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Lack of Conserved miRNA Deregulation in HPV-Induced Squamous Cell Carcinomas

Department of Genetics and Microbiology, Faculty of Science, Charles University, 12844 Prague, Czech Republic
BIOCEV-Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University, 25250 Vestec, Czech Republic
Genomics Core Facility, EMBL, 69117 Heidelberg, Germany
Author to whom correspondence should be addressed.
Academic Editor: Vladimir N. Uversky
Biomolecules 2021, 11(5), 764;
Received: 13 April 2021 / Revised: 12 May 2021 / Accepted: 15 May 2021 / Published: 20 May 2021
(This article belongs to the Special Issue Non-Coding RNAs in Cancer Diagnosis and Therapy)
Squamous cell carcinomas (SCCs) in the anogenital and head and neck regions are associated with high-risk types of human papillomaviruses (HR-HPV). Deregulation of miRNA expression is an important contributor to carcinogenesis. This study aimed to pinpoint commonly and uniquely deregulated miRNAs in cervical, anal, vulvar, and tonsillar tumors of viral or non-viral etiology, searching for a common set of deregulated miRNAs linked to HPV-induced carcinogenesis. RNA was extracted from tumors and nonmalignant tissues from the same locations. The miRNA expression level was determined by next-generation sequencing. Differential expression of miRNAs was calculated, and the patterns of miRNA deregulation were compared between tumors. The total of deregulated miRNAs varied between tumors of different locations by two orders of magnitude, ranging from 1 to 282. The deregulated miRNA pool was largely tumor-specific. In tumors of the same location, a low proportion of miRNAs were exclusively deregulated and no deregulated miRNA was shared by all four types of HPV-positive tumors. The most significant overlap of deregulated miRNAs was found between tumors which differed in location and HPV status (HPV-positive cervical tumors vs. HPV-negative vulvar tumors). Our results imply that HPV infection does not elicit a conserved miRNA deregulation in SCCs. View Full-Text
Keywords: squamous cell carcinoma; human papillomavirus; microRNA squamous cell carcinoma; human papillomavirus; microRNA
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MDPI and ACS Style

Nunvar, J.; Pagacova, L.; Vojtechova, Z.; Azevedo, N.T.D.d.; Smahelova, J.; Salakova, M.; Tachezy, R. Lack of Conserved miRNA Deregulation in HPV-Induced Squamous Cell Carcinomas. Biomolecules 2021, 11, 764.

AMA Style

Nunvar J, Pagacova L, Vojtechova Z, Azevedo NTDd, Smahelova J, Salakova M, Tachezy R. Lack of Conserved miRNA Deregulation in HPV-Induced Squamous Cell Carcinomas. Biomolecules. 2021; 11(5):764.

Chicago/Turabian Style

Nunvar, Jaroslav, Lucie Pagacova, Zuzana Vojtechova, Nayara T.D.d. Azevedo, Jana Smahelova, Martina Salakova, and Ruth Tachezy. 2021. "Lack of Conserved miRNA Deregulation in HPV-Induced Squamous Cell Carcinomas" Biomolecules 11, no. 5: 764.

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