Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Circadian Rhythms in Action: Cellular and Molecular Mechanisms Revealed by Model Organisms submission deadline 31 May 2026 | Viewed by 85 | Submission Open
Keywords: circadian rhythm; molecular regulation; cellular mechanisms; model organisms; time-restricted feeding; metabolism; aging; neurodegeneration
Mitochondria Beyond Energy: Signaling, Immunity, and Cell Fate submission deadline 31 May 2026 | Viewed by 78 | Submission Open
Keywords: mitochondria; stem cells; cell fate; organogenesis; immunometabolism
DNA Damage and Repair in Targeted Cancer Therapy
edited by Mohd Saleem Dar, Sajad Ahmad Bhat and
submission deadline 31 May 2026 | Viewed by 69 | Submission Open
Keywords: cancer cells; DNA damage and repair mechanism; genome organization; BER; NER; MMR; HR; and NHEJ; targeted therapy; inhibitors/PROATCS; drug resistance; drug toxicity; biomarkers; personalized medicine
Skeletal Muscle Aging and Regeneration: Mitochondrial Health, Molecular Signaling, and Therapeutic Interventions
edited by
submission deadline 31 May 2026 | Viewed by 67 | Submission Open
Keywords: aging; skeletal muscle; regeneration; satellite cells; muscle stem cells; muscle wasting; mitochondria; fibro-adipogenic progenitor cells; repair
Advances in Ion Channel Biology: From Molecular Mechanisms to Therapeutic Targets
edited by Shridhar Sanghvi, and
submission deadline 31 May 2026 | Viewed by 49 | Submission Open
Keywords: ion channels; electrophysiology; cryo-electron microscopy; channelopathy; membrane protein; gating mechanism; structural biology
B Cells in Action: Interaction Dynamics and Functional Decisions
edited by Michael L. Atchison and
submission deadline 31 May 2026 | Viewed by 42 | Submission Open
Keywords: B cell development and differentiation; adaptive immunity; germinal center B cell; class-switch recombination; immunosuppression; cytokines; inflammation; epigenetic regulation; metabolic reprogramming; immune response
(This special issue belongs to the Section Cellular Immunology)
Endometrial Cancer: From Molecular Mechanisms to Therapeutic Approaches
edited by Tomaž Büdefeld and
submission deadline 31 May 2026 | Viewed by 42 | Submission Open
Keywords: endometrial cancer; genetic mutation; epigenetics; cell signaling; TIME; metastasis; biomarker; therapy; drug delivery; risk factor
Epigenetic and Cellular Regulation in Hematologic Disorders
edited by
submission deadline 31 May 2026 | Viewed by 41 | Submission Open
Keywords: epigenetics; hematologic disorders; leukemia; myelodysplastic syndrome; thrombosis; thrombocytopenia; bleeding
Cellular and Molecular Mechanisms of Heart Development
edited by Jun K. Takeuchi
submission deadline 31 May 2026 | Viewed by 39 | Submission Open
Keywords: heart development; cardiovascular; epigenetics; cell fate; differentiation; cardiac growth; cardiac morphogenesis; heart regeneration; cardiac organoid
Cellular Mechanisms and Therapeutic Potentials of Neurodevelopmental Defects submission deadline 31 May 2026 | Viewed by 35 | Submission Open
Keywords: neurodevelopmental disorders; neuronal connectivity; precocious therapies; synaptic plasticity; neurogenesis; glial function
(This special issue belongs to the Section Cells of the Nervous System)
Decoding Heart Failure: From Mechanisms to Treatment
edited by and Dirk L. Brutsaert
submission deadline 31 May 2026 | Viewed by 32 | Submission Open
Keywords: heart failure; pathological process; molecular mechanisms; cellular mechanisms; genetic mechanisms; therapeutic target
Stem Cell-Based Strategies for Cardiac Tissue Engineering and Regeneration
edited by Munira Xaymardan and
submission deadline 31 May 2026 | Viewed by 13 | Submission Open
Keywords: cardiac tissue engineering; stem cells; cardiomyocytes; cardiac organoids; engineered heart tissues; biomaterials; scaffolds; gene therapy; RNA reprogramming; cardiac fibrosis; cardiac regeneration; myocardial repair; translational studies
(This special issue belongs to the Section Stem Cells)
Cellular Responses to Heavy Metals: From Intestinal Uptake to Disease submission deadline 31 May 2026 | Submission Open
Keywords: cadmium (Cd) bioavailability; heavy metal intestinal uptake; heavy metal-induced cardiotoxicity; heavy metal-induced neurotoxicity; heavy metal-induced osteotoxicity; heavy metals and malignancies
Molecular Mechanisms and Therapeutic Strategies for Skeletal Muscle Disorders submission deadline 31 May 2026 | Submission Open
Keywords: skeletal muscle; muscular disorders; myokines; muscle regeneration; muscle atrophy; inflammation; stress response; myoblast
Molecular Mechanisms of Fibrosis in Chronic Liver Diseases
edited by , Regina Golan-Gerstl and Ihab Ansari
submission deadline 1 Jun 2026 | Viewed by 184 | Submission Open
Keywords: liver fibrosis; MASH; immune checkpoints; epigenetic regulation; hepatic stellate cells (HSCs); antifibrotic therapy; molecular mechanisms; inflammation; ROS
Human Pluripotent Stem Cells and Organoids: Current Trends and Future Perspectives submission deadline 1 Jun 2026 | Viewed by 93 | Submission Open
Keywords: human pluripotent stem cells; organoids; disease modeling; regenerative medicine; genome editing; single-cell omics; tissue engineering; drug discovery; precision medicine
(This special issue belongs to the Section Stem Cells)
Macrophages in Cancer: Immunosuppression, Immunoregulation, and Immunotherapy
edited by
submission deadline 5 Jun 2026 | 2 articles | Viewed by 9124 | Submission Open
Keywords: macrophage; immunosuppression; immunoregulation; immunotherapy; tumor immune microenvironment
(This special issue belongs to the Section Cellular Immunology)
Novel Insights into Molecular Mechanisms and Therapy of Myeloma
edited by and
submission deadline 10 Jun 2026 | 5 articles | Viewed by 13566 | Submission Open
Keywords: multiple myeloma; CAR-T therapy; relapse; methylation; drug resistance; treatment strategy; molecular mechanism; novel target; biomarker
(This special issue belongs to the Section Cellular Pathology)
The Metabolic Edge: How Cancer Cells Adapt, Survive, and Resist Therapy
edited by
submission deadline 10 Jun 2026 | Viewed by 59 | Submission Open
Keywords: cancer metabolism; metabolic rewiring; therapy resistance; metabolic plasticity; nutrient uptake; mitochondrial remodeling; tumor microenvironment; metabolic vulnerabilities
(This special issue belongs to the Section Cellular Metabolism)
Lipid Mediators in Cardiometabolic Regulation and Disease
edited by Adeniyi Michael Adebesin
submission deadline 10 Jun 2026 | Viewed by 1 | Submission Open
Keywords: lipid mediators; lipoprotein; fatty acid metabolites; cellular membranes; cardiometabolic regulation; cellular metabolism; adipogenesis; signaling pathways; receptors; lipid transport proteins
(This special issue belongs to the Section Cellular Metabolism)
The Role of Oxidative Stress in Cardiovascular Diseases—2nd Edition
edited by and
submission deadline 15 Jun 2026 | 1 articles | Viewed by 3433 | Submission Open
Keywords: oxidative stress; antioxidants; apoptosis; atherosclerosis; blood vessel; heart failure; hypertension; inflammation; mitochondria; microcirculation; reactive oxygen species
(This special issue belongs to the Section Cells of the Cardiovascular System)
Novel Insights into Developing Therapeutic Strategies for Neurological Disorders
edited by , Joanna A. Korecka and
submission deadline 15 Jun 2026 | Viewed by 198 | Submission Open
Keywords: neurological disorders; RNA therapeutics; gene therapy; antisense oligonucleotides; gene editing; cell therapy; precision medicine; neurodegenerative diseases; neurodevelopmental disorders; neurogenetic disorders
Regulation of Hormone Secretion from Islets in Health and Disease
edited by
submission deadline 15 Jun 2026 | Viewed by 195 | Submission Open
Keywords: islet hormone secretion; paracrine signaling; autocrine regulation; intra-islet communication; islet cell plasticity; transdifferentiation; multi-hormonal dysregulation; circadian regulation; single-cell omics; islet inflammation and immune crosstalk
Overcoming Resistance to Immune Checkpoint Inhibitors in Cancer: Mechanisms, Models, and Therapeutic Strategies
edited by Nai-Yun Sun, and
submission deadline 15 Jun 2026 | Viewed by 63 | Submission Open
Keywords: immune checkpoint inhibitors; primary resistance; acquired resistance; tumor microenvironment; immune exhaustion; preclinical cancer models; genetic and epigenetic alterations; excluded/desert tumors; inflamed tumors; cancer immunotherapy
Bone and Soft Tissue Tumors: Molecular Mechanisms and Emerging Therapeutics
edited by
submission deadline 15 Jun 2026 | Viewed by 50 | Submission Open
