2026 March-1 - 78 articles
Breast cancer is a leading cause of cancer-related mortality in women, necessitating new treatment strategies. Curcumin (Cur), a natural polyphenol, and gemcitabine (Gem), a standard chemotherapeutic, were investigated for their combined anticancer e...
Pigs are a major source of animal protein and an important model for studying domestication, adaptation, and the genetics of complex traits. Over the past decade, pig genomics has progressed from generating reference assemblies and variant catalogues...
Botulinum toxin (BoNT) is a highly specific molecular enzyme whose therapeutic action is based on the proteolytic cleavage of SNARE proteins, most notably SNAP-25. Despite the deterministic nature of this molecular mechanism, the clinical effects of...
The TIFY family, known as a novel group of transcription factors unique to the plant, plays a number of roles and has been functionally characterized in numerous plant species. However, TIFY proteins remain unexplored in litchi. Here, we identified 1...
Orthohalarachne attenuata and O. diminuata mites are parasites of the respiratory system of Pinnipeds. During hosts’ dives, mites must cope with changing conditions of oxygen availability in the nasal cavity. Adults and nymphs live inside the h...
This study aimed to investigate the effect and underlying mechanism of Taxus cuspidata seed oil (TCSO) on carbon tetrachloride (CCl4)-induced hepatic fibrosis in mice. A mouse model of hepatic fibrosis was established by CCl4 induction, and the model...
Climate warming is an important driver influencing soil microbial involvement in carbon cycling. To clarify the responses of carbon-fixing microorganisms in alpine lakeshore wetlands, we conducted a warming experiment using open-top chambers (OTCs) i...
The intestinal barrier undergoes profound changes with age, impacting local immunity and systemic health, yet the mechanisms coordinating immune and microbial dynamics across the lifespan remain incompletely understood. Toll-like receptor 4 (TLR4) se...
Canine monocytotropic ehrlichiosis (CME), caused by the intracellular bacterium Ehrlichia canis, is a significant tick-borne disease in dogs that requires effective vaccination strategies. This study aimed to evaluate recombinant TRP19 (rTRP19), a hi...
Climate change, together with intensifying human activities, is reshaping global plant invasion dynamics and increasingly threatening ecosystem stability and biodiversity. Cockleburs are highly invasive weeds with strong ecological plasticity and dis...
The transition from Sanger to next-generation sequencing (NGS) for HIV-1 drug resistance testing offers enhanced sensitivity but also introduces bioinformatic variability. This study evaluated four strategies: the commercial Exatype platform, the aca...
The microstructure and ultrastructure of the sperm of Japanese eel, Anguilla japonica, artificially induced with weekly injections with carp pituitary (CP) and human chorionic gonadotropin (HCG), was studied, and milt from 10 out of 20 mature fish wa...
Cold exposure may influence reproductive health through vascular changes, yet its mechanisms remain underexplored. This study aimed to investigate the impact of cold exposure on uterine blood vessels and the expression of the AMPK/PGC-1α gene a...
Cortex Lycii Radicis, a medicinal plant, has been reported to inhibit epithelial–mesenchymal transition (EMT) and exhibit anti-lung cancer properties. Our previous study identified its major compound, Kukoamine B (KuB), as an inhibitor of membr...
Molting determines survival and growth in cultured crustaceans, yet its specific regulatory mechanisms remain complex. This study integrated transcriptomics and microbiome analyses to elucidate molting regulation in crayfish (Procambarus clarkii). Cr...
Optimizing cryo-resuscitation from frozen sperm would improve access to cryopreserved rat models. In this study, the possibility of replacing intracytoplasmic sperm injection (ICSI) with in vitro fertilization (IVF) for model cryo-resuscitation from...
The vaginal microbiome (VM), a complex and dynamic microbial ecosystem, is now recognized as a central determinant of female reproductive and gynecologic health. Under homeostatic conditions, a Lactobacillus-dominant ecosystem maintains vaginal acidi...
Cardiovascular disease has become the leading cause of death worldwide, underscoring the urgent need for widespread cardiac monitoring, while the Electrocardiogram (ECG) remains the diagnostic gold standard, the complexity of its acquisition limits i...
This study provides a systematic and multidimensional evaluation of flesh quality differences between triploid (T-PZ) and allotetraploid (A-PZ) Pengze crucian carp, addressing a significant gap in genetic improvement of this economically important aq...
Postbiotics produced by beneficial bacteria are emerging as safe dietary approaches to intestinal inflammation. We evaluated intestinal bacterial metabolites (IBM), a cell-free fermented soybean extract generated by co-culturing 31 Lactobacillus/Bifi...
V. parahaemolyticus has several virulence factors, including thermostable direct hemolysin (TDH), TDH-related hemolysin (TRH), and two separate type III secretion systems (T3SSs), T3SS1 and T3SS2. T3SS1 is responsible for cytotoxicity, primarily thro...
Patients with high-risk neuroblastoma (NB) continue to have long-term survival rates below 60%, with relapse occurring in more than half of patients, likely driven by chemoresistant minimal residual disease in the bone marrow (BM-MRD). Although sever...
The greater horseshoe bat (Rhinolophus ferrumequinum), which is widely distributed across the temperate regions of China, primarily consists of two major evolutionary lineages: a northeastern (NE) lineage with a hibernation period of 6–8 months...
