Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Extracellular Vesicles Based Drug Delivery submission deadline 25 Jun 2026 | Viewed by 403 | Submission Open
Keywords: EV engineering; targeting; therapy; natural carrier; exosomes
Regenerating Poorly Vascularized Tissues
edited by Simone Pacini
submission deadline 25 Jun 2026 | Viewed by 254 | Submission Open
Keywords: regenerative medicine; avascular tissue; angiogenesis; vasculogenesis; cell-based medicinal products; bioengineered materials; cell transplantation
(This special issue belongs to the Section Tissues and Organs)
Novel Insights in Chronic Epilepsy—from Molecular Mechanisms to Future Therapies
edited by Kjell Heuser and
submission deadline 25 Jun 2026 | Viewed by 42 | Submission Open
Keywords: epilepsy; epileptogenesis; seizure mechanisms; neuroinflammation; glial cells; reactive gliosis; astrocytes; microglia; antiseizure medication
Cutaneous Regeneration and Tissue Engineering: From Hair Follicle Regeneration to Skin Restoration
edited by Soung-Hoon Lee
submission deadline 25 Jun 2026 | Viewed by 37 | Submission Open
Keywords: skin regeneration; hair follicle regeneration; tissue engineering; regenerative biology; biomaterial scaffolds; organoids and 3D skin models; wound healing; acellular matrices; exosome-based therapy; translational dermatology
The Function of Stem Cells in the Biomedical Applications
edited by Rakesh Kumar Srivastava
submission deadline 25 Jun 2026 | Viewed by 35 | Submission Open
Keywords: stem cells; regenerative medicine; cell therapy; differentiation; disease modeling; tissue engineering; drug discovery
Systemic Sclerosis: Cellular Mechanisms, Innovative Diagnostics and Advanced Therapeutics
edited by Muhammad Soyfoo
submission deadline 25 Jun 2026 | Viewed by 32 | Submission Open
Keywords: systemic sclerosis; fibrosis; myofibroblasts; immune dysregulation; endothelial dysfunction; extracellular matrix (ECM); autoimmune disease
Inflammation and Atherosclerosis: Emerging Mechanisms, Biomarkers and Therapeutic Opportunities
edited by Victoria McGilligan
submission deadline 25 Jun 2026 | Viewed by 29 | Submission Open
Keywords: atherosclerosis; inflammation; inflammatory biomarkers; anti-inflammatory therapies; plaque vulnerability; diagnostics and prognostics
Diabetes-Induced Organ Damage: Cellular Mechanisms and Therapeutic Opportunities submission deadline 30 Jun 2026 | 8 articles | Viewed by 34570 | Submission Open
Keywords: diabetes mellitus; vascular lesions; nephropathy; cardiomyopathy; neuropathy; retinopathy; therapeutic opportunities
(This special issue belongs to the Section Tissues and Organs)
Exclusive Review Papers in Parkinson's Research
edited by and Ronald F. Pfeiffer
submission deadline 30 Jun 2026 | 2 articles | Viewed by 8525 | Submission Open
Keywords: Parkinson’ s disease; alpha-synuclein; substantia nigra; mitochondria; non-motor symptoms; dopamine; levodopa
(This special issue belongs to the Section Cellular Aging)
Role of Calpains in Health and Diseases
edited by and Peter A. Greer
submission deadline 30 Jun 2026 | 5 articles | Viewed by 7130 | Submission Open
Keywords: calpain; physiology; biochemistry; disease; mutation; target; inhibitor
(This special issue belongs to the Section Cellular Pathology)
Pathology and Treatments of Amyotrophic Lateral Sclerosis (ALS)
edited by Laxman Gangwani
submission deadline 30 Jun 2026 | 2 articles | Viewed by 4739 | Submission Open
Keywords: amyotrophic lateral sclerosis (ALS); pathology; molecular mechanisms; treatments; symptom management; biological mechanisms; risk factors; innovative treatments
(This special issue belongs to the Section Cellular Pathology)
Myocardial Ischemia/Reperfusion Injury: Mechanisms and New Directions in Cardioprotection
edited by Sauri Hernandez-Resendiz
submission deadline 30 Jun 2026 | 2 articles | Viewed by 4344 | Submission Open
Keywords: myocardial infarction; heart failure; ischemia/reperfusion injury; no-reflow phenomenon; oxidative stress; cell death; cardiac metabolism; mitochondrial quality control; inflammation; cardioprotection
(This special issue belongs to the Section Tissues and Organs)
Emerging Topics in Smooth Muscle Cell Fate and Plasticity in Atherosclerosis submission deadline 30 Jun 2026 | 4 articles | Viewed by 3824 | Submission Open