Keywords: sarcoma; bone and soft tissue tumors; molecular pathology; dysregulated signaling pathways; genetic and epigenetic alterations; therapeutic resistance; novel molecular biomarkers; therapeutic strategies; in vitro and in vivo models
Mechanisms of Antimicrobial Treatment in Human Diseases
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 2823 | Submission Open
Keywords: multidrug resistance; epidemiology; novel antimicrobial resistance traits
(This special issue belongs to the Section Cellular Pathology)
Progress of Nanoparticles in the Treatment of Cancers
edited by and Nafees Ahamad
submission deadline 20 Jun 2026 | 1 articles | Viewed by 1264 | Submission Open
Keywords: nanoparticles; cancer treatment; cellular mechanisms; molecular biology; pathophysiology; drug delivery; drug resistance; immunotherapy; tumor microenvironment
(This special issue belongs to the Section Cell Microenvironment)
Beyond Bystanders: The Emerging Roles of Glia in Brain Health and Disease
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 664 | Submission Open
Keywords: astrocytes; microglia; oligodendrocytes; neuroinflammation; neuroimmunology; synaptic plasticity; blood– brain barrier; neuropsychiatric disorders
(This special issue belongs to the Section Cells of the Nervous System)
Molecular Anatomy and Function of Sensory Organs and Sensory Tissues
edited by
submission deadline 20 Jun 2026 | Viewed by 277 | Submission Open
Keywords: sensory organ; sensory tissue; vision; hearing; skin; sensory structures of internal organs
(This special issue belongs to the Section Tissues and Organs)
The Orchestration of Glial Cells in Health and Disease
edited by Keying Zhu
submission deadline 25 Jun 2026 | 1 articles | Viewed by 1069 | Submission Open
Keywords: microglia; oligodendrocytes; astrocytes; myelin; neuroinflammation
Regenerating Poorly Vascularized Tissues
edited by Simone Pacini
submission deadline 25 Jun 2026 | Viewed by 233 | Submission Open
Keywords: regenerative medicine; avascular tissue; angiogenesis; vasculogenesis; cell-based medicinal products; bioengineered materials; cell transplantation
(This special issue belongs to the Section Tissues and Organs)
Cutaneous Regeneration and Tissue Engineering: From Hair Follicle Regeneration to Skin Restoration
edited by Soung-Hoon Lee
submission deadline 25 Jun 2026 | Viewed by 23 | Submission Open
Keywords: skin regeneration; hair follicle regeneration; tissue engineering; regenerative biology; biomaterial scaffolds; organoids and 3D skin models; wound healing; acellular matrices; exosome-based therapy; translational dermatology
Novel Insights in Chronic Epilepsy—from Molecular Mechanisms to Future Therapies
edited by Kjell Heuser and
submission deadline 25 Jun 2026 | Viewed by 21 | Submission Open
Keywords: epilepsy; epileptogenesis; seizure mechanisms; neuroinflammation; glial cells; reactive gliosis; astrocytes; microglia; antiseizure medication
Inflammation and Atherosclerosis: Emerging Mechanisms, Biomarkers and Therapeutic Opportunities
edited by Victoria McGilligan
submission deadline 25 Jun 2026 | Viewed by 20 | Submission Open
Keywords: atherosclerosis; inflammation; inflammatory biomarkers; anti-inflammatory therapies; plaque vulnerability; diagnostics and prognostics
The Function of Stem Cells in the Biomedical Applications
edited by Rakesh Kumar Srivastava
submission deadline 25 Jun 2026 | Viewed by 17 | Submission Open
Keywords: stem cells; regenerative medicine; cell therapy; differentiation; disease modeling; tissue engineering; drug discovery
Systemic Sclerosis: Cellular Mechanisms, Innovative Diagnostics and Advanced Therapeutics
edited by Muhammad Soyfoo
submission deadline 25 Jun 2026 | Viewed by 8 | Submission Open
Keywords: systemic sclerosis; fibrosis; myofibroblasts; immune dysregulation; endothelial dysfunction; extracellular matrix (ECM); autoimmune disease
Diabetes-Induced Organ Damage: Cellular Mechanisms and Therapeutic Opportunities submission deadline 30 Jun 2026 | 7 articles | Viewed by 31429 | Submission Open
Keywords: diabetes mellitus; vascular lesions; nephropathy; cardiomyopathy; neuropathy; retinopathy; therapeutic opportunities
(This special issue belongs to the Section Tissues and Organs)
Exclusive Review Papers in Parkinson's Research
edited by and Ronald F. Pfeiffer
submission deadline 30 Jun 2026 | 1 articles | Viewed by 7237 | Submission Open
