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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advanced Review Papers in ‘Tissue and Organs’

edited by

Chao Xie

submission deadline 31 Oct 2026 | Viewed by 68 | Submission Open

Keywords: tissue biology; organ development and morphogenesis; tissue architecture and organization; stem cells and progenitor cells; tissue regeneration and repair; extracellular matrix; cell– cell communication; cellular microenvironment; tissue remodeling; 3D tissue models and bioengineering

(This special issue belongs to the Section Tissues and Organs)

Epigenetic Regulation of Cellular Plasticity in Brain Tumors

edited by

Sree Deepthi Muthukrishnan

and Erina Vlashi

submission deadline 31 Oct 2026 | Viewed by 64 | Submission Open

Keywords: brain tumors; epigenetic modifiers; tumor plasticity; epigenetic heterogeneity; microenvironment-epigenetic interactions; therapy resistance

(This special issue belongs to the Section Cell and Gene Therapy)

Molecular Genetics of Cystic Kidney Disease

edited by

John Sayer

and Juliana Galvis

submission deadline 31 Oct 2026 | Viewed by 53 | Submission Open

Keywords: cystic kidney disease; polycystic kidney disease; cilia; PKD1; PKD2; autosomal dominant; renal epithelium; animal models; disease mechanisms; organoids

(This special issue belongs to the Section Cell and Gene Therapy)

Glycolysis in Tumorigenesis: Mechanisms and Therapeutic Implications

edited by

Fabrizio Marcucci

, Shibo Wei and

Marco Cordani

submission deadline 1 Nov 2026 | 2 articles | Viewed by 1752 | Submission Open

Keywords: glycolysis; tumorigenesis; moonlighting functions; Warburg effect; metabolic reprogramming; tumor microenvironment; therapeutic targets; cancer metabolism

Role of Inflammasomes in Neurological Disorders

edited by

Juan Pablo de Rivero Vaccari

submission deadline 1 Nov 2026 | Viewed by 229 | Submission Open

Keywords: inflammasome; pyroptosis; caspase-1; ASC specks; IL-1beta; PANoptosis; CNS injury; neurodegenerative diseases; biomarkers; Alzheimer’ s disease; Parkinson’ s disease; multiple sclerosis; amyotrophic lateral sclerosis

(This special issue belongs to the Section Cellular Neuroscience)

Plasticity of Skeletal, Cardiac and Smooth Muscles in COPD: Repair and Remodeling

edited by

Joaquim Gea Guiral

submission deadline 5 Nov 2026 | 3 articles | Viewed by 6342 | Submission Open

Keywords: injury; repair; adaptation; aerobic metabolism; muscle mass; limb muscles; respiratory muscles; proteolysis

Cancer Stem Cells in Triple-Negative Breast Cancer

edited by

Antonella Zannetti

and

Maria Grazia Caprio

submission deadline 5 Nov 2026 | Viewed by 412 | Submission Open

Keywords: cancer stem cells; TNBC; signal pathways; epithelial– mesenchymal transition; tumor microenvironment; targeted therapy; biomarkers

Advancements in Research on hiPSC-Derived Cells

edited by Akhilesh Kumar

submission deadline 10 Nov 2026 | 2 articles | Viewed by 7408 | Submission Open

Keywords: hiPSCs; hematopoietic progenitors; T cells; NK cells; cardiac cells; B cells; macrophages; neutrophiles; CRISPR/Cas9 technology; genetic engineering

(This special issue belongs to the Section Stem Cells)

Hematologic Diseases: From Cellular and Molecular Mechanisms to Therapies

edited by

Wei Du

and

Pier Paolo Piccaluga

submission deadline 10 Nov 2026 | 2 articles | Viewed by 3392 | Submission Open

Keywords: hematologic diseases; mechanisms; therapies

Cellular Senescence and Transformation: Unraveling the Biological Links Between Aging and Cancer

edited by

Yongye Huang

, Lin Yuan and Yang Yu

submission deadline 10 Nov 2026 | 2 articles | Viewed by 1527 | Submission Open

Keywords: aging; cancer; stem cells; gene editing; oncogene; apoptosis; targeted therapy; epigenetics

