Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Gene Editing Using Synthetic Nucleic Acids
edited by Debmalya Bhunia
submission deadline 25 Apr 2026 | Viewed by 9 | Submission Open
Keywords: gene editing; synthetic nucleic acids; genetic diseases; targeted gene therapy; antisense binding
(This special issue belongs to the Section Cell and Gene Therapy)
Pathogenesis and Novel Therapies in Epithelial Cancers
edited by Jung Wook Park and Sanjeevram Dhandapani
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1686 | Submission Open
Keywords: transformation; malignant; oncogene; tumor suppressor; molecular mechanisms; epigenetic; metabolic; immune; biomarkers; personalized medicine; primary cells; small-molecule inhibitor
(This special issue belongs to the Section Cellular Pathology)
Advancements in Cardiac Metabolism
edited by
submission deadline 30 Apr 2026 | 2 articles | Viewed by 1389 | Submission Open
Keywords: cardiovascular disease; metabolism; fatty acids; heart failure; mitochondrial dysfunction
(This special issue belongs to the Section Cells of the Cardiovascular System)
Advances in Cardiomyocyte and Stem Cell Biology in Heart Disease
edited by Ki Ho Park
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1227 | Submission Open
Keywords: cardiomyocytes; stem cells; heart disease; regenerative medicine; ion channels; protein therapeutics; bioengineering; molecular biology
(This special issue belongs to the Section Cells of the Cardiovascular System)
Cellular Mechanisms and Targeted Therapy of Acute Myeloid Leukemia
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1152 | Submission Open
Keywords: Acute Myeloid Leukemia (AML); molecular targets; gene therapy; drug resistance; targeted therapy; leukemia stem cells; oncogenic mutations; apoptosis; cell cycle regulation
(This special issue belongs to the Section Cellular Pathology)
Immune Cells from Pluripotent Stem Cells
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 899 | Submission Open
Keywords: pluripotent stem cells; T cells; B cells; macrophages; natural killer (NK) cells; dendritic cells; megakaryocytes; platelets
(This special issue belongs to the Section Stem Cells)
Role of Gamma Delta T Cells in Immunotherapy
edited by and Wenwei Tu
submission deadline 30 Apr 2026 | Viewed by 357 | Submission Open
Keywords: gamma delta T cells; adoptive cell therapy; chimeric antigen receptors; bispecific antibodies; cancer immunotherapy; tumor microenvironment; phosphoantigens; butyrophilin 2A1/3A1; virus infection; multidrug-resistant bacteria; extracellular vesicles
(This special issue belongs to the Section Cellular Immunology)
Synaptic Dysregulation in Nervous System Disorders
edited by Pragya Goel
submission deadline 30 Apr 2026 | Viewed by 286 | Submission Open
Keywords: synapses; synaptic transmission; synaptic plasticity; neurodegeneration; neuropsychiatric disorders; neurodevelopmental diseases
(This special issue belongs to the Section Cells of the Nervous System)
Interleukin-1 Signaling in Cancer: Novel Mechanisms and Therapeutic Opportunities
edited by Afshan Fathima Nawas and
submission deadline 30 Apr 2026 | Viewed by 90 | Submission Open
Keywords: interleukin-1 signaling; tumor microenvironment; inflammatory pathways; cytokine networks; cancer cell proliferation; epigenetic regulation in cancer; non-coding RNAs; immune modulation; cancer metabolism
Advances in Liquid Biopsy for Early Detection and Monitoring of Cancer
edited by Nicola Normanno, and
submission deadline 30 Apr 2026 | Viewed by 60 | Submission Open
Keywords: ctDNA; circulating tumor cells; microRNAs; exosomes; methylation; fragmentomics; early detection; minimal residual disease; artificial intelligence
Post-Transcriptional Control of Stem Cell Fate and Neural Development
edited by
submission deadline 30 Apr 2026 | Viewed by 3 | Submission Open
Keywords: post-transcriptional regulation; stem cell biology; neural development; developmental biology
(This special issue belongs to the Section Stem Cells)
Retinal Disorders: Cellular Mechanisms and Targeted Therapies
edited by
submission deadline 15 May 2026 | 5 articles | Viewed by 7320 | Submission Open
Keywords: inherited eye diseases; genome; omics; gene editing; iPS cells; animal models; single cell analysis; AI; epigenetics
(This special issue belongs to the Section Cellular Pathology)
Molecular and Translational Advances in Metastatic Breast Cancer Research
edited by
submission deadline 15 May 2026 | Viewed by 41 | Submission Open
