Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Post-Transcriptional Control of Stem Cell Fate and Neural Development
edited by
submission deadline 30 Apr 2026 | Viewed by 29 | Submission Open
Keywords: post-transcriptional regulation; stem cell biology; neural development; developmental biology
(This special issue belongs to the Section Stem Cells)
Kidney Development: Cellular and Molecular Insights submission deadline 30 Apr 2026 | Viewed by 17 | Submission Open
Keywords: kidney development; nephrogenesis; single-cell RNA-seq/ATAC-seq; congenital anomalies of the kidney and urinary tract (CAKUT); blood pressure regulation
Mechanisms and Therapies of Cell Death Pathways
edited by and Deniz Gulfem Ozturk
submission deadline 30 Apr 2026 | Viewed by 15 | Submission Open
Keywords: cell death; mitochondrial regulation; BCL-2 family; non-apoptotic cell death; cell death pathways interactions; small molecules; therapeutic strategy; therapy resistance
(This special issue belongs to the Section Cellular Pathology)
Noncoding RNAs: Immunity, Mechanisms, and Biomarker Potential
edited by
submission deadline 30 Apr 2026 | Viewed by 11 | Submission Open
Keywords: noncoding RNAs (ncRNAs); MicroRNAs (miRNAs); long noncoding RNAs (lncRNAs); circular RNAs (circRNAs); immune regulation; tumor microenvironment; immune checkpoints; cancer immunotherapy; liquid biopsy biomarkers; immune evasion
Lipoprotein and the Cardiovascular Diseases Therapy
edited by Verity Ramirez and Wenliang Song
submission deadline 30 Apr 2026 | Submission Open
Keywords: lipoprotein; cholesterol; cardiovascular disease; lipid-lowering therapy
(This special issue belongs to the Section Cells of the Cardiovascular System)
Cellular Senescence and Transformation: Unraveling the Biological Links Between Aging and Cancer
edited by , Lin Yuan and Yang Yu
submission deadline 10 May 2026 | Viewed by 26 | Submission Open
Keywords: aging; cancer; stem cells; gene editing; oncogene; apoptosis; targeted therapy; epigenetics
Retinal Disorders: Cellular Mechanisms and Targeted Therapies
edited by
submission deadline 15 May 2026 | 5 articles | Viewed by 9224 | Submission Open
Keywords: inherited eye diseases; genome; omics; gene editing; iPS cells; animal models; single cell analysis; AI; epigenetics
(This special issue belongs to the Section Cellular Pathology)
Molecular and Translational Advances in Metastatic Breast Cancer Research
edited by
submission deadline 15 May 2026 | Viewed by 76 | Submission Open
Keywords: metastatic breast cancer; tumor microenvironment; therapeutic resistance; immunotherapy; targeted therapy; cancer biomarkers; personalized medicine; translational oncology; circulating tumor cells; molecular mechanisms of metastasis
Heparanase and Heparanase-2: Function, Regulation, Signaling, and Disease submission deadline 20 May 2026 | 1 articles | Viewed by 1268 | Submission Open
Keywords: heparanase (Hpa1); heparanase-2 (Hpa2); tumor microenvironment; extracellular matrix; tumor progression; tumor suppression; metastatic niche; glycocalyx; immune cells; inflammation
(This special issue belongs to the Section Cell Signaling)
The Placental Matrix: Trophoblasts, Decidualization, and Embryo Implantation
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 1097 | Submission Open
Keywords: trophoblast; decidualization; embryo implantation; uterus; infection; cancer; reproductive immunology; reproductive toxicology; cellular differentiation
(This special issue belongs to the Section Tissues and Organs)
Basic Mechanisms and Emerging Therapeutic Strategies for Spinal Cord Injury
edited by and Angela R. Filous
submission deadline 25 May 2026 | Viewed by 88 | Submission Open
Keywords: spinal cord injury; neuroinflammation; neural regeneration; axon growth; neurons; glial cells; oligodendrocytes; myelin; astrocytes; microglia
Cellular and Molecular Insights into Female Reproductive Biology
edited by
submission deadline 25 May 2026 | Viewed by 37 | Submission Open
Keywords: female reproductive biology; cellular mechanisms; reproductive aging; microfluidics; fertility preservation; stem cells; uterine endocrinology; infertility; reproductive health; gametogenesis
(This special issue belongs to the Section Reproductive Cells and Development)
