Stem Cells and Metabolism in Acute Myeloid Leukemia: Mechanisms, Models, and Therapeutic Opportunities
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 25 September 2026 | Viewed by 384
Special Issue Editors
Interests: acute myeloid leukemia (AML); FLT3-ITD; hypoxia and metabolism; leukemia stem cells; patient-derived organoids; drug resistance mechanisms; translational therapeutics
Interests: AML; cancer biology; metabolism
Special Issue Information
Dear Colleagues,
Acute myeloid leukemia (AML) persistence and relapse are closely linked to leukemic stem cells (LSCs) and their metabolic adaptations within the hypoxic bone-marrow niche. This Special Issue will bring together mechanistic, translational, and technological advances at the intersection of stemness and metabolism in AML. We welcome original research, short communications, methods, and reviews spanning metabolic control of LSC maintenance and quiescence; microenvironmental remodeling; and next-generation disease models. We especially encourage studies that connect metabolic circuitry to therapeutic vulnerabilities—alone or in combination with FLT3, BCL-2, and epigenetic inhibitors—and that incorporate biomarker-driven patient selection. By consolidating cutting-edge insights and clinically actionable strategies, the collection aims to accelerate precision therapies that eradicate LSCs and overcome metabolic plasticity in AML.
Dr. Giovannino Silvestri
Dr. Aditi Chatterjee
Prof. Dr. Maria Baer
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- AML
- leukemic stem cells
- hypoxia
- metabolism
- fatty-acid oxidation
- one-carbon metabolism
- proteostasis
- bone-marrow niche
- multi-omics
- metabolic inhibitors
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