Keywords: metastatic breast cancer; tumor microenvironment; therapeutic resistance; immunotherapy; targeted therapy; cancer biomarkers; personalized medicine; translational oncology; circulating tumor cells; molecular mechanisms of metastasis
Basic Mechanisms and Emerging Therapeutic Strategies for Spinal Cord Injury
edited by and Angela R. Filous
submission deadline 25 May 2026 | Viewed by 55 | Submission Open
Keywords: spinal cord injury; neuroinflammation; neural regeneration; axon growth; neurons; glial cells; oligodendrocytes; myelin; astrocytes; microglia
Proteomic Applications in Ageing and Neurodegenerative Conditions submission deadline 31 May 2026 | 4 articles | Viewed by 17512 | Submission Open
(This special issue belongs to the Section Cell Methods)
Intervertebral Disc Degeneration and Regeneration: New Molecular Mechanisms and Therapeutics—Second Edition
edited by
submission deadline 31 May 2026 | 3 articles | Viewed by 8098 | Submission Open
Keywords: spine; intervertebral disc; biomaterial; stem cell; gene therapy
(This special issue belongs to the Section Cellular Pathology)
Cellular and Molecular Basis of Brain Tumor
edited by , Tomasz S. Mandat and Grzegorz Turek
submission deadline 31 May 2026 | Viewed by 102 | Submission Open
Keywords: brain tumor; glioma; tumor microenvironment; molecular oncology; epigenetics; tumor stem cells; biomarkers; therapeutic resistance; non-coding RNA; translational research
(This special issue belongs to the Section Cellular Pathology)
Sex Differences in Cardiovascular Structure and Function—From Mechanisms to Therapeutics submission deadline 31 May 2026 | Viewed by 71 | Submission Open
Keywords: cardiovascular diseases; sex hormones; sex differences; vascular and cell signaling; therapeutic targets
Development and Characterization of Innovative In Vitro Models
edited by Fengyan Deng and Chongbei Zhao
submission deadline 31 May 2026 | Viewed by 47 | Submission Open
Keywords: 3D organoid development; iPSC; iPSC reprogramming; primary cell derivation; cell immortalization; disease model development; stem cell therapy; molecular biology; cell signaling
Inflammatory Signaling and Vascular Dysfunction in Atherosclerosis
edited by and Jianzhong Shen
submission deadline 31 May 2026 | Viewed by 18 | Submission Open
Keywords: inflammation in atherosclerosis; atherothrombosis; cell signaling
Molecular Mechanisms of Fibrosis in Chronic Liver Diseases
edited by , Regina Golan-Gerstl and Ihab Ansari
submission deadline 1 Jun 2026 | Viewed by 111 | Submission Open
Keywords: liver fibrosis; MASH; immune checkpoints; epigenetic regulation; hepatic stellate cells (HSCs); antifibrotic therapy; molecular mechanisms; inflammation; ROS
Human Pluripotent Stem Cells and Organoids: Current Trends and Future Perspectives submission deadline 1 Jun 2026 | Submission Open
Keywords: human pluripotent stem cells; organoids; disease modeling; regenerative medicine; genome editing; single-cell omics; tissue engineering; drug discovery; precision medicine
(This special issue belongs to the Section Stem Cells)
Novel Insights into Developing Therapeutic Strategies for Neurological Disorders
edited by , Joanna A. Korecka and
submission deadline 15 Jun 2026 | Viewed by 93 | Submission Open
Keywords: neurological disorders; RNA therapeutics; gene therapy; antisense oligonucleotides; gene editing; cell therapy; precision medicine; neurodegenerative diseases; neurodevelopmental disorders; neurogenetic disorders
Regulation of Hormone Secretion from Islets in Health and Disease
edited by
submission deadline 15 Jun 2026 | Viewed by 22 | Submission Open
Keywords: islet hormone secretion; paracrine signaling; autocrine regulation; intra-islet communication; islet cell plasticity; transdifferentiation; multi-hormonal dysregulation; circadian regulation; single-cell omics; islet inflammation and immune crosstalk
Mechanisms of Antimicrobial Treatment in Human Diseases
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 2512 | Submission Open
Keywords: multidrug resistance; epidemiology; novel antimicrobial resistance traits
(This special issue belongs to the Section Cellular Pathology)
The Orchestration of Glial Cells in Health and Disease
edited by Keying Zhu
submission deadline 25 Jun 2026 | Viewed by 143 | Submission Open
Keywords: microglia; oligodendrocytes; astrocytes; myelin; neuroinflammation
Diabetes-Induced Organ Damage: Cellular Mechanisms and Therapeutic Opportunities submission deadline 30 Jun 2026 | 6 articles | Viewed by 23045 | Submission Open
