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Journal of Clinical Medicine, Volume 7, Issue 11

2018 November - 86 articles

Cover Story: The liver transplantation following donation after cardiac death (DCD) has been receded by the high risks of dispiriting outcomes like biliary complications, hepatic artery thrombosis and primary nonfunction. The reasons behind increased susceptibility to DCD livers are lucid, however, plausible explanations suggest that the microthrombi formation and disruption of biliary ductal microcirculation secondary to obligatory acirculatory phase. The administration of a thrombolytic agent (thrombolytic flush), tissue plasminogen activator (tPA), into the hepatic artery prior to reperfusion dissolve any potential microthrombi in the biliary microcirculation and thereby mitigate the occurrence of these complications. However, the implications of this novel concept in the liver transplantation following DCD livers are yet to be fully explored. View this paper.
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Articles (86)

  • Article
  • Open Access
21 Citations
3,701 Views
9 Pages

Is It Possible to Maintain High Compliance with the Enhanced Recovery after Surgery (ERAS) Protocol?—A Cohort Study of 400 Consecutive Colorectal Cancer Patients

  • Magdalena Pisarska,
  • Natalia Gajewska,
  • Piotr Małczak,
  • Michał Wysocki,
  • Piotr Major,
  • Katarzyna Milian-Ciesielska,
  • Andrzej Budzyński and
  • Michał Pędziwiatr

4 November 2018

The aim of our study was to evaluate the implementation and degree of adherence to the Enhanced Recovery after Surgery (ERAS) protocol in a group of 400 patients operated laparoscopically for colorectal cancer, and to assess its impact on the short-t...

(This article belongs to the Section Oncology)
  • Article
  • Open Access
10 Citations
3,997 Views
10 Pages

Moderating Effect of Insulin Resistance on the Relationship between Gray Matter Volumes and Cognitive Function

  • Jiyeon Lee,
  • Jihyeon Kim,
  • Seong A Shin,
  • Soowon Park,
  • Dong Hyun Yoon,
  • Hongrae Kim,
  • Yu Kyeong Kim,
  • Min Kyong Moon,
  • Bo Kyung Koo and
  • Jun-Young Lee

4 November 2018

Background: It is controversial whether exposure to insulin resistance accelerates cognitive deterioration. The present study aimed to investigate the association between insulin resistance and gray matter volume loss to predict the cognitive decline...

(This article belongs to the Special Issue Mild Cognitive Impairment)
  • Article
  • Open Access
60 Citations
8,027 Views
11 Pages

Self-Efficacy of People with Chronic Conditions: A Qualitative Directed Content Analysis

  • Fatemeh Ebrahimi Belil,
  • Fatemeh Alhani,
  • Abbas Ebadi and
  • Anooshirvan Kazemnejad

3 November 2018

Background: Given the increasing prevalence of chronic illnesses and their complications, supporting and empowering chronically ill patients seems crucial. Self-efficacy is considered as a predictor for empowerment. The purpose of this study to explo...

(This article belongs to the Section Epidemiology & Public Health)
  • Review
  • Open Access
28 Citations
4,007 Views
7 Pages

Oxidative Stress and Cardiovascular-Renal Damage in Fabry Disease: Is There Room for a Pathophysiological Involvement?

  • Verdiana Ravarotto,
  • Francesca Simioni,
  • Gianni Carraro,
  • Giovanni Bertoldi,
  • Elisa Pagnin and
  • Lorenzo A. Calò

2 November 2018

Fabry disease is an X-linked lysosomal storage disease caused by mutations in the GLA gene that lead to a reduction or an absence of the enzyme α-galactosidase A, resulting in the progressive and multisystemic accumulation of globotriaosylceram...

