The Potential of Induced Pluripotent Stem Cells

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 651

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Guest Editor
Department of Biomedical Engineering, Hong Kong Polytechnic University, Hong Kong, China
Interests: immunotherapy; cell engineering; bio-nanotechnology engineering
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Special Issue Information

Dear Colleagues,

Pluripotent stem cells (PSCs) have emerged as a transformative tool in regenerative medicine and disease modeling due to their unique ability to differentiate into any cell type in the human body. Over the past decade, significant advancements have been made in PSC engineering, including methods to efficiently reprogram somatic cells into induced pluripotent stem cells (iPSCs), genome editing techniques to precisely modify PSCs, and the development of novel culture systems to maintain PSC pluripotency and differentiation potential. As a guest editor for this journal, I am excited to present a collection of articles highlighting the latest breakthroughs and trends in PSC engineering. These articles cover a wide range of topics, including the use of CRISPR/Cas9 technology to correct genetic mutations in iPSCs for disease modeling and cell therapy, the application of bioengineering principles to enhance PSC differentiation into specific cell lineages, and the exploration of 3D organoid models derived from PSCs for drug screening and personalized medicine. Through this Special Issue, we aim to provide readers with a comprehensive overview of the current state-of-the-art in PSC engineering and its potential implications for advancing biomedical research and clinical applications. We hope that these articles will inspire further research and collaboration in this rapidly evolving field.

Dr. Yun Chang
Guest Editor

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Keywords

  • pluripotent stem cells
  • reprogramming
  • engineering
  • regenerative medicine
  • differentiation
  • therapeutic applications
  • biomaterials

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Published Papers (1 paper)

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Review

48 pages, 5608 KiB  
Review
Induced Pluripotent Stem Cells-Based Regenerative Therapies in Treating Human Aging-Related Functional Decline and Diseases
by Peijie Yu, Bin Liu, Cheng Dong and Yun Chang
Cells 2025, 14(8), 619; https://doi.org/10.3390/cells14080619 - 21 Apr 2025
Viewed by 253
Abstract
A significant increase in life expectancy worldwide has resulted in a growing aging population, accompanied by a rise in aging-related diseases that pose substantial societal, economic, and medical challenges. This trend has prompted extensive efforts within many scientific and medical communities to develop [...] Read more.
A significant increase in life expectancy worldwide has resulted in a growing aging population, accompanied by a rise in aging-related diseases that pose substantial societal, economic, and medical challenges. This trend has prompted extensive efforts within many scientific and medical communities to develop and enhance therapies aimed at delaying aging processes, mitigating aging-related functional decline, and addressing aging-associated diseases to extend health span. Research in aging biology has focused on unraveling various biochemical and genetic pathways contributing to aging-related changes, including genomic instability, telomere shortening, and cellular senescence. The advent of induced pluripotent stem cells (iPSCs), derived through reprogramming human somatic cells, has revolutionized disease modeling and understanding in humans by addressing the limitations of conventional animal models and primary human cells. iPSCs offer significant advantages over other pluripotent stem cells, such as embryonic stem cells, as they can be obtained without the need for embryo destruction and are not restricted by the availability of healthy donors or patients. These attributes position iPSC technology as a promising avenue for modeling and deciphering mechanisms that underlie aging and associated diseases, as well as for studying drug effects. Moreover, iPSCs exhibit remarkable versatility in differentiating into diverse cell types, making them a promising tool for personalized regenerative therapies aimed at replacing aged or damaged cells with healthy, functional equivalents. This review explores the breadth of research in iPSC-based regenerative therapies and their potential applications in addressing a spectrum of aging-related conditions. Full article
(This article belongs to the Special Issue The Potential of Induced Pluripotent Stem Cells)
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