- Editorial
2,435 Views
9 Pages
Acknowledgement to Reviewers of Metabolites in 2019
- Metabolites Editorial Office
- 3.7Impact Factor
- 6.9CiteScore
- 15 daysTime to First Decision
Metabolites, Volume 10, Issue 1
January 2020 - 41 articles
Cover Story: Metabolomics is a powerful tool, but its full utility is still impeded by several challenges. These include the accurate chemical identification of all metabolites and limited depth-of-coverage of current methods. This article presents a four-dimensional solution using UHPLC-trapped ion mobility spectrometry coupled to tandem mass spectrometry (UHPLC-TIMS-TOF-MS). Multidimensional UHPLC-TIMS separations offer additional depth of coverage through increased peak capacities, while metabolite identification confidence is simultaneously enhanced by incorporating orthogonal collision cross-section (CCS) data matching. Thus, a CCS library of plant natural products was generated to facilitate metabolite identifications, and its use was demonstrated with extracts from the model legume Medicago truncatula. View this paper.
- Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
- You may sign up for email alerts to receive table of contents of newly released issues.
- PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.
Articles (41)
- Article
35 Citations
4,729 Views
14 Pages
Comparative Analysis of β-Carotene Production by Mucor circinelloides Strains CBS 277.49 and WJ11 under Light and Dark Conditions
- Tahira Naz,
- Shaista Nosheen,
- Shaoqi Li,
- Yusuf Nazir,
- Kiren Mustafa,
- Qing Liu,
- Victoriano Garre and
- Yuanda Song
Carotenoids are natural potent antioxidants and free radical scavengers which are able to modulate the pathogenesis of some cancers and heart diseases in human, indicating their importance in being provided through the diet. Mucor circinelloides accu...
- Article
23 Citations
4,054 Views
12 Pages
Sulfonamide Inhibition Profile of the β-Carbonic Anhydrase from Malassezia restricta, An Opportunistic Pathogen Triggering Scalp Conditions
- Sonia Del Prete,
- Andrea Angeli,
- Cynthia Ghobril,
- Julien Hitce,
- Cécile Clavaud,
- Xavier Marat,
- Claudiu T. Supuran and
- Clemente Capasso
The critical CO2 hydration reaction to bicarbonate and protons is catalyzed by carbonic anhydrases (CAs, EC 4.2.1.1). Their physiological role is to assist the transport of the CO2 and HCO3− at the cellular level, which will not be ensured by t...
- Article
25 Citations
6,514 Views
12 Pages
Study of the Royal Jelly Free Fatty Acids by Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS)
- Maroula G. Kokotou,
- Christiana Mantzourani,
- Rodalia Babaiti and
- George Kokotos
The lipidome of royal jelly (RJ) consists of medium-chained (8–12 carbon atoms) free fatty acids. We present herein a liquid chromatography-high resolution mass spectrometry (HRMS) method that permits the determination of RJ fatty acids and at...
- Article
28 Citations
6,341 Views
14 Pages
Cervicovaginal Microbiome and Urine Metabolome Paired Analysis Reveals Niche Partitioning of the Microbiota in Patients with Human Papilloma Virus Infections
- Nataliya Chorna,
- Josefina Romaguera and
- Filipa Godoy-Vitorino
In this study, we evaluate the association between vaginal and cervical human papillomavirus infections high-risk types (HPV+H), negative controls (HPV−), the bacterial biota, and urinary metabolites via integration of metagenomics, metabolomic...
- Review
276 Citations
19,927 Views
30 Pages
Metabolomics in the Context of Plant Natural Products Research: From Sample Preparation to Metabolite Analysis
- Mohamed A. Salem,
- Leonardo Perez de Souza,
- Ahmed Serag,
- Alisdair R. Fernie,
- Mohamed A. Farag,
- Shahira M. Ezzat and
- Saleh Alseekh
Plant-derived natural products have long been considered a valuable source of lead compounds for drug development. Natural extracts are usually composed of hundreds to thousands of metabolites, whereby the bioactivity of natural extracts can be repre...
- Article
69 Citations
21,638 Views
18 Pages
Comprehensive Circulatory Metabolomics in ME/CFS Reveals Disrupted Metabolism of Acyl Lipids and Steroids
- Arnaud Germain,
- Dinesh K. Barupal,
- Susan M. Levine and
- Maureen R. Hanson
The latest worldwide prevalence rate projects that over 65 million patients suffer from myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), an illness with known effects on the functioning of the immune and nervous systems. We performed an e...
- Article
31 Citations
5,354 Views
11 Pages
Metabolomic Profiling of Fungal Pathogens Responsible for Root Rot in American Ginseng
- Natasha DesRochers,
- Jacob P. Walsh,
- Justin B. Renaud,
- Keith A. Seifert,
- Ken K.-C. Yeung and
- Mark W. Sumarah
Ginseng root is an economically valuable crop in Canada at high risk of yield loss caused by the pathogenic fungus Ilyonectria mors-panacis, formerly known as Cylindrocarpon destructans. While this pathogen has been well-characterized from morphologi...
- Article
3 Citations
3,080 Views
14 Pages
Discovering Temporal Patterns in Longitudinal Nontargeted Metabolomics Data via Group and Nuclear Norm Regularized Multivariate Regression
- Zhaozhou Lin,
- Qiao Zhang,
- Shengyun Dai and
- Xiaoyan Gao
Temporal associations in longitudinal nontargeted metabolomics data are generally ignored by common pattern recognition methods such as partial least squares discriminant analysis (PLS-DA) and orthogonal partial least squares discriminant analysis (O...
- Article
19 Citations
5,170 Views
23 Pages
Testicular Caspase-3 and β-Catenin Regulators Predicted via Comparative Metabolomics and Docking Studies
- Mohammed S. Hifnawy,
- Mahmoud A. Aboseada,
- Hossam M. Hassan,
- Asmaa M. AboulMagd,
- Adel F. Tohamy,
- Samraa H. Abdel-Kawi,
- Mostafa E. Rateb,
- El Moataz Bellah El Naggar,
- Miaomiao Liu and
- Ronald J. Quinn
- + 2 authors
Many routes have been explored to search for effective, safe, and affordable alternatives to hazardous female contraceptives. Herbal extracts and their secondary metabolites are some of the interesting research areas to address this growing issue. Th...
of 5
Get Alerted
Add your email address to receive forthcoming issues of this journal.
Metabolites - ISSN 2218-1989