Stem Cells and Metabolism in Acute Myeloid Leukemia: Mechanisms, Models, and Therapeutic Opportunities

Dear Colleagues,

Acute myeloid leukemia (AML) persistence and relapse are closely linked to leukemic stem cells (LSCs) and their metabolic adaptations within the hypoxic bone-marrow niche. This Special Issue will bring together mechanistic, translational, and technological advances at the intersection of stemness and metabolism in AML. We welcome original research, short communications, methods, and reviews spanning metabolic control of LSC maintenance and quiescence; microenvironmental remodeling; and next-generation disease models. We especially encourage studies that connect metabolic circuitry to therapeutic vulnerabilities—alone or in combination with FLT3, BCL-2, and epigenetic inhibitors—and that incorporate biomarker-driven patient selection. By consolidating cutting-edge insights and clinically actionable strategies, the collection aims to accelerate precision therapies that eradicate LSCs and overcome metabolic plasticity in AML.

Dr. Giovannino Silvestri
Dr. Aditi Chatterjee
Prof. Dr. Maria Baer
Guest Editors

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