tumor vasculature; metastasis

(This special issue belongs to the Section Cellular Pathology)

Brain Injury: Traumatic and Non-Traumatic Pathophysiology, Translational Approaches and Novel Treatment Strategies

edited by Thomas Kapapa,

Hayrettin Tumani

and Andreas Pfnür

submission deadline 15 Nov 2026 | Viewed by 296 | Submission Open

Keywords: traumatic brain injury; stroke; blood– brain barrier; neuroinflammation; neuroimmunology

(This special issue belongs to the Section Tissues and Organs)

New Mechanistic Insights and Novel Therapeutic Options for Pulmonary Vascular Disease (PVD)

edited by

Yong-Xiao Wang

submission deadline 15 Nov 2026 | Viewed by 200 | Submission Open

Keywords: pulmonary vascular disease; pulmonary hypertension; pulmonary arterial hypertension; vascular contraction; vascular remodeling

Cellular Mechanisms and Molecular Signaling in Heart Failure

edited by Przemyslaw Leszek

submission deadline 15 Nov 2026 | Viewed by 74 | Submission Open

Keywords: heart failure; cellular mechanisms and molecular signaling; new directions in cellular mechanisms promising for novel heart failure therapies

(This special issue belongs to the Section Cells of the Cardiovascular System)

Post-Transcriptional Control of Stem Cell Fate and Neural Development

edited by

Kun Tan

submission deadline 16 Nov 2026 | 1 articles | Viewed by 1453 | Submission Open

Keywords: post-transcriptional regulation; stem cell biology; neural development; developmental biology

(This special issue belongs to the Section Stem Cells)

Placenta in Tissue Engineering and Regeneration

edited by

Gayathri Rajaraman

submission deadline 16 Nov 2026 | Viewed by 495 | Submission Open

Keywords: placenta; stem cells; tissue engineering; clinical application; organ repair; regenerative medicine; biomaterials; clinical practice; bio-scaffolds; tissue regeneration

Cellular Signalling Pathways in the Endocrine Pancreas and Diabetes

edited by

Catharina Alam

submission deadline 16 Nov 2026 | Viewed by 302 | Submission Open

Keywords: diabetes; cell signalling; molecular mechanisms; cell stress; endocrine pancreas; β -cells

(This special issue belongs to the Section Cell Signaling)

Kidney Development: Cellular and Molecular Insights

edited by

Renfang Song Taylor

submission deadline 18 Nov 2026 | 1 articles | Viewed by 996 | Submission Open

Keywords: kidney development; nephrogenesis; single-cell RNA-seq/ATAC-seq; congenital anomalies of the kidney and urinary tract (CAKUT); blood pressure regulation

Neurodevelopmental Factors of Autism Spectrum Disorder: Etiology to Therapy

edited by

George Ayoub

submission deadline 20 Nov 2026 | Viewed by 427 | Submission Open

Keywords: autism spectrum disorder; developmental factors; genetic contributions; environmental influences; gene– environment interactions; developing therapies

Molecular Mechanisms and Treatment Strategies in Metabolic Syndromes and Neurological Disorders

edited by

Shaohua Qi

and

George Augustine

submission deadline 20 Nov 2026 | Viewed by 354 | Submission Open

Keywords: neurological disorders; metabolic syndromes; neurodegenerative disease; systems biology; precision medicine; target therapy

(This special issue belongs to the Section Cellular Neuroscience)

Cellular and Molecular Mechanisms of Microglia/Macrophages in the Nervous System

edited by Emanuela Paldino

submission deadline 20 Nov 2026 | Viewed by 331 | Submission Open

Keywords: microglia; macrophages; neurological disorders

Molecular Mechanisms of Autophagy, Apoptosis and Senescence and Therapeutic Advances in Cancer Progression

edited by

Katerina Gioti

and

Apostolos Beloukas

submission deadline 20 Nov 2026 | Viewed by 312 | Submission Open

Keywords: cancer progression; cell death; senescence; cancer therapy

Fibrosis in Chronic Inflammatory Diseases

edited by

Mirko Manetti

Irene Rosa

and

Eloisa Romano

submission deadline 25 Nov 2026 | 8 articles | Viewed by 23597 | Submission Open

Keywords: fibrosis; fibroblasts; myofibroblasts; inflammation; molecular pathways; pathogenetic mechanisms; therapeutic targets

(This special issue belongs to the Section Cellular Pathology)

Recent Advances in the Study of Tau Protein

edited by

Santosh Jadhav

submission deadline 25 Nov 2026 | 2 articles | Viewed by 10081 | Submission Open

Keywords: tau protein; post-translational modification; tauopathy filaments; neuro-immune interactions

(This special issue belongs to the Section Cellular Neuroscience)

Cellular Differentiation in Health and Disease

edited by Christine K. C. Loo and

Grant A. Ramm

submission deadline 25 Nov 2026 | 1 articles | Viewed by 3675 | Submission Open

Keywords: cellular differentiation; tumour microenvironment; human development; regeneration/healing; cell signaling pathways; tumour differentiation

(This special issue belongs to the Section Cell Microenvironment)

Synaptic Senescence in Health and Neurodegeneration: Cellular and Molecular Mechanisms

edited by

Isabel Martinez-Pena y Valenzuela

submission deadline 25 Nov 2026 | Viewed by 444 | Submission Open

Keywords: synapses; synaptic transmission; aging; senescent synapse; neurodegeneration; synaptic plasticity; glial cells

Displaying special issue 551-600 on page 12 of 14.

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