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Biology, Volume 12, Issue 8

August 2023 - 112 articles

Cover Story: Recent studies have shown that exosome (EXO)-derived microRNAs (miRNAs), as well as intracellular miRNAs, play a crucial role in mediating MSC functions. In this work, we used 3D culture and IFN-γ to prime the MSC therapeutic effects in terms of functional miRNAs. Within MSC biological replicates, our analysis revealed stable variations in intracellular miRNA expression, while significant variability in the expression of EXO-derived miRNAs was observed. Moreover, deregulated miRNAs highlighted their involvement in tissue repair/regeneration pathways. 3D culture and IFN-γ treatment appear to be promising strategies for enhancing MSC therapeutic effects in terms of miRNA expression, and the identified miRNAs may contribute to understanding the molecular mechanisms underlying the miRNA-mediated therapeutic effects of MSCs. View this paper
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Articles (112)

  • Review
  • Open Access
22 Citations
8,794 Views
27 Pages

Acute Myocardial Infarction and Risk of Cognitive Impairment and Dementia: A Review

  • Elizabeth Hui En Thong,
  • Ethan J. W. Quek,
  • Jing Hong Loo,
  • Choi-Ying Yun,
  • Yao Neng Teo,
  • Yao Hao Teo,
  • Aloysius S. T. Leow,
  • Tony Y. W. Li,
  • Vijay K. Sharma and
  • Benjamin Y. Q. Tan
  • + 4 authors

21 August 2023

Cognitive impairment (CI) shares common cardiovascular risk factors with acute myocardial infarction (AMI), and is increasingly prevalent in our ageing population. Whilst AMI is associated with increased rates of CI, CI remains underreported and infr...

  • Review
  • Open Access
6 Citations
6,314 Views
18 Pages

An Updated Overview of Existing Cancer Databases and Identified Needs

  • Brittany K. Austin,
  • Ali Firooz,
  • Homayoun Valafar and
  • Anna V. Blenda

21 August 2023

Our search of existing cancer databases aimed to assess the current landscape and identify key needs. We analyzed 71 databases, focusing on genomics, proteomics, lipidomics, and glycomics. We found a lack of cancer-related lipidomic and glycomic data...

  • Article
  • Open Access
5 Citations
3,154 Views
17 Pages

21 August 2023

Introduction: Hypertension, a leading cause of death, was investigated in this study to understand the role of specific brain regions in regulating blood pressure. The lateral parabrachial nucleus (LPBN), Kolliker-fuse nucleus (KF), and periductal gr...

  • Review
  • Open Access
5 Citations
2,381 Views
15 Pages

Intestinal Flora in Chemotherapy Resistance of Biliary Pancreatic Cancer

  • Liuhui Bai,
  • Xiangdong Yan,
  • Jin Lv,
  • Ping Qi,
  • Xiaojing Song and
  • Lei Zhang

21 August 2023

Biliary pancreatic malignancy has an occultic onset, a high degree of malignancy, and a poor prognosis. Most clinical patients miss the opportunity for surgical resection of the tumor. Systemic chemotherapy is still one of the important methods for t...

  • Article
  • Open Access
7 Citations
2,714 Views
12 Pages

Ontogenetic Shifts in Body Morphology of Demersal Sharks’ Species (Order: Squaliformes) Inhabiting the Western-Central Mediterranean Sea, with Implications for Their Bio-Ecological Role

  • Andrea Bellodi,
  • Antonello Mulas,
  • Louise Daniel,
  • Alessandro Cau,
  • Cristina Porcu,
  • Pierluigi Carbonara and
  • Maria Cristina Follesa

19 August 2023

Several elasmobranch species undergo shifts in body proportions during their ontogenetic growth. Such morphological changes could reflect variation in diet, locomotion, or, more broadly, in the species’ interactions with their environment. Howe...

  • Article
  • Open Access
5 Citations
4,168 Views
20 Pages

19 August 2023

The excessive use of synthetic pesticides has caused environmental problems and human health risks and increased the development of resistance in several organisms. Allelochemicals, secondary metabolites produced as part of the defense mechanisms in...

  • Article
  • Open Access
3 Citations
2,804 Views
29 Pages

19 August 2023

Regression models are extensively used to explore the relationship between a dependent variable and its covariates. These models work well when the dependent variable is categorical and the data are supposedly independent, as is the case with general...

  • Article
  • Open Access
1 Citations
2,425 Views
17 Pages

Effect of Mesenchymal Stem Cells Overexpressing BMP-9 Primed with Hypoxia on BMP Targets, Osteoblast Differentiation and Bone Repair

  • Jessica Emanuella Rocha Moura Paz,
  • Leticia Faustino Adolpho,
  • Jaqueline Isadora Reis Ramos,
  • Rayana Longo Bighetti-Trevisan,
  • Robson Diego Calixto,
  • Fabiola Singaretti Oliveira,
  • Adriana Luisa Gonçalves Almeida,
  • Marcio Mateus Beloti and
  • Adalberto Luiz Rosa

19 August 2023

Bone formation is driven by many signaling molecules including bone morphogenetic protein 9 (BMP-9) and hypoxia-inducible factor 1-alpha (HIF-1α). We demonstrated that cell therapy using mesenchymal stem cells (MSCs) overexpressing BMP-9 (MSCs+...

  • Article
  • Open Access
12 Citations
3,195 Views
16 Pages

The Application of the Generalized Additive Model to Represent Macrobenthos near Xiaoqing Estuary, Laizhou Bay

  • Lulei Liu,
  • Ang Li,
  • Ling Zhu,
  • Suyan Xue,
  • Jiaqi Li,
  • Changsheng Zhang,
  • Wenhan Yu,
  • Zhanfei Ma,
  • Haonan Zhuang and
  • Zengjie Jiang
  • + 1 author

18 August 2023

Macrobenthos is widely used as an indicator of ecological health in marine monitoring and assessment. The present study aimed to characterize the interrelationships between the distribution of the macrobenthos community and environmental factors near...

  • Article
  • Open Access
6 Citations
2,552 Views
19 Pages

18 August 2023

Hirame novirhabdovirus (HIRRV) is one of most serious viral pathogens causing significant economic losses to the flounder (Paralichthys olivaceus)-farming industry. Previous studies have shown that the outbreak of HIRRV is highly temperature-dependen...

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Biology - ISSN 2079-7737