Keywords: Parkinson’ s disease; alpha-synuclein; substantia nigra; mitochondria; non-motor symptoms; dopamine; levodopa
(This special issue belongs to the Section Cellular Aging)
Emerging Topics in Smooth Muscle Cell Fate and Plasticity in Atherosclerosis submission deadline 30 Jun 2026 | 3 articles | Viewed by 3128 | Submission Open
Keywords: vascular smooth muscle cells; lineage tracing; fate mapping; VSMC plasticity; (single cell) (spatial) omics; vascular heterogeneity; atherosclerosis
(This special issue belongs to the Section Cellular Pathology)
Study on Immune Activity of Natural Products
edited by Xiu-Min Li
submission deadline 30 Jun 2026 | 2 articles | Viewed by 1774 | Submission Open
Keywords: natural products; bioactive compounds; immune activity; immunomodulation; inflammation; autoimmune diseases; immunotherapy; therapeutic potential
MicroRNAs: Regulators of Cellular Fate
edited by
submission deadline 30 Jun 2026 | 2 articles | Viewed by 1700 | Submission Open
Keywords: microRNA targets; microRNA conservation; microRNA pathway; microRNA mimics; microRNA antagonist; disease biomarker
Emerging Topics in Cachexia
edited by Gabriela Salim Ferreira De Castro
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1018 | Submission Open
Keywords: cachexia; skeletal muscle loss; adipose tissue loss; inflammation; sarcopenia; cancer; body composition; biomarkers
Retinoic Acid and Retinoid X Receptors - Series II submission deadline 30 Jun 2026 | Viewed by 467 | Submission Open
Keywords: nuclear receptor signaling; retinoic acid receptor; retinoid X receptor; pharmacology; structure/function relationships; genomic and non-genomic signaling; post-translational modification; homeostasis and disease; development; origin and evolution
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
Cellular and Molecular Mechanisms in Gastrointestinal Diseases submission deadline 30 Jun 2026 | Viewed by 458 | Submission Open
Keywords: gastrointestinal pathophysiology  ; epithelial– mesenchymal transition (EMT)  ; inflammation and immune regulation  ; tumor microenvironment  ; cell signaling pathways  ; stem cell biology in GI tract  ; molecular biomarkers  ; organoids and disease modeling  ; microbiome– host interactions  ; drug discovery
(This special issue belongs to the Section Tissues and Organs)
Kidney and Lung Disorders: The Role of Tubular and Alveolar Epithelia in Health, Disease, Infection, and Organ Crosstalk
edited by Aparna Renigunta and
submission deadline 30 Jun 2026 | Viewed by 301 | Submission Open
Keywords: renal tubular disorders; alveolar lung diseases; transport mechanism; intracellular signaling; viral infection; crosstalk; dialysis; ventilation
Nuclear Pore Complex in Nanomedicine: Third Edition
edited by
submission deadline 30 Jun 2026 | Viewed by 254 | Submission Open
Keywords: intracellular transport; NPC; mitosis; nano; cancer; brain
Crossroad Between Oxidative Stress and DNA Damage and Repair in Stroke
edited by , and Moorthi Ponnusamy
submission deadline 30 Jun 2026 | Viewed by 194 | Submission Open
Keywords: oxidative stress; DNA damage; DNA repair; stroke; ischemic stroke; neuroinflamamtion; intracranial hemorrhagic stroke; neuronal death
(This special issue belongs to the Section Cells of the Nervous System)
Protein and RNA Regulation in Cells
edited by and
submission deadline 30 Jun 2026 | Viewed by 188 | Submission Open
Keywords: gene expression; post-transcriptional regulation; post-translational modifications; non-coding RNAs; regulatory networks; protein degradation; RNA decay
The Role of PPARs in Disease - Volume IV submission deadline 30 Jun 2026 | Viewed by 127 | Submission Open
Keywords: PPAR; immune function; liver; adipose tissue; cardiovascular system; muscle; brain; neurological disease; psychiatric diseases; cancer; transcriptional regulation; ligands; agonists/antagonists
(This special issue belongs to the Section Cells of the Cardiovascular System)
Cellular and Molecular Mechanisms of Hepatobiliary Diseases submission deadline 30 Jun 2026 | Viewed by 116 | Submission Open
Keywords: hepatobiliary diseases; bile metabolism; hepatobiliary models; artificial intelligence; cholestatic diseases; systems medicine; spatio-temporal liver models
(This special issue belongs to the Section Tissues and Organs)
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