Mechanisms of miRNA Metabolism and Extracellular Transport

Dear Colleagues,

The gene regulatory role of microRNAs (miRNAs) in metazoan cells is becoming increasingly interesting with the discovery of new ways that these tiny regulators are controlled in diverse human cell types by RNA binders, metabolites, and other cellular and extracellular factors. Intercellular communication of miRNAs via extracellular vesicles ensures the exchange of epigenetic signals across cell boundaries, which has implications for gene expression homeostasis—a process that is jeopardized in diseases. Active research on various aspects of miRNA is revealing how the regulation of miRNAs is connected to human physiology. However, new challenges require the development of new research tools to address persistent questions that remain unanswered about miRNAs and their downstream effectors.

This Special Issue will focus on original reports and reviews on the identification of miRNA export regulators, miRNA binders, the mechanism of miRNA turnover, miRNA sponges, miRNA storage, miRNA inactivation, miRNA processing, miRNA internalization, miRNAs as biomarkers, inter- and intratissue miRNA exchange, or miRNA biogenesis.

Prof. Dr. Suvendra N Bhattacharyya
Guest Editor

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