Hepatoblastoma: Molecular Mechanisms and Therapeutic Strategies
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 31 March 2026 | Viewed by 40
Special Issue Editor
Interests: hepatoblastoma; MYC oncogenes; tumor suppressors; molecular oncology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Hepatoblastoma (HB) is a rare yet highly aggressive primary liver malignancy that predominantly affects children under four years of age. Despite significant improvements in survival rates for low-risk patients through modern multidisciplinary treatments, the prognosis for recurrent, high-risk, or metastatic HB remains poor. Moreover, traditional chemotherapy continues to face challenges related to toxicity and drug resistance. In recent years, advancements in high-throughput sequencing and molecular pathology have shed light on the molecular characteristics of HB. Notably, the aberrant activation of key pathways such as Wnt/β-catenin and Hippo/YAP has been identified as a core mechanism driving HB development. These insights offer promising new avenues for the development of targeted therapies and personalized treatment strategies.
This Special Issue aims to systematically elucidate the molecular pathogenesis of HB and explore its potential for translation, thereby facilitating the transition from basic research to precision medicine. We invite contributions that address, but are not limited to, the following topics:
- Molecular pathogenesis:
Wnt/β-catenin pathway;
Hippo/YAP pathway;
Epigenetic dysregulation.
- Molecular differences between HB and hepatocellular carcinoma (HCC);
- Molecular classification and prognostic biomarkers of HB;
- Novel targeted and immunotherapy strategies.
Both original research articles and high-quality reviews are welcome. Contributions should provide novel insights or critical syntheses that advance the understanding of hepatoblastoma.
Dr. Edward V. Prochownik
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- hepatoblastoma
- APC
- ARID1
- β-catenin
- hepatocellular carcinoma
- hippo
- YAP
- pathogenesis
- therapeutic strategies
- molecular mechanisms
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