Molecular and Cellular Mechanisms of Heart Regeneration

edited by Mira Pronobis and

Dinender K. Singla

submission deadline 10 Nov 2026 | 1 articles | Viewed by 687 | Submission Open

Keywords: cardiac regeneration; cardiomyocyte proliferation; tissue remodeling; cardiovascular repair; regenerative therapy; cellular plasticity; myocardial infarction; heart failure

(This special issue belongs to the Section Cells of the Cardiovascular System)

Methane Biosynthesis

edited by

Divya Prakash

, James Ferry and

Shikha Singh Chauhan

submission deadline 10 Nov 2026 | Viewed by 408 | Submission Open

Keywords: methane; methanogenesis; methanogens; carbon cycle; gut microbiota; energy conservation; human diseases

New Insights into Platelet Physiology and Dysfunction

edited by Serena Valsami and

Sotiris Fortis

submission deadline 10 Nov 2026 | Viewed by 75 | Submission Open

Keywords: platelets; platelet function; platelet physiology; platelet dysfunction; platelet disorders; platelet biology; pathophysiology; platelet transfusion; hereditary platelet disorders; acquired platelet disorders

(This special issue belongs to the Section Cells of the Cardiovascular System)

Recent Advances in Novel Cell and Gene Therapies for the Treatment of Immune Diseases

edited by Qingdong Guan

submission deadline 15 Nov 2026 | 5 articles | Viewed by 15160 | Submission Open

Keywords: cell therapy; gene therapy; chimeric antigen receptor T cells; T cell receptor-engineered T cells; tumor-infiltrating lymphocytes; hematopoietic stem cells; chimeric antigen receptor NK cells; induced pluripotent stem cells; mesenchymal stem/stromal cells; immune regulatory cells

(This special issue belongs to the Section Cellular Immunology)

Mast Cells in Health and Disease: Current Insights and Future Perspectives on Development, Activation, Functional Roles, and Therapeutic Strategies

edited by

Aida Paivandy

submission deadline 15 Nov 2026 | 7 articles | Viewed by 8443 | Submission Open

Keywords: mast cell granules; mast cell mediators; mast cell development; mast cell survival; mast cell activation; mast cell activating and inhibitory receptors; receptor signaling; allergic and non-allergic pathologies; immunity and host defense; mast cell-directed therapeutic approaches

(This special issue belongs to the Section Cellular Immunology)

Host–Pathogen Interactions and Immune Responses

edited by Harish Chandra

submission deadline 15 Nov 2026 | 4 articles | Viewed by 4812 | Submission Open

Keywords: multidrug-resistant bacteria; environmental mycobacteria; exosomes; oxidative stress; catalases; antimicrobial resistance; polycyclic aromatic hydrocarbons (PAHs); cellular signaling

(This special issue belongs to the Section Cellular Immunology)

Mechanisms and Therapies in Chronic Pain

edited by Nikesh Kunder and June Bryan I. de la Peña

submission deadline 15 Nov 2026 | 1 articles | Viewed by 2390 | Submission Open

Keywords: chronic pain; pain mechanisms; pain targets; opioid alternatives; neurobiology; pre-clinical; translational research; pathophysiology; pain management

(This special issue belongs to the Section Cellular Pathology)

Molecular Basis of Gynecological Disorders and Associated Infertility

edited by

Ahmad Albaghdadi

and

Nihar R. Nayak

submission deadline 15 Nov 2026 | 1 articles | Viewed by 982 | Submission Open

Keywords: gynecological disorders; endometriosis; polycystic ovary syndrome (PCOS); cervical cancer; ovarian cancer; uterine and vaginal pathologies

(This special issue belongs to the Section Cellular Pathology)

Metabolic Regulation of Cell Behavior and Implications for Aging

edited by

Eloy Bejarano

and José Antonio Rodríguez Navarro

submission deadline 15 Nov 2026 | Viewed by 356 | Submission Open

Keywords: metabolism; cellular aging; senescence; proteostasis; oxidative stress; glycation; autophagy

