26 October 2026
Background/Objectives: Serum uric acid, which has endogenous antioxidant properties, has shown inconsistent associations with muscle health. Bioelectrical impedance-derived phase angle reflects cell membrane integrity and muscle quality, but its rela...
26 October 2026
Objectives: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely used to treat obesity. However, their mechanism of action on adipose tissues remains incompletely understood. Methods: We exploited advanced three-dimensional imaging to inve...
26 October 2026
Background: Body mass index (BMI) screening may fail to identify normal-weight obesity (NWO) despite excess adiposity and unfavorable metabolic profiles. Methods: In this randomized trial, 30 women (aged 20–39 years; BMI 18.5–24.9 kg/m2,...
26 October 2026
Background/Objectives: The waist-to-height ratio (WHtR) is a sensitive marker of central obesity. This study examined the longitudinal trajectory of WHtR in patients with type 2 diabetes (T2DM) initiating sodium–glucose cotransporter-2 (SGLT-2)...
24 October 2026
Background/Objectives: Localized drug delivery platforms offer promising therapeutic approaches for oral mucosal conditions, including recurrent aphthous stomatitis. Methods: In this study, electrospun polyvinyl alcohol (PVA) nanofibrous matrices inc...
23 October 2026
Background/Objectives: Essential thrombocythemia (ET) is a JAK-STAT-driven myeloproliferative neoplasm with an incompletely defined metabolic phenotype. This study aimed to characterize the plasma metabolome of ET and to determine whether it differs...
22 October 2026
Background: Cereal vinegar sediment (CVS), a byproduct formed during traditional grain vinegar storage, possesses lipid-lowering, glucose-lowering, and antioxidant properties. However, its effects on gut microbial and metabolic responses to short-ter...
Background: This study investigated associations of maternal supplementary feeding during late gestation and lactation with the colostrum metabolome, growth performance, antioxidant status, and rumen microbiota of offspring. Methods: Colostrum collec...
With its label-free and high-resolution molecular imaging capabilities, Time-of-Flight Secondary Ion Mass Spectrometry (TOF-SIMS) has been increasingly applied in biological and biomedical research. However, the research landscape and developmental t...
Background: Exercise timing may influence cardiovascular and metabolic responses, but the available evidence varies across populations, exercise protocols, and assessment periods. Objectives: To compare the cardiovascular and metabolic effects of mor...
Objective: Behçet’s disease (BD) is a systemic vasculitis characterized by thrombo-inflammation. This cross-sectional study compared inflammatory indices obtained from complete blood counts (CBC), focusing particularly on red blood cell...
Background/Objectives: Fermentation is recognized for improving the nutritional content and health benefits of soy products. Gastro-AD® (GAD) is a postbiotic ingredient produced from soy flour by controlled fermentation with a proprietary strain...
Objective: Shenqi Granules is a traditional Chinese medicine formula derived from the classic prescription Shenqi Formula (SQF), composed of Astragali Radix (Huangqi) and Codonopsis Radix (Dangshen). SQF shows neuroprotection in cerebral ischemia-rep...
Background/Objectives: Elastic-band resistance and plyometric training, which differ in eccentric and impact loading, are commonly added to tennis conditioning, but their effects on circulating markers related to extracellular-matrix turnover and ant...
21 October 2026
Background/Objectives: Foundational studies on brain carbohydrate metabolism are reviewed. More recent results on the unique functionality of lactate and the possibility of augmenting cerebral carbohydrate (CHO) uptake with exogenous lactate to suppl...
Acute fatty liver of pregnancy (AFLP) is a rare microvesicular steatotic liver disease of late gestation, linked to impaired mitochondrial fatty acid β-oxidation, in which management centres on recognition and delivery before overt hepatic and m...
Background: Linking metabolite composition to biological activities remains challenging in herbal medicines, where diverse metabolites may collectively contribute to pharmacological effects. Although metabolite profiling is fundamental to quality ass...
Background: Global expansion of Litopenaeus vannamei aquaculture has intensified the reliance on antibiotics for disease control, raising concerns about hepatotoxicity, microbiota dysbiosis and antimicrobial resistance. Synthesized scorpion venom-der...
Background: This research aimed to examine the associations between the total “Nutrition Knowledge Scale” score and metabolic profile indicators among fitness center members, and to explore whether selected nutrition knowledge items diffe...
Metabolic dysfunction-associated steatotic liver disease (MASLD) connects nutritional exposures with cardiometabolic risk and vulnerability during aging. Nutrition provides an actionable foundation for care, while metabolomics may clarify variation i...
Background/Objectives: Gastro-AD® (GAD) is a fermented soy-derived postbiotic supported by clinical and preclinical evidence related to gastric comfort and mucosal injury. Although fermentation-derived metabolites have been characterized, the pep...
Background/Objectives: Evidence suggests that plant-based diets are associated with reduced risk of chronic inflammatory diseases and lower circulating C-reactive protein (CRP) levels. However, associations with other inflammatory biomarkers, includi...
Background/Objectives: Sulfur mustard (SM) is an old warfare agent that remains a threat to both military personnel and civilians. SM contamination occurs through three main routes: dermal contact, inhalation, and ocular exposure. The clinical conseq...
Background: Exercise-induced reactive oxygen species (ROS) participate in both oxidative stress and physiological adaptation. Erythrocytes rely on NADPH-generating and thiol-related antioxidant systems to maintain redox homeostasis during exercise. A...
