Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cell and Immune Therapeutics for Gliomas
edited by and
submission deadline 10 Jan 2025 | 1 articles | Viewed by 8328
Keywords: immune modulation; T-cell activation; tumour-associated macrophages; tumour microenvironment; stem cells
(This special issue belongs to the Section Cell Microenvironment)
Kidney Disease Models, Cellular Mechanism and Potential Treatment
edited by
submission deadline 10 Jan 2025 | 1 articles | Viewed by 1143
Keywords: kidney disease; signaling pathways; therapy; biomarker; prevention
(This special issue belongs to the Section Tissues and Organs)
Cell Death Mechanisms and Therapeutic Opportunities in Glioblastoma
edited by
submission deadline 15 Jan 2025 | 20 articles | Viewed by 49175 | Submission Open
Keywords: apoptosis; autophagy; cell death mechanisms; cell signaling; glioblastoma; therapeutic opportunities
(This special issue belongs to the Section Cells of the Nervous System)
Multifaceted Roles of Mesenchymal Stem Cells in Health and Disease
edited by and Bartłomiej Łukaszuk
submission deadline 15 Jan 2025 | 2 articles | Viewed by 3034 | Submission Open
Keywords: diabetes mellitus; dyslipidemia; insulin resistance; metabolic syndrome; mesenchymal stem cells; obesity
(This special issue belongs to the Section Stem Cells)
Emerging Targets and Therapeutic Potential Drugs in Tumor Progression and Therapeutic Resistance
edited by , and Yuancheng Li
submission deadline 15 Jan 2025 | 1 articles | Viewed by 2589 | Submission Open
Keywords: cancer; tumor progression; therapeutic resistance; molecular targets; tumor microenvironment; innovative therapies; targeted drug delivery; natural product
(This special issue belongs to the Section Cell Microenvironment)
Cellular and Clinical Mechanisms of Obesity and Diabetes and Their Complications submission deadline 15 Jan 2025 | 1 articles | Viewed by 2483 | Submission Open
Keywords: obesity; type 1 diabetes; type 2 diabetes; metabolic disorders; complications; signaling pathways; pathophysiology; insulin; β -cell
(This special issue belongs to the Section Cellular Pathology)
Role of Autophagy in Plant Cells
edited by
submission deadline 15 Jan 2025 | 1 articles | Viewed by 1671 | Submission Open
Keywords: autophagy; endoplasmic reticulum; TOR; vacuoles; lysosomes; mitochondria; plastids
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Hedgehog Signaling: Advances in Development and Cancer—Second Edition
edited by
submission deadline 15 Jan 2025 | Viewed by 269 | Submission Open
Keywords: hedgehog signaling; hh gene; smoothened (SMO)
The Role of Microglia in Neurodegenerative Diseases and Neuroinflammation
edited by
submission deadline 15 Jan 2025 | Viewed by 219 | Submission Open
Keywords: microglia; central nervous system; neurodegenerative diseases; neurodegeneration; Alzheimer’ s disease (AD); Parkinson’ s disease (PD)
(This special issue belongs to the Section Cellular Aging)
Development and Functions of Novel NK Cell Subsets submission deadline 15 Jan 2025 | Viewed by 218 | Submission Open
Keywords: NK cells; subsets of NK; tissue-resident NK; NK subsets within TME; adaptive NK; memory NK; regulatory NK
(This special issue belongs to the Section Cellular Immunology)
Downstream Pathways in Lysosomal Disorders from Basic Science to Clinical Contexts
edited by
submission deadline 20 Jan 2025 | 3 articles | Viewed by 5392 | Submission Open
Keywords: lysosomal storage diseases; omics; autophagy; mitochondria; advance therapy; biomarkers; precision medicine; genetic diseases; epigenetics; neurodegeneration
(This special issue belongs to the Section Cells of the Nervous System)
Adipose-Derived Stem Cells: Current Applications and Future Directions
edited by
submission deadline 20 Jan 2025 | 1 articles | Viewed by 750 | Submission Open
Keywords: cell therapy; regenerative medicine; adipose-derived stem cells (ADSCs); exosome; cytokine
(This special issue belongs to the Section Stem Cells)
Metallodrugs against Cancer Cells: Mechanisms of Action and Molecular Targets
edited by and Elisa Abás
submission deadline 20 Jan 2025 | 1 articles | Viewed by 691 | Submission Open
Keywords: cell death; cytotoxicity; molecular mechanism; cell imaging; theragnostic; photodynamic therapy; chemotherapy; gene expression; drug uptake; SAR studies
