Surface Plasmon Resonance-Based Biosensors and Their Applications
A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 2376
Special Issue Editor
Special Issue Information
Dear Colleagues,
Surface plasmon resonance (SPR) refers to the quasi-particles of the collective oscillation of electrons and photons (electromagnetic waves) at metal–dielectric interfaces. SPR produces intense localized electromagnetic fields, leading to superior detection sensitivity. Various SPR-based methods have been shown to be information-rich tools for analyzing biological materials, with some offering exceedingly high sensitivity at the single-molecule level, and others enabling label-free, non-destructive, and in situ observation of various biological processes. SPR has also been shown to immobilize suspended entities such as biomolecules, akin in its underlying physics to the well-known optical tweezers.
Significant advances have been made over the past several decades in biomedical diagnostics, drug discovery, food safety, environmental monitoring, and beyond. Of special interest is subjects such as sensitivity beyond current detection limits to include subtleties such as secondary and tertiary conformational differences in proteins, the challenge of single-molecule/single-vesicle detection with sufficiently high throughput to ensure statistical significance, and the fundamental trade-offs between the ability to observe biological processes in situ at the single-molecule level (such as protein–protein interactions) and the unavoidable disturbance to the object under observation (such as denaturing proteins).
This Special Issue aims to provide a communication platform for researchers and technologists in this promising sub-field of research straddling biology, physics, and engineering, and to serve as a repository of information on the pertinent aspects of engineering and technology development, as well as cases of successful (or not so successful) applications. Ultimately, we hope to foster interdisciplinary collaboration and drive forward the continued growth of this exciting and bourgeoning field.
Prof. Dr. Ya-Hong Xie
Guest Editor
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Keywords
- surface plasmon resonance
- nano-structures
- biosensing
- drug discovery
- food safety
- environmental monitoring
- biomarker discovery
- diagnostic
- proteomics
- single-molecule detection
- machine learning
- protein folding
- label-free
- plasmonic tweezers
- sensitivity
- specificity
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