(This article belongs to the Section Endocrinology & Metabolism)
  • Article
  • Open Access
44 Citations
15,199 Views
14 Pages

Mechanical Stretching Simulates Cardiac Physiology and Pathology through Mechanosensor Piezo1

  • Tzyy-Yue Wong,
  • Wang-Chuan Juang,
  • Chia-Ti Tsai,
  • Ching-Jiunn Tseng,
  • Wen-Hsien Lee,
  • Sheng-Nan Chang and
  • Pei-Wen Cheng

2 November 2018

The dynamics of a living body enables organs to experience mechanical stimulation at cellular level. The human cardiomyocytes cell line provides a source for simulating heart dynamics; however, a limited understanding of the mechanical stimulation ef...

(This article belongs to the Section Cardiology)
  • Review
  • Open Access
70 Citations
16,190 Views
13 Pages

1 November 2018

Alzheimer’s disease (AD) is characterized by progressive memory dysfunction, oxidative stress, and presence of senile plaques formed by amyloid beta (A β ) accumulation in the brain. AD is one of the most important causes of morbidity...

(This article belongs to the Special Issue Mild Cognitive Impairment)
  • Article
  • Open Access
9 Citations
4,015 Views
17 Pages

Hydroxysteroid 11-Beta Dehydrogenase 1 Overexpression with Copy-Number Gain and Missense Mutations in Primary Gastrointestinal Stromal Tumors

  • Chien-Feng Li,
  • Ting-Ting Liu,
  • Jui-Chu Wang,
  • Shih-Chen Yu,
  • Yen-Yang Chen,
  • Fu-Min Fang,
  • Wan-Shan Li and
  • Hsuan-Ying Huang

1 November 2018

The lipid-metabolizing enzymes remain underexplored in gastrointestinal stromal tumors (GISTs). Through transcriptomic reappraisal, hydroxysteroid 11-beta dehydrogenase-1 (HSD11B1) was identified as a top-upregulated, progression-associated gene. To...

(This article belongs to the Section Clinical Laboratory Medicine)
  • Article
  • Open Access
14 Citations
3,844 Views
8 Pages

Angiopoietin-2: A Potential Mediator of the Glycocalyx Injury in Adult Nephrotic Patients

  • Maria Moura Santana Chaves,
  • Matheus de Souza Mendes,
  • Maximilian Pinho Schwermann,
  • Raquel Queiroz,
  • Regina Freitas Coelho,
  • Francisco Thiago Santos Salmito,
  • Gdayllon Cavalcante Meneses,
  • Alice Maria Costa Martins,
  • Ana Cristina de Oliveira Monteiro Moreira and
  • Alexandre Braga Libório

31 October 2018

Introduction: Glomerulopathy is a group of diseases that affect mainly young adults between the ages of 20 and 40 years. Recently, it has been demonstrated that syndecan-1, a biomarker of endothelial glycocalyx damage, is increased in nephrotic patie...

(This article belongs to the Special Issue Clinical Symptoms, Diagnostics and Treatments of Chronic Kidney Diseases (CKD))
  • Article
  • Open Access
7 Citations
6,505 Views
19 Pages

The Dark Side of Female HIV Patient Care: Sexual and Reproductive Health Risks in Pre- and Post-Clinical Treatments

  • Thu Hong Khuat,
  • Thu Trang Do,
  • Van Anh T. Nguyen,
  • Xuan Thai Vu,
  • Phuong Thao T. Nguyen,
  • Kien Tran,
  • Manh Tung Ho,
  • Hong Kong T. Nguyen,
  • Thu Trang Vuong and
  • Quan Hoang Vuong
  • + 1 author

31 October 2018

This study examines the pre- and post-clinical issues in human immunodeficiency virus (HIV) care and treatment for women and girls of high-risk population groups—namely sex workers, injecting drug users, women living with HIV, primary sexual pa...

(This article belongs to the Section Oncology)
  • Review
  • Open Access
16 Citations
6,961 Views
13 Pages

Immunopharmacology of Post-Myocardial Infarction and Heart Failure Medications

  • Mona Panahi,
  • Nimai Vadgama,
  • Mathun Kuganesan,
  • Fu Siong Ng and
  • Susanne Sattler

31 October 2018

The immune system responds to acute tissue damage after myocardial infarction (MI) and orchestrates healing and recovery of the heart. However, excessive inflammation may lead to additional tissue damage and fibrosis and exacerbate subsequent functio...

