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J. Clin. Med. 2018, 7(11), 407;

The Role of Irisin in Alzheimer’s Disease

Department of Food Science and Nutrition, Dong A University, Busan 49315, Korea
Author to whom correspondence should be addressed.
Received: 3 October 2018 / Revised: 26 October 2018 / Accepted: 29 October 2018 / Published: 1 November 2018
(This article belongs to the Special Issue Mild Cognitive Impairment)
PDF [633 KB, uploaded 1 November 2018]


Alzheimer’s disease (AD) is characterized by progressive memory dysfunction, oxidative stress, and presence of senile plaques formed by amyloid beta (A β ) accumulation in the brain. AD is one of the most important causes of morbidity and mortality worldwide. AD has a variety of risk factors, including environmental factors, metabolic dysfunction, and genetic background. Recent research has highlighted the relationship between AD and systemic metabolic changes such as glucose and lipid imbalance and insulin resistance. Irisin, a myokine closely linked to exercise, has been associated with glucose metabolism, insulin sensitivity, and fat browning. Recent studies have suggested that irisin is involved in the process in central nervous system (CNS) such as neurogenesis and has reported the effects of irisin on AD as one of the neurodegenerative disease. Here, we review the roles of irisin with respect to AD and suggest that irisin highlight therapeutic important roles in AD. Thus, we propose that irisin could be a potential future target for ameliorating AD pathology and preventing AD onset. View Full-Text
Keywords: irisin; Alzheimer’s disease (AD); glucose metabolism; insulin resistance; neurogenesis irisin; Alzheimer’s disease (AD); glucose metabolism; insulin resistance; neurogenesis

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Kim, O.Y.; Song, J. The Role of Irisin in Alzheimer’s Disease. J. Clin. Med. 2018, 7, 407.

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