Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Toxicology in Cells: Cellular Mechanisms, Molecular Responses, and Modern Models
edited by Maria Jurczuk and
submission deadline 30 Jul 2026 | Viewed by 149 | Submission Open
Keywords: cellular toxicology; oxidative stress; apoptosis; autophagy; biomarkers; nanotoxicology; organ-on-chip; toxicogenomics; epigenetic regulation; mitochondrial dysfunction
New Advances in Immunomodulation Using Biomaterials
edited by and Vaishali Inamdar
submission deadline 30 Jul 2026 | Viewed by 103 | Submission Open
Keywords: immunomodulation; biomaterials; cell– material interactions; biocompatibility; immune system
Mitochondria in Cancer Immune Evasion and Immunotherapy
edited by Loredana Moro and
submission deadline 30 Jul 2026 | Viewed by 90 | Submission Open
Keywords: mitochondria; mtDNA; immunity; cancer immune evasion; tumor microenvironment; immune tolerance; lymphocytes; inflammation; immune response
(This special issue belongs to the Section Cellular Immunology)
Cancer Cytopathology: Structural Features and Intracellular Events in Malignancy submission deadline 30 Jul 2026 | Viewed by 57 | Submission Open
Keywords: cancer cells; cytopathology; tumor microenvironment; cell culture; biopsies
(This special issue belongs to the Section Cellular Pathology)
Targeted Therapy and Immunotherapy in Breast Cancer: Molecular Mechanisms and Translational Advances
edited by Saranya Chumsri, Hatem H. Soliman and
submission deadline 30 Jul 2026 | Viewed by 48 | Submission Open
Keywords: breast cancer; targeted therapy; immunotherapy; biomarkers of response; therapeutic resistance
(This special issue belongs to the Section Cellular Immunology)
In Vitro Models for Assessing Toxicity and Cellular Effects
edited by , , and Camilla Paoletti
submission deadline 30 Jul 2026 | Submission Open
Keywords: alternative testing; NAMs; 3D in vitro models; organ-on-chip; millifluidic cultures; toxicity; biomaterials; 3Rs; organoids
Cellular Mechanisms of Anti-Cancer Therapies
edited by Ilgen Mender and
submission deadline 31 Jul 2026 | 8 articles | Viewed by 21458 | Submission Open
Keywords: anti-cancer therapies; innovative treatment strategies; cellular mechanisms; drug resistance; personalized medicine
(This special issue belongs to the Section Cellular Pathology)
How Can We Optimise Cancer Therapy? Tumour Microenvironment and Immune Evasion Strategies submission deadline 31 Jul 2026 | 6 articles | Viewed by 11572 | Submission Open
Keywords: immunosurveillance; immune evasion in cancer; tumour microenvironment; immune suppression; immunotherapy; immune checkpoints; cancer immunity; drug intervention
(This special issue belongs to the Section Cell Microenvironment)
Advances in the Discovery of Retinal Degeneration submission deadline 31 Jul 2026 | 5 articles | Viewed by 7599 | Submission Open
Keywords: retinal cell biology; photoreceptors; oxidative stress; inflammation; blood– retinal barriers; diabetic retinopathy; clinical eye research; inherited retinal diseases; ocular immunology
(This special issue belongs to the Section Cellular Pathology)
Cellular and Molecular Mechanisms of Vascular-Related Diseases
edited by and
submission deadline 31 Jul 2026 | 7 articles | Viewed by 7114 | Submission Open
Keywords: cellular and molecular mechanisms; cardiovascular disease; cerebrovascular disease; vascular signaling; vascular dysfunctions in cns disorders; vascular dysfunctions in diabetes; vascular dysfunction in chronic kidney disease; tumor metastasis via vascular system
(This special issue belongs to the Section Cellular Pathology)
Osteoblasts, Osteoclasts and Bone Diseases: Cellular Crosstalk and Therapeutic Opportunities
