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In Vivo Mitochondrial Function in Idiopathic and Genetic Parkinson’s Disease

Excellence Center for advanced MR techniques and Neurology unit, Fondazione IRCCS Cà Granda Maggiore Policlinico Hospital, Via Sforza 35, 20122 Milan, Italy
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Metabolites 2020, 10(1), 19; https://doi.org/10.3390/metabo10010019
Received: 18 November 2019 / Revised: 20 December 2019 / Accepted: 26 December 2019 / Published: 28 December 2019
(This article belongs to the Special Issue Mitochondria and Metabolism in Disorders)
Parkinson’s disease (PD) is associated with brain mitochondrial dysfunction. High-energy phosphates (HEPs), which rely on mitochondrial functioning, may be considered potential biomarkers for PD. Phosphorus magnetic resonance spectroscopy (31P-MRS) is a suitable tool to explore in vivo cerebral energetics. We considered 10 31P-MRS studies in order to highlight the main findings about brain energetic compounds in patients affected by idiopathic PD and genetic PD. The studies investigated several brain areas such as frontal lobes, occipital lobes, temporoparietal cortex, visual cortex, midbrain, and basal ganglia. Resting-state studies reported contrasting results showing decreased as well as normal or increased HEPs levels in PD patients. Functional studies revealed abnormal PCr + βATP levels in PD subjects during the recovery phase and abnormal values at rest, during activation and recovery in one PD subject with PINK1 gene mutation suggesting that mitochondrial machinery is more impaired in PD patients with PINK1 gene mutation. PD is characterized by energetics impairment both in idiopathic PD as well as in genetic PD, suggesting that mitochondrial dysfunction underlies the disease. Studies are still sparse and sometimes contrasting, maybe due to different methodological approaches. Further studies are needed to better assess the role of mitochondria in the PD development. View Full-Text
Keywords: brain energetics; parkinson’s disease; PINK1 mutation; mitochondria; 31P-MRS; phosphorus brain energetics; parkinson’s disease; PINK1 mutation; mitochondria; 31P-MRS; phosphorus
MDPI and ACS Style

Dossi, G.; Squarcina, L.; Rango, M. In Vivo Mitochondrial Function in Idiopathic and Genetic Parkinson’s Disease. Metabolites 2020, 10, 19.

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