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Most Recent

  • Case Report
  • Open Access

Multi-Omics Characterization of a Novel SSR4 Variant in Congenital Disorders of Glycosylation

  • Nurulamin Abu Bakar,
  • Nurul Izzati Hamzan,
  • Elyssa Milus Majawit,
  • Siti Nurwani Ahmad Ridzuan,
  • Noor Hafizah Hassan,
  • Anasufiza Habib and
  • Lock-Hock Ngu

8 December 2025

Background: Congenital disorders of glycosylation (CDG) are rare inborn errors of metabolism with multisystemic manifestations. SSR4-CDG is an ultra-rare X-linked subtype caused by pathogenic variants in SSR4, a component of the translocon-associated...

  • Article
  • Open Access
102 Views
20 Pages

Investigation of Volatile Compounds in Varied Types of Gardenia White Teas Utilizing HS–SPME–GC–MS and Multivariate Analysis

  • Shenghong Zheng,
  • Chunju Peng,
  • Qi Huang,
  • Ke Zhang,
  • Zhengwen Niu,
  • Guanghui Zeng,
  • Huajing Kang and
  • Hongling Chai

5 December 2025

Gardenia tea is esteemed for its delicate and fragrant aroma. Background: However, there is a scarcity of studies focused on the aromatic properties of gardenia-scented white tea, particularly regarding how these aroma profiles evolve over different...

  • Review
  • Open Access
623 Views
21 Pages

5 December 2025

Background/Objectives: Ultra-processed foods (UPFs) have become a dominant component of the modern diet, paralleling the rise in obesity and chronic disease prevalence worldwide. This narrative review aims to synthesize evidence on how dietary proces...

  • Article
  • Open Access
202 Views
20 Pages

Untargeted Metabolomics Reveals Distinct Soil Metabolic Profiles Across Land Management Practices

  • Zane A. Vickery,
  • Hector F. Castro,
  • Stephen P. Dearth,
  • Eric D. Tague,
  • Aimée T. Classen,
  • Jessica A. Moore,
  • Michael S. Strickland and
  • Shawn R. Campagna

4 December 2025

Background/Objectives: Land management practices strongly influence soil biochemical processes, yet conventional soil measurements often overlook dynamic small-molecule variation underlying nutrient cycling and microbial activity. This study aimed to...

  • Article
  • Open Access
133 Views
25 Pages

Integrative Network Pharmacology and Multi-Omics Analysis Reveal Key Targets and Mechanisms of Saikosaponin B1 Against Acute Lung Injury

  • Yuanfei Niu,
  • Meiting Liu,
  • Shuang Cui,
  • Kaiyang Liu,
  • Mengyuan Yang,
  • Xiaozhen Hu,
  • Changhui Zheng,
  • Lianmei Wang and
  • Junling Cao

4 December 2025

Background/Objectives: Acute lung injury (ALI) is a severe condition driven largely by inflammation and has limited therapeutic options. Although saikosaponin B1 (SSB1), a primary bioactive saponin from Bupleurum Radix, has demonstrated anti-inflamma...

  • Article
  • Open Access
162 Views
20 Pages

Multi-Omics Analysis Reveals Distinct Lipid Remodelling and Mitochondrial Stress in SH-SY5Y Cells Modelling Parkinson’s Disease

  • Shu Wang,
  • Zhen Ni,
  • Gaoge Wang,
  • Jingzheng Zhang,
  • Yunfu Tan,
  • Enliang Hong,
  • Yunting Wang,
  • Huan Chen,
  • Hongwei Hou and
  • Qingyuan Hu

4 December 2025

Background: Neurotoxin-based in vitro models are commonly used to replicate the mitochondrial dysfunction and oxidative stress associated with Parkinson’s disease (PD). While these models reproduce similar hallmark features of PD pathology, the...

  • Article
  • Open Access
144 Views
10 Pages

Plasma Metabolite Profiles of Children with Autism Spectrum Disorder

  • Benjamin H. Mullin,
  • Madeleine Stuckey,
  • Suzanne J. Brown,
  • Shelby Mullin,
  • Purdey J. Campbell,
  • Frank Dudbridge,
  • Cristina Menni,
  • John P. Walsh,
  • Andrew J. O. Whitehouse and
  • Scott G. Wilson

4 December 2025

Background/Objectives: Autism spectrum disorder (ASD), a neurodevelopmental condition characterised by social and communication differences, is complex and aetiologically heterogeneous. Untargeted metabolomics is emerging as a tool in screening for b...

  • Article
  • Open Access
104 Views
30 Pages

Untargeted Metabolomics for Profiling of Cascara, Senna, Rhubarb, and Frangula Metabolites

  • Paola Nezi,
  • Alessia Lucia Prete,
  • Filippo Costanti,
  • Vittoria Cicaloni,
  • Mattia Cicogni,
  • Laura Tinti,
  • Laura Salvini and
  • Monica Bianchini

3 December 2025

Background/Objectives: Natural products containing hydroxyanthracene derivatives (HADs) such as Cascara (Rhamnus purshiana), Frangula (Rhamnus frangula), Rhubarb (Rheum palmatum), and Senna (Cassia angustifolia) have long been used for their laxative...

  • Review
  • Open Access
190 Views
24 Pages

Innovative Detection and Mitigation of Ergot Alkaloids in Cereals: Advancing Food Safety

  • Maria Balatsou,
  • Aikaterini Koutsaviti,
  • Yiannis Sarigiannis and
  • Christos C. Petrou

3 December 2025

Background/Objectives: Ergot alkaloids are mycotoxins produced mainly by fungi of the genus Claviceps, infecting a wide variety of plants, especially cereals. These toxins usually manifest as black, hardened sclerotia (ergots), though they may also b...

  • Article
  • Open Access
175 Views
17 Pages

2 December 2025

Background/Objectives: δ1-Pyrroline-5-carboxylic acid (P5C) is a key intermediate in both the pathways leading in plants to proline synthesis, as well as in the proline catabolic route that takes place in the mitochondrion. Instead of being fur...

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Metabolites - ISSN 2218-1989