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Biosensors
Special Issues
Wearable Sensors and Systems for Continuous Health Monitoring
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Wearable Sensors and Systems for Continuous Health Monitoring

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Wearable Biosensors".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 1743

Special Issue Editors

Dr. Shuang Huang

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Guest Editor
Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Biomedical Engineering, Sun Yat-sen University, Shenzhen 518107, China
Interests: electrochemistry; wearable
Dr. Yeyun Cai

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Guest Editor
State Key Laboratory of Autonomous Intelligent Unmanned Systems, Beiing Institute of Technology, Beiing, China
Interests: wearable devices and intelligent algorithms
Dr. Qiangqiang Ouyang

E-Mail Website
Guest Editor
College of Electronic Engineering, South China Agricultural University, Guangzhou 510642, China
Interests: tactile sensors; medical robots

Special Issue Information

Dear Colleagues,

Early monitoring of human health status is critical for improving treatment outcomes and has, therefore, garnered increasing attention from both academia and industry. To provide researchers and readers with timely insights into this rapidly advancing field, this Special Issue focuses on recent progress in wearable health-monitoring devices. Such devices enable continuous, minimally or non-invasive, and user-friendly assessment of physiological and pathological states, holding great promise for personalized healthcare and disease prevention.

The scope of this Special Issue encompasses a wide spectrum of wearable monitoring approaches, including, but not limited to, the following: biochemical detection of disease biomarkers, intelligent disease diagnosis, electrophysiological signal recording, blood-pressure and cardiovascular monitoring, motion and activity tracking, as well as self-powered wearable systems that integrate energy harvesting with sensing and processing functions. We encourage submissions that report innovative device architectures, novel materials and fabrication methods, system integration, data analytics, intelligent algorithms, and practical demonstrations of reliable long-term monitoring. Both original research articles and comprehensive reviews that highlight emerging concepts and future directions are welcome.

Dr. Shuang Huang
Dr. Yeyun Cai
Dr. Qiangqiang Ouyang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • wearable sensors
  • health monitoring
  • disease biomarkers
  • electrophysiological signals
  • blood pressure and cardiovascular monitoring
  • motion and activity tracking
  • personalized healthcare

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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32 pages, 6343 KB  
Article
Transcriptomic Evaluation of Hollow Microneedles-Mediated Drug Delivery for Rheumatoid Arthritis Therapy
by Zhibo Liu, Xiaotong Li, Suhang Liu, Yijing Cai, Xingyuan Xu, Siqi Gao, Chuanjie Yao, Linge Wang, Xi Xie, Yanbin Cai, Lelun Jiang, Jing Liu, Mingqiang Li, Yan Li, Xinshuo Huang and Huijiuan Chen
Biosensors 2025, 15(12), 782; https://doi.org/10.3390/bios15120782 - 27 Nov 2025
Viewed by 451
Abstract
Microneedle array-based drug delivery offers a minimally invasive and safe approach for breaching the skin barrier, enabling localized and targeted treatment—an advantage particularly valuable in chronic condition management, such as rheumatoid arthritis (RA). RA presents a multifaceted pathophysiology, often necessitating long-term pharmacological management. [...] Read more.
Microneedle array-based drug delivery offers a minimally invasive and safe approach for breaching the skin barrier, enabling localized and targeted treatment—an advantage particularly valuable in chronic condition management, such as rheumatoid arthritis (RA). RA presents a multifaceted pathophysiology, often necessitating long-term pharmacological management. However, conventional oral administration may lead to systemic drug distribution, increasing the likelihood of adverse effects, and ultimately undermining therapeutic efficacy. In this study, a hollow microneedle array was employed for effective delivery of Tofacitinib and the antioxidant N-acetylcysteine (NAC). A comprehensive evaluation was conducted across multiple levels, in which inflammation and cartilage degradation were assessed histologically using hematoxylin-eosin (H&E) and Safranin O–Fast Green staining. Radiologically, micro-computed tomography (micro-CT) was employed to visualize bone structure alterations. On the molecular level, enzyme-linked immunosorbent assay (ELISA) was used to quantify inflammatory cytokines and oxidative stress markers. Furthermore, differentially expressed genes and enriched signaling pathways were identified through transcriptomic profiling pre- and post-treatment. And the potential regulatory targets and mechanistic insights into the therapeutic response were elucidated through correlation analyses between gene expression profiles and pathological indicators. This study provides a mechanistic and computational basis for precision targeted therapy, validates the efficacy and safety of microneedle delivery in a rheumatoid arthritis (RA) model, and demonstrates its potential application in local drug delivery strategies. Full article
(This article belongs to the Special Issue Wearable Sensors and Systems for Continuous Health Monitoring)
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Review

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32 pages, 9289 KB  
Review
Wearable Electrochemical Biosensors for Monitoring and Management of Chronic Wounds
by Lingxia Zuo, Yinbing Liu, Jianrong Zhang, Linlin Wang and Jun-Jie Zhu
Biosensors 2025, 15(12), 785; https://doi.org/10.3390/bios15120785 - 1 Dec 2025
Viewed by 1080
Abstract
Chronic wounds constitute a major global public health challenge, characterized by a high risk of infection, prolonged healing times, and frequent recurrence. Conventional wound assessment methods, which primarily rely on visual clinical inspection and laboratory-based analyses, are limited by inherent subjectivity, delayed feedback, [...] Read more.
Chronic wounds constitute a major global public health challenge, characterized by a high risk of infection, prolonged healing times, and frequent recurrence. Conventional wound assessment methods, which primarily rely on visual clinical inspection and laboratory-based analyses, are limited by inherent subjectivity, delayed feedback, and a lack of capacity for real-time monitoring of the dynamic biochemical changes at the wound site. Significantly, recent advancements in flexible electronics, nanomaterials, and energy harvesting technologies have boosted the rapid development of wearable electrochemical biosensors. These devices have emerged as a transformative platform for the continuous, non-invasive analysis of critical biomarkers within the wound microenvironment, including pH, temperature, inflammatory cytokines, metabolites, and pathogen-derived molecules. This review critically examines the latest progress in wearable electrochemical biosensors for wound monitoring and management. Key discussions include (1) the special requirements for sensor design, targeting the chronic wound’s pathological characteristics; (2) cutting-edge development in self-powered systems, multimodal sensor integration, closed-loop theranostics, and artificial intelligence (AI)-assisted decision-making; and (3) a critical appraisal of challenges in accuracy, stability, biocompatibility, energy management, and clinical translation. Finally, the review explores future trends, such as biodegradable sensors, multi-parameter fusion algorithms, and remote intelligent management systems, with the aim of establishing a foundational framework and providing technical guidance for developing next-generation intelligent wound care solutions. Full article
(This article belongs to the Special Issue Wearable Sensors and Systems for Continuous Health Monitoring)
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