From Fat to Flame: Targeting Adipose Tissue in Chronic Inflammation and Exploring Therapeutic Strategies submission deadline 29 May 2026 | Viewed by 223 | Submission Open
Keywords: obesity; inflammasomes; immune system; microbiota
(This special issue belongs to the Section Tissues and Organs)
Proteomic Applications in Ageing and Neurodegenerative Conditions submission deadline 31 May 2026 | 4 articles | Viewed by 17968 | Submission Open
(This special issue belongs to the Section Cell Methods)
Intervertebral Disc Degeneration and Regeneration: New Molecular Mechanisms and Therapeutics—Second Edition
edited by
submission deadline 31 May 2026 | 3 articles | Viewed by 9280 | Submission Open
Keywords: spine; intervertebral disc; biomaterial; stem cell; gene therapy
(This special issue belongs to the Section Cellular Pathology)
The Multifaceted Role of Molecular Chaperones in Cancer: Pro-Tumoral or Therapeutic Function submission deadline 31 May 2026 | 1 articles | Viewed by 1122 | Submission Open
Keywords: molecular chaperones; cancer biology; carcinogenesis; tumor progression; diagnostic/prognostic biomarkers; anti-tumor therapeutic strategies; in vitro/in vivo experimental approaches; in silico computational approaches
Cellular and Molecular Basis of Brain Tumor
edited by , Tomasz S. Mandat and Grzegorz Turek
submission deadline 31 May 2026 | Viewed by 123 | Submission Open
Keywords: brain tumor; glioma; tumor microenvironment; molecular oncology; epigenetics; tumor stem cells; biomarkers; therapeutic resistance; non-coding RNA; translational research
(This special issue belongs to the Section Cellular Pathology)
Sex Differences in Cardiovascular Structure and Function—from Mechanisms to Therapeutics submission deadline 31 May 2026 | Viewed by 110 | Submission Open
Keywords: cardiovascular diseases; sex hormones; sex differences; vascular and cell signaling; therapeutic targets
Inflammatory Signaling and Vascular Dysfunction in Atherosclerosis
edited by and Jianzhong Shen
submission deadline 31 May 2026 | Viewed by 92 | Submission Open
Keywords: inflammation in atherosclerosis; atherothrombosis; cell signaling
Development and Characterization of Innovative In Vitro Models
edited by Fengyan Deng and Chongbei Zhao
submission deadline 31 May 2026 | Viewed by 89 | Submission Open
Keywords: 3D organoid development; iPSC; iPSC reprogramming; primary cell derivation; cell immortalization; disease model development; stem cell therapy; molecular biology; cell signaling
Circadian Rhythms in Action: Cellular and Molecular Mechanisms Revealed by Model Organisms submission deadline 31 May 2026 | Viewed by 36 | Submission Open
Keywords: circadian rhythm; molecular regulation; cellular mechanisms; model organisms; time-restricted feeding; metabolism; aging; neurodegeneration
DNA Damage and Repair in Targeted Cancer Therapy
edited by Mohd Saleem Dar, Sajad Ahmad Bhat and
submission deadline 31 May 2026 | Viewed by 27 | Submission Open
Keywords: cancer cells; DNA damage and repair mechanism; genome organization; BER; NER; MMR; HR; and NHEJ; targeted therapy; inhibitors/PROATCS; drug resistance; drug toxicity; biomarkers; personalized medicine
Regulatory Mechanisms of Vascular Smooth Muscle Cells in Vascular Disease Progression
edited by and
submission deadline 31 May 2026 | Viewed by 23 | Submission Open
Keywords: vascular smooth muscle cells; immune cells; inflammation; vascular disease; atherosclerosis; aneurysm; cellular crosstalk; phenotypic transition
(This special issue belongs to the Section Cells of the Cardiovascular System)
Molecular Mechanisms of Fibrosis in Chronic Liver Diseases
edited by , Regina Golan-Gerstl and Ihab Ansari
submission deadline 1 Jun 2026 | Viewed by 141 | Submission Open
Keywords: liver fibrosis; MASH; immune checkpoints; epigenetic regulation; hepatic stellate cells (HSCs); antifibrotic therapy; molecular mechanisms; inflammation; ROS
Human Pluripotent Stem Cells and Organoids: Current Trends and Future Perspectives submission deadline 1 Jun 2026 | Viewed by 70 | Submission Open
Keywords: human pluripotent stem cells; organoids; disease modeling; regenerative medicine; genome editing; single-cell omics; tissue engineering; drug discovery; precision medicine
