Ubiquitin Ligases in Health and Diseases
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Signaling".
Deadline for manuscript submissions: 30 January 2026 | Viewed by 6
Special Issue Editor
Special Issue Information
Dear Colleagues,
Ubiquitin ligases, central players in the ubiquitin–proteasome system, orchestrate the precise regulation of protein stability, localization, and function through the covalent attachment of ubiquitin molecules. These enzymes are critical for maintaining cellular homeostasis, influencing processes such as cell cycle progression, DNA repair, immune response, and signal transduction. Dysregulation of ubiquitin ligases has been implicated in a myriad of diseases, including cancer, neurodegenerative disorders, and autoimmune conditions, highlighting their pivotal role in both health and disease.
This Special Issue delves into the multifaceted roles of ubiquitin ligases, exploring their molecular mechanisms, physiological functions, and pathological implications. Contributions from leading researchers provide insights into the structural diversity of ubiquitin ligases, their substrate specificity, and the intricate regulatory networks they govern. Additionally, the Special Issue will highlight emerging therapeutic strategies targeting ubiquitin ligases, offering hope for the development of novel treatments for diseases driven by ubiquitin pathway dysregulation.
Dr. Haitao Luan
Guest Editor
Manuscript Submission Information
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Keywords
- ubiquitination
- E3 ubiquitin ligase
- Proteasome
- protein degradation
- cell cycle regulation
- immune response
- neurodegeneration
- cancer
- autoimmune disorders
- therapeutic targeting
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