Background: Job stress is a common occupational hazard and has been linked to adverse mental and cardiometabolic outcomes; however, the metabolic responses to job stress remain incompletely understood. This study aimed to characterize plasma metaboli...
Inflammation and intermediary metabolism are closely interconnected [...]
Lactate is a metabolic substrate, an extracellular signaling molecule, and a precursor for protein lactylation, with diverse effects on macrophage immunity. Evidence from infection, tissue injury, efferocytosis, and cancer indicates that lactate-asso...
Kashin–Beck disease (KBD) is an endemic osteoarthropathy characterized by the degeneration and necrosis of articular cartilage and epiphyseal growth plate cartilage, with disease onset occurring predominantly during childhood. Its etiology has...
Background/Objectives: This study evaluated the associations of shift work with serum vitamin D levels, excessive daytime sleepiness (EDS), and symptoms of anxiety and depression among female nurses working at a university hospital. Methods: This was...
Background/Objectives: This study subjected four-week-old oats (Avena sativa L. cv. Qinqiong and Avena sativa L. cv. Menglong) to saline–alkali stress for 6, 12, 24, and 48 h, and non-targeted metabolomics was used to analyse root metabolites u...
Background: The ergogenic role of caffeine in taekwondo-specific performance has not been comprehensively synthesized. This study aimed to evaluate the effects of caffeine supplementation on performance outcomes in taekwondo athletes. Methods: PubMed...
Background: Nasopharyngeal carcinoma (NPC) is a malignancy highly prevalent in southern China. Metabolic reprogramming is a hallmark of cancer, yet the interplay between the systemic and local metabolic landscapes of NPC remains poorly characterized....
16 October 2026
Background: Graves’ disease is a systemic autoimmune disorder that may affect ocular structures even in the absence of clinically apparent ophthalmopathy. Optical coherence tomography (OCT) enables objective assessment of neuroretinal structure...
Background/Objectives: The aim of this study was to compare the biochemical, histological, immunohistochemical and ultrastructural hepatic phenotypes associated with carbohydrate-, fat- and protein-enriched diets initiated during post-weaning growth....
Background: The gut–vascular axis linking gut microbiota, intestinal barrier, and vascular endothelium is a key pathophysiological interface in chronic metabolic diseases. Dysbiosis and “leaky gut” enable bacterial products and gut-...
Allergic conjunctivitis (AC) is a common inflammatory ocular surface disease characterised by ocular itch, conjunctival redness, tearing, and frequent eye rubbing. Although the link between AC, eye rubbing and development of keratoconus is well estab...
Background and Objectives: Re-amputation is an important adverse outcome of diabetic foot disease. This study compared age and preoperative inflammatory parameters between patients with and without subsequent re-amputation and examined their adjusted...
Background/Objectives: Metabolomics has the potential to enhance the definition of medication response phenotypes in early-phase clinical trials, yet global uptake and distribution are not well characterised. This study provides an international asse...
The rising prevalence of obesity, type 2 diabetes, and cardiovascular disease has made the identification of reliable biomarkers a central priority in metabolic research [...]
Background: Chronic exposure to ultraviolet (UV) radiation, particularly UVB, is the primary driver of skin photoaging. Ferro-aging, a recently identified iron-triggered, lipid peroxidation-driven cellular senescence program distinct from acute ferro...
Background: The clinical relevance of a mildly elevated first-trimester thyroid-stimulating hormone (TSH) concentration is uncertain, recent meta-analyses disagree, and few studies have directly contrasted a TSH of 2.5–4.0 mIU/L with a TSH abov...
Astrocytes and oligodendrocytes contribute to the metabolic, homeostatic and structural organization of the developing brain, yet their interactions evolve across development and remain incompletely characterized during the earliest stages of life. T...
Background/Objectives: High-fat diet (HFD) feeding disrupts systemic metabolism and hypothalamic mechanisms that coordinate energy balance. Whether quercetin modifies coordinated hypothalamic transcription linking m6A-related regulation with leptin&n...
Background/Objectives: Low-grade chronic inflammation is recognized as part of the systemic profile of polyendocrine metabolic ovarian syndrome (PMOS, formerly polycystic ovary syndrome, PCOS), although whether this inflammatory signal tracks insulin...
Background: Novel Synthetic Opioids (NSOs) currently represent the third most prevalent group among New Psychoactive Substances (NPS), yet they represent the category associated with the highest health risk. Their extreme pharmacological potency comp...
Type 2 diabetes combined with obesity is a prevalent metabolic comorbidity with high clinical heterogeneity, leading to inconsistent treatment efficacy and difficult long-term standardized management. Emerging evidence indicates that the small GTPase...
Plant specialized metabolites play important roles in plant–microbe interactions. Beyond direct antimicrobial activity, some can attenuate pathogen virulence without markedly inhibiting microbial growth. Many gram-negative phytopathogenic bacte...
Background/Objectives: This study evaluated the effects of dietary defatted black soldier fly (Hermetia illucens) larvae meal (DBSFLM) as a partial replacement of traditional dietary protein sources on growth performance, carcass traits, meat quality...
Cardiovascular disease (CVD) remains a major contributor to global mortality and disease burden and encompasses a range of conditions commonly associated with metabolic disturbances, endothelial dysfunction, and chronic inflammation. Emerging evidenc...
Background/Objectives: Silene dichotoma Ehrh. subsp. dichotoma is a relatively understudied member of a genus known for diverse secondary metabolites. This study integrated phytochemical characterization, biological activity assessment, and LC–...
