The Amazing World of IDPs in Human Diseases II

Dear Colleagues,

Following a very successful first run, we are pleased to announce the launch of a second edition of a Special Issue on intrinsically disordered proteins (IDPs) in human diseases.

It is now clearly established that some proteins or protein regions are devoid of any stable secondary and/or tertiary structure under physiological conditions, but still possess fundamental biological functions. These IDPs or regions (IDRs) have peculiar features due to their plasticity, their capacity to bind their biological targets with high specificity and low affinity, and the possibility of interaction with numerous partners. IDPs and IDRs are especially prevalent in eukaryotes, suggesting the necessity of disorder, associated signaling, and regulation in nucleated cells where they are involved in many key functions. However, a correlation between intrinsic disorder and human diseases such as cancer, diabetes, amyloidosis, and neurodegenerative disease is also now evident, highlighting the great importance of the topic.

For this Special Issue, we invite researchers to contribute with original research articles and reviews on the amazing world of the IDPs or IDRs involved in human diseases. Contributions focusing on the prediction, identification, and characterization of these, with emphasis on their role in cell signaling and regulation, are particularly welcome.

Dr. Simona Maria Monti
Dr. Giuseppina De Simone
Dr. Emma Langella
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.