Atherosclerosis and Thrombosis: Molecular and Pathological Research Advance

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".

Deadline for manuscript submissions: 25 September 2026 | Viewed by 729

Special Issue Editors


E-Mail Website
Guest Editor
Department of Molecular Oncology, Institute for Medical Research, University of Belgrade, 11000 Belgrade, Serbia
Interests: vegf; il-6; myeloproliferative neoplasm; ruxolitinib; angiogenesis; hydroxyurea; nitric oxide synthase; erythroid progenitors; cell cycle; apoptosis

E-Mail Website
Guest Editor
Department of Molecular Oncology, Institute for Medical Research, Institute of National Significance for the Republic of Serbia, University of Belgrade, Dr. Subotića 4, PO BOX 39, 11129 Belgrade, Serbia
Interests: oncology; hematology; molecular oncology; breast cancer

E-Mail Website
Guest Editor
Department of Molecular Oncology, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia
Interests: thrombocythemia; primary myelofibrosis; mutation

Special Issue Information

Dear Colleagues,

Atherosclerosis and thrombosis continue to be leading contributors to cardiovascular morbidity and mortality worldwide. Recent advances in vascular biology have revealed that endothelial dysfunction, oxidative stress, lipid accumulation, and immune cell activation play central roles in plaque development and rupture. These discoveries have paved the way for translational research efforts aimed at identifying reliable biomarkers and developing targeted therapies. The integration of molecular profiling into patient-derived data enables a more nuanced understanding of individual disease trajectories, paving the way for precision medicine in cardiovascular care.

This Special Issue will bring together the latest research studies on the molecular landscape of atherosclerosis and thrombosis, as well as presenting translational advances that go beyond basic discoveries to inform clinical practice, with a focus on improving outcomes in patients at risk for thrombotic events and atherosclerotic disease.

Dr. Tijana Subotički
Dr. Olivera Mitrović Ajtić
Prof. Dr. Vladan P. Čokić
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • atherosclerosis
  • thrombosis
  • molecular mechanisms
  • translational research
  • precision medicine

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

20 pages, 2981 KB  
Article
Inflammatory Signaling and Endothelial Activation Drive Thrombosis in Hodgkin and Non-Hodgkin Lymphoma
by Emilija Živković, Olivera Mitrović-Ajtić, Jelena Ivanović, Dragoslava Djikić, Tijana Subotički, Miloš Diklić, Milica Vukotić, Teodora Dragojević, Darko Antić and Vladan P. Čokić
Cells 2026, 15(8), 667; https://doi.org/10.3390/cells15080667 - 9 Apr 2026
Viewed by 381
Abstract
The high incidence of thrombosis in lymphoma is largely due to chronic inflammation and endothelial dysfunction. To elucidate the mechanisms underlying thrombus formation and fibrinolysis, we investigated interactions between circulating endothelial cells and peripheral blood mononuclear cells (MNCs), along with inflammatory signaling pathways, [...] Read more.
The high incidence of thrombosis in lymphoma is largely due to chronic inflammation and endothelial dysfunction. To elucidate the mechanisms underlying thrombus formation and fibrinolysis, we investigated interactions between circulating endothelial cells and peripheral blood mononuclear cells (MNCs), along with inflammatory signaling pathways, in patients with follicular lymphoma (FL), Hodgkin lymphoma (HL), and diffuse large B-cell lymphoma (DLBCL), independent of the presence of thrombosis, compared to healthy controls by flow cytometry, immunoblotting, and fluorometric assays. We observed increased tissue factor (TF) expression on CD31+ endothelial cells in DLBCL and FL. In DLBCL, inducible nitric oxide synthase expression was elevated in MNCs, while reduced nitrite levels correlated with an advanced clinical stage in patients with thrombosis. In lymphoma, nuclear factor kappa B (NFκB) signaling was activated in MNCs, while signal transducer and activator of transcription 3 (STAT3) activation was increased in DLBCL with thrombosis. Trans-endothelial migration of MNC was enhanced in HL, FL and DLBCL with thrombosis and reduced by inflammatory cytokine tumor necrosis factor alpha (TNF-α) that promoted platelet aggregation like interleukin-6 (IL-6) in HL and FL. Fibrinolytic analyses showed reduced tissue type plasminogen activator in lymphoma, whereas increased urokinase-type plasminogen activator (uPA) was linked to poorer total survival in DLBCL with thrombosis, suggesting a compensatory role in early thrombus resolution. These findings indicate that chronic inflammation promotes endothelial activation, dysregulated fibrinolysis, and increased vascular permeability, contributing to heightened thrombotic risk. This study provides mechanistic insight into lymphoma-associated thrombosis and identifies TF, uPA, and the inflammatory signaling pathways as potential biomarkers and therapeutic targets. Full article
Show Figures

Figure 1

Back to TopTop