edited by
submission deadline 31 Jul 2026 | 3 articles | Viewed by 5532 | Submission Open
Keywords: osteoblasts; osteoclasts; bone remodelling; osteoporosis; skeletal diseases; bone homeostasis; bone interactions; bone crosstalk; targeted therapies
(This special issue belongs to the Section Cellular Pathology)
Advances in the Cellular and Molecular Mechanisms of Cardiovascular Diseases
edited by and Katie S. Wraith
submission deadline 31 Jul 2026 | 6 articles | Viewed by 5480 | Submission Open
Keywords: thrombosis; smooth muscle; endothelium; atherosclerosis; inflammation
(This special issue belongs to the Section Cells of the Cardiovascular System)
Mechanisms of Lung Growth and Regeneration submission deadline 31 Jul 2026 | 3 articles | Viewed by 5302 | Submission Open
Keywords: stem cells; niche; aging; growth factors; extracellular matrix; organoids; fibrosis; single-cell RNAseq
(This special issue belongs to the Section Cell Microenvironment)
Cellular and Molecular Mechanisms in Neuropsychiatric and Neurological Disorders
edited by Irina Balan
submission deadline 31 Jul 2026 | 3 articles | Viewed by 3937 | Submission Open
Keywords: cellular mechanisms; molecular mechanisms; neuropsychiatric disorders; neurological disorders; neuroinflammation; neuronal signaling; gene expression; synaptic function; glial cells; peripheral factors
(This special issue belongs to the Section Cellular Pathology)
Genetic Mechanisms in Cellular Genomics and Therapeutics
edited by Elaine T. Lim and Yingleong Chan
submission deadline 31 Jul 2026 | 1 articles | Viewed by 3155 | Submission Open
Keywords: genetics of human diseases; functional genomics; cellular mechanisms; genomics or stem cell technologies; therapeutics research and development for human diseases
Integrated Approaches Between Metabolomics and Cellular Aging
edited by Maria Nikolaou and
submission deadline 31 Jul 2026 | 2 articles | Viewed by 2629 | Submission Open
Keywords: metabolomics; cellular aging; senescence; mitochondrial dysfunction; DNA damage; biomarkers; metabolism
(This special issue belongs to the Section Cellular Aging)
Standardization and Metrological Advancements in Cellular and Genomic Diagnostics for Cancer
edited by and Marika Fava
submission deadline 31 Jul 2026 | 1 articles | Viewed by 2224 | Submission Open
Keywords: cancer diagnostics; cellular analysis; genomic profiling; precision medicine; metrology in diagnostics; next generation sequencing (NGS); reference measurement systems (RMSs); quality assurance (QA); IVDR compliance; SI-traceable standards
Cellular and Molecular Mechanisms of Heart Diseases
edited by
submission deadline 31 Jul 2026 | 1 articles | Viewed by 1899 | Submission Open
Keywords: heart failure; HFrEF; HFpEF; molecular signaling; therapeutic interventions; ejection fraction; fibrosis; metabolism; mitochondrial dysfunction; cardiovascular therapies
(This special issue belongs to the Section Cellular Pathology)
Cellular and Molecular Mechanisms in Immune Regulation—Second Edition
edited by Fábio Rinaldo Santori and Natalia B. Ivanova
submission deadline 31 Jul 2026 | 3 articles | Viewed by 1839 | Submission Open
Keywords: innate immunity; dendritic cells; macrophages; T cells; B cells; cytokines; immunotherapy
(This special issue belongs to the Section Cellular Pathology)
Biochemical Mechanisms and Physiological Implication of Stem Cell Differentiation submission deadline 31 Jul 2026 | 1 articles | Viewed by 814 | Submission Open
Keywords: stem cells; differentiation; 3D cultures; co-cultures; biochemistry; physiology; epigenetics
(This special issue belongs to the Section Stem Cells)