Keywords: vascular smooth muscle cells; lineage tracing; fate mapping; VSMC plasticity; (single cell) (spatial) omics; vascular heterogeneity; atherosclerosis
(This special issue belongs to the Section Cellular Pathology)
Study on Immune Activity of Natural Products
edited by Xiu-Min Li
submission deadline 30 Jun 2026 | 3 articles | Viewed by 2605 | Submission Open
Keywords: natural products; bioactive compounds; immune activity; immunomodulation; inflammation; autoimmune diseases; immunotherapy; therapeutic potential
MicroRNAs: Regulators of Cellular Fate
edited by
submission deadline 30 Jun 2026 | 2 articles | Viewed by 1897 | Submission Open
Keywords: microRNA targets; microRNA conservation; microRNA pathway; microRNA mimics; microRNA antagonist; disease biomarker
Emerging Topics in Cachexia
edited by Gabriela Salim Ferreira De Castro
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1128 | Submission Open
Keywords: cachexia; skeletal muscle loss; adipose tissue loss; inflammation; sarcopenia; cancer; body composition; biomarkers
Cellular and Molecular Mechanisms in Gastrointestinal Diseases submission deadline 30 Jun 2026 | Viewed by 486 | Submission Open
Keywords: gastrointestinal pathophysiology  ; epithelial– mesenchymal transition (EMT)  ; inflammation and immune regulation  ; tumor microenvironment  ; cell signaling pathways  ; stem cell biology in GI tract  ; molecular biomarkers  ; organoids and disease modeling  ; microbiome– host interactions  ; drug discovery
(This special issue belongs to the Section Tissues and Organs)
Retinoic Acid and Retinoid X Receptors - Series II submission deadline 30 Jun 2026 | Viewed by 469 | Submission Open
Keywords: nuclear receptor signaling; retinoic acid receptor; retinoid X receptor; pharmacology; structure/function relationships; genomic and non-genomic signaling; post-translational modification; homeostasis and disease; development; origin and evolution
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
Kidney and Lung Disorders: The Role of Tubular and Alveolar Epithelia in Health, Disease, Infection, and Organ Crosstalk
edited by Aparna Renigunta and
submission deadline 30 Jun 2026 | Viewed by 308 | Submission Open
Keywords: renal tubular disorders; alveolar lung diseases; transport mechanism; intracellular signaling; viral infection; crosstalk; dialysis; ventilation
Nuclear Pore Complex in Nanomedicine: Third Edition
edited by
submission deadline 30 Jun 2026 | Viewed by 260 | Submission Open
Keywords: intracellular transport; NPC; mitosis; nano; cancer; brain
Protein and RNA Regulation in Cells
edited by and
submission deadline 30 Jun 2026 | 1 articles | Viewed by 219 | Submission Open
Keywords: gene expression; post-transcriptional regulation; post-translational modifications; non-coding RNAs; regulatory networks; protein degradation; RNA decay
Crossroad Between Oxidative Stress and DNA Damage and Repair in Stroke
edited by , and Moorthi Ponnusamy
submission deadline 30 Jun 2026 | Viewed by 202 | Submission Open
Keywords: oxidative stress; DNA damage; DNA repair; stroke; ischemic stroke; neuroinflamamtion; intracranial hemorrhagic stroke; neuronal death
(This special issue belongs to the Section Cellular Neuroscience)
Cellular and Molecular Mechanisms in Reproductive Biology and Fertility
edited by and Antonio Malvasi
submission deadline 30 Jun 2026 | Viewed by 192 | Submission Open
Keywords: gametogenesis; fertilization; fertility; endocrinology; implantation; gametogenesis regulation; embryo– maternal interaction; reproductive signaling; IVF; in vitro fertilization; ovarian stimulation
(This special issue belongs to the Section Reproductive Cells and Development)
Neuromuscular Disorders: Advances in Cellular and Molecular Understanding, Emerging Therapies, and Outcome Measures
edited by and
submission deadline 30 Jun 2026 | Viewed by 169 | Submission Open
Keywords: neuromuscular disorders; pathophysiology; biomarkers; treatment; impairment and disability measures; outcome measures
(This special issue belongs to the Section Tissues and Organs)
The Role of PPARs in Disease - Volume IV submission deadline 30 Jun 2026 | Viewed by 158 | Submission Open
Keywords: PPAR; immune function; liver; adipose tissue; cardiovascular system; muscle; brain; neurological disease; psychiatric diseases; cancer; transcriptional regulation; ligands; agonists/antagonists
