Special Issues

Biology publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Physiology and Pathophysiology of the Kidney
edited by Gang Liu
submission deadline 30 Nov 2025 | 3 articles | Viewed by 4976 | Submission Open
Keywords: renal physiology; renal hemodynamics; kidney injury; regenerative therapies; urology
(This special issue belongs to the Section Physiology)
Mitochondrial Dysfunction and Aging
edited by Huiliang Zhang
submission deadline 30 Nov 2025 | 1 articles | Viewed by 3513 | Submission Open
Keywords: mitochondrial dysfunction; aging; cardiovascular diseases; Alzheimer’ s disease and related dementia; stem cell; skeletal muscle; kidney
(This special issue belongs to the Section Medical Biology)
Germ, Sertoli and Leydig Cells in the Testis
edited by and María Fernanda Riera
submission deadline 30 Nov 2025 | 1 articles | Viewed by 3339 | Submission Open
Keywords: Sertoli cells; Leydig cells; spermatogonia; spermatocytes; spermatozoa; stem cell niche; testis; omics analysis; environmental toxicants; non-coding RNAs  
(This special issue belongs to the Section Cell Biology)
Genetics and Cell Biology in Crop Improvement
edited by , , Jie Huang and Xixi Liu
submission deadline 30 Nov 2025 | 1 articles | Viewed by 2449 | Submission Open
Keywords: plant genomics and genetics; gene cloning and function; crop molecular breeding; germplasm enhancement; genetic engineering; plant cell biology; crop adaptability
(This special issue belongs to the Section Plant Science)
Exposure to Heavy Metals: Advances in Cytotoxicity and Genotoxicity
edited by Qianru Chi and Yi Zhao
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1861 | Submission Open
Keywords: heavy metal pollutants; exposure assessment; toxic mechanism; biomarkers; metabolomics; environmental quality monitoring; bioinformatics analysis methods
(This special issue belongs to the Section Toxicology)
Diet and Environmental Stress Impacts on Farm Animal Production
edited by and Michael Chimonyo
submission deadline 30 Nov 2025 | Viewed by 947 | Submission Open
Keywords: animal production; feed types; feed preparation; feed additives; diet quality and palatability; climate variability; housing environment
(This special issue belongs to the Section Zoology)
Managing Hybridizing Populations: Threats or Opportunities for Conservation?
edited by and Marco Musiani
submission deadline 30 Nov 2025 | Viewed by 753 | Submission Open
Keywords: natural hybridization; anthropogenic hybridization; adaptive introgression; hybrid fitness; coexistence of wildlife and free-ranging domestic animals; management of hybridizing populations
(This special issue belongs to the Section Conservation Biology and Biodiversity)
Breast Cancer: Molecular and Cellular Mechanism and Biomarkers submission deadline 30 Nov 2025 | Viewed by 380 | Submission Open
Keywords: breast cancer; biomarkers; molecular mechanisms; multidrug resistance; personalized medicine; molecular targeted therapy; gene expression
(This special issue belongs to the Section Cancer Biology)
Global Fisheries Resources, Fisheries, and Carbon-Sink Fisheries submission deadline 15 Dec 2025 | 24 articles | Viewed by 25021 | Submission Open
Keywords: fisheries; habitats; overfishing; fishery resource biology; economic aquatic animal behavior; stock enhancement by releasing; environmental DNA; fisheries management; climate change; ecosystems; ecological models; carbon-sink; aquatic ecological ranches; fisheries products
Biogeochemical Element Cycling in Plant–Soil Systems: Implications for Ecosystem Dynamics and Services
edited by and Wajid Zaman
submission deadline 15 Dec 2025 | 11 articles | Viewed by 19225 | Submission Open
Keywords: autotrophs; biomass production; climate stabilization; ecosystem functions; ecosystem management; ecosystem policy; global change; heterotrophs; pollination; soil fertility; soil macro-organisms; soil micro-organisms
(This special issue belongs to the Section Ecology)
Environmental DNA (eDNA) for Assessment of Coastal Marine Biodiversity submission deadline 15 Dec 2025 | 2 articles | Viewed by 2625 | Submission Open