(This special issue belongs to the Section Cellular Pathology)
Antiphospholipid Syndrome: Molecular Mechanisms and Novel Therapies
edited by and Simona Truglia
submission deadline 20 Jan 2025 | Viewed by 477 | Submission Open
Keywords: antiphospholipid syndrome; pathophysiology; management; treatment; antiphospholipid antibodies; molecular mechanisms; new biomarkers; diagnostic tests
(This special issue belongs to the Section Cellular Pathology)
Regulation of Fibroblasts and Fibrosis in Cardiovascular Disease
edited by
submission deadline 20 Jan 2025 | Viewed by 299 | Submission Open
Keywords: fibrosis; fibroblasts; cardiovascular; inflammation; extracellular matrix; collagen
(This special issue belongs to the Section Cells of the Cardiovascular System)
Unveiling Axon-Glia Communication in Health and Disease
edited by and Samuele Negro
submission deadline 20 Jan 2025 | Viewed by 266 | Submission Open
Keywords: glia-axon communication; oligodendrocytes; astrocytes; microglia; Schwann cells; enteric glia; neurodevelopment; neurodegeneration; neuroregeneration; cancer; pain; aging
(This special issue belongs to the Section Cells of the Nervous System)
Signaling Pathways in Endometrial Cancer Cells
edited by
submission deadline 20 Jan 2025 | Viewed by 178 | Submission Open
Keywords: endometrial cancer; cellular signaling; cell metabolism; DNA damage repair pathway; the PI3K/AKT/mTOR pathway; the RAS/MAPK pathway; molecular classification
(This special issue belongs to the Section Cell Signaling)
Diagnostic, Prognostic and Therapeutic Biomarkers Related to Civilization Diseases: Molecular Aspects and State of the Art—Second Edition submission deadline 20 Jan 2025 | Viewed by 167 | Submission Open
Keywords: pathomechanisms of civilization diseases; risk factors; assessment of therapeutic efficacy; monitored therapy; prognostic markers; anti-inflammatory-inflammatory imbalance; antioxidant-prooxidant imbalance
Cellular and Molecular Mechanisms in Reproductive System Diseases
edited by Arnab Ghosh, and Sujoy K. Dhara
submission deadline 25 Jan 2025 | 7 articles | Viewed by 13459 | Submission Open
Keywords: male reproductive system; female reproductive system; hormonal regulation; reproductive immunology; adverse pregnancy outcomes; infertility; sexually transmitted infections (STIs)
(This special issue belongs to the Section Reproductive Cells and Development)
Adult Stem Cells in Human Disease
edited by Esther Wolfs, Tim Vangansewinkel and
submission deadline 25 Jan 2025 | 1 articles | Viewed by 1790 | Submission Open
Keywords: dental pulp stem cells; disease; regenerative medicine; disease modeling
(This special issue belongs to the Section Stem Cells)
New Insights into Adipose-Derived Stem Cells (ADSCs)
edited by , and William D’Angelo
submission deadline 30 Jan 2025 | 3 articles | Viewed by 7430 | Submission Open
Keywords: adipose-derived stem cells; immunomodulation; exosomes; cell therapy; clinical translation
(This special issue belongs to the Section Stem Cells)
The Cell Biology of Heart Disease
edited by Rajeshwary Ghosh and
submission deadline 30 Jan 2025 | Viewed by 428 | Submission Open
Keywords: cardiomyopathy; endothelial dysfunction; cellular senescence; fibrosis; myocardial infarction; inflammation; mitochondrial dysfunction; CAD; arrhythmia; heart failure
(This special issue belongs to the Section Cells of the Cardiovascular System)
Signaling in Cancer Stem Cells
edited by Upasana Ray
submission deadline 30 Jan 2025 | Viewed by 373 | Submission Open
Keywords: cancer stem cells (CSCs); stem cells signaling pathways; cancer progression and metastasis; therapeutic resistance; targeting cancer stem cells signaling; cancer heterogeneity; targeted therapy for CSCs; identifying biomarkers for CSCs
(This special issue belongs to the Section Stem Cells)
Roles and Mechanisms of Ubiquitin Ligases (E3) and Deubiquitinases (DUBs)
edited by , Tsunehiro Mizushima and Hideki Yashiroda
submission deadline 31 Jan 2025 | 10 articles | Viewed by 18886 | Submission Open
Keywords: E3 ubiquitin ligases; deubiquitinases; ubiquitin; ubiquitination; proteasome
(This special issue belongs to the Section Cell Signaling)
The Emerging Role of Astrocytes in Health and Neurological Diseases
edited by
submission deadline 31 Jan 2025 | 6 articles | Viewed by 15397 | Submission Open