(This article belongs to the Section Cardiology)
  • Review
  • Open Access
230 Citations
27,158 Views
20 Pages

Effects of Mind–Body Exercises (Tai Chi/Yoga) on Heart Rate Variability Parameters and Perceived Stress: A Systematic Review with Meta-Analysis of Randomized Controlled Trials

  • Liye Zou,
  • Jeffer Eidi Sasaki,
  • Gao-Xia Wei,
  • Tao Huang,
  • Albert S. Yeung,
  • Octávio Barbosa Neto,
  • Kevin W. Chen and
  • Stanley Sai-chuen Hui

31 October 2018

Background: Heart rate variability (HRV) as an accurate, noninvasive measure of the Autonomous Nervous System (ANS) can reflect mental health (e.g., stress, depression, or anxiety). Tai Chi and Yoga (Tai Chi/Yoga), as the most widely practiced mind&n...

(This article belongs to the Special Issue Psychosomatic Medicine)
  • Article
  • Open Access
39 Citations
4,988 Views
10 Pages

Physical Frailty and Cognitive Functioning in Korea Rural Community-Dwelling Older Adults

  • Dong Hyun Yoon,
  • Su Seung Hwang,
  • Dong Won Lee,
  • Chung Gun Lee and
  • Wook Song

31 October 2018

Cognitive frailty is a heterogeneous clinical manifestation characterized by the simultaneous presence of physical frailty and cognitive impairment. The objective of this study was to investigate the association between physical frailty and cognitive...

(This article belongs to the Special Issue Sarcopenia in Older Adults)
  • Article
  • Open Access
29 Citations
6,572 Views
10 Pages

31 October 2018

Spinach is one of the most widely consumed vegetables, and is known as for both physical and mental health maintenance. However, there is little information about how spinach protects one from stress. In the present study, we created three extracts f...

(This article belongs to the Section Mental Health)
  • Case Report
  • Open Access
14 Citations
13,090 Views
4 Pages

Pericardial Cyst: Never Too Late to Diagnose

  • Katrina Lennon Collins,
  • Fady Zakharious,
  • Amit K. J. Mandal and
  • Constantinos G. Missouris

30 October 2018

Pericardial cysts are uncommon benign lesions of the middle mediastinum, making up less than 6% of all mediastinal masses. They are often detected as incidental findings on chest imaging and some can resolve spontaneously. Rarely, however, they may c...

(This article belongs to the Section Cardiology)
  • Review
  • Open Access
109 Citations
12,002 Views
15 Pages

Shared Features of Endothelial Dysfunction between Sepsis and Its Preceding Risk Factors (Aging and Chronic Disease)

  • Jesus F. Bermejo-Martin,
  • Marta Martín-Fernandez,
  • Cristina López-Mestanza,
  • Patricia Duque and
  • Raquel Almansa

30 October 2018

Acute vascular endothelial dysfunction is a central event in the pathogenesis of sepsis, increasing vascular permeability, promoting activation of the coagulation cascade, tissue edema and compromising perfusion of vital organs. Aging and chronic dis...

(This article belongs to the Section Hematology)
  • Case Report
  • Open Access
1 Citations
4,572 Views
5 Pages

An Infant with Xpert® Confirmed TB Meningitis in Central Viet Nam

  • Phuong T. K. Nguyen,
  • Trang T. B. Thai,
  • Julie Huynh and
  • Ben J. Marais

29 October 2018

A 5-month-old boy presented with a focal seizure. Disseminated (miliary) tuberculosis (TB) was diagnosed on chest radiograph and TB meningitis was confirmed using Xpert MTB/RIF®. The case represents the first instance of cerebrospinal fluid Xpert...

