Special Issue "Exogenous and Endogenous Alkaline Phosphatase in Health and Disease"

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Enzymology".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editors

Prof. Dr. Jan Bilski
E-Mail Website
Guest Editor
Department of Biomechanics and Kinesiology, Faculty of Health Sciences, Jagiellonian University Medical College, 31-531 Krakow, Poland
Interests: inflammatory bowel diseases; colitis; intestinal permeability; leaky gut; intestinal alkaline phosphatase; physical exercise; muscle fat crosstalk; myokines; adipokines
Prof. Dr. Tomasz Brzozowski
E-Mail Website
Guest Editor
Department of Physiology, Faculty of Medicine, Jagiellonian University Medical College, 31-531 Krakow, Poland
Interests: brain–gut axis; experimental colitis; intestinal permeability; inflammatory bowel diseases; proinflammatory cytokines; adipokines; myokines; lipopolysaccharide; microbiota; obesity
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Special Issue Information

Dear Colleagues,

Alkaline phosphatases (APs) are a superfamily of membrane-bound, zinc-containing metalloenzymes that catalyze the hydrolytic removal of phosphate from a wide variety of molecules. The mammalian AP family includes several isozymes, termed tissue-nonspecific APs (TNAPs), which are expressed in bone, liver, and kidneys, and tissue-specific AP, a type of enzyme found in the gut, placenta, and germ cells. TNAP plays an essential role in mineralization of bone in mammals, and TNAP deficiency can lead to hypophosphatasia, a hereditary metabolic defect characterized by severe rickets in children and osteomalacia and dental problems in adults. Overexpression of TNAP in the vasculature was suggested to induce vascular calcification and cardiac hypertrophy.

In recent years, intestinal alkaline phosphatase (IAP) has been of particular interest as a critical factor in maintaining gastrointestinal homeostasis acting by dephosphorylation of other pro-inflammatory mediators, tightening the intestinal mucosal barrier and preventing dysbiosis. Reduced IAP activity may increase the risk of disease through changes in the microbiome, increased intestinal inflammation, and permeability, leading to inflammatory diseases of the gastrointestinal tract. The association of decreased IAP activity with type 2 diabetes, metabolic syndrome, and ischemic heart disease has also been suggested.

AP may be a potentially important therapeutic target in many disorders. For example, the use of specific TNAP inhibitors could prevent vascular calcification and further cardiovascular complications. On the other hand, supplementation with IAP may be a potential therapeutic agent for dysbiosis and intestinal and systemic inflammations often associated with lower gut diseases. Administration of exogenous IAP may also counteract aging-related changes in gastrointestinal function. Furthermore, the human recombinant form of IAP has been developed and has been safely administered to humans without any side effects.

The purpose of this Special Issue is to expand and update our understanding of the role of AP in physiological and pathological processes in our body and AP as a potential target in new therapeutic strategies. Thus, this Special Issue of Biomolecules, entitled “Exogenous and Endogenous Alkaline Phosphatase in Health and Disease”, welcomes the submission of manuscripts either describing original research or reviewing the scientific literature which focuses on this challenging topic.

Prof. Dr. Jan Bilski
Prof. Dr. Tomasz Brzozowski
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • alkaline phosphatase
  • intestinal alkaline phosphatase
  • placental alkaline phosphatase
  • tissue-nonspecific alkaline phosphatase
  • hypophosphatasia
  • lipopolysaccharide
  • inflammation
  • intestine
  • intestinal permeability
  • leaky gut
  • microbiota
  • obesity
  • cardiovascular diseases

Published Papers

This special issue is now open for submission.
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