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Pathogens, Volume 14, Issue 12

December 2025 - 115 articles

Cover Story: Antimicrobial resistance (AMR) is an increasing concern in food animal production, as viral diseases in swine herd frequently drive secondary bacterial infections and antimicrobial use. This study examined U.S. swine veterinarians’ perspectives on the role of viral vaccines in reducing antimicrobial use and mitigating AMR. Through a national survey and follow-up interviews, veterinarians identified porcine reproductive and respiratory syndrome, swine influenza, and rotaviral enteritis as priority targets for vaccine improvement due to their economic impact and frequent association with antimicrobial treatment. The respondents highlighted limitations of current vaccines, including limited cross protection and short duration of immunity. Despite these challenges, veterinarians supported vaccination as a key strategy to reduce antimicrobial use. View this paper
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Articles (115)

  • Article
  • Open Access
266 Views
24 Pages

Prevalence and Intensity of Perkinsus sp. Infection in Mizuhopecten yessoensis and Its Impact on the Immune Status of Bivalves

  • Elizaveta Tsoy,
  • Ayna Tumas,
  • Mariia Mokrina,
  • Andrei Grinchenko,
  • Vadim Kumeiko,
  • Daria Lanskikh and
  • Yulