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Biosensors
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Advanced Electrochemical Biosensing: Materials, Mechanisms, and Applications
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Advanced Electrochemical Biosensing: Materials, Mechanisms, and Applications

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor Materials".

Deadline for manuscript submissions: 15 May 2026 | Viewed by 3245

Special Issue Editors

Prof. Dr. Dan Wu

E-Mail Website
Guest Editor
School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China
Interests: biosensors; energy catalysis; electrochemical analysis
Dr. Beibei Wang

E-Mail Website
Guest Editor
School of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476005, China
Interests: electrochemiluminescence; porphyrins and their derivatives; biosensing analysis; food analysis; environ-mental analysis
Dr. Yu Du

E-Mail Website
Guest Editor
School of Water Conservancy and Environment, University of Jinan, Jinan 250022, China
Interests: electrochemical biosensing; chemical sensing; environmental analysis
Prof. Dr. Qin Wei

E-Mail Website
Guest Editor
School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China
Interests: chemical and biosensing technologies; scientific instrument development; environmental remediation; the study of new energy materials and their catalytic applications
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues

In recent years, advanced photoelectrochemical (PEC), electrochemiluminescence (ECL), and electrochemical (EC) technologies have made significant strides in enabling highly sensitive and selective detection across a wide range of applications. These emerging approaches hold great promise for tackling global challenges such as food safety, environmental pollution, and early disease diagnosis.

This Special Issue highlights recent advances in the design, synthesis, and application of novel materials and sensing platforms based on PEC, ECL, and EC techniques. Particular emphasis is placed on innovative strategies and multifunctional sensing systems for the rapid, accurate, and cost-effective detection of food contaminants (e.g., pesticides, antibiotics, and additives), environmental pollutants (e.g., heavy metals and endocrine-disrupting chemicals), and clinically relevant tumor biomarkers.

We welcome original research articles, reviews, and short communications that contribute to the understanding and development of these interdisciplinary sensing technologies. Submissions may cover, but are not limited to, the following topics:

  • Photoelectrochemical sensors.
  • Electrochemiluminescence sensors.
  • Electrochemical sensors.
  • Ratiometric, multi-channel, or visual sensor platforms.
  • Porous materials (e.g., MOFs, COFs, and metal nanomaterials) in sensing applications.
  • Signal amplification and conversion strategies.
  • Portable and point-of-care detection systems.
  • Sensing applications in food safety, environmental monitoring, and biomedical diagnostics.

The goal of this Special Issue is to bring together cutting-edge research and foster cross-disciplinary collaboration between material scientists, chemists, biotechnologists, and environmental/biomedical engineers to advance real-world sensing solutions.

Prof. Dr. Dan Wu
Dr. Beibei Wang
Dr. Yu Du
Prof. Dr. Qin Wei
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • photoelectrochemical
  • electrochemiluminescence
  • electrochemistry
  • sensors
  • food safety
  • environmental monitoring
  • tumor biomarker detection

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (4 papers)

