The Blueprint of Female Reproductive Longevity: From Ovarian Biology to Modifiable Risks and Protective Strategies
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Reproductive Cells and Development".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 368
Special Issue Editors
Interests: female reproduction; in vitro ovarian folliculogenesis; ovarian follicle; oocyte; fertility preservation; meiotic competence; animal reproduction
Special Issue Information
Dear Colleagues,
The female reproductive lifespan is governed by complex cellular and molecular mechanisms that regulate ovarian development, folliculogenesis, and the age-related decline in fertility. However, beyond intrinsic aging processes, environmental factors and lifestyle choices also play a crucial role in modulating ovarian function and reproductive longevity. This Special Issue will explore the biological, genetic, and epigenetic determinants of ovarian decline, including the roles of metabolic and hormonal signaling, stem cell contributions, and molecular pathways in influencing reproductive aging. Additionally, it will focus on the impact of external influences such as exposure to environmental toxins, pollution, dietary imbalances, and other lifestyle factors that may contribute to ovarian aging and fertility decline. A key objective is to identify strategies for prevention and intervention, addressing how modifiable factors can help preserve ovarian function and mitigate reproductive aging.
We welcome original research and review articles that investigate ovarian biology at the cellular and molecular levels, as well as studies examining environmental and lifestyle influences on reproductive health. By integrating insights from cell biology, developmental biology, reproductive medicine, and environmental health, this Special Issue will advance our understanding of female reproductive longevity and inform approaches to safeguarding fertility.
Dr. Chiara Di Berardino
Dr. Yves St.-Pierre
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- ovarian aging
- folliculogenesis
- oocyte quality
- hormonal regulation
- epigenetics of reproduction
- reproductive lifespan
- stem cells in ovarian function
- oxidative stress and fertility
- metabolic influences on reproduction
- cellular signaling in ovarian decline
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