Advances in Adipocyte Biology Research and Their Relevance to Metabolic Health
edited by
submission deadline 31 Jul 2026 | 1 articles | Viewed by 607 | Submission Open
Keywords: adipose tissue; obesity; inflammation; thermogenesis; adipokines
Rho Family Small GTPases in Health and Diseases
edited by
submission deadline 31 Jul 2026 | Viewed by 324 | Submission Open
Keywords: Rho signalling; Rho guanine nucleotide exchange factor; Rho GTPase-activating protein; Rho effector; dysregulation of Rho GTPases; Rho pathway inhibitors  
(This special issue belongs to the Section Cell Signaling)
Molecular Research in Osteoporosis submission deadline 31 Jul 2026 | Viewed by 293 | Submission Open
Keywords: osteoporosis; osteosarcopenia; bone– muscle crosstalk; genetics; epigenetics; transcriptomics; biomarkers; therapeutic strategy
(This special issue belongs to the Section Cellular Pathology)
Is Gene Therapy the Answer to Overcoming Diabetes? submission deadline 31 Jul 2026 | Viewed by 254 | Submission Open
Keywords: gene therapy; type 1 diabetes; type 2 diabetes; glycemic control; beta-cell transcription factors; insulin granules; viral vectors
Advances in Toxoplasma gondii Treatment, Immunology and Host–Parasite Interaction
edited by Namrata Anand
submission deadline 31 Jul 2026 | Viewed by 244 | Submission Open
Keywords: T. gondii; treatment strategies; secretory proteins; immune response; exosomes; nanoparticle; congenital infection; host– parasite interaction
(This special issue belongs to the Section Cellular Immunology)
Immunometabolic Reprogramming in Diabetic Kidney Disease: The Interplay of Innate Immunity, Oxidative Stress, and Cellular Metabolism
edited by , Sandra Kostić and Anita Racetin
submission deadline 31 Jul 2026 | Viewed by 220 | Submission Open
Keywords: diabetic kidney disease; immunometabolism; innate immunity; oxidative stress; metabolic reprogramming; inflammasome; renal fibrosis; mitochondrial dysfunction; non-coding RNAs; multi-omics integration
Kinin System in Health and Disease: Cellular and Molecular Perspectives
edited by Marcos Gregnani and Leonardo Martins
submission deadline 31 Jul 2026 | Viewed by 203 | Submission Open
Keywords: kallikrein– kinin system; bradykinin receptors; inflammation; cardiovascular disease; molecular pathways
(This special issue belongs to the Section Cellular Pathology)
Aquaporins at the Crossroads of Human Health and Disease
edited by
submission deadline 31 Jul 2026 | Viewed by 189 | Submission Open
Keywords: aquaporins; membrane molecular transport; channels proteins in health and disease; novel drug targets; cellular biophysics
ALK Signaling Pathways in NSCLC: From Cell Biology to Therapeutic Insights submission deadline 31 Jul 2026 | Viewed by 154 | Submission Open
Keywords: anaplastic lymphoma kinase (ALK); non-small-cell lung cancer (NSCLC); ALK tyrosine kinase inhibitors (ALK-TKIs); drug resistance; signal transduction and oncogenic pathways; molecular diagnostics (IHC; FISH; NGS); targeted therapy
Extracellular Vesicles: Drivers, Biomarkers and Therapeutics in Cardiovascular Disease submission deadline 31 Jul 2026 | Viewed by 109 | Submission Open
Keywords: cardiovascular disease; extracellular vesicles; biomarkers; therapeutics; drug delivery; RNA therapeutics; fibrosis; atherosclerosis; liquid biopsy
Recent Advances in Vitamin D and K in Cancer submission deadline 31 Jul 2026 | Viewed by 83 | Submission Open
Keywords: vitamin D; vitamin K; VDR signaling; tumor microenvironment; cancer prevention; molecular pathways; apoptosis and proliferation; oxidative stress; immunomodulation; therapeutic resistance
From Molecular Mechanisms to Treatment Progress of Ovarian Cancer
