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Cells
Special Issues
Ovarian Cancer and Endometriosis
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Ovarian Cancer and Endometriosis

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".

Deadline for manuscript submissions: 20 May 2025 | Viewed by 1040

Special Issue Editors

Dr. Ji-Hye Ahn

E-Mail Website
Guest Editor
Department of Korean Pharmacy, College of Pharmacy, Woosuk University, Jeonbuk 55338, Republic of Korea
Interests: pharmaceutical; anti-cancer agents; immunomodulatory; natural products; signaling pathway
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Jung-Hye Choi

E-Mail Website
Guest Editor
College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea
Interests: ovarian cancer; endometriosis; pharmaceutical science; inflammation; natural product; tumor microenvironment; chemoresistance; apoptosis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This special issue delves into ovarian cancer and endometriosis, focusing on the microenvironmental factors, cell-cell interactions, drug resistance mechanisms, and the potential of natural products in treatment. Ovarian cancer, a leading cause of gynecological cancer-related deaths, often presents diagnostic and therapeutic challenges. Endometriosis, a benign but often debilitating condition, has been implicated in increased ovarian cancer risk. This issue explores how the microenvironment, including immune cells, stromal cells, and extracellular matrix components, influences tumor progression and endometriosis pathology. The role of cell-cell interactions in promoting malignant transformation and therapy resistance will be examined. Additionally, we will highlight the impact of natural products on modulating these interactions and their potential as therapeutic agents. By integrating recent advances in molecular biology, pharmacology, and clinical research, this special issue aims to provide a comprehensive understanding of the interplay between ovarian cancer and endometriosis and to pave the way for innovative therapeutic strategies.

Dr. Ji-Hye Ahn
Prof. Dr. Jung-Hye Choi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ovarian cancer
  • endometriosis
  • microenvironment
  • cell-cell interaction
  • drug resistance
  • natural product

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Published Papers (1 paper)

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Research

19 pages, 6384 KiB  
Article
A Critical Role of Intracellular PD-L1 in Promoting Ovarian Cancer Progression
by Rui Huang, Brad Nakamura, Rosemary Senguttuvan, Yi-Jia Li, Antons Martincuks, Rania Bakkar, Mihae Song, David K. Ann, Lorna Rodriguez-Rodriguez and Hua Yu
Cells 2025, 14(4), 314; https://doi.org/10.3390/cells14040314 - 19 Feb 2025
Viewed by 825
Abstract
Disrupting the interaction between tumor-cell surface PD-L1 and T cell membrane PD-1 can elicit durable clinical responses. However, only about 10% of ovarian cancer patients respond to PD-1/PD-L1 blockade. Here, we show that PD-L1 expression in ovarian cancer-patient tumors is predominantly intracellular. Notably, [...] Read more.
Disrupting the interaction between tumor-cell surface PD-L1 and T cell membrane PD-1 can elicit durable clinical responses. However, only about 10% of ovarian cancer patients respond to PD-1/PD-L1 blockade. Here, we show that PD-L1 expression in ovarian cancer-patient tumors is predominantly intracellular. Notably, PARP inhibitor treatment highly increased intracellular PD-L1 accumulation in both ovarian cancer-patient tumor samples and cell lines. We investigated whether intracellular PD-L1 might play a critical role in ovarian cancer progression. Mutating the PD-L1 acetylation site in PEO1 and ID8Brca1−/− ovarian cancer cells significantly decreased PD-L1 levels and impaired colony formation, which was accompanied by cell cycle G2/M arrest and apoptosis induction. PEO1 and ID8Brca1−/− tumors with PD-L1 acetylation site mutation also exhibited significantly reduced growth in mice. Furthermore, targeting intracellular PD-L1 with a cell-penetrating antibody effectively decreased ovarian tumor-cell intracellular PD-L1 level and induced tumor-cell growth arrest and apoptosis, as well as enhanced DNA damage and STING activation, both in vitro and in vivo. In conclusion, we have shown the critical role of intracellular PD-L1 in ovarian cancer progression. Full article
(This article belongs to the Special Issue Ovarian Cancer and Endometriosis)
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