Pathogens, Volume 14, Issue 12

Despite the economic importance of Mizuhopecten yessoensis, little is known about their parasites and immunity. This study, the first to examine the prevalence and intensity of Perkinsus across three age groups of scallops from four locations in the...

Pulmonary diseases caused by nontuberculous mycobacteria are increasingly becoming common worldwide and are occurring more frequently alongside pulmonary tuberculosis. Given that pulmonary diseases resulting from nontuberculous mycobacteria and pulmo...

Bacterial contaminants in ambulances could have a major impact on morbidities, mortalities, and healthcare resources, especially if these bacteria are antimicrobial-resistant. As far as we know, this is the first study in Al-Qassim region to evaluate...

Ceftazidime-avibactam (CA) and CA plus aztreonam (ATM) are the preferred treatment options for KPC and MBL carbapenemase-producing Enterobacterales infections (CPEis). All episodes of monomicrobial CPEis in immunosuppressed patients (IPs) admitted fr...

Visceral leishmaniasis (VL) is a severe zoonotic disease characterized by high mortality and a pronounced systemic inflammatory response. Although Pentraxin 3 (PTX3) has been implicated in infectious and inflammatory disorders, its role in human VL r...

Diagnosis of rickettsial infections is challenging due to nonspecific clinical symptoms and limitations of current diagnostic methods. Molecular assays allow early detection but are limited by cost and technical demands, whereas conventional serologi...

Urinary tract infections are among the most common bacterial infections worldwide, with increasing antimicrobial resistance posing a significant public health challenge. This study aimed to determine the demographic distribution, antimicrobial suscep...

People who use crack cocaine (PWUCC) constitute a key population due to vulnerability and marginalization, especially in a socio-ecologically diverse, relatively isolated region with limited public health infrastructure. This study aimed to perform a...

Measles, also known as rubeola, is a highly contagious and potentially life-threatening disease caused by the measles virus. It classically presents with fever, cough, coryza, conjunctivitis, and a maculopapular rash. Despite the availability of an e...

The ongoing global monkeypox outbreak since 2022 has highlighted the urgent need for vaccine development. Current vaccination strategies rely on cross-protective immunity provided by orthopoxvirus-based live-attenuated vaccines. However, these vaccin...

The oral cavity acts as the anatomical gateway to the respiratory tract, sharing both microbiological and pathophysiological links with the lower airways. Although radiotherapy is a cornerstone treatment for lung cancer, reliable oral microbiome biom...

Dengue Virus (DENV) induces assembly of the NOD-like receptor (NLR) family pyrin domain containing-3 (NLRP3) inflammasome and autophagy, which are closely interconnected processes playing crucial roles in lipid metabolism and DENV replication. Howeve...

Glioblastoma (GB) is a highly aggressive brain tumor with a very poor prognosis. Treatment usually consists of surgery, followed by radiotherapy and chemotherapy, but the prognosis remains poor due to its resistance to therapies and a high recurrence...

Root-knot nematodes, known for their broad host range and the challenges associated with their control, cause significant losses in global agricultural productivity. The mitogen-activated protein kinase (MAPK) pathway amplifies signals through a phos...

Antibiotic resistance can be considered one of the major bacterial pathogenesis factors, and its increase is an important public health concern. Among resistant bacteria, staphylococci can express high levels of resistance, representing some of the m...

Oz virus, an emerging tick-borne thogotovirus, has been reported to cause fatal human infection in Japan. However, its ecology and geographic distribution remain largely unknown. In this study, we developed a double-antigen sandwich enzyme-linked imm...

Background: Standardized Er:YAG laser settings for microbial reduction remain undefined, and existing studies rarely compare multiple species under identical conditions. This work aimed to characterize susceptibility across selected microorganisms us...

Avian haemosporidians have been widely studied because they provide important insights into parasite distribution and diversity. However, most available data come from passerines, resulting in gaps regarding other bird groups, primarily due to the di...

Salmonella is a Gram-negative enteric bacterium responsible for the foodborne and waterborne disease salmonellosis, which was the second most reported foodborne gastrointestinal infection in humans in the European Union in 2023. Animals represent the...

Background: Acute Respiratory Infections are a common reason for Pediatric Emergency Department (PED) visits. Differentiating bacterial and viral infections may be challenging and might result in incorrect antibiotic prescriptions and exacerbation of...

Porcine circovirus types 2 (PCV2) and 3 (PCV3) are major pathogens affecting swine health and productivity, yet important gaps remain in understanding their evolution and circulation in Europe, particularly within wild boar populations that may serve...

Leishmania (L.) infantum infections in dogs can cause severe recurrent disease. The aim of this study was to investigate different parameters for early detection of disease relapses in L. infantum-infected dogs in Germany. Fifty-two dogs naturally in...

Tick bites acquired in the northern or southern hemisphere can transmit microbes that may cause illness. The most prevalent infection is Lyme borreliosis (LB), with all proven cases to date having been acquired in the northern hemisphere. The existen...

Listeria monocytogenes is a major foodborne pathogen associated with increasing global public health concern due to numerous outbreaks. Rapid pathogen detection is critical for reducing both the incidence and severity of foodborne illnesses. Recent a...

Japanese encephalitis virus (JEV) is a mosquito-borne zoonotic flavivirus causing severe neurological disease across Asia, and genotype V (GV) is now predominant in Korea. Despite frequent detection of GV in mosquitoes, human-derived complete genome...

