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Biomolecules, Volume 11, Issue 5

May 2021 - 156 articles

Cover Story: Cardiac glycosides (CGs), well known for their cardiotonic properties, are commonly used in cardiac medicine. The biological activity of CGs is derived from the inhibition of Na+/ K+-ATPase, which is responsible for maintaining the resting potential and the balance of intracellular ions. Recently, novel applications of CGs have emerged. Since the ATPase is involved in a complex signalling cascade linked to apoptosis, CGs could be useful as anticancer agents. In addition, CGs are capable of inducing immunogenic cell death of cancer cells resulting in a strong induction of the anticancer immune response, in some cases leading to tumour eradication. In addition, CGs affect levels of various immune system markers and, thus, could be used to treat inflammation and some autoimmune diseases. Due to their immunogenic activity, CGs represent potentially very useful clinical, multifunctional compounds. View this paper
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Articles (156)

  • Article
  • Open Access
17 Citations
3,811 Views
10 Pages

Gene Polymorphisms of the Renin-Angiotensin-Aldosterone System as Risk Factors for the Development of In-Stent Restenosis in Patients with Stable Coronary Artery Disease

  • Madina Azova,
  • Kalima Timizheva,
  • Amira Ait Aissa,
  • Mikhail Blagonravov,
  • Olga Gigani,
  • Anna Aghajanyan and
  • Leyla Tskhovrebova

This study investigated the renin-angiotensin-aldosterone system (RAAS) gene polymorphisms as possible genetic risk factors for the restenosis development in patients with drug-eluting stents. 113 participants had coronary artery disease and underwen...

  • Article
  • Open Access
10 Citations
3,573 Views
15 Pages

Lack of Conserved miRNA Deregulation in HPV-Induced Squamous Cell Carcinomas

  • Jaroslav Nunvar,
  • Lucie Pagacova,
  • Zuzana Vojtechova,
  • Nayara Trevisan Doimo de Azevedo,
  • Jana Smahelova,
  • Martina Salakova and
  • Ruth Tachezy

Squamous cell carcinomas (SCCs) in the anogenital and head and neck regions are associated with high-risk types of human papillomaviruses (HR-HPV). Deregulation of miRNA expression is an important contributor to carcinogenesis. This study aimed to pi...

  • Feature Paper
  • Review
  • Open Access
9 Citations
4,588 Views
17 Pages

Transient Receptor Potential (TRP) Channels in Haematological Malignancies: An Update

  • Federica Maggi,
  • Maria Beatrice Morelli,
  • Massimo Nabissi,
  • Oliviero Marinelli,
  • Laura Zeppa,
  • Cristina Aguzzi,
  • Giorgio Santoni and
  • Consuelo Amantini

Transient receptor potential (TRP) channels are improving their importance in different cancers, becoming suitable as promising candidates for precision medicine. Their important contribution in calcium trafficking inside and outside cells is coming...

  • Review
  • Open Access
22 Citations
6,597 Views
12 Pages

Can Cannabidiol Affect the Efficacy of Chemotherapy and Epigenetic Treatments in Cancer?

  • Courtney Griffiths,
  • James Aikins,
  • David Warshal and
  • Olga Ostrovsky

The success of cannabinoids with chronic neuropathic pain and anxiety has been demonstrated in a multitude of studies. With the high availability of a non-intoxicating compound, cannabidiol (CBD), an over-the-counter medication, has generated heighte...

  • Review
  • Open Access
88 Citations
15,703 Views
32 Pages

The potential to treat neurodegenerative diseases (NDs) of the major bioactive compound of green tea, epigallocatechin-3-gallate (EGCG), is well documented. Numerous findings now suggest that EGCG targets protein misfolding and aggregation, a common...

  • Editorial
  • Open Access
6 Citations
3,796 Views
6 Pages

Bio-Based Formulations for Sustainable Applications in Agri-Food-Pharma

  • Minaxi Sharma,
  • Rajeev Bhat,
  • Zeba Usmani,
  • David Julian McClements,
  • Pratyoosh Shukla,
  • Vinay B. Raghavendra and
  • Vijai Kumar Gupta

Currently, there is a strong enduring interest towards obtaining high-value, sustainable bio-based bioactive compounds from natural resources, as there is great demand for these compounds in various market sectors such as agriculture, food, pharma, c...

  • Article
  • Open Access
4 Citations
2,875 Views
11 Pages

We analyzed children with urolithiasis with age- and gender-matched healthy children. Calcium (mmol/mmol creatinine) and the calcium/citrate ratio (mol/mmol) are the only variables that differentiate children before puberty from healthy children (ROC...

  • Article
  • Open Access
8 Citations
3,501 Views
16 Pages

Mechanical Sensing Element PDLIM5 Promotes Osteogenesis of Human Fibroblasts by Affecting the Activity of Microfilaments

  • Xiaolan Huang,
  • Rongmei Qu,
  • Yan Peng,
  • Yuchao Yang,
  • Tingyu Fan,
  • Bing Sun,
  • Asmat Ullah Khan,
  • Shutong Wu,
  • Kuanhai Wei and
  • Chujiang Xu
  • + 3 authors

Human skin fibroblasts (HSFs) approximate the multidirectional differentiation potential of mesenchymal stem cells, so they are often used in differentiation, cell cultures, and injury repair. They are an important seed source in the field of bone ti...

  • Systematic Review
  • Open Access
27 Citations
7,837 Views
59 Pages

IRDs are one of the leading causes of visual loss in children and young adults. Mutations in over 271 genes lead to retinal dysfunction, degeneration and sight loss. Though no cure exists, gene augmentation therapy has brought hope to the field. This...

  • Article
  • Open Access
15 Citations
3,342 Views
15 Pages

Thermal Properties and Structural Features of Multilayer Films Based on Chitosan and Anionic Polysaccharides

  • Galina N. Gubanova,
  • Valentina A. Petrova,
  • Svetlana V. Kononova,
  • Elena N. Popova,
  • Valentina E. Smirnova,
  • Alexander N. Bugrov,
  • Vera V. Klechkovskaya and
  • Yury A. Skorik

This study investigates the thermal and structural properties of multilayer composites based on chitosan (CS) and polyanions with different functionalities, including sodium sulfoethyl cellulose (SEC), sodium alginate (ALG), and sodium hyaluronate (H...

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Biomolecules - ISSN 2218-273X