Cellular and Molecular Insights into Gynecologic Tumors

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: 30 September 2026 | Viewed by 1192

Special Issue Editors


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Guest Editor
1. Clinic for Gynecology and Obstetrics, University Clinical Centre of Serbia, 11000 Belgrade, Serbia
2. Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia
Interests: infertility; reproductive endocrinology; IVF; myoma; gynecology; perinatology; pharmacogenetic; personalized medicine; PCOS; endometriosis

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Guest Editor
Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, 303 E. Superior Street, 4-117, Chicago, IL 60611, USA
Interests: cancer biology; cancer genetics; endometriosis; pathology
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Special Issue Information

Dear Colleagues,

Gynecologic cancers, including ovarian, endometrial, and cervical tumors, remain major challenges in women’s health. Understanding the cellular and molecular mechanisms driving these cancers is essential for improving diagnosis, prognosis, and treatment strategies. This Special Issue aims to explore recent advances in the biology of gynecologic tumors, with a focus on cancer stem cells, genetic mutations, and the tumor microenvironment. We welcome contributions that highlight molecular pathways involved in tumorigenesis, metastasis, and resistance to therapy, as well as emerging biomarkers for early detection. Studies that offer novel therapeutic approaches, including targeted treatments and immunotherapies, are also encouraged.

We look forward to advancing our understanding of gynecologic tumors through this collection of cutting-edge research.

Dr. Mladen Anđić
Prof. Dr. Jianjun Wei
Guest Editors

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Keywords

  • gynecologic cancers
  • cervical cancer
  • endometrial cancer
  • ovarian tumors
  • tumor microenvironment
  • molecular biomarkers
  • genetic mutations
  • targeted therapies

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Published Papers (1 paper)

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Research

21 pages, 3031 KB  
Article
The Effects of BRCA1 and BRCA2 Promoter Methylation on Clinicopathological Characteristics and Clinical Outcomes in HGSOC
by Katarina Živić, Ivana Boljević, Milica Nedeljković, Milana Matović, Radmila Janković and Miljana Tanić
Cells 2026, 15(3), 277; https://doi.org/10.3390/cells15030277 - 1 Feb 2026
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Abstract
Ovarian cancer is a highly lethal disease. Tumors with a deficiency in the homologous recombination repair pathway (HRD) resulting from mutations in BRCA1/2 genes have a favorable response to platinum-based chemotherapy and targeted therapy with PARP inhibitors (PARPi) mediated by synthetic [...] Read more.
Ovarian cancer is a highly lethal disease. Tumors with a deficiency in the homologous recombination repair pathway (HRD) resulting from mutations in BRCA1/2 genes have a favorable response to platinum-based chemotherapy and targeted therapy with PARP inhibitors (PARPi) mediated by synthetic lethality. Promoter methylation of BRCA1/2 genes was previously associated with HRD, but little is known about whether it translates to clinical benefit. Here, we evaluated the prevalence of BRCA1/2 promoter methylation in HGSOC patients from Serbia and examined their clinicopathological characteristics and the effect on progression-free and overall survival. Using methylation-specific PCR, we screened for hypermethylation in the promoter region of BRCA1/2 genes in a cohort of 244 patients. We found fully methylated BRCA1 and BRCA2 promoter in 4.1% and 0.45% of patients, and 23.36% and 11.21% intermediately methylated cases, respectively. Full BRCA1/2 promoter methylation was significantly associated with younger age of onset (55 and 58 years, respectively) compared to BRCA1/2-mutated cases, suggestive of BRCAness phenotype. However, in the exploratory analysis of 68 patients with clinical follow-up, we did not find a strong survival advantage for BRCA1/2 methylated over BRCA1/2-intact cases, yet more moderate effects cannot be ruled out due to the cohort size. Full article
(This article belongs to the Special Issue Cellular and Molecular Insights into Gynecologic Tumors)
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