Originally identified in Kenya in 1921, African swine fever (ASF) primarily remained a sub-Saharan concern for nearly a century [...]

Since its discovery in 2001, Human Metapneumovirus (hMPV) has been identified globally, exhibiting predictable seasonal outbreaks primarily affecting young children, the elderly, and individuals with preexisting health conditions. The virus is transm...

During the first week of T. b. brucei infection, pro-inflammatory IFN-γ production drives acute anaemia by promoting red blood cell clearance by activated macrophages in concert with insufficient bone marrow compensation. The latter is followed...

High-risk human papillomavirus (HR-HPV) infection with genotypes such as HPV-16 and HPV-18 is a well-established risk factor for cervical cancer; however, its prevalence in oropharyngeal sites among asymptomatic women remains less clearly defined. We...

Equine bacterial abortion presents substantial economic and One Health challenges; however, comprehensive epidemiological data from China are limited. This study sought to ascertain the overall prevalence of key pathogens—namely, Chlamydia spp....

Outbreaks of hemorrhagic septicemia (HS) caused by Pasteurella multocida serogroup B are endemic in Kazakhstan. These outbreaks have repeatedly led to mass mortality events among wild saigas and economic losses to farms. The aim of this study was to...

Oropouche virus (OROV) is an emerging and underreported arbovirus with dengue-like symptoms confounding diagnosis. OROV is also neuroinvasive, with a small number of cases presenting severe neurological symptoms. There have been recently reported dea...

Tick-borne pathogens (TBPs) pose a significant threat to canine health in Nigeria. Despite this, there is little data on the molecular identification of ticks and TBPs of dogs in Nigeria. This study assessed the prevalence of ticks and TBPs in Nigeri...

Background: Human papillomavirus (HPV) is a highly prevalent sexually transmitted infection that can lead to cervical and other anogenital and oropharyngeal cancers. Despite available vaccines, vaccination coverage remains low in Bulgaria. This study...

In this study, the insert length, location within the coat protein-encoding gene, and sequence orientation of the target fragment were optimized to construct an efficient virus-induced gene silencing (VIGS) system in melon using a Begomovirus solanum...

This scoping review of original literature published before 1 March 2025 examined the demographic and simple clinical and laboratory findings associated with the development of severe leptospirosis. The definition of severe leptospirosis varied in di...

Antibiotic resistance (AR) has long been interpreted through the lens of genetic mutations and horizontal gene transfer. Yet, mounting evidence suggests that epigenetic regulation, including DNA and RNA methylation, histone-like proteins, and small n...

Ebola virus (EBOV) infection constitutes a significant global public health threat, and no curative treatment is currently available for it. Rapid and accurate detection of EBOV nucleic acid is crucial for controlling the spread of Ebola virus diseas...

Leishmania RNA virus 1 (LRV-1) is a double-stranded RNA virus identified in several Leishmania spp. LRV-1 has been associated with increased disease severity and therapeutic failure in cutaneous leishmaniasis (CL). Although LRV-1 has been reported in...

Antimicrobial resistance (AMR) among commensal Escherichia coli from poultry is a growing concern for food safety and public health. This study investigated AMR patterns in E. coli isolated from broiler neck skin at slaughter, comparing organic, anti...

Cystic Echinococcosis (CE) is a rare but serious parasitic disease caused by Echinococcus granulosus sensu lato, representing only 1–2% of all hydatid disease cases. Due to its nonspecific clinical presentation, its diagnosis and management pos...

Coxiella burnetii (C. burnetii) is a zoonotic pathogen with significant public and veterinary significance. Whilst livestock are considered as primary reservoirs of the pathogen, ticks play a crucial role in transmission and environmental contaminati...

Background: Co-infections with HIV, HBV, and HDV pose significant public health challenges, especially in populations exposed parenterally. Romania hosts a unique pediatric HIV cohort of individuals born 1987–1995 who acquired HIV iatrogenicall...

Orthohantaviruses are zoonotic pathogens that cause severe diseases in humans primarily through inhalation of aerosols from rodent excreta. Recent studies suggest that ectoparasites may be potential vectors for Orthohantaviruses. This study aimed to...

Antimicrobial resistance (AMR) is an increasing concern in food animal production. In swine herds, viral infections often lead to secondary bacterial disease and higher antimicrobial use (AMU). This study describes how U.S. swine veterinarians view t...

Acute Diarrheal Disease (ADD) remains a major global health concern, with rotavirus A (RVA) and human adenovirus (HAdV) as key viral agents. This study evaluated the positivity rate and molecular characterization of RVA and HAdV in fecal samples from...

Root knot nematodes (RKNs; Meloidogyne spp.) are among the biotic stressors that reduce growth and yield by 25–100% in solanaceous crops like tomato. The present study screened 35 eggplant accessions against RKNs (inoculum: 1 J2/g soil). Averag...

The genus Hepacivirus (HCV) has long been a dynamic group, increasing its number by myriads of species collectively referred to as non-primate hepaciviruses (NPHVs). NPHV exhibits a broad hepatotropism and is often attributed to chronic infection in...

Background: During pregnancy, mothers and their infants are at increased risk for complications due to COVID-19 infection, influenza, and pertussis. At the time of writing, the previous advisory committee on immunization practices (ACIP) recommended...

Urinary tract infections (UTIs) represent one of the most frequent bacterial infections worldwide, with Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) as the predominant uropathogens. The emergence of extended-spectrum β-la...