Keywords: astrocyte network; gliotransmitters; astrocytes in learning and memory; astrocytes and the blood– brain barrier; astrocyte pathologies
(This special issue belongs to the Section Cells of the Nervous System)
Advanced Technology for Cellular Imaging
edited by Alessandro Grinzato, and
submission deadline 31 Jan 2025 | 7 articles | Viewed by 12796 | Submission Open
Keywords: electron tomography; fluorescence microscopy; live cell imaging; multimodal imaging; super resolution microscopy; cell– cell interaction
(This special issue belongs to the Section Cell Methods)
Understanding Spinal Cord Injury and Repair: From Molecules to Neurocircuits and Multimodal Prostheses
edited by
submission deadline 31 Jan 2025 | 7 articles | Viewed by 12689 | Submission Open
(This special issue belongs to the Section Cells of the Nervous System)
Organ and Tissue Fibrosis: Molecular Signals and Cellular Mechanisms
edited by
submission deadline 31 Jan 2025 | 6 articles | Viewed by 12431 | Submission Open
Keywords: fibrosis; scarring; cytokine; myofibroblasts; extracellular matrix; growth factors; mesenchymal transition
(This special issue belongs to the Section Tissues and Organs)
Molecular Mechanisms of Cell Division and Chromosome Segregation: What Can Go Wrong? submission deadline 31 Jan 2025 | 5 articles | Viewed by 10696 | Submission Open
Keywords: mitosis; cell division; genetic instability; aneuploidy; lagging chromosomes; chrosomomes misalignment; mitotic checkpoint; microtubules attachment; kinetochores; microtubules dynamics
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
Microenvironmental Factors and Functional Modulation in Mesenchymal Stem Cells 2.0 submission deadline 31 Jan 2025 | 5 articles | Viewed by 8685 | Submission Open
Keywords: mesenchymal stem cells; inflammation; microenvironment; regeneration of mesenchymal stem cell receptors; stem cell differentiation
(This special issue belongs to the Section Stem Cells)
Molecular and Cellular Mechanisms of Cardiovascular and Metabolic Diseases
edited by
submission deadline 31 Jan 2025 | 4 articles | Viewed by 8083 | Submission Open
Keywords: mitochondrial dysfunction; endoplasmic reticulum (ER) stress; oxidative/nitrosative stress; diabetes; obesity; diet; atherosclerosis; hypertension; metabolomics; cell death; nutraceuticals/functional foods
(This special issue belongs to the Section Cells of the Cardiovascular System)
Cellular Mechanisms in Autoimmune Encephalitis: Biology and Potential Therapeutic Implications
edited by and Dominique Fernandes
submission deadline 31 Jan 2025 | 1 articles | Viewed by 4446 | Submission Open
Keywords: neuroimmunology; pathogenesis; diagnosis; neuroimmune disorders; autoimmune encephalitis
(This special issue belongs to the Section Cells of the Nervous System)
Mitochondria and Other Organelles in Neurodegenerative Diseases
edited by Tian Liu
submission deadline 31 Jan 2025 | 2 articles | Viewed by 4253 | Submission Open
Keywords: mitochondria dysfunction; ER stress; TDP-43 pathology; protein aggregation; tauopathy; neuroinflammation; neurodegeneration; neurodegenerative diseases; therapeutic approaches
(This special issue belongs to the Section Intracellular and Plasma Membranes)
Demystifying the Role of the Immune System in Modulating Pathogenic Fibrosis
edited by Gerlinde Wernig and
submission deadline 31 Jan 2025 | 1 articles | Viewed by 2335 | Submission Open
Keywords: unifying fibrotic mechanisms; genetic markers of disease; innate immunity; drug discovery
(This special issue belongs to the Section Cellular Pathology)
Cilia-Based New Discoveries: Ciliogenesis, Function, and Human Diseases submission deadline 31 Jan 2025 | 2 articles | Viewed by 1686 | Submission Open
Keywords: primary cilium; human disease; cell signaling; mTOR; Hedgehog; WNT; PDGFRalpha
Cellular and Molecular Events in Intervertebral Disc Development, Homeostasis and Disease
edited by
submission deadline 31 Jan 2025 | 1 articles | Viewed by 1506 | Submission Open
Keywords: disc development; healthy intervertebral disc; IVD
Ion Channel Involvement in Neurological and Neuromuscular Disorders submission deadline 31 Jan 2025 | 1 articles | Viewed by 1415 | Submission Open
Keywords: ion channels; neurological diseases; neuromuscular diseases; personalized therapy
(This special issue belongs to the Section Cells of the Nervous System)
Research on the Amyloid in Alzheimer’s Disease
