The Blueprint of Female Reproductive Longevity: From Ovarian Biology to Modifiable Risks and Protective Strategies

Dear Colleagues,

The female reproductive lifespan is governed by complex cellular and molecular mechanisms that regulate ovarian development, folliculogenesis, and the age-related decline in fertility. However, beyond intrinsic aging processes, environmental factors and lifestyle choices also play a crucial role in modulating ovarian function and reproductive longevity. This Special Issue will explore the biological, genetic, and epigenetic determinants of ovarian decline, including the roles of metabolic and hormonal signaling, stem cell contributions, and molecular pathways in influencing reproductive aging. Additionally, it will focus on the impact of external influences such as exposure to environmental toxins, pollution, dietary imbalances, and other lifestyle factors that may contribute to ovarian aging and fertility decline. A key objective is to identify strategies for prevention and intervention, addressing how modifiable factors can help preserve ovarian function and mitigate reproductive aging.

We welcome original research and review articles that investigate ovarian biology at the cellular and molecular levels, as well as studies examining environmental and lifestyle influences on reproductive health. By integrating insights from cell biology, developmental biology, reproductive medicine, and environmental health, this Special Issue will advance our understanding of female reproductive longevity and inform approaches to safeguarding fertility.

Dr. Chiara Di Berardino
Dr. Yves St.-Pierre
Guest Editors

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