Keywords: eDNA metabarcoding; coastal marine ecosystems; biodiversity; genetic distances; ecological indicators
(This special issue belongs to the Section Ecology)
Computational Modeling of Drug Delivery
edited by and Arezoo M. Ardekani
submission deadline 25 Dec 2025 | 2 articles | Viewed by 3376 | Submission Open
Keywords: computational modeling; drug delivery; computational fluid dynamics; biofluids; quantitative biotransport; mathematical models; artificial intelligence
(This special issue belongs to the Section Biophysics)
Experimental Biology 100 Years After the Foundation of the Italian Society: A Celebratory Special Issue submission deadline 31 Dec 2025 | 15 articles | Viewed by 52622 | Submission Open
Keywords: anatomy; histology; embryology; physiology; biochemistry; cell biology; genetics; pharmacology; anthropology; cancerology; pathology; microbiology; advanced microscopy and imaging; aging; aquatic environments; artificial intelligence applied to biomedicine; biodiversity and modeling; biology of reproduction and infertility; biomedical and pharmaceutical biotechnology; cellular stress; environment and health; micro- and nanovesicles in biomedicine; neuroscience; nutrition and food supplements; plant biology; precision medicine; regenerative medicine; structural biology; urban biodiversity and climate change
Adaptation of Living Species to Environmental Stress
edited by and Sonia Del Prete
submission deadline 31 Dec 2025 | 12 articles | Viewed by 37377 | Submission Open
Keywords: adaptation; environmental stress; evolutionary response; physiological adaptation; behavioral adaptation; morphological adaptation; climate change; conservation biology; biodiversity; ecological resilience; sound waves
(This special issue belongs to the Section Ecology)
Physiology and Pathophysiology of Obesity
edited by Yifei Kang
submission deadline 31 Dec 2025 | 9 articles | Viewed by 31231 | Submission Open
Keywords: dietary intervention; alternative food; food supplementation; weight loss; weight management; obesity comorbidities; obesity pathophysiology
(This special issue belongs to the Section Physiology)
Innovative Biotechnologies for Advancing Protein Function Investigation
edited by Yongjuan Zhao, Wanhua Li and Qiwen Deng
submission deadline 31 Dec 2025 | 6 articles | Viewed by 30832 | Submission Open
Keywords: protein imaging and visualization; high-throughput screening; computational methodologies; protein engineering; protein– protein interactions; protein– ligand interactions; biological mechanisms
(This special issue belongs to the Section Biotechnology)
Advances in Wildlife Conservation and Habitat Management in the Anthropocene submission deadline 31 Dec 2025 | 12 articles | Viewed by 25691 | Submission Open
Keywords: innovative technologies; advanced monitoring techniques; habitat suitability modeling; species distribution modeling; climate change scenarios; anthropogenic; biotic; and abiotic stressors; environmental impact assessments; invasive species management; disease outbreak impacts; long-term ecological monitoring; protected area effectiveness; keystone species conservation; threatened species; adaptive conservation strategies; conservation planning; wildlife conservation; habitat management
(This special issue belongs to the Section Ecology)
Physiological, Biochemical, and Molecular Response in Plants under Light-Emitting Diode (LED) Treatment (Volume II) submission deadline 31 Dec 2025 | 9 articles | Viewed by 22092 | Submission Open
Keywords: antioxidants; bioactive compounds; biotic and abiotic stress; food quality; LED; nutrients; plant defense; plant response; productivity
(This special issue belongs to the Section Plant Science)
Nutrition, Environment, and Fish Physiology
edited by
submission deadline 31 Dec 2025 | 12 articles | Viewed by 20004 | Submission Open
Keywords: fish; physiology; nutrition; environment; effects   TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in English   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com
(This special issue belongs to the Section Marine and Freshwater Biology)
Animal Models in Toxicology
edited by
submission deadline 31 Dec 2025 | 8 articles | Viewed by 19640 | Submission Open
