Advances in DNA Damage Responses in Viral Infection
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: 20 September 2026 | Viewed by 121
Special Issue Editor
Interests: DNA damage response; DNA repair; cell cycle regulation; mutation p53 proteins; protein kinases; cell biology; peptides; viruses, adenovirus; Karposi’s sarcoma associated herpes virus (KSHV)
Special Issue Information
Dear Colleagues,
Over 50 years ago, it was demonstrated that certain DNA viruses, such as Adenovirus type 12 and Herpes Simplex Virus, could cause specific, non-random damage to cellular DNA following infection. As the cellular DNA damage response has become well-characterised in the twenty-first century, it is apparent that almost all, or perhaps all, DNA viruses have a close relationship with many of the components of the pathways involved in the detection and repair of DNA damage.
Initial studies of adenoviruses showed that homologous recombination was inactivated by the degradation of key proteins following infection, but subsequent investigations by numerous laboratories indicated that most DNA viruses require various components of the DNA damage response pathways for optimal replication. Many different DNA damage response proteins are present at the sites of viral replication, although their specific function there remains largely unknown. It seems reasonable to suppose that they are necessary to produce viral genomes, but much further research is required to elucidate precisely how this may occur, including the viral and cellular proteins involved. Similarly, the detailed role of the DNA damage response in the cellular anti-viral response remains to be further elucidated. Finally, numerous RNA viruses, even though many replicate solely in the cytoplasm, have a close relationship with the DNA damage response, again requiring repair pathways for replication.
This Special Issue aims to bring together a collection of original research articles and comprehensive reviews that address these exciting frontiers.
Dr. Roger J. Grand
Guest Editor
Manuscript Submission Information
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Keywords
- DNA damage response
- DNA viruses
- RNA viruses
- viral replication
- DNA repair pathways
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