Cancer and Vessels: Insights at the Cellular and Molecular Levels

edited by Francesco Pezzella and Tom Donnem

submission deadline 15 Nov 2026 | Viewed by 325 | Submission Open

Keywords: angiogenesis; vessel co-option; tumor microenvironment; tumor blood vessels; tumor vasculature; metastasis

(This special issue belongs to the Section Cellular Pathology)

Brain Injury: Traumatic and Non-Traumatic Pathophysiology, Translational Approaches and Novel Treatment Strategies

edited by Thomas Kapapa,

Hayrettin Tumani

and Andreas Pfnür

submission deadline 15 Nov 2026 | Viewed by 301 | Submission Open

Keywords: traumatic brain injury; stroke; blood– brain barrier; neuroinflammation; neuroimmunology

(This special issue belongs to the Section Tissues and Organs)

New Mechanistic Insights and Novel Therapeutic Options for Pulmonary Vascular Disease (PVD)

edited by

Yong-Xiao Wang

submission deadline 15 Nov 2026 | Viewed by 206 | Submission Open

Keywords: pulmonary vascular disease; pulmonary hypertension; pulmonary arterial hypertension; vascular contraction; vascular remodeling

Cellular Mechanisms and Molecular Signaling in Heart Failure

edited by Przemyslaw Leszek

submission deadline 15 Nov 2026 | Viewed by 77 | Submission Open

Keywords: heart failure; cellular mechanisms and molecular signaling; new directions in cellular mechanisms promising for novel heart failure therapies

(This special issue belongs to the Section Cells of the Cardiovascular System)

Post-Transcriptional Control of Stem Cell Fate and Neural Development

edited by

Kun Tan

submission deadline 16 Nov 2026 | 1 articles | Viewed by 1494 | Submission Open

Keywords: post-transcriptional regulation; stem cell biology; neural development; developmental biology

(This special issue belongs to the Section Stem Cells)

Placenta in Tissue Engineering and Regeneration

edited by

Gayathri Rajaraman

submission deadline 16 Nov 2026 | Viewed by 502 | Submission Open

Keywords: placenta; stem cells; tissue engineering; clinical application; organ repair; regenerative medicine; biomaterials; clinical practice; bio-scaffolds; tissue regeneration

Cellular Signalling Pathways in the Endocrine Pancreas and Diabetes

edited by

Catharina Alam

submission deadline 16 Nov 2026 | Viewed by 305 | Submission Open

Keywords: diabetes; cell signalling; molecular mechanisms; cell stress; endocrine pancreas; β -cells

(This special issue belongs to the Section Cell Signaling)

Kidney Development: Cellular and Molecular Insights

edited by

Renfang Song Taylor

submission deadline 18 Nov 2026 | 1 articles | Viewed by 1049 | Submission Open

Keywords: kidney development; nephrogenesis; single-cell RNA-seq/ATAC-seq; congenital anomalies of the kidney and urinary tract (CAKUT); blood pressure regulation

Neurodevelopmental Factors of Autism Spectrum Disorder: Etiology to Therapy

edited by

George Ayoub

submission deadline 20 Nov 2026 | Viewed by 433 | Submission Open

Keywords: autism spectrum disorder; developmental factors; genetic contributions; environmental influences; gene– environment interactions; developing therapies

Molecular Mechanisms and Treatment Strategies in Metabolic Syndromes and Neurological Disorders

edited by

Shaohua Qi

and

George Augustine

submission deadline 20 Nov 2026 | Viewed by 359 | Submission Open

Keywords: neurological disorders; metabolic syndromes; neurodegenerative disease; systems biology; precision medicine; target therapy

(This special issue belongs to the Section Cellular Neuroscience)