Keywords: diabetes mellitus; vascular lesions; nephropathy; cardiomyopathy; neuropathy; retinopathy; therapeutic opportunities
(This special issue belongs to the Section Tissues and Organs)
MicroRNAs: Regulators of Cellular Fate
edited by
submission deadline 30 Jun 2026 | 1 articles | Viewed by 724 | Submission Open
Keywords: microRNA targets; microRNA conservation; microRNA pathway; microRNA mimics; microRNA antagonist; disease biomarker
Emerging Topics in Cachexia
edited by Gabriela Salim Ferreira De Castro
submission deadline 30 Jun 2026 | 1 articles | Viewed by 714 | Submission Open
Keywords: cachexia; skeletal muscle loss; adipose tissue loss; inflammation; sarcopenia; cancer; body composition; biomarkers
Retinoic Acid and Retinoid X Receptors - Series II submission deadline 30 Jun 2026 | Viewed by 433 | Submission Open
Keywords: nuclear receptor signaling; retinoic acid receptor; retinoid X receptor; pharmacology; structure/function relationships; genomic and non-genomic signaling; post-translational modification; homeostasis and disease; development; origin and evolution
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
The Role of PPARs in Disease - Volume IV submission deadline 30 Jun 2026 | Viewed by 83 | Submission Open
Keywords: PPAR; immune function; liver; adipose tissue; cardiovascular system; muscle; brain; neurological disease; psychiatric diseases; cancer; transcriptional regulation; ligands; agonists/antagonists
(This special issue belongs to the Section Cells of the Cardiovascular System)
Biochemical Interaction and Supramolecular Complexes of Receptors in Cell Membranes submission deadline 8 Jul 2026 | Viewed by 554 | Submission Open
Keywords: membrane receptors; molecular complex; membrane microdomains
Role of Hippo Signaling in Cancer submission deadline 15 Jul 2026 | Viewed by 19 | Submission Open
Keywords: angiogenesis; cancer metabolism; cancer stemness; chemoresistance; endothelial cell plasticity; epithelial-to-mesenchymal transition (EMT); hippo signaling pathway; immunotherapy; mechanotransduction; targeted cancer therapy; TEAD transcription factors; therapeutic resistance; tumor microenvironment; tumorigenesis; YAP/TAZ; new therapeutic modalities to target YAP/TAZ-driven tumors including ferroptosis
(This special issue belongs to the Section Cell Signaling)
Novel Molecular Targets for the Treatment of Sleep Disorders
edited by
submission deadline 25 Jul 2026 | Viewed by 205 | Submission Open
Keywords: sleep disorders; molecular targets; glymphatic system; neuroinflammation; circadian rhythms; microbiome; biomarkers; pharmacological therapy; gene therapy; neurodegeneration
Immunometabolic Reprogramming in Diabetic Kidney Disease: The Interplay of Innate Immunity, Oxidative Stress, and Cellular Metabolism
edited by , Sandra Kostić and Anita Racetin
submission deadline 31 Jul 2026 | Viewed by 33 | Submission Open
Keywords: diabetic kidney disease; immunometabolism; innate immunity; oxidative stress; metabolic reprogramming; inflammasome; renal fibrosis; mitochondrial dysfunction; non-coding RNAs; multi-omics integration
Study on Ovarian Follicle Development
edited by Cecily V. Bishop and Jessica Cristina Lemos Motta
submission deadline 10 Aug 2026 | Viewed by 70 | Submission Open
Keywords: follicular development; ovarian follicle activation; ovarian reserve; in vitro follicle culture; translational reproductive biology
Cellular and Molecular Mechanisms of Abiotic Stress Tolerance in Plants
edited by Aziz Khan and
submission deadline 25 Aug 2026 | 2 articles | Viewed by 6121 | Submission Open
Keywords: abiotic stress; molecular mechanism; gene expression; cellular adaptation; signal transduction; plant physiology; molecular pathway; stress resilience; crop productivity; agronomic performance
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Gut Microbiota, Metabolites, and Immune Regulation in Gastrointestinal Diseases
edited by
submission deadline 31 Aug 2026 | Viewed by 19 | Submission Open
Keywords: gut microbiota; microbial metabolites; inflammation; immunology; gut-barrier; gastrointestinal disease
Current Status and Future Challenges of Liquid Biopsy—2nd Edition
edited by and
submission deadline 31 Dec 2027 | Viewed by 52 | Submission Open
Keywords: minimal residual disease (MRD); ctDNA; cfDNA; heterogeneity; comprehensive genomic profiling; biomarker; diagnosis; personalization; prognostic marker
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