Novel Insight into Endothelial Cells in Vascular Disease
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 20 March 2026 | Viewed by 37
Special Issue Editor
Special Issue Information
Dear Colleagues,
Endothelial cells (ECs) are now recognized as active regulators of vascular integrity, remodeling, and pathology. Beyond serving as a passive barrier, ECs integrate hemodynamic, metabolic, and inflammatory cues to coordinate vessel growth, stabilization, and repair.
This Special Issue highlights emerging insights into EC biology across a spectrum of vascular diseases, including but not limited to hereditary hemorrhagic telangiectasia (HHT), arteriovenous malformations (AVMs), vascular calcification, atherosclerosis, and fibrosis. In these conditions, EC dysfunction promotes the initiation and progression of disease through abnormal signaling, lineage plasticity, or maladaptive crosstalk with neighboring cells.
We will explore novel pathways and the mechanisms that underlie endothelial dysfunction. In addition, we will discuss new therapeutic strategies, including targeted molecular interventions and drug development aimed at restoring vascular disease.
By integrating advances in genetics, signaling, biomechanics, and translational models, this Special Issue aims to provide a comprehensive overview of how endothelial cells shape vascular disease and opportunities for innovative treatments.
Dr. Li Zhang
Guest Editor
Manuscript Submission Information
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Keywords
- endothelial cells
- vascular diseases
- vascular signaling
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