Keywords: animal model; biomarker of harm; pharmacokinetics; route of exposure; toxicology; toxin
(This special issue belongs to the Section Toxicology)
Immune Microenvironment and Molecular Mechanism of Glioma
edited by Carolina Cristina Jancic
submission deadline 31 Dec 2025 | 3 articles | Viewed by 17593 | Submission Open
Keywords: gliomas; tumor microenvironment; immune response; tumor evasion; tumor resistance; immunotherapy TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in Latin   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate Latin to Simplified ChinesePRO Never translate Latin Never translate admin.mdpi.com
(This special issue belongs to the Section Cancer Biology)
Molecular Mechanisms of Plant Stress Adaptation
edited by
submission deadline 31 Dec 2025 | 5 articles | Viewed by 15077 | Submission Open
Keywords: plant adaptation; environmental stress; molecular mechanism; genetic improvement; stress tolerance
(This special issue belongs to the Section Plant Science)
Recent Advances in Tumor Microenvironment Biology
edited by Hongbin Wang
submission deadline 31 Dec 2025 | 3 articles | Viewed by 12249 | Submission Open
Keywords: tumor microenvironment; immune cells’ stromal cells; extracellular matrix; angiogenesis; metabolic reprogramming; tumor-associated macrophages; tumor-infiltrating lymphocytes; cytokine signaling; therapeutic targeting strategies  
(This special issue belongs to the Section Cancer Biology)
Differential Gene Expression and Coexpression (2nd Edition) submission deadline 31 Dec 2025 | 5 articles | Viewed by 12043 | Submission Open
Keywords: inflammation; cyclooxygenase 2; microsomal prostaglandin E synthase 1; cancer; epithelial mesenchymal transition; biomarkers; immunotherapy; metabolism; myeloid and lymphoid cells
(This special issue belongs to the Section Bioinformatics)
Animal Models of Pancreatic Diseases
edited by Preeti Chhabra and Kenneth Brayman
submission deadline 31 Dec 2025 | 4 articles | Viewed by 11170 | Submission Open
Keywords: animal models; pancreatic diseases; pancreatitis; pancreatic cancer; diabetes; pathogenesis; therapeutic targets; preclinical testing
(This special issue belongs to the Section Physiology)
Advances in Aquatic Ecological Disasters and Toxicology
edited by and
submission deadline 31 Dec 2025 | 8 articles | Viewed by 8054 | Submission Open
Keywords: aquatic ecological disasters; aquatic toxicology; aquatic ecosystem; algal blooms; pollutants
Stem Cells in Neurological Disorders: Challenges and Opportunities
edited by Ying Liu and Qi Lin Cao
submission deadline 31 Dec 2025 | 3 articles | Viewed by 8010 | Submission Open
Keywords: stem cell research; neurological disorders; induced pluripotent stem cells (iPSCs); cell replacement therapy; gene editing in neurology; stem cell-derived exosomes; neuroregeneration; disease modeling; neuroprotective strategies; regenerative medicine
(This special issue belongs to the Section Neuroscience)
State of the Art in Fish Nutrition: Antimicrobials, Immunostimulants, Synbiotics and Alternative Protein Sources
edited by Jiun-Yan Loh
submission deadline 31 Dec 2025 | 3 articles | Viewed by 7693 | Submission Open
Keywords: probiotics; prebiotics; synbiotics; immunostimulants; antimicrobial peptides; alternative protein/single-cell protein sources; insect meals; aquatic species; metabolisms; disease resistances
(This special issue belongs to the Section Zoology)
Young Investigators in Biochemistry and Molecular Biology
edited by
submission deadline 31 Dec 2025 | 7 articles | Viewed by 6264 | Submission Open
Keywords: protein structure and function; DNA Methylation; apoptosis; computational biology; molecular development biology; molecular enzymology; molecular evolution; molecular immunology; molecular virology; systems biology; proteins and nucleic acids; protein trafficking; proteomics; structural and functional genomics; transcriptomics; signaling
(This special issue belongs to the Section Biochemistry and Molecular Biology)
Epibiosis in Aquatic Environments submission deadline 31 Dec 2025 | 3 articles | Viewed by 5228 | Submission Open