(This special issue belongs to the Section Stem Cells)
Novel Insights into Molecular Mechanisms and Therapy of Myeloma
edited by and
submission deadline 10 Jun 2026 | 5 articles | Viewed by 10947 | Submission Open
Keywords: multiple myeloma; CAR-T therapy; relapse; methylation; drug resistance; treatment strategy; molecular mechanism; novel target; biomarker
(This special issue belongs to the Section Cellular Pathology)
Regulation of Hormone Secretion from Islets in Health and Disease
edited by
submission deadline 15 Jun 2026 | Viewed by 157 | Submission Open
Keywords: islet hormone secretion; paracrine signaling; autocrine regulation; intra-islet communication; islet cell plasticity; transdifferentiation; multi-hormonal dysregulation; circadian regulation; single-cell omics; islet inflammation and immune crosstalk
Novel Insights into Developing Therapeutic Strategies for Neurological Disorders
edited by , Joanna A. Korecka and
submission deadline 15 Jun 2026 | Viewed by 149 | Submission Open
Keywords: neurological disorders; RNA therapeutics; gene therapy; antisense oligonucleotides; gene editing; cell therapy; precision medicine; neurodegenerative diseases; neurodevelopmental disorders; neurogenetic disorders
Mechanisms of Antimicrobial Treatment in Human Diseases
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 2638 | Submission Open
Keywords: multidrug resistance; epidemiology; novel antimicrobial resistance traits
(This special issue belongs to the Section Cellular Pathology)
Progress of Nanoparticles in the Treatment of Cancers
edited by and Nafees Ahamad
submission deadline 20 Jun 2026 | 1 articles | Viewed by 1129 | Submission Open
Keywords: nanoparticles; cancer treatment; cellular mechanisms; molecular biology; pathophysiology; drug delivery; drug resistance; immunotherapy; tumor microenvironment
(This special issue belongs to the Section Cell Microenvironment)
The Orchestration of Glial Cells in Health and Disease
edited by Keying Zhu
submission deadline 25 Jun 2026 | 1 articles | Viewed by 186 | Submission Open
Keywords: microglia; oligodendrocytes; astrocytes; myelin; neuroinflammation
Diabetes-Induced Organ Damage: Cellular Mechanisms and Therapeutic Opportunities submission deadline 30 Jun 2026 | 6 articles | Viewed by 26525 | Submission Open
Keywords: diabetes mellitus; vascular lesions; nephropathy; cardiomyopathy; neuropathy; retinopathy; therapeutic opportunities
(This special issue belongs to the Section Tissues and Organs)
MicroRNAs: Regulators of Cellular Fate
edited by
submission deadline 30 Jun 2026 | 2 articles | Viewed by 1126 | Submission Open
Keywords: microRNA targets; microRNA conservation; microRNA pathway; microRNA mimics; microRNA antagonist; disease biomarker
Study on Immune Activity of Natural Products
edited by Xiu-Min Li
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1014 | Submission Open
Keywords: natural products; bioactive compounds; immune activity; immunomodulation; inflammation; autoimmune diseases; immunotherapy; therapeutic potential
Emerging Topics in Cachexia
edited by Gabriela Salim Ferreira De Castro
submission deadline 30 Jun 2026 | 1 articles | Viewed by 865 | Submission Open
Keywords: cachexia; skeletal muscle loss; adipose tissue loss; inflammation; sarcopenia; cancer; body composition; biomarkers
Retinoic Acid and Retinoid X Receptors - Series II submission deadline 30 Jun 2026 | Viewed by 449 | Submission Open
Keywords: nuclear receptor signaling; retinoic acid receptor; retinoid X receptor; pharmacology; structure/function relationships; genomic and non-genomic signaling; post-translational modification; homeostasis and disease; development; origin and evolution
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
Nuclear Pore Complex in Nanomedicine: Third Edition
edited by
submission deadline 30 Jun 2026 | Viewed by 210 | Submission Open
Keywords: intracellular transport; NPC; mitosis; nano; cancer; brain
The Role of PPARs in Disease - Volume IV submission deadline 30 Jun 2026 | Viewed by 113 | Submission Open
Keywords: PPAR; immune function; liver; adipose tissue; cardiovascular system; muscle; brain; neurological disease; psychiatric diseases; cancer; transcriptional regulation; ligands; agonists/antagonists