Cellular and Molecular Mechanisms of Microglia/Macrophages in the Nervous System

edited by Emanuela Paldino

submission deadline 20 Nov 2026 | Viewed by 334 | Submission Open

Keywords: microglia; macrophages; neurological disorders

Molecular Mechanisms of Autophagy, Apoptosis and Senescence and Therapeutic Advances in Cancer Progression

edited by

Katerina Gioti

and

Apostolos Beloukas

submission deadline 20 Nov 2026 | Viewed by 316 | Submission Open

Keywords: cancer progression; cell death; senescence; cancer therapy

Fibrosis in Chronic Inflammatory Diseases

edited by

Mirko Manetti

Irene Rosa

and

Eloisa Romano

submission deadline 25 Nov 2026 | 8 articles | Viewed by 23718 | Submission Open

Keywords: fibrosis; fibroblasts; myofibroblasts; inflammation; molecular pathways; pathogenetic mechanisms; therapeutic targets

(This special issue belongs to the Section Cellular Pathology)

Recent Advances in the Study of Tau Protein

edited by

Santosh Jadhav

submission deadline 25 Nov 2026 | 2 articles | Viewed by 10181 | Submission Open

Keywords: tau protein; post-translational modification; tauopathy filaments; neuro-immune interactions

(This special issue belongs to the Section Cellular Neuroscience)

Cellular Differentiation in Health and Disease

edited by Christine K. C. Loo and

Grant A. Ramm

submission deadline 25 Nov 2026 | 1 articles | Viewed by 3703 | Submission Open

Keywords: cellular differentiation; tumour microenvironment; human development; regeneration/healing; cell signaling pathways; tumour differentiation

(This special issue belongs to the Section Cell Microenvironment)

Synaptic Senescence in Health and Neurodegeneration: Cellular and Molecular Mechanisms

edited by

Isabel Martinez-Pena y Valenzuela

submission deadline 25 Nov 2026 | Viewed by 451 | Submission Open

Keywords: synapses; synaptic transmission; aging; senescent synapse; neurodegeneration; synaptic plasticity; glial cells

Genetic Mechanisms and Pathological Links in Neurodevelopmental Disorders

edited by Luigi Balasco and

Cinzia Severini

submission deadline 25 Nov 2026 | Viewed by 142 | Submission Open

Keywords: neurodevelopmental disorders; genetics; pathogenic mechanisms; genetic animal models; gene– environment interactions; rare variants; common variants; developmental neurobiology; molecular mechanisms; genotype– phenotype relationships

(This special issue belongs to the Section Cellular Neuroscience)

New Advances in Anticancer Therapy

edited by

Dooil Jeoung

submission deadline 30 Nov 2026 | 5 articles | Viewed by 13096 | Submission Open

Keywords: antibody-based immunotherapy; cell therapy; personalized anticancer therapy; RNA vaccines; nanotechnology

(This special issue belongs to the Section Cellular Pathology)

Advances in Cardiomyocyte and Stem Cell Biology in Heart Disease

edited by

Ki Ho Park

submission deadline 30 Nov 2026 | 5 articles | Viewed by 9622 | Submission Open

Keywords: cardiomyocytes; stem cells; heart disease; regenerative medicine; ion channels; protein therapeutics; bioengineering; molecular biology

(This special issue belongs to the Section Cells of the Cardiovascular System)

Harnessing the Tumor Microenvironment and Signaling Pathways for Precision Cancer Therapy

edited by Behzad M. Toosi and

Andrew Freywald

submission deadline 30 Nov 2026 | 3 articles | Viewed by 6957 | Submission Open

Keywords: tumor microenvironment (TME); signaling pathways; precision cancer therapy; immune evasion; metabolic pathways; tumor– stroma interactions; therapeutic targets; personalized medicine; cancer metastasis; molecular oncology

(This special issue belongs to the Section Cell Microenvironment)

Molecular Insights into cAMP/PKA Pathway Regulation in Health and Disease

edited by

Elie Seaayfan

and

Martin Kömhoff

submission deadline 30 Nov 2026 | 1 articles | Viewed by 2737 | Submission Open

Keywords: cAMP/PKA signaling; protein kinase A (PKA); cyclic AMP; EPAC; signal transduction; cellular homeostasis; metabolic regulation; disease mechanisms; molecular signaling; therapeutic targets; cross-talk in signaling pathways; protein– protein interactions; post-translational modifications; pharmacological interventions

