Transient Receptor Potential (TRP) Channels: Markers and Therapeutic Targets for Cancer?

Dear Colleagues,

It is now evident that ion channels such as the transient receptor potential (TRP) channels play a crucial role in the development and progression of cancer. Although these channels are frequently and abundantly expressed in many tumors, their expression and activity in the context of specific types of cancer is revealing many different roles to clarify. There is also the need to identify the specific TRP contribution in each phase of the cancerous process, from tumor growth, invasion, angiogenesis, and drug resistance to metastasis formation.

Hence, this Special Issue of Biomolecules is dedicated to exploring the roles of TRP in cancer. The main goal is to collect articles that describe recent progress in elucidating the mechanisms by which these channels modulate tumor progression. Despite the extensive research efforts, neoplastic diseases remain a leading cause of death and morbidity worldwide together with the rapid evolution of resistance in tumor cells to the current therapeutic opportunities. Therefore, clinical research must promote innovative strategies targeting unexplored cancer-relevant markers, such as TRP channels, which could hold promise. Several natural products, such as capsaicinoids, cannabinoids, and terpenes, have been demonstrated to be TRP channel modulators and have significantly contributed to our current knowledge on TRP biology. Therefore, we encourage scientists of diverse backgrounds to contribute original research or review articles covering studies on TRP characterization and translational approaches of clinical relevance.

Dr. Morelli Maria Beatrice
Dr. Amantini Consuelo
Guest Editors

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