Keywords: conservation; biodiversity; animals; aquatic environments; marine biology; marine zoology; marine ecology; radiation biology; interspecific interactions; evolution
The Potential of Genetics and Plant Breeding in Crop Improvement submission deadline 31 Dec 2025 | 6 articles | Viewed by 5133 | Submission Open
Keywords: plants; plant signaling pathways; growth and development; genomics; transcriptomics; proteomics; metabolomics; gene transformation; molecular biology; biochemistry; molecular breeding; genome editing; CRISPR/Cas9; marker-assisted selection; genome-wide selection; crop improvement; genetic diversity; quality traits; yield; disease resistance; environmental stress; plant-microbe interactions; drought tolerance; salinity resistance; oxidative stress; phytohormone
(This special issue belongs to the Section Plant Science)
Molecular Biology of Plants
edited by
submission deadline 31 Dec 2025 | 4 articles | Viewed by 5076 | Submission Open
Keywords: transcriptome; metabolome; genome editing; genetic modification; stress resistance; yield improvement; secondary metabolites; flowering
(This special issue belongs to the Section Plant Science)
Radiation and Biology: Investigating Cellular, Organismal, and Environmental Responses submission deadline 31 Dec 2025 | 3 articles | Viewed by 4907 | Submission Open
Keywords: radiation-induced DNA damage and repair pathways; oxidative stress and redox signaling in radiation response; radiation-induced epigenetic modifications; radiation-induced immunomodulation and inflammation; radiation-induced carcinogenesis and disease susceptibility; ecological consequences of ionizing radiation
(This special issue belongs to the Section Medical Biology)
Feeding Biology and Nutrition in Insects
edited by and Christopher W. Weldon
submission deadline 31 Dec 2025 | 3 articles | Viewed by 4419 | Submission Open
Keywords: diet; digestion; ecology; evolution; feeding; insects; mass-rearing; microbiome; nutrients; taste
(This special issue belongs to the Section Ecology)
Young Researchers in Plant Sciences
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 4365 | Submission Open
Keywords: biodiversity; biogeography; biotic and abiotic stress responses; carbon sequestration; ecosystem functions; gene– function relationships; photosynthesis; phytohormones; phytoremediation; plant interactions with viruses; bacteria; fungi; plants; and animals; primary and secondary metabolism; seed development; signalling pathways; structure– function simulation modelling
(This special issue belongs to the Section Plant Science)
Unveiling Novel Gene Functions: Mechanisms, Evolution and Applications
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4327 | Submission Open
Keywords: Novel Gene Mechanisms; Molecular Pathways; Systems Biology; Moonlighting Genes; Adaptive Evolution; Synthetic Biology Applications
(This special issue belongs to the Section Genetics and Genomics)
Large Animal Experimental and Epidemiological Models for Diseases submission deadline 31 Dec 2025 | 3 articles | Viewed by 4293 | Submission Open
Keywords: large animal model; dog; pig; ruminants; experimental study; epidemiological study; infectious diseases; non-infectious diseases; treatment; disease control; disease prediction
(This special issue belongs to the Section Medical Biology)
Insecticide Resistance: Molecular Mechanisms and Ecological Implications
edited by Kaikai Mao
submission deadline 31 Dec 2025 | 1 articles | Viewed by 4052 | Submission Open
Keywords: insecticide resistance; molecular mechanism; regulatory network; ecological impact; non-target impact; resistance genes; pest resistance management
(This special issue belongs to the Section Ecology)
Arthropods as Vectors of Human and Animal Pathogens: Vector Ecology and Disease Transmission
edited by Panpim Thongsripong
submission deadline 31 Dec 2025 | 4 articles | Viewed by 3782 | Submission Open
Keywords: vector; disease ecology; vector-borne pathogens; mosquito; tick; flies; sandflies; triatomine; tsetse; fleas; mites
(This special issue belongs to the Section Infection Biology)
Sustainable Management of Aquatic Animal Health: Advances in Immunology, Pathogenesis, and Innovative Disease Control Strategies
