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Open AccessArticle

The Effect of Training on Erythrocyte Energy Status and Plasma Purine Metabolites in Athletes

1
Department of Athletics, Strength and Conditioning, Poznan University of Physical Education, Królowej Jadwigi 27/39, 61-871 Poznan, Poland
2
Department of Biochemistry, Medical University of Gdansk, Dębinki 1, 80-211 Gdansk, Poland
3
Department of Physiology, Faculty of Biology, The University of Szczecin, ul. Felczaka 3c, 71-412 Szczecin, Poland
*
Authors to whom correspondence should be addressed.
Metabolites 2020, 10(1), 5; https://doi.org/10.3390/metabo10010005
Received: 2 December 2019 / Revised: 15 December 2019 / Accepted: 16 December 2019 / Published: 19 December 2019
This study aimed to assess the changes in red blood cell (RBC) energy status and plasma purine metabolites concentration over a one-year training cycle in endurance-trained (EN; n = 11, 20–26 years), and sprint-trained (SP; n = 11, 20–30 years) competitive athletes in comparison to recreationally-trained individuals (RE; n = 11, 20–26 years). Somatic, physiological, and biochemical variables were measured in four training phases differing in exercise load profile: transition, general, specific, and competition. Significantly highest values of RBC adenylate energy charge (AEC; p ≤ 0.001), ATP-to-ADP and ADP-to-AMP ratios (p ≤ 0.05), and plasma levels of adenosine (Ado; p ≤ 0.05) were noted in the competition phase in the EN and SP, but not in the RE group. Significantly lowest plasma levels of adenosine diphosphate (ADP; p ≤ 0.05), adenosine monophosphate (AMP; p ≤ 0.001), inosine (Ino; p ≤ 0.001), and hypoxanthine (Hx; p ≤ 0.001) accompanied by higher erythrocyte hypoxanthine-guanine phosphoribosyltransferase (HGPRT) activity (p ≤ 0.001), were observed in the competition phase in both athletic groups. No significant alterations were found in the erythrocyte concentration of guanine nucleotides in any group. In conclusion, periodized training of competitive athletes’ results in a favorable adaptation of RBC metabolism. The observed changes cover improved RBC energy status (increased AEC and ATP/ADP ratio) and reduced purine loss with more efficient erythrocyte purine pool recovery (increased HGPRT activity and plasma levels of Ado; decreased Hx and Ino concentration). View Full-Text
Keywords: adenylate metabolites; purine derivatives; HGPRT; training periodization adenylate metabolites; purine derivatives; HGPRT; training periodization
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Pospieszna, B.; Kusy, K.; Słomińska, E.M.; Dudzinska, W.; Ciekot-Sołtysiak, M.; Zieliński, J. The Effect of Training on Erythrocyte Energy Status and Plasma Purine Metabolites in Athletes. Metabolites 2020, 10, 5.

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