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Metabolites, Volume 10, Issue 1 (January 2020) – 41 articles
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Cover Story (view full-size image) Metabolomics is a powerful tool, but its full utility is still impeded by several challenges. These [...] Read more. Metabolomics is a powerful tool, but its full utility is still impeded by several challenges. These include the accurate chemical identification of all metabolites and limited depth-of-coverage of current methods. This article presents a four-dimensional solution using UHPLC-trapped ion mobility spectrometry coupled to tandem mass spectrometry (UHPLC-TIMS-TOF-MS). Multidimensional UHPLC-TIMS separations offer additional depth of coverage through increased peak capacities, while metabolite identification confidence is simultaneously enhanced by incorporating orthogonal collision cross-section (CCS) data matching. Thus, a CCS library of plant natural products was generated to facilitate metabolite identifications, and its use was demonstrated with extracts from the model legume Medicago truncatula. View this paper.