edited by and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 3266 | Submission Open
Keywords: aquatic animal health; immunology; pathogenesis; CRISPR-based innovations; sustainable aquaculture
(This special issue belongs to the Section Immunology)
Responses and Resistance Mechanisms of Plants Under Environmental Stress
edited by
submission deadline 31 Dec 2025 | 4 articles | Viewed by 3261 | Submission Open
Keywords: disease resistance; cold tolerance; defense priming; pathogen perception
(This special issue belongs to the Section Plant Science)
Mechanisms of Genetic and Epigenetic Regulation Underlying Plant Resistance
edited by Feng Zhang, and
submission deadline 31 Dec 2025 | 5 articles | Viewed by 3231 | Submission Open
Keywords: plant biotic and abiotic stresses; multi-omics; genetic engineering; genome editing; epigenetic regulation
(This special issue belongs to the Section Plant Science)
The Application of Microorganisms and Plants in Soil Improvement submission deadline 31 Dec 2025 | 2 articles | Viewed by 2475 | Submission Open
Keywords: environmental microbiology; microbial diversity; microbial metabolism; nutrient transformation; plant growth promotion; rhizosphere effect; soil improvement
(This special issue belongs to the Section Microbiology)
Living Resources of the Deep Sea: Biological Profiles and Environmental Linkages
edited by and
submission deadline 31 Dec 2025 | 3 articles | Viewed by 2212 | Submission Open
Keywords: deep-sea fisheries; spawning-ground shifts; habitat– environment coupling; rare deep-sea biodiversity; molecular adaptation; environmental DNA (eDNA); acoustic monitoring; fishery remote-sensing
(This special issue belongs to the Section Marine and Freshwater Biology)
RNA Biology and mRNA in Diseases
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 2159 | Submission Open
Keywords: stress granule; cRISPR/Cas13; vaccine; mRNA drug; antisense oligonucleotides; RNA methylation; microRNA; long non-coding RNA; RNA binding; RNA activation; circular RNA; fluorescent RNA; cell surface RNA; cancer; neurodegenerative disease
(This special issue belongs to the Section Biochemistry and Molecular Biology)
Deciphering the Biological Activity of Natural Compounds: Metabolic Control and Health Repercussions submission deadline 31 Dec 2025 | 1 articles | Viewed by 2090 | Submission Open
Keywords: bioactive compounds; cytotoxic activity; pharmacology; enzyme inhibition; antioxidants; molecular mechanisms; anti-inflammatory activity; in vivo/vitro models; phytochemical analysis/evaluation
(This special issue belongs to the Section Plant Science)
Experimental Biology, Life Science and One Health: From Basic to Translational Research
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 2010 | Submission Open
Keywords: anatomy; histology; embryology; aquatic environment and ecosystem; biotechnology and bioengineering; cell stress; environment and health; extracellular vesicles; fight against cancer; movement and nutrition science; neuroscience; plant ecology and ecosystem; regenerative biomedicine
Research on Morphology and Sensorimotor Systems of Insect Antennae
edited by Lifeng Meng
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1442 | Submission Open
Keywords: antennae structure; sensilla; olfaction; olfactory receptors; sensory integration; antenna lobe; pheromones; predator avoidance; foraging behavior
(This special issue belongs to the Section Zoology)
Protein Kinases: Key Players in Carcinogenesis
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1366 | Submission Open
Keywords: protein kinases; carcinogenesis; molecular mechanisms; kinase inhibitors; cancer stem cells
(This special issue belongs to the Section Cancer Biology)
Pathobiology of Cardiac Arrhythmias and Heart Failure Issues
edited by Mohit Hulsurkar
submission deadline 31 Dec 2025 | 1 articles | Viewed by 871 | Submission Open
Keywords: cardiac arrhythmias; atrial fibrillation; heart failure; ion channelopathy; cardiac fibrosis; cardiomyopathy
(This special issue belongs to the Section Physiology)
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