edited by Amal M. El-Naggar
submission deadline 31 Jul 2026 | Viewed by 80 | Submission Open
Keywords: ovarian cancer; molecular mechanisms; therapeutic targets; drug resistance; biomarkers; preclinical models; targeted therapy; immunotherapy; tumor microenvironment; translational research
(This special issue belongs to the Section Reproductive Cells and Development)
Molecular Signatures and Cellular Pathways of Immune Dysfunction in HIV and Tuberculosis
edited by , Pradeep Kumar Sheokand, , Ekta Saini and Prashant Bajpai
submission deadline 31 Jul 2026 | Viewed by 79 | Submission Open
Keywords: immune cell dysfunction; immune persistence; T cell exhaustion; chronic infection; host– pathogen interactions; cellular immunity; molecular immune signaling; single-cell immunology; immune cell plasticity; infection-induced immune remodeling
(This special issue belongs to the Section Cellular Immunology)
Emerging Insights into Natural Killer Cell Immunity in Infection and Cancer—2nd Edition
edited by Sachin Mulik, Weshely Kujur, and Sumit Sen Santara
submission deadline 31 Jul 2026 | Viewed by 74 | Submission Open
Keywords: CAR NK cells; cancer immunotherapy; cell therapy; viral infection; memory NK cells; NK cell targeted therapies; NK-immune cell crosstalk; exosomes
(This special issue belongs to the Section Cellular Immunology)
Histological Classification of Lung Cells Across Animal Models and Life Stages
edited by
submission deadline 31 Jul 2026 | Viewed by 72 | Submission Open
Keywords: lung parenchyma; histological classification; normal lung anatomy; spatial organization; animal models; non-rodent models; comparative lung anatomy; lung ageing
(This special issue belongs to the Section Tissues and Organs)
Sex Differences in Molecular Mechanisms Linking Neuronal Stress and Inflammation
edited by John R. Bethea and Kayla Lee Nguyen
submission deadline 31 Jul 2026 | Viewed by 68 | Submission Open
Keywords: ER stress; intracellular signaling; neuronal stress; immune activation; sex differences; neuro-immune interactions
(This special issue belongs to the Section Cellular Neuroscience)
Signaling Dynamics in Cancer
edited by Claudia Voena, Riccardo Taulli and Francesca Bersani
submission deadline 31 Jul 2026 | Viewed by 64 | Submission Open
Keywords: cancer signaling; cancer biology; tumor microenvironment; tumor progression; biomarkers; therapeutics
(This special issue belongs to the Section Cell Signaling)
Advances in the Gut–Liver–Brain Axis in Human Health and Disease
edited by
submission deadline 31 Jul 2026 | Viewed by 60 | Submission Open
Keywords: gut– liver– brain axis; microbiota; liver metabolism; neuroinflammation; metabolic disease; neurodegeneration; gut– brain communication
Uncovering Placental Inflammatory Pathways Affecting the Developing Brain submission deadline 31 Jul 2026 | Viewed by 50 | Submission Open
Keywords: neuroplacentology; neuroinflammation; hypoxia– ischemia; developing brain; ASD; CP; ADHD; learning disabilities; preclinical model; cell culture
(This special issue belongs to the Section Reproductive Cells and Development)
Recent Insights into the Role of Metal Ions in the Nervous System
edited by Richard H. Dyck
submission deadline 31 Jul 2026 | Viewed by 47 | Submission Open
Keywords: metal ions; neurobiology; zinc signalling; copper homeostasis; iron metabolism; calcium signalling; magnesium; lithium; metallomics; synaptic transmission; neuromodulation; ion transporters; metal-binding proteins; oxidateive stress; mitochondrial function; neurodevelopment; synaptic plasticity; neuroinflammation; neurodegeneration; neuropsychiatric disorders; autism spectrum disorder; schizophrenia; Alzheimer disease; Parkinson disease; imaging of metal ions; metal ion dysregulation