edited by Archna Sharma
submission deadline 31 Jan 2025 | 1 articles | Viewed by 1301 | Submission Open
Keywords: amyloid; Alzheimer’ s disease; amyloid biomarkers; brain network; anti-amyloid immunotherapy; inducible pluripotent stem cells; neuron and non-neuron differentiation; brain organoids; amyloidopathy animal models
(This special issue belongs to the Section Cellular Aging)
New Targets and Therapeutic Approaches Based on Molecular Mechanisms in Tumorigenesis and Cancer Metastasis
edited by
submission deadline 31 Jan 2025 | 1 articles | Viewed by 1195 | Submission Open
Keywords: metastasis; cancer; therapy; precision medicine; cancer stem cells; immuno-oncology; tumor microenvironment; antibody
(This special issue belongs to the Section Cell Microenvironment)
Neuroinflammation in Brain Health and Diseases
edited by Debashis Dutta and Nemil Bhatt
submission deadline 31 Jan 2025 | 1 articles | Viewed by 999 | Submission Open
Keywords: neuroinflammation; gliosis; inflammasome; neurodegeneration; neurotherapeutics
Pathogenesis of Diabetic Kidney Disease
edited by Jia Fu
submission deadline 31 Jan 2025 | Viewed by 329 | Submission Open
Keywords: diabetic kidney disease (DKD); molecular mechanism; oxidative stress; chronic kidney disease; pathogenesis; diagnostic and therapeutic strategies; inflammation; metabolic dysfunction
(This special issue belongs to the Section Cellular Pathology)
Impact of Platelet Defects on Pathophysiological Processes II submission deadline 31 Jan 2025 | Viewed by 282 | Submission Open
Keywords: platelet physiology; platelet pathophysiology; inherited platelet defects; signaling; bleeding; sepsis; acquired platelet disorder; developmental pathogenesis
(This special issue belongs to the Section Cellular Pathology)
The Interplay between the Immune and Central Nervous Systems in Health and Disease: Current Insights and Future Directions
edited by
submission deadline 31 Jan 2025 | Viewed by 269 | Submission Open
Keywords: astrocytes; immunotherapy; inflammatory response; innate and adaptive immunity; microglia; neuroinflammation; neurological diseases; psychiatric disorders; therapeutic avenues
(This special issue belongs to the Section Cellular Immunology)
Molecular Research of Cardiomyopathy
edited by and
submission deadline 31 Jan 2025 | Viewed by 259 | Submission Open
Keywords: cardiomyopathy; heart failure; hypertrophic cardiomyopathy; cellular and molecular rehabilitation
(This special issue belongs to the Section Cells of the Cardiovascular System)
The Diverse Roles of DNA Methylation and Hydroxymethylation in Embryonic Development
edited by
submission deadline 31 Jan 2025 | Viewed by 222 | Submission Open
Keywords: DNA methylation; DNA hydroxymethylation; mouse embryonic development; human embryonic development; Tet; Dnmt
Regulation of Cell Division
edited by Katie Shannon
submission deadline 31 Jan 2025 | Viewed by 216 | Submission Open
Keywords: mitosis; kinetochore; chromosome segregation; actomyosin ring; cytokinesis; septation; mitotic exit network; spindle assembly checkpoint
(This special issue belongs to the Section Cell Proliferation and Division)
The Role Glial Cells in Neurodegenerative Disorders
edited by
submission deadline 31 Jan 2025 | Viewed by 206 | Submission Open
Keywords: neurodegeneration; neuroinflammation; microglia; astrocytes; neuron; extracellular vesicles; therapeutics
Natural Killer (NK) Cells in Immunity: Limitations and Potential
edited by Rehan Mujeeb Faridi
submission deadline 31 Jan 2025 | Viewed by 188 | Submission Open
Keywords: natural killer cells; adaptive NK cells; infection
(This special issue belongs to the Section Cellular Immunology)
Regulatory T Cells and Autoimmunity
edited by Fan Pan
submission deadline 10 Feb 2025 | 2 articles | Viewed by 4763 | Submission Open
Keywords: regulatory T cells; immune tolerance; Foxp3; autoimmune disease (AD); immunotherapy
(This special issue belongs to the Section Cellular Immunology)
Novel Biomarkers in Eye Diseases
edited by
submission deadline 10 Feb 2025 | Viewed by 130 | Submission Open
Keywords: biomarkers; tears; ocular surface; retina; ocular fluids; inflammation; neuromodulation; parainflammation; omics; lab-on-chip
(This special issue belongs to the Section Cellular Pathology)
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