(This article belongs to the Section Vascular Medicine)
  • Article
  • Open Access
4 Citations
5,407 Views
9 Pages

Manualised Cognitive Behaviour Therapy for Anorexia Nervosa: Use of Treatment Modules in the ANTOP Study

  • Gaby Resmark,
  • Brigid Kennedy,
  • Maria Mayer,
  • Katrin Giel,
  • Florian Junne,
  • Martin Teufel,
  • Martina De Zwaan and
  • Stephan Zipfel

29 October 2018

Standardised treatment manuals facilitate therapy planning and enhance comparability for research purposes. Within the Anorexia Nervosa Treatment of Out Patients (ANTOP) study, the largest multisite outpatient intervention trial in anorexia nervosa (...

(This article belongs to the Special Issue Anorexia Nervosa)
  • Review
  • Open Access
39 Citations
10,620 Views
10 Pages

The Current Description and Future Need for Multidisciplinary PCOS Clinics

  • Wendy M. Wolf,
  • Rachel A. Wattick,
  • Olivia N. Kinkade and
  • Melissa D. Olfert

28 October 2018

Polycystic Ovarian Syndrome (PCOS), with common symptoms of irregular menstrual cycles, ovarian cysts, and hirsutism, is thought to be the most common endocrine disorder found in women, and use of multidisciplinary teams has been shown to be effectiv...

(This article belongs to the Section Obstetrics & Gynecology)
  • Article
  • Open Access
19 Citations
6,094 Views
15 Pages

28 October 2018

Dengue is a mosquito-borne viral disease that is a threat to global health. However, information relating to mortality ≤7 days after dengue onset and ≤3 days after presentation is limited. We retrospectively analyzed 1086 adults with dengue dur...

(This article belongs to the Section Hematology)
  • Article
  • Open Access
22 Citations
4,378 Views
10 Pages

The Safety of Selective Use of Splenic Flexure Mobilization in Sigmoid and Rectal Resections—Systematic Review and Meta-Analysis

  • Michał Nowakowski,
  • Piotr Małczak,
  • Magdalena Mizera,
  • Mateusz Rubinkiewicz,
  • Anna Lasek,
  • Mateusz Wierdak,
  • Piotr Major,
  • Andrzej Budzyński and
  • Michał Pędziwiatr

27 October 2018

Background: According to traditional textbooks on surgery, splenic flexure mobilization is suggested as a mandatory part of open rectal resection. However, its use in minimally invasive access seems to be limited. This stage of the procedure is consi...

(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
  • Article
  • Open Access
24 Citations
6,400 Views
13 Pages

The Impact of Sepsis on the Outcomes of COPD Patients: A Population-Based Cohort Study

  • Cheng-Hsin Chen,
  • Chih-Cheng Lai,
  • Ya-Hui Wang,
  • Cheng-Yi Wang,
  • Hao-Chien Wang,
  • Chong-Jen Yu,
  • Likwang Chen and
  • Taiwan Clinical Trial Consortium for Respiratory Diseases (TCORE)

27 October 2018

This study aims to identify the impact of new-onset sepsis in patients with chronic obstructive pulmonary disease (COPD) including the effects on acute exacerbations, pneumonia and mortality. Using the National Health Insurance Research Database of T...

(This article belongs to the Section Respiratory Medicine)
  • Article
  • Open Access
12 Citations
3,323 Views
16 Pages

Trends of Medication Usage and Associated Outcomes for Taiwanese Patients with Inflammatory Bowel Disease from 2001 to 2015

  • Meng-Tzu Weng,
  • Chien-Chih Tung,
  • Yuan-Ting Chang,
  • Yew-Loong Leong,
  • Yu-Ting Wang,
  • Jau-Min Wong and
  • Shu-Chen Wei

27 October 2018

Background: No nationwide, long-term follow-up study has assessed medication-associated outcomes for Asian patients with inflammatory bowel disease (IBD). This study examined medication-associated outcomes for Taiwanese patients with IBD. Methods: In...

(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
  • Article
  • Open Access
14 Citations
3,135 Views
12 Pages

Circulating Levels of Osteopontin Predict Patients’ Outcome after Resection of Colorectal Liver Metastases

  • Sven H. Loosen,
  • Daniel Heise,
  • Cees H. Dejong,
  • Sanchari Roy,
  • Frank Tacke,
  • Christian Trautwein,
  • Christoph Roderburg,
  • Tom Luedde,
  • Ulf P. Neumann and
  • Marcel Binnebösel

26 October 2018

For colorectal liver metastases (CRLM), surgical resection is the only potentially curative therapy, but even successfully resected patients often face disease recurrence, leading to 5-year survival rate below 50%. Despite available preoperative stra...

