2026 June - 50 articles
Copper ions (Cu2+) and intracellular biothiols are tightly coupled in cellular redox regulation, where copper–thiol coordination governs oxidative stress and metal homeostasis. However, analytical platforms capable of sequentially monitoring Cu...
Molecularly imprinted polymers (MIPs) offer robust, cost-effective, and highly selective alternatives to fragile biological receptors. Specifically, electropolymerization has emerged as a versatile strategy that enables the precise, in situ formation...
Alzheimer’s disease (AD) has become a neurodegenerative disease with an increasing incidence rate and a large economic and social burden worldwide. Amyloid-beta oligomer (AβO) has been confirmed as a key neurotoxic species and a core diagn...
Epilepsy can be effectively controlled with appropriately selected antiepileptic drugs and carefully titrated dosage regimens. Although lamotrigine exhibits favorable pharmacokinetic properties following oral administration, fluctuations in plasma co...
The development of new technologies enabling rapid, frequent, and reagent-free monitoring of kidney function is recognized as being of paramount importance. In this work, mid-(MIR) and near-infrared (NIR) spectroscopy were compared for the prediction...
Surface-enhanced Raman scattering (SERS) offers a powerful route for biomolecular detection because it combines molecular specificity with high sensitivity, rapid optical readout, and multiplexing capability. In real biological samples, however, anal...
Human saliva is a heterogeneous bodily fluid with a complex composition, which contains antibodies, proteins, and viruses, making it applicable in clinical diagnosis. There are several advantages of the analysis of saliva samples over other biofluids...
Wearable healthcare technologies are transforming the healthcare landscape by enabling remote, real-time health data collection, supporting early diagnosis, personalizing treatment plans, and reducing healthcare costs and medical burdens. Central to...
4-Chlorophenoxyacetic acid (4-CPA), a synthetic auxin analog, is employed in agriculture both as a plant growth regulator and as a constituent of herbicide formulations. Consequently, the establishment of simple and rapid detection methods is essenti...
Chemical contaminants in food pose a serious threat to public health, driving the need for sensitive, rapid, and on-site screening methods. Lateral flow immunoassay (LFIA) is rapid and portable but suffers from single-signal readout and insufficient...
Genetically encoded biosensors are now central tools, deployed either as intracellular reporters to advance basic research, or as whole-cell reagents that detect analytes in diverse sample-types. Across the diversity of molecular scaffolds and modes...
Food allergies are one of the most critical food safety issues, with epidemiological studies confirming a global increase. In this context, effective and sensitive analytical methods play a crucial role in ensuring allergen-free food products. To fac...
Phenylephrine is a widely used α1-adrenergic agonist employed as a decongestant and vasoconstrictor in numerous pharmaceutical formulations. Considering its widespread use and its relevance in biological monitoring and anti-doping control, the...
Optically Pumped Magnetometers (OPMs) have emerged as a promising technology for developing flexible, wearable magnetoencephalography (OPM-MEG) systems, offering high spatiotemporal resolution without the need for cryogenic cooling. However, their ap...
Acid phosphatase (ACP) is a clinically important enzyme whose early-stage detection is hindered by its extremely low abundance, nonspecific tissue distribution, and rapid loss of activity under conventional analytical conditions. Herein, we present a...
Chronic diseases such as cardiovascular disorders, diabetes, neurological conditions, and kidney disease continue to rise worldwide. These conditions create a growing demand for continuous, non-invasive, and personalized health monitoring technologie...
Traditional solid-contact ion-selective electrodes (SC-ISEs) are severely constrained by a long-standing thermodynamic bottleneck, which requires hours of pre-conditioning and stabilization to establish a stable phase-boundary potential. To fundament...
Early detection of dental caries remains a significant clinical challenge, as conventional diagnostic methods lack sensitivity for incipient lesions. Raman spectroscopy offers high chemical specificity for enamel characterization; however, clinical t...
As the primary peripheral relay station for vibrissal tactile information, the trigeminal ganglion (TG) features heterogeneous three-dimensional (3D) cytoarchitecture that eludes full characterization using conventional two-dimensional methodologies....
Surface plasmon resonance (SPR) is a key tool for quantifying biomolecular interactions, and its use in studying interacting components outside cellular systems is well-established. Over the past 20–25 years, cell-based SPR techniques have emer...
Single-molecule Förster resonance energy transfer (smFRET) enables direct measurement of nanoscale conformational dynamics and heterogeneity in biomolecules, but quantitative interpretation of smFRET data critically depends on well-controlled ex...
One of the major obstacles in early cancer detection in dogs is the limited sensitivity in detecting circulating tumor DNAs (ctDNAs) with low abundances. Standard next-generation sequencing (NGS) without error correction typically achieves detection...
Mycotoxins are toxic secondary metabolites produced by filamentous fungi, which extensively contaminate agricultural products such as grains and nuts. Common mycotoxins, including aflatoxin B1, ochratoxin A, and deoxynivalenol, can induce liver cance...
Biosensors are analytical devices that integrate a biological or synthetic recognition element (e [...]
Nanobiosensors, with their unique physicochemical properties, are transformative tools for diagnosing and monitoring neurodegenerative diseases and mental disorders. This article systematically reviews the latest progress of nanomaterial systems and...
Electrocardiogram (ECG) analysis is a cornerstone non-invasive diagnostic technique for detecting cardiac arrhythmias, which remain a leading cause of mortality worldwide. While recent advances in deep learning have significantly improved automated a...
Food safety problems caused by pesticide residues, heavy metals, foodborne pathogens, mycotoxins and other hazards seriously threaten public health. Traditional detection methods have the limitations of cumbersome operation, high cost and poor stabil...
Celiac patients require strict avoidance of gliadin, the primary immunotoxic component of gluten, making sensitive detection essential for food safety. A label-free and reagentless capacitive aptasensor for gliadin detection was developed using an am...
ADHD is typically assessed through reports from parents, teachers, or clinicians, but these reports may not fully capture how motor behavior is organized at the signal level. This cross-sectional study examined whether X-axis acceleration features de...
Ultraviolet (UV) light is emerging as an important tool for biosensing, biomedical signal readout, and dose monitoring because of its strong and selective interactions with nucleic acids, proteins, and other biological components. This review summari...
Herbal medicines represent a significant global market, yet food safety remains threatened by counterfeit products morphologically resembling authentic samples. Models trained on limited datasets are prone to shortcut learning, relying on superficial...
The contamination by foodborne pathogens posed a significant health threat and huge economic burden. Traditional detection methods were limited by cumbersome and time-consuming procedures, low automation, and reliance on expensive instrumentation, ma...
This study investigates the fabrication of laser-scribed graphene (LSG) electrodes on polyimide substrates using a CO2 laser cutter for label-free L-Histidine detection in artificial sweat. Two-level full factorial and central composite designs were...
This review examines recent advances in multifunctional probes that integrate optical and electrochemical channels for in vitro/in vivo studies. Integration of electrodes with optical fibers provides a powerful platform for localized light delivery a...
Sweat contains abundant ions, offering a rich source of physiological information for non-invasive health monitoring. Wearable sweat sensors have become a promising technology due to advances in electrochemical devices, sensing materials and structur...
The authentication of fish maw is of considerable importance for preventing product substitution and protecting market confidence in high-value aquatic foods. This study developed a rapid and nondestructive authentication strategy by combining hypers...
Magnetic sensors offer a physically grounded and non-invasive approach to probing biological processes that remain inaccessible to optical, electrochemical, and radio-frequency techniques in complex agricultural environments. In recent years, advance...
Vitamin D3 is an essential fat-soluble vitamin for the human body. Its metabolite, 25-hydroxyvitamin D3 (25(OH)D3), serves as the primary biomarker to assess vitamin D levels. The monitoring of 25(OH)D3 concentration is crucial for human health asses...
Protein biomarkers can be used for monitoring the occurrence and development of diseases. Accurate, sensitive, and low-cost methods for protein detection can facilitate therapeutic intervention, improve clinical outcome, and reduce economic pressure...
Acute respiratory diseases caused by viral pathogens such as Influenza A continue to represent a major global health challenge, emphasizing the need for rapid, sensitive, and accessible diagnostic tools. In this work, a carbon screen-printed electrod...
This study compares the performance of novel fluorescent nanobiosensors and liquid chromatography–mass spectrometry (LC-MS) for detecting organophosphorus pesticide residues in Angelica sinensis. Key parameters such as recovery rate and relativ...
Early and reliable identification of cardiac disorders from Phonocardiogram (PCG) signals acquired from wearable biosensors is critical to support clinical decision making and reduce subjectivity in auscultation-based assessments. This study proposes...
Background: The growing demand for versatile laboratory automation is exemplified in the context of liquid biopsy, where multi-analyte approaches are increasingly recognised for their potential to enhance diagnostic sensitivity in oncology. However,...
We present an optimized method for producing semiconducting polymer dots using a water–ethanol mixed antisolvent during nanoprecipitation. Compared to conventional Pdots made with pure water as the antisolvent, these newly produced Pdots exhibi...
Diabetic chronic wounds, characterized by persistent inflammation and a complex microenvironment, pose a major challenge to global healthcare. Traditional dressings act merely as passive physical barriers, lacking the ability to sense biochemical flu...
Advances in wearable device and sensor technologies progressively shift respiratory monitoring from the clinical setting to real-world conditions. This rapidly developing field allows for more accurate diagnostics. However, reliable monitoring during...
Brain-on-a-chip (BOC) refers to a miniaturized in vitro platform that integrates living neuronal networks on a micro-engineered chip, enabling the simulation of brain functions, neural activities and physiological responses. BOC technology is an adva...
Two-dimensional-material-based FET biosensors have gained attention for being label-free and having ultra-sensitive detection capability. The high carrier mobility and large surface-to-volume ratio of 2D materials enable low detection limits under bu...
Sensors are an established driver of diagnostics and prevention in the medical field, including orthopaedics. Today, the subclass of ion-selective sensors (ISSs) is on the leading edge due to its advantages, enabled by technological advancements in m...
Magnetic polymeric microspheres are pivotal solid-phase carriers in chemiluminescence enzyme immunoassays (CLEIA). However, their practical clinical application is frequently hindered by non-specific adsorption, irreversible aggregation, and the intr...