(This special issue belongs to the Section Cells of the Cardiovascular System)
Bone and Tooth Biology: Development and Regeneration
edited by Xiaofang Wang
submission deadline 30 Jun 2026 | Viewed by 37 | Submission Open
Keywords: bone; tooth; osteogenesis; odontogenesis; enamel; dentin; cementum; amelogenesis; dentinogenesis; regeneration; stem cells  
Mitochondrial Dynamics and Remodelling
edited by Edmund Carvalho
submission deadline 30 Jun 2026 | Submission Open
Keywords: mitochondrial dynamics; fission; fusion; mitophagy; cristae remodeling; bioenergetics; ER– mitochondria contacts; immune reprogramming; signaling pathways; therapeutic targeting
Tau Pathobiology and Excitotoxicity in Neurodegeneration and Epilepsy
edited by Janet Van Eersel
submission deadline 30 Jun 2026 | Submission Open
Keywords: tau; excitotoxicity; dementia; epilepsy; seizures; hyperexcitation
Biochemical Interaction and Supramolecular Complexes of Receptors in Cell Membranes submission deadline 8 Jul 2026 | Viewed by 597 | Submission Open
Keywords: membrane receptors; molecular complex; membrane microdomains
Role of Hippo Signaling in Cancer submission deadline 15 Jul 2026 | Viewed by 40 | Submission Open
Keywords: angiogenesis; cancer metabolism; cancer stemness; chemoresistance; endothelial cell plasticity; epithelial-to-mesenchymal transition (EMT); hippo signaling pathway; immunotherapy; mechanotransduction; targeted cancer therapy; TEAD transcription factors; therapeutic resistance; tumor microenvironment; tumorigenesis; YAP/TAZ; new therapeutic modalities to target YAP/TAZ-driven tumors including ferroptosis
(This special issue belongs to the Section Cell Signaling)
Inflammation in the Brain: From Molecular and Cellular Mechanisms to Therapeutic Strategies
edited by Sujatha Kannan and
submission deadline 15 Jul 2026 | Viewed by 17 | Submission Open
Keywords: neuroinflammation; microglia; astrocytes; immune signaling; neurodegeneration; neuroimmunology; brain injury; therapeutic strategies
Novel Molecular Targets for the Treatment of Sleep Disorders
edited by
submission deadline 25 Jul 2026 | Viewed by 242 | Submission Open
Keywords: sleep disorders; molecular targets; glymphatic system; neuroinflammation; circadian rhythms; microbiome; biomarkers; pharmacological therapy; gene therapy; neurodegeneration
Advances in the Discovery of Retinal Degeneration submission deadline 31 Jul 2026 | 4 articles | Viewed by 5022 | Submission Open
Keywords: retinal cell biology; photoreceptors; oxidative stress; inflammation; blood– retinal barriers; diabetic retinopathy; clinical eye research; inherited retinal diseases; ocular immunology
(This special issue belongs to the Section Cellular Pathology)
Immunometabolic Reprogramming in Diabetic Kidney Disease: The Interplay of Innate Immunity, Oxidative Stress, and Cellular Metabolism
edited by , Sandra Kostić and Anita Racetin
submission deadline 31 Jul 2026 | Viewed by 114 | Submission Open
Keywords: diabetic kidney disease; immunometabolism; innate immunity; oxidative stress; metabolic reprogramming; inflammasome; renal fibrosis; mitochondrial dysfunction; non-coding RNAs; multi-omics integration
Study on Ovarian Follicle Development
edited by Cecily V. Bishop and Jessica Cristina Lemos Motta
submission deadline 10 Aug 2026 | Viewed by 109 | Submission Open
Keywords: follicular development; ovarian follicle activation; ovarian reserve; in vitro follicle culture; translational reproductive biology
Cellular and Molecular Mechanisms of Abiotic Stress Tolerance in Plants
edited by Aziz Khan and
submission deadline 25 Aug 2026 | 2 articles | Viewed by 7094 | Submission Open
Keywords: abiotic stress; molecular mechanism; gene expression; cellular adaptation; signal transduction; plant physiology; molecular pathway; stress resilience; crop productivity; agronomic performance
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Gut Microbiota, Metabolites, and Immune Regulation in Gastrointestinal Diseases
edited by and Subir Kumar Juin
submission deadline 31 Aug 2026 | Viewed by 75 | Submission Open
Keywords: gut microbiota; microbial metabolites; inflammation; immunology; gut-barrier; gastrointestinal disease
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