(This article belongs to the Section Oncology)
  • Article
  • Open Access
66 Citations
7,910 Views
19 Pages

26 October 2018

While considerable evidence supporting the positive influence of acute exercise on cognitive inhibition, little is known regarding the underlying cognitive processes. There is also little neuroelectric evidence regarding the effects on older adults o...

(This article belongs to the Special Issue The Effects of Exercise on Cognitive Function)
  • Article
  • Open Access
9 Citations
3,765 Views
11 Pages

26 October 2018

Background: Several comparison studies have suggested that kidney transplantation (KT) could reduce mortality in patients with end-stage renal disease (ESRD). Selection criteria bias is common in the selection of dialysis patients for control groups....

(This article belongs to the Section Nephrology & Urology)
  • Review
  • Open Access
45 Citations
9,897 Views
13 Pages

Mitochondrial Neurogastrointestinal Encephalomyopathy (MNGIE-MTDPS1)

  • Massimiliano Filosto,
  • Stefano Cotti Piccinelli,
  • Filomena Caria,
  • Serena Gallo Cassarino,
  • Enrico Baldelli,
  • Anna Galvagni,
  • Irene Volonghi,
  • Mauro Scarpelli and
  • Alessandro Padovani

26 October 2018

Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE-MTDPS1) is a devastating autosomal recessive disorder due to mutations in TYMP, which cause a loss of function of thymidine phosphorylase (TP), nucleoside accumulation in plasma and tissues...

(This article belongs to the Special Issue Advances in Metabolic Myopathies)
  • Article
  • Open Access
7 Citations
4,233 Views
11 Pages

Clinical Utility of Definitive Drug–Drug Interaction Testing in Primary Care

  • John Peabody,
  • Mary Tran,
  • David Paculdo,
  • Joshua Schrecker,
  • Czarlota Valdenor and
  • Elaine Jeter

25 October 2018

Drug–drug interactions (DDIs) are a leading cause of morbidity and mortality. New tools are needed to improve identification and treatment of DDIs. We conducted a randomized controlled trial to assess the clinical utility of a new test to ident...

(This article belongs to the Section Epidemiology & Public Health)
  • Article
  • Open Access
25 Citations
5,011 Views
11 Pages

High Risk of Deep Neck Infection in Patients with Type 1 Diabetes Mellitus: A Nationwide Population-Based Cohort Study

  • Geng-He Chang,
  • Meng-Chang Ding,
  • Yao-Hsu Yang,
  • Yung-Hsiang Lin,
  • Chia-Yen Liu,
  • Meng-Hung Lin,
  • Ching-Yuan Wu,
  • Cheng-Ming Hsu and
  • Ming-Shao Tsai

25 October 2018

Objective: To investigate the risk of deep neck infection (DNI) in patients with type 1 diabetes mellitus (T1DM). Methods: The database of the Registry for Catastrophic Illness Patients, affiliated to the Taiwan National Health Insurance Research Dat...

(This article belongs to the Special Issue Head and Neck Critical Illness: Basic and Clinical Research Implications)
  • Article
  • Open Access
36 Citations
3,420 Views
8 Pages

25 October 2018

Background: Low blood ALT, Alanine aminotransferase activity and high FRAIL (Fatigue, Resistance, Ambulation, Illnesses and Loss of Weight) questionnaire scores were previously shown to be associated with frailty and increased risk of mortality. We a...

  • Article
  • Open Access
18 Citations
6,748 Views
12 Pages

Association of Depression and Cervical Spondylosis: A Nationwide Retrospective Propensity Score-Matched Cohort Study

  • Shih-Yi Lin,
  • Fung-Chang Sung,
  • Cheng-Li Lin,
  • Li-Wei Chou,
  • Chung-Y. Hsu and
  • Chia-Hung Kao

25 October 2018

Objective: Depression is a psychiatric disorder associated with poorer health outcomes. Inappropriate mechanical stress and aging are factors associated with developing cervical spondylosis. The connection between cervical spondylosis and depression...

