Adipose-Derived Stem Cells and Their Extracellular Microvesicles (ExMVs) for Tissue Engineering and Regenerative Medicine Applications

Dear Colleagues,

Adipose-derived mesenchymal stem cells (ASCs) and their extracellular microvesicles (ExMVs) are promising therapeutic tools in the field of regenerative medicine for both human as well as veterinary medicine. For many years, ASCs have been successfully applied in animal regenerative medicine, and, currently, few clinical trials take place with the application of ASCs. This is due to their multilineage differentiation potential, and the fact that they are easy to collect and possess abundant paracrine activity. More and more data explain the pro-regenerative potential of ASCs by their paracrine and endocrine affects, transferring cytokines and hormones, mRNA or miRNA, which target injured tissue and enhance their regeneration. However, as has been recently shown, donor age and disease limit their regenerative potential. Therefore, the search for a strategy that will improve their clinical potential seems to be reasonable. Moreover, ASCs are widely combined with various types of scaffold, including ceramics or polymers, for tissue regeneration. The aim of this Special Issue is to provide an updated point of view about clinical and pre-clinical studies with applications of ASCs or their extracellular microvesicles (ExMVs). Original research articles, short communications, as well as review articles, will be acceptable for this Special Issue.

Dr. Krzysztof Marycz
Guest Editor

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