(This special issue belongs to the Section Cellular Neuroscience)
Endothelial Phenotype Transition and Vascular Calcification Mechanisms
edited by and Jeffrey J. Hsu
submission deadline 31 Jul 2026 | Viewed by 30 | Submission Open
Keywords: endothelial cell; vascular calcification; cell plasticity; endothelial-to-mesenchymal transition (EndMT); vascular biology
Molecular Drivers of Oncogenesis and Tumor Evolution: Mechanisms and Cellular Pathways submission deadline 31 Jul 2026 | Viewed by 18 | Submission Open
Keywords: oncogenesis; cancer progression; cancer biology; tumor immunology; tumor microenvironment; metastasis; angiogenesis; metabolic reprogramming; therapy resistance
AI and Multi-Modal Data Integration in Neurobiology and Neurological Diseases
edited by Jeon Lee
submission deadline 31 Jul 2026 | Viewed by 11 | Submission Open
Keywords: artificial intelligence; multi-modal integration; multi-omics; neurobiology; neurological disease; molecular characterization; neuronal biomarker; cellular pathway
(This special issue belongs to the Section Cellular Neuroscience)
Tau-Targeted Treatment of Alzheimer’s Disease
edited by Amritpal Mudher, Katerina Papanikolopoulou, Lovesha Sivanantharajah and
submission deadline 31 Jul 2026 | Viewed by 3 | Submission Open
Keywords: tau protein; Alzheimer's disease; therapeutic targeting; tauopathy; neurodegeneration; disease models; drug discovery; protein aggregation
(This special issue belongs to the Section Cellular Neuroscience)
NF-κB Signaling in Inflammation: Molecular Mechanisms and Therapeutic Targets
edited by Gaetano Spinelli and
submission deadline 1 Aug 2026 | Viewed by 114 | Submission Open
Keywords: NF-κ B signaling; inflammation; canonical and non-canonical pathways; immune regulation; post-translational modifications; signal transduction; inflammatory diseases; autoimmune disorders; cancer; tumor microenvironment; oncogenesis; metabolic diseases; neuroinflammation; therapeutic targets; drug development
Stem Cells in Congenital Heart Disease: Novel Approaches and Regenerative Strategies
edited by , and Wei Shi
submission deadline 1 Aug 2026 | Viewed by 41 | Submission Open
Keywords: stem cell; congenital heart defect; iPSC; maturation; regeneration; cardiac arrhythmia; heart failure
(This special issue belongs to the Section Stem Cells)
Inflammation at the Nexus of Neurodegeneration: Cellular Mechanisms, Biomarkers and Therapeutic Targets
edited by Kirstan A. Vessey
submission deadline 1 Aug 2026 | Viewed by 26 | Submission Open
Keywords: neuroinflammation; microglia; astrocytes; neurovascular unit; inflammasome; cytokine signaling; cell death pathways; biomarkers; retinal degeneration; neurodegenerative disease
(This special issue belongs to the Section Cellular Neuroscience)
Intestinal Stem Cells submission deadline 5 Aug 2026 | Viewed by 251 | Submission Open
Keywords: stem cells; self-renewal; enterocytes; intestinal organoid; villus; crypt
(This special issue belongs to the Section Stem Cells)
Focus on Machinery of Cell Death
edited by , Prashanta Kumar Panda and
submission deadline 10 Aug 2026 | 8 articles | Viewed by 21737 | Submission Open
Keywords: cell death; autophagy; apoptosis; necrosis; ferroptosis; metabolism; stem cell biology; infection; aging; development; Alzheimer’ s; neurodegeneration; therapy
(This special issue belongs to the Section Cellular Pathology)
Cell Therapies in Cancer Treatment
edited by
submission deadline 10 Aug 2026 | 1 articles | Viewed by 2834 | Submission Open
Keywords: cellular therapies; cancer; immune
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