(This article belongs to the Section Mental Health)
  • Article
  • Open Access
86 Citations
12,359 Views
11 Pages

24 October 2018

Endometriosis occurs when endometrial tissue exists outside the uterine cavity. The presence of ectopic endometrial tissue and resultant inflammation cause serious symptoms, including chronic pelvic pain, dysmenorrhea, dyspareunia, and infertility. P...

(This article belongs to the Section Obstetrics & Gynecology)
  • Article
  • Open Access
5 Citations
4,571 Views
11 Pages

Association of Tramadol and Hypoglycemia in Diabetic Asians

  • Shang-Yi Li,
  • Hsin-Hung Chen,
  • Cheng-Li Lin,
  • Su-Yin Yeh and
  • Chia-Hung Kao

24 October 2018

To evaluate the association between tramadol and hypoglycemia in diabetic Asians. The data adopted in this study were derived from a subset of the National Health Insurance (NHI) Research Database, which comprises data on one million randomly sampled...

(This article belongs to the Section Pharmacology)
  • Article
  • Open Access
17 Citations
3,758 Views
14 Pages

24 October 2018

We investigated the effects of statins on tuberculosis (TB) and pneumonia risks in asthma–chronic pulmonary disease overlap syndrome (ACOS) patients. We extracted data of patients diagnosed as having ACOS during 2000–2010 from the Taiwan...

(This article belongs to the Section Respiratory Medicine)
  • Article
  • Open Access
6 Citations
3,615 Views
10 Pages

Plasma Aldosterone Concentration as a Determinant for Statin Use among Middle-Aged Hypertensive Patients for Atherosclerotic Cardiovascular Disease

  • Jui-Hsiang Lin,
  • Yu-Feng Lin,
  • Wei-Jie Wang,
  • Yuh-Feng Lin,
  • Shih-Chieh Jeff Chueh,
  • Vin-Cent Wu,
  • Tzong-Shinn Chu,
  • Kwan-Dun Wu and
  • On behalf of the Taiwan Primary Aldosteronism Investigation (TAIPAI) Study Group

24 October 2018

The use of statin therapy on the prevention of atherosclerotic cardiovascular disease (ASCVD) is recommended by the American College of Cardiology (ACC) and the American Heart Association (AHA); nevertheless, its validation on primary aldosteronism (...

(This article belongs to the Special Issue Developing Novel Therapies to Prevent Atherosclerosis)
  • Article
  • Open Access
26 Citations
5,886 Views
18 Pages

24 October 2018

Endocrine disorders, including equine metabolic syndrome (EMS), are a serious issue in veterinary medicine and horse breeding. Furthermore, EMS was shown to affect the cytophysiological properties of adipose-derived stem cells, reducing their therape...

(This article belongs to the Special Issue Adipose-Derived Stem Cells and Their Extracellular Microvesicles (ExMVs) for Tissue Engineering and Regenerative Medicine Applications)
  • Article
  • Open Access
52 Citations
4,401 Views
10 Pages

Remnant Lipoprotein Cholesterol and Cardiovascular and Cerebrovascular Events in Patients with Non-Alcoholic Fatty Liver Disease

  • Daniele Pastori,
  • Francesco Baratta,
  • Marta Novo,
  • Nicholas Cocomello,
  • Francesco Violi,
  • Francesco Angelico and
  • Maria Del Ben

23 October 2018

Non-alcoholic fatty liver disease (NAFLD) is characterized by an atherogenic dyslipidaemia and an increased cardiovascular risk. Remnant lipoprotein cholesterol (RLP-C) is emerging as a novel cardiovascular risk factor, but its predictive value in pa...

(This article belongs to the Section Vascular Medicine)

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J. Clin. Med. - ISSN 2077-0383