The Role of Light in Ocular Health and Disease

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: 30 September 2026 | Viewed by 2790

Editors


E-Mail Website
Guest Editor
The John Curtin School of Medical Research, Australian National University, Canberra, Australia
Interests: photobiomodulation treatment; retinal degenerations; retinal biology; human anatomy; neuroanatomy; medical education

E-Mail
Guest Editor
CIQUIBIC-Departamento de Química Biológica, Facultad de Ciencias Quimicas, Universidad Nacional de Córdoba, Córdoba, Argentina
Interests: retina; neurodegeneration; light damage

E-Mail Website
Guest Editor
School of Optometry and Vision Science, The University of Auckland, Auckland, New Zealand
Interests: retina; retinal degeneration; neurochemistry; metabolism; neurotransmitter

Special Issue Information

Dear Colleagues,

This Special Issue focuses on the critical role of light in the health and disease of the eye. This is a rapidly evolving field, attracting increasing attention across vision science, ophthalmology, and neuroscience. Light is not only essential for vision but also influences circadian rhythms, retinal neurotransmission, and cellular homeostasis. It also has healing capabilities if used appropriately. However, inappropriate exposure to light has been implicated in a range of ocular pathologies, including retinal degeneration, myopia, cataract formation, and oxidative stress-related damage to the cornea and lens. 

We invite manuscripts that explore the diverse mechanisms through which light impacts ocular physiology and pathology, encompassing both the anterior and posterior segments of the eye. Of particular interest are studies on light-induced retinal changes, protective versus harmful wavelengths, anterior segment responses to light exposure, and the cellular and molecular pathways linking light to ocular disease. We also welcome research on innovative diagnostic and therapeutic approaches that leverage light, such as light-based treatments, and preventive strategies. This Special Issue brings together advances in basic science to highlight how light shapes eye health, identify knowledge gaps, and guide future interventions. We encourage contributions that address this timely and dynamic area of research and showcase how light can be a vital resource, treatment approach, or risk factor for ocular health.

Dr. Krisztina Valter
Dr. María Ana Contín
Dr. Monica Acosta
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • light
  • photobiology
  • light exposure
  • circadian rhythms
  • vision
  • light-induced retinal damage
  • phototoxicity
  • photoprotection
  • retinal degeneration
  • light modulation
  • oxidative stress
  • light therapy
  • photobiomodulation
  • blue light effects
  • Protective wavelengths
  • harmful wavelengths
  • ocular phototransduction
  • light-based therapeutics

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Jump to: Review

12 pages, 9134 KB  
Article
Investigating the Effects of UVC Exposure at the Limbus
by Bethany P. Torr, Jennifer P. Craig, Simon J. Dean, Trevor Sherwin and Sanjay Marasini
Cells 2026, 15(11), 967; https://doi.org/10.3390/cells15110967 - 23 May 2026
Viewed by 293
Abstract
Purpose: Preclinical studies report low-intensity ultraviolet C (UVC) light to be safe and effective in treating murine bacterial keratitis, however, limbal impacts of UVC have yet to be investigated directly. This study evaluated the depth and density of UVC-induced DNA damage in the [...] Read more.
Purpose: Preclinical studies report low-intensity ultraviolet C (UVC) light to be safe and effective in treating murine bacterial keratitis, however, limbal impacts of UVC have yet to be investigated directly. This study evaluated the depth and density of UVC-induced DNA damage in the porcine and human limbus following UVC exposures of varying supratherapeutic dose. Methods: The corneoscleral junction (limbus) of full-thickness porcine corneas was exposed to supratherapeutic doses of UVC light (265 nm, 1.93 mW/cm2) for 5, 10, 15, 30, or 60 min (exposure groups) or remained unexposed for the same durations (control groups), with a sample size of 6 per group. In parallel, human corneal tissue was exposed to UVC for 1 or 5 min and processed identically. Following exposure, all tissues were frozen, dissected, and analysed using immunohistochemistry to detect cyclobutane pyrimidine dimers (CPDs) as markers of DNA damage. CPD distribution, depth, and density were subsequently evaluated. Results: CPDs were localised predominantly in the superficial corneal epithelial layers, irrespective of the UVC dose. The mean ± SD thickness of the corneal epithelium in the UVC-exposed groups was 38.9 ± 18.9 µm, and the average depth of CPD formation was 13.3 ± 8.43 µm. The proportions of cells affected by CPDs within the corneal epithelium (mean ± SD) were 47.8 ± 25.6%, 58.5 ± 16.2%, 39.9 ± 26.4%, 41.3 ± 27.3%, and 38.9 ± 28.3% for exposure durations of 5, 10, 15, 30, and 60 min, respectively (p > 0.05). Human cornea showed similarly limited penetration, with no difference in CPD proportions between the 1 and 5 min UVC exposures (p = 0.70). Conclusions: UVC-induced DNA damage in both species was confined to the superficial cellular layers of the cornea, with no detectable damage observed in deeper tissues, including those where limbal stem cells reside, even after supratherapeutic doses of up to one hour of exposure. Full article
(This article belongs to the Special Issue The Role of Light in Ocular Health and Disease)
Show Figures

Figure 1

Review

Jump to: Research

40 pages, 2235 KB  
Review
Photobiomodulation Therapy: The Dawn of Myopia Control
by Kate Gettinger, Yinuo Huang, Kazuo Tsubota, Kazuno Negishi and Toshihide Kurihara
Cells 2026, 15(6), 526; https://doi.org/10.3390/cells15060526 - 16 Mar 2026
Cited by 1 | Viewed by 2064
Abstract
As the prevalence of myopia, or near-sightedness, continues to rise globally, it becomes imperative to determine the mechanisms driving myopia so that appropriate interventions to mitigate it can be developed. Light appears to be critical for normal ocular development, and over the past [...] Read more.
As the prevalence of myopia, or near-sightedness, continues to rise globally, it becomes imperative to determine the mechanisms driving myopia so that appropriate interventions to mitigate it can be developed. Light appears to be critical for normal ocular development, and over the past several decades research has explored the connection between light exposure and myopia development. This review explores the growing field of photobiomodulation, or the use of light to modulate biological processes, to prevent myopia development. To complete this review, relevant texts published from January 1990 to December 2025 were retrieved from the PubMed database using a combination of search terms covering myopia and ocular development, light exposure conditions related to myopia, myopia development in relation to circadian and diurnal regulation, nonvisual opsins and myopia, and light-induced ocular damage. Through this review, we see that photobiomodulation offers a potential intervention to control myopia progression, but the mechanisms behind light’s influence on ocular development remain complex and incompletely understood. This review aims to summarize what is currently known to serve as a basis for future research and to delineate important findings. Full article
(This article belongs to the Special Issue The Role of Light in Ocular Health and Disease)
Show Figures

Figure 1

Back to TopTop