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Research

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15 pages, 6196 KB  
Article
Fabrication of Co-Doped Covalent Organic Framework Nanosheets with Mild Interlayer Stress for Quantitative Detection of Alzheimer’s Disease Biomarkers
by Yubing Lv, Yanli Zhou, Zi Liu, Hui Dong, Hejie Zheng, Sihan Cheng, Xu Wang, Chaoran Lv and Maotian Xu
Biosensors 2026, 16(5), 271; https://doi.org/10.3390/bios16050271 - 8 May 2026
Viewed by 275
Abstract
Alzheimer’s disease (AD) seriously affects human health worldwide. Nicotinamide adenine dinucleotide (NADH) and glutamate are important biomarkers of AD, which play an indispensable role in the pathogenesis of AD. Herein, two ligands were used to synthesize a layered covalent organic framework (TPCOF) via [...] Read more.
Alzheimer’s disease (AD) seriously affects human health worldwide. Nicotinamide adenine dinucleotide (NADH) and glutamate are important biomarkers of AD, which play an indispensable role in the pathogenesis of AD. Herein, two ligands were used to synthesize a layered covalent organic framework (TPCOF) via amide bond formation, which was loaded with cobalt to obtain Co-TPCOF. TPCOF has a twisted 2D layered structure, along with large interlayer spacing and porosity, enabling precise Co coordination and stable loading of metal nanoparticles/enzymes to support electrocatalysis. A Co-TPCOF was immobilized on a screen-printed electrode (SPE) to catalyze the oxidation of NADH. After that, the oxidation product NAD+ of NADH and the NAD+-dependent dehydrogenase immobilized on the electrode jointly catalyzed the glutamate in the solution. COFs’ unique structures endow Co-TPCOFs with excellent NADH catalytic activity. The Co-TPCOF/SPE showed good linearity for NADH (10 nM-5 mM, LOD 7.07 nM) and GDH/Co-TPCOF/SPE for glutamate (50 μM-5 mM, LOD 3.74 μM). The biosensor can sensitively detect trace NADH and glutamate in human serum, providing an adequate technical means and theoretical reference for the pathological research of AD. Full article
(This article belongs to the Special Issue Advanced Electrochemical Biosensing: Materials, Mechanisms, and Applications)
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17 pages, 1867 KB  
Article
Synergistic PdMoCu Trimetallic Metallene-Enhanced Electrochemiluminescence Biosensor for Ultrasensitive Detection of Microcystin-LR
by Xiaochen Yang, Linsheng Wang, Jing Tu, Yanlei Li, Lun Yang and Zhongfeng Gao
Biosensors 2026, 16(5), 264; https://doi.org/10.3390/bios16050264 - 2 May 2026
Viewed by 637
Abstract
The development of highly sensitive and reliable strategies for microcystin-LR (MC-LR) monitoring remains critical for environmental safety and public health protection. Herein, we report a metallene-enabled electrochemiluminescence (ECL) biosensing platform based on ultrathin PdMoCu trimetallic metallenes for femtogram-level MC-LR detection. The two-dimensional PdMoCu [...] Read more.
The development of highly sensitive and reliable strategies for microcystin-LR (MC-LR) monitoring remains critical for environmental safety and public health protection. Herein, we report a metallene-enabled electrochemiluminescence (ECL) biosensing platform based on ultrathin PdMoCu trimetallic metallenes for femtogram-level MC-LR detection. The two-dimensional PdMoCu metallenes provide abundant active sites and accelerated interfacial charge-transfer kinetics through synergistic electronic modulation among Pd, Mo, and Cu atoms, significantly enhancing the Ru(bpy)32+/TPrA ECL efficiency. By integrating a programmable H1–aptamer duplex interface, electrostatic enrichment of Ru(bpy)32+ was achieved, enabling target-responsive luminophore release via aptamer-triggered structural switching. This cooperative amplification mechanism, combining catalytic acceleration and DNA-mediated signal modulation, results in a sensitive signal-off detection mode. Under optimized conditions, the biosensor exhibited a wide linear response from 0.1 pg mL−1 to 50 ng mL−1 with a detection limit as low as 37 fg mL−1. The platform demonstrated excellent selectivity against structural analogues, high reproducibility, and satisfactory recovery (99.3–102.0%) in real tap water samples. This work not only highlights the catalytic potential of trimetallic metallenes in ECL systems but also establishes a generalizable interfacial engineering strategy for ultrasensitive detection of trace environmental contaminants. Full article
(This article belongs to the Special Issue Advanced Electrochemical Biosensing: Materials, Mechanisms, and Applications)
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17 pages, 1840 KB  
Article
Novel Electrochemical Sensing Strategy for Organophosphorus Pesticide Residues
by Mingzhuo Xu, Chen He, Jiajing Zhang, Hao Yang and Xiuzhong Wang
Biosensors 2026, 16(4), 208; https://doi.org/10.3390/bios16040208 - 7 Apr 2026
Viewed by 538
Abstract
Organophosphorus pesticide residues (OPPs) pose significant threats to ecological systems and human health, and conventional detection techniques are cumbersome, time-consuming, and costly. Herein, a facile electrochemical biosensor has been constructed based on a methyl green/chitosan (MG/Chi) composite membrane-modified electrode for the selective detection [...] Read more.
Organophosphorus pesticide residues (OPPs) pose significant threats to ecological systems and human health, and conventional detection techniques are cumbersome, time-consuming, and costly. Herein, a facile electrochemical biosensor has been constructed based on a methyl green/chitosan (MG/Chi) composite membrane-modified electrode for the selective detection of OPPs, using isazofos (Isa) as the model analyte. Experimental results demonstrated that Isa significantly decreases the redox peak current of the modified electrode in buffer solution, and a good linear relationship was observed between the change in peak current and Isa concentration within a specific range. This biosensor exhibits excellent anti-interference capability and high sensitivity, with a limit of detection (LOD) as low as 0.60 μM. Furthermore, it was successfully applied for the quantitative determination of OPPs in real food and environmental samples, which confirms its reliable practical applicability and potential for on-site monitoring. Full article
(This article belongs to the Special Issue Advanced Electrochemical Biosensing: Materials, Mechanisms, and Applications)
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Review

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26 pages, 3049 KB  
Review
Progress in Electrode Modifiers for Nitrite Electrochemical Sensing Applications
by Mohammad Aslam, Saood Ali, Khaled Hamdy, Danishuddin, Khursheed Ahmad and Rohit Kumar Singh Gautam
Biosensors 2025, 15(12), 783; https://doi.org/10.3390/bios15120783 - 27 Nov 2025
Cited by 3 | Viewed by 1313
Abstract
It is well known that nitrite is widely used in industrial and agricultural sectors as a preservative, corrosion inhibitor, and intermediate in chemical synthesis; consequently, nitrite residues are often present in food, water, and the environment as a result of meat curing, fertilizer [...] Read more.
It is well known that nitrite is widely used in industrial and agricultural sectors as a preservative, corrosion inhibitor, and intermediate in chemical synthesis; consequently, nitrite residues are often present in food, water, and the environment as a result of meat curing, fertilizer use, and wastewater discharge. Despite having several applications, nitrite exerts toxic effects on human beings and aquatic life. Therefore, the monitoring of nitrite is of particular significance to avoid negative impacts on human health, the environment, and aquatic life. Previously, the electrochemical method has been extensively used for the development of nitrite sensors using various advanced electrode materials. Additionally, zinc oxide (ZnO), cerium oxide (CeO2), titanium dioxide (TiO2), copper oxide (CuO), iron oxides, nickel oxide (NiO), polymers, MXenes, reduced graphene oxide (rGO), carbon nanotubes (CNTs), graphitic carbon nitride (gCN), metal–organic frameworks (MOFs), and other composites have been utilized as electrocatalysts for the fabrication of nitrite electrochemical sensors. This review article provides an overview of the construction of nitrite sensors using advanced electrode materials. The electrochemical activities of the reported nitrite sensors are discussed. Furthermore, limitations and future perspectives regarding the determination of nitrite are discussed. Full article
(This article belongs to the Special Issue Advanced Electrochemical Biosensing: Materials, Mechanisms, and Applications)
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