To decipher the molecular response mechanism of melon to saline–alkaline stress, seedlings of the melon cultivar “Xikaixin” were treated with 50 mmol·L−1 mixed solutions of NaCl and NaHCO3 at ratios of 1:1, 1:2, and 2:1...
The genus Meristotheca (Gigartinales, Solieriaceae) comprises edible red algae that are economically important food ingredients in Korea, Japan, and China. In Korea, two species, Meristotheca coacta and Meristotheca papulosa, have been identified, wi...
Rearing density influences pig productivity and welfare, but its behavioral and physio-logical effects remain unclear. This study evaluated how increasing space allowance from 0.57 to 0.97 m2/pig affects growth, agonistic behavior, and stress in grow...
COVID-19 is known to impair red blood cell (RBC) function, which may affect oxygen transport and disease progression. However, the metabolic consequences of SARS-CoV-2 infection on RBCs and how these changes relate to disease severity and sex differe...
Intravenous delivery of recombinant adeno-associated virus serotype 9 can lead to reporter activation in cell types beyond the vasculature, but the routes enabling downstream parenchymal labeling remain unclear. Here, we provide a systematic, time-re...
The identification of species complexes in freshwater snails remains challenging due to limited diagnostic morphological characters and incomplete taxonomic knowledge in many taxa. Within the family Bithyniidae, species have traditionally been classi...
Empoasca onukii severely damages tea plants as a major sap-sucking pest, leading to the increasing adoption of biopesticides as a sustainable alternative to chemical control. However, existing research has largely focused on the final lethal effects...
In response to growing global concerns about the impacts of environmental changes on marine ecosystems, scientists have increasingly turned their attention to the role of aquatic environments in shaping biodiversity. This study aimed to assess the bi...
Non-specific lipid transfer proteins (nsLTPs) play a crucial role in lipid transport across membranes, contributing to cellular integrity and structural stability. These proteins are characterized by the presence of eight conserved cysteine residues...
Disparities in root fungal endophyte (RFE) communities are well documented among plant species, yet differences among plant functional groups (PFGs) remain unclear. Given that RFE community structure is influenced by host plant abundance and species-...
The important economic traits of ruminants result from interactions between genetic background and environmental factors, but key traits such as reproductive performance, feed efficiency, disease resistance, and livestock product quality are often no...
White-flowered alfalfa (Medicago sativa L.) persisting in Qinghai–Tibet Plateau’s saline–alkali habitats provides a unique model to explore floral color polymorphism-linked ecological adaptation. We systematically compared phenotypi...
The cactus Pelecyphora chihuahuensis is endemic to northern Mexico and represents an interesting subject on the integration of classical taxonomy with modern biotechnological tools to solve conservation issues. Because of its narrow ecological range...
Fungal mastitis is rare but poses a significant problem for dairy farmers. It is often underestimated and under-researched, with most studies and treatments focusing on bacterial infections. Antibiotics are ineffective against fungi, and they exacerb...
Muscomorpha is one of the most diverse groups in Brachycera, yet its higher-level phylogenetic relationships remain controversial, primarily concerning the monophyly and placement of Syrphoidea, the position of Platypezoidea, internal relationships i...
Precise drug target discovery is pivotal to mitigating the escalating costs and high attrition rates that characterize pharmaceutical research and development. Given that traditional single-omics methods often fail to elucidate the systemic complexit...
Responses to cutaneous injury differ fundamentally across developmental stages in several mammal species. During early human gestation, when the fetus is less than 24 weeks old, wounds are capable of restoring normal tissue architecture without formi...
In the original publication [...]
Autoimmune diseases arise from complex interactions between genetic susceptibility, immune regulation, and tissue-specific inflammatory processes, yet most risk variants identified by genome-wide association studies occur in non-coding regions with p...
Gabon harbors one of Africa’s richest assemblages of non-human primates (NHPs), yet integrated national-scale evidence on their conservation status remains limited. To inform conservation strategies, we conducted the first nationwide assessment...
Locus coeruleus (LC) noradrenergic neurons project their axons to the cerebellar cortex and modulate cerebellar circuit function via distinct adrenergic receptor (AR) subtypes. The present study investigated the mechanism by which optogenetic activat...
Among various ethanologenic microorganisms, thermotolerant Zymomonas mobilis has emerged as a promising candidate for industrial ethanol production at elevated temperatures. However, the comparative fermentation efficiency and the underlying molecula...
Microbial volatile organic compounds (VOCs) mediate rhizosphere plant-microbe interactions, yet their integrated effects on plant microbiome assembly and host transcriptional regulation remain unresolved. Here we address this gap by investigating how...
Exposure to fluoride is strongly associated with impaired intestinal function. Probiotics are widely regarded as an effective strategy to maintain microbial homeostasis and to mitigate the progression of fluoride-induced intestinal injury. This study...
Autoimmune hepatitis (AIH) is an inflammatory liver disease characterised by immune-mediated hepatic injury, often leading to liver failure. The underlying molecular mechanisms of AIH remain poorly elucidated, hindering diagnostic and therapeutic adv...
Snow leopards (Panthera uncia) are a flagship species for global biodiversity conservation, and their effective protection relies on accurate habitat assessment. This study focused on the Chengdu section of the Giant Panda National Park (Pengzhou, Du...
This study focused on optimizing endoglucanase production using a peculiar fungal co-culture comprising Rhizopus arrhizus and Aspergillus fumigatus, identified through morphological and 18S rDNA analyses. The co-culture achieved the highest enzyme pr...
of 2
