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The Pentose Phosphate Pathway in Yeasts–More Than a Poor Cousin of Glycolysis

Department of Genetics, Faculty of Biology/Chemistry, University of Osnabrück, Barbarastrasse 11, D-49076 Osnabrück, Germany
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Academic Editors: Grzegorz Janusz, Daniel Kracher and Anna Pawlik
Biomolecules 2021, 11(5), 725; https://doi.org/10.3390/biom11050725
Received: 31 March 2021 / Revised: 4 May 2021 / Accepted: 10 May 2021 / Published: 12 May 2021
(This article belongs to the Special Issue Fungal Metabolism - Enzymes and Bioactive Compounds)
The pentose phosphate pathway (PPP) is a route that can work in parallel to glycolysis in glucose degradation in most living cells. It has a unidirectional oxidative part with glucose-6-phosphate dehydrogenase as a key enzyme generating NADPH, and a non-oxidative part involving the reversible transketolase and transaldolase reactions, which interchange PPP metabolites with glycolysis. While the oxidative branch is vital to cope with oxidative stress, the non-oxidative branch provides precursors for the synthesis of nucleic, fatty and aromatic amino acids. For glucose catabolism in the baker’s yeast Saccharomyces cerevisiae, where its components were first discovered and extensively studied, the PPP plays only a minor role. In contrast, PPP and glycolysis contribute almost equally to glucose degradation in other yeasts. We here summarize the data available for the PPP enzymes focusing on S. cerevisiae and Kluyveromyces lactis, and describe the phenotypes of gene deletions and the benefits of their overproduction and modification. Reference to other yeasts and to the importance of the PPP in their biotechnological and medical applications is briefly being included. We propose future studies on the PPP in K. lactis to be of special interest for basic science and as a host for the expression of human disease genes. View Full-Text
Keywords: carbohydrate metabolism; oxidative stress; reduction power; bioethanol; cancer carbohydrate metabolism; oxidative stress; reduction power; bioethanol; cancer
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MDPI and ACS Style

Bertels, L.-K.; Fernández Murillo, L.; Heinisch, J.J. The Pentose Phosphate Pathway in Yeasts–More Than a Poor Cousin of Glycolysis. Biomolecules 2021, 11, 725. https://doi.org/10.3390/biom11050725

AMA Style

Bertels L-K, Fernández Murillo L, Heinisch JJ. The Pentose Phosphate Pathway in Yeasts–More Than a Poor Cousin of Glycolysis. Biomolecules. 2021; 11(5):725. https://doi.org/10.3390/biom11050725

Chicago/Turabian Style

Bertels, Laura-Katharina, Lucía Fernández Murillo, and Jürgen J. Heinisch. 2021. "The Pentose Phosphate Pathway in Yeasts–More Than a Poor Cousin of Glycolysis" Biomolecules 11, no. 5: 725. https://doi.org/10.3390/biom11050725

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