Cellular and Molecular Basis of Brain Tumor

edited by

Wojciech Czyżewski

, Tomasz S. Mandat, Grzegorz Turek and Radosław Mlak

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2391 | Submission Open

Keywords: brain tumor; glioma; tumor microenvironment; molecular oncology; epigenetics; tumor stem cells; biomarkers; therapeutic resistance; non-coding RNA; translational research

(This special issue belongs to the Section Cellular Pathology)

Novel Insights into Molecular and Cellular Mechanisms Underlying Chronic Pain

edited by

Mariacristina Mazzitelli

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1888 | Submission Open

Keywords: pain; pain management; sexual dimorphism; neurons; non-neuronal factors

(This special issue belongs to the Section Cellular Pathology)

LPS-Induced Inflammatory Diseases

edited by

Lin-Hua Jiang

and

Pankaj Kumar

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1815 | Submission Open

Keywords: lipopolysaccharide (LPS); endotoxemia; inflammation; LPS signaling; acute lung injury; inflammatory cytokines; therapeutic targets

(This special issue belongs to the Section Cellular Pathology)

Extracellular Vesicles in Disease Pathogenesis, Therapeutics and Biomarker Discovery

edited by

Susmita Sil

submission deadline 30 Nov 2026 | 2 articles | Viewed by 1753 | Submission Open

Keywords: extracellular vesicles; exosomes; exomeres; apoptotic bodies; macrovesicles; EV-cargoes; EVs as biomarkers; EVs in therapy

(This special issue belongs to the Section Intracellular and Plasma Membranes)

Autoimmune Diseases: Immune Cells and Genetic and Epigenetic Regulations

edited by

Moncef M. Zouali

submission deadline 30 Nov 2026 | 2 articles | Viewed by 1489 | Submission Open

Keywords: autoimmune diseases; immune cells; lymphocytes; antigen-presenting cells; natural killer cells; innate lymphoid cells; epigenetic modifications; autoimmunity

(This special issue belongs to the Section Cellular Immunology)

How Does Gene Regulation Affect Cancer Development?

edited by

Ru Chih C. Huang

and

Kotohiko Kimura

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1434 | Submission Open

Keywords: cancer; mutation; transcription factor; non-coding RNA; micro-RNA; gene regulation; histones; gene promoters; anticancer drugs

(This special issue belongs to the Section Cell Microenvironment)

Glycosylation and Glycoproteins in Human Disease

edited by

Mana Mukherjee

and

Bingmei Fu

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1291 | Submission Open

Keywords: glycobiology; glycosylation; glycoproteins; glycolipids; glycan biomarkers; congenital disorders of glycosylation (cdg); immune modulation; glycan profiling; glycoengineering; host– pathogen interactions; therapeutic glycoproteins; bioorthogonal chemistry

Genome Editing in Biomedicine

edited by

Fu-Lei Tang

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1172 | Submission Open

Keywords: genome manipulation; CRISPR/Cas systems; base editing and prime editing; cellular models (organoids/stem cells); stem cell editing; animal models; genetically engineered mouse models (GEMMs); translational research; cell therapy; editing efficiency; virus-like particles (VLPs)

(This special issue belongs to the Section Cell and Gene Therapy)

Stem Cell Secretome: Therapeutic Potential in Regenerative Medicine

edited by Emanuela Mari

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1141 | Submission Open

Keywords: paracrine factors and tissue regeneration; secretome conditioned by microenvironment or stimuli; extracellularvesicles vs. soluble fraction; formulations and delivery of the therapeutic secretome

(This special issue belongs to the Section Stem Cells)

B Cells in Action: Interaction Dynamics and Functional Decisions

edited by Michael L. Atchison and

Sulagna Sanyal

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1129 | Submission Open

Keywords: B cell development and differentiation; adaptive immunity; germinal center B cell; class-switch recombination; immunosuppression; cytokines; inflammation; epigenetic regulation; metabolic reprogramming; immune response

(This special issue belongs to the Section Cellular Immunology)

Displaying special issue 551-600 on page 12 of 13.

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