Table of Contents
J. Clin. Med., Volume 7, Issue 11 (November 2018)
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Cover Story (view full-size image) The liver transplantation following donation after cardiac death (DCD) has been receded by the high [...] Read more. The liver transplantation following donation after cardiac death (DCD) has been receded by the high risks of dispiriting outcomes like biliary complications, hepatic artery thrombosis and primary nonfunction. The reasons behind increased susceptibility to DCD livers are lucid, however, plausible explanations suggest that the microthrombi formation and disruption of biliary ductal microcirculation secondary to obligatory acirculatory phase. The administration of a thrombolytic agent (thrombolytic flush), tissue plasminogen activator (tPA), into the hepatic artery prior to reperfusion dissolve any potential microthrombi in the biliary microcirculation and thereby mitigate the occurrence of these complications. However, the implications of this novel concept in the liver transplantation following DCD livers are yet to be fully explored. View this paper.