(This special issue belongs to the Section Cells of the Cardiovascular System)
Cellular and Molecular Mechanisms of Hepatobiliary Diseases submission deadline 30 Jun 2026 | Viewed by 128 | Submission Open
Keywords: hepatobiliary diseases; bile metabolism; hepatobiliary models; artificial intelligence; cholestatic diseases; systems medicine; spatio-temporal liver models
(This special issue belongs to the Section Tissues and Organs)
Bone and Tooth Biology: Development and Regeneration
edited by Xiaofang Wang
submission deadline 30 Jun 2026 | Viewed by 89 | Submission Open
Keywords: bone; tooth; osteogenesis; odontogenesis; enamel; dentin; cementum; amelogenesis; dentinogenesis; regeneration; stem cells  
Mitochondrial Dynamics and Remodelling
edited by Edmund Carvalho
submission deadline 30 Jun 2026 | Viewed by 89 | Submission Open
Keywords: mitochondrial dynamics; fission; fusion; mitophagy; cristae remodeling; bioenergetics; ER– mitochondria contacts; immune reprogramming; signaling pathways; therapeutic targeting
Cellular Signalling Pathways in the Endocrine Pancreas and Diabetes
edited by
submission deadline 30 Jun 2026 | Viewed by 82 | Submission Open
Keywords: diabetes; cell signalling; molecular mechanisms; cell stress; endocrine pancreas; β -cells
(This special issue belongs to the Section Cell Signaling)
Tau Pathobiology and Excitotoxicity in Neurodegeneration and Epilepsy
edited by Janet Van Eersel
submission deadline 30 Jun 2026 | Viewed by 75 | Submission Open
Keywords: tau; excitotoxicity; dementia; epilepsy; seizures; hyperexcitation
Translating Extracellular Vesicle Science submission deadline 30 Jun 2026 | Viewed by 72 | Submission Open
Keywords: extracellular vesicles (EVs); EV isolation; EV purification; EV characterization; EV images; EV tracking; EV-based diagnostics; EV-based monitoring; EV therapeutics; blood biomarkers; translational medicine; exosomes; cell signaling
Neural Stem Cells and Progenitors: Mechanisms of Neurogenesis and Regenerative Potential
edited by Lidia De Filippis and Maurizio Gelati
submission deadline 30 Jun 2026 | Viewed by 64 | Submission Open
Keywords: neural stem cells; cancer stem cells; neuroregeneration; neurodegenerative diseases; CNS; neurorepair; neurogenesis; neuroinflammation
Nuclear Organization and Nucleocytoplasmic Transport in Neuronal Development and Disease: Mechanisms and Therapeutic Opportunities submission deadline 30 Jun 2026 | Viewed by 64 | Submission Open
Keywords: nuclear organization; nucleocytoplasmic transport; neuronal development; neurodegeneration; nuclear pore complex (NPC); nuclear lamina; RNA trafficking; chromatin regulation; therapeutic targeting; neurodevelopmental disorders
(This special issue belongs to the Section Cellular Neuroscience)
The Immunology of Allergy and Asthma submission deadline 30 Jun 2026 | Viewed by 51 | Submission Open
Keywords: type 2 immunity; rhinitis; food allergy; anaphylaxis; drug allergy; dermatitis; eczema; airway inflammation; IgE response; tissue remodelling; disease remission
Role of Macrophages in Tissue Repair
edited by
submission deadline 30 Jun 2026 | Viewed by 45 | Submission Open
Keywords: macrophages; inflammation; tissue repair; phagocytosis
(This special issue belongs to the Section Tissues and Organs)
Multifaceted Nature of Immune Responses to Viral Infection
edited by Homayon Ghiasi and Susmit Suvas
submission deadline 30 Jun 2026 | Viewed by 41 | Submission Open
Keywords: viral infection; innate and adaptive immunity; protection; RNA and DNA viruses; autoimmunity; immune escape
Inflammation in Target Organs—Second Edition
edited by
submission deadline 30 Jun 2026 | Viewed by 29 | Submission Open
Keywords: inflammation; fibrosis; cardio-renal; vascular; liver; brain
(This special issue belongs to the Section Cellular Immunology)
Epithelial-Immune Cell Interactions in Gut Homeostasis and Inflammation
edited by Neeraj Kapur
submission deadline 30 Jun 2026 | Viewed by 9 | Submission Open
Keywords: gut homeostasis; epithelial barrier; immune cell crosstalk; barrier dysfunction; intestinal inflammation; microbiota; dysbiosis
(This special issue belongs to the Section Cellular Immunology)
Synaptic Condensates: Liquid–Liquid Phase Separation of Pre- and Postsynaptic Scaffold Proteins in Synapse Development and Memory Formation
edited by Norbert Bencsik and
submission deadline 30 Jun 2026 | Viewed by 8 | Submission Open
