Research Progress of Nanomaterial-Mediated Biosensors: From Fabrication to Signal Amplification
A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor Materials".
Deadline for manuscript submissions: 31 December 2026 | Viewed by 137
Special Issue Editor
Special Issue Information
Dear Colleagues,
Nanomaterial-mediated biosensors are reshaping how chemical and biological information is captured, converted, and amplified into measurable signals. By engineering materials at the nanoscale (0D/1D/2D/3D nanostructures; porous and hybrid composites; plasmonic, catalytic, and semiconducting architectures), researchers can simultaneously tailor surface chemistry, charge/energy transport, and analyte–interface interactions, often achieving performance that is difficult to reach with conventional bulk materials. This Special Issue, “Research Progress of Nanomaterial-Mediated Biosensors: From Fabrication to Signal Amplification,” focuses on the full pipeline from materials/device fabrication to signal transduction and amplification strategies. We welcome contributions on scalable synthesis and patterning, interface functionalization (bioreceptors, antifouling layers, and molecular recognition motifs), device integration (microfluidics, flexible/wearable platforms, and paper-based formats), and multimodal readouts (electrochemical, photoelectrochemical, FET-based, optical/fluorescent, plasmonic/SERS, piezoelectric, and hybrid schemes).
A key emphasis is on signal amplification, including nanozyme- and catalyst-enabled cascades, plasmonic “hot-spot” engineering, redox cycling and nanostructured electrodes, DNA/aptamer nanotechnology, CRISPR-enabled detection, and integrated preconcentration/clean-up for complex samples. In addition to nanomaterials, this Special Issue explicitly includes small-molecule and dye-based colorimetric biosensors (e.g., indicator displacement assays, chromogenic/fluorogenic probes, nanoparticle aggregation colorimetry, and smartphone-assisted color analysis) that translate molecular events into rapid, instrument–light diagnostics. Submissions may include original research, critical reviews, and perspectives addressing analytical figures of merit, real-sample validation, reproducibility/standardization, and translation toward practical biosensing systems in healthcare, environmental monitoring, food safety, and industrial/process analytics.
Dr. Kshitij RB Singh
Guest Editor
Manuscript Submission Information
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Keywords
- nanomaterial-mediated biosensors
- signal amplification
- colorimetric biosensing (dye-based probes)
- electrochemical biosensors/impedimetric biosensing
- plasmonic biosensors and SERS
- nanozymes/catalytic amplification
- 2D materials (graphene, MXenes)
- flexible and wearable biosensors
- point-of-care diagnostaics/paper-based devices
- microfluidics-integrated sensing
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