Brain Organoids for Disease Modeling
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".
Deadline for manuscript submissions: closed (30 November 2025) | Viewed by 1168
Special Issue Editor
Interests: brain organoids; iPSCs; neurodevelopmental disorders
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Brain organoids are three-dimensional, stem cell-derived models that recapitulate key aspects of human brain development and organization. These self-organizing structures provide a powerful platform to study human-specific neurodevelopmental processes and disease mechanisms that are difficult to capture using traditional 2D cultures or animal models.
This Special Issue will explore the application of brain organoids in modeling neurological and psychiatric disorders, including autism spectrum disorder, bipolar disorder, Alzheimer's disease, and viral infections, such as Zika and SARS-CoV-2. Topics of interest include the generation of region-specific brain organoids, incorporation of microglia or vasculature for enhanced complexity, single-cell omics approaches to dissect disease pathways, and high-throughput platforms for drug screening. Studies addressing patient-derived iPSC models, gene editing techniques, and functional assays to assess neuronal activity are also encouraged.
By highlighting recent advances and challenges, this Special Issue aims to provide a comprehensive overview of how brain organoids are transforming our understanding of human brain diseases and paving the way toward precision medicine and therapeutic discovery.
Dr. Jonghun Kim
Guest Editor
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Keywords
- brain organoids
- induced pluripotent stem cells (iPSCs)
- neurodevelopmental disorders
- neurodegenerative diseases
- neuronal activity
- organoid-based drug screening
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