Keywords: liquid– liquid phase separation (LLPS); synaptic plasticity; synapse development; postsynaptic density (PSD); scaffold proteins; synaptic dysfunction; neural circuits
(This special issue belongs to the Section Cellular Neuroscience)
Cell Metabolism in Endocrine Diseases
edited by Ranjodh Gill
submission deadline 30 Jun 2026 | Viewed by 7 | Submission Open
Keywords: endocrine system; hormones; metabolism; cellular pathways; homeostasis; diabetes mellitus; insulin resistance; thyroid disorders; hypothyroidism; hyperthyroidism; cortisol; Cushing's syndrome
(This special issue belongs to the Section Cellular Metabolism)
Innate-Like T Cells: The Variegated Roles of Semi-Invariant TCRs in Health and Disease
edited by and Akshat Sharma
submission deadline 5 Jul 2026 | Viewed by 2297 | Submission Open
Keywords: innate-like T cells; cancer; autoimmunity; cytokines; immune mechanisms
(This special issue belongs to the Section Cellular Pathology)
Biochemical Interaction and Supramolecular Complexes of Receptors in Cell Membranes submission deadline 8 Jul 2026 | 1 articles | Viewed by 1258 | Submission Open
Keywords: membrane receptors; molecular complex; membrane microdomains
Experimental Systems to Model Aging Processes
edited by , and Ralf Dahm
submission deadline 10 Jul 2026 | 4 articles | Viewed by 8869 | Submission Open
Keywords: aging; ageing; age-related; longevity; model; animal; signalling pathway; mechanism; in vitro; in vivo; cell culture; marker
(This special issue belongs to the Section Cellular Aging)
Ripening and Degradation Mechanisms of Neutrophil Extracellular Traps
edited by and Maximilian Dölling
submission deadline 10 Jul 2026 | Viewed by 535 | Submission Open
Keywords: neutrophil extracellular traps; degradation of NETs; ripening of NETs
(This special issue belongs to the Section Cellular Immunology)
Tumor Stroma Interaction
edited by
submission deadline 15 Jul 2026 | 1 articles | Viewed by 3017 | Submission Open
Keywords: cells; cancer; inflammation; exocytosis; immune system; tumor stroma
Inflammation in the Brain: From Molecular and Cellular Mechanisms to Therapeutic Strategies
edited by Sujatha Kannan and
submission deadline 15 Jul 2026 | 1 articles | Viewed by 572 | Submission Open
Keywords: neuroinflammation; microglia; astrocytes; immune signaling; neurodegeneration; neuroimmunology; brain injury; therapeutic strategies
Role of Hippo Signaling in Cancer submission deadline 15 Jul 2026 | Viewed by 81 | Submission Open
Keywords: angiogenesis; cancer metabolism; cancer stemness; chemoresistance; endothelial cell plasticity; epithelial-to-mesenchymal transition (EMT); hippo signaling pathway; immunotherapy; mechanotransduction; targeted cancer therapy; TEAD transcription factors; therapeutic resistance; tumor microenvironment; tumorigenesis; YAP/TAZ; new therapeutic modalities to target YAP/TAZ-driven tumors including ferroptosis
(This special issue belongs to the Section Cell Signaling)
MET: Signaling, Regulation, and Biological Roles
edited by Abdulhameed Al-Ghabkari and William W. Lockwood
submission deadline 15 Jul 2026 | Viewed by 59 | Submission Open
Keywords: MET; HGF (hepatocyte growth factor); MET signaling; receptor tyrosine kinase (RTK); cancer; tumor progression; receptor activation; MET-targeted therapy
(This special issue belongs to the Section Cell Signaling)
Second Edition of Advances in Adipose Tissue Biology
edited by
submission deadline 20 Jul 2026 | 2 articles | Viewed by 4451 | Submission Open
Keywords: adipocyte differentiation; progenitors; and stem cells; adipokines; myokines; hepatokines; cytokines; cellular signaling; and molecular crosstalk; white adipose tissue (WAT) and brown adipose tissue (BAT); beige fat and browning of WAT; research techniques and methodologies; diagnostics and therapeutics; genomics; metabolomics; other ‘ omics’ technologies; metabolic syndrome; obesity; insulin resistance; cancer
(This special issue belongs to the Section Tissues and Organs)
Novel Molecular Targets for the Treatment of Sleep Disorders
edited by
submission deadline 25 Jul 2026 | Viewed by 300 | Submission Open
Keywords: sleep disorders; molecular targets; glymphatic system; neuroinflammation; circadian rhythms; microbiome; biomarkers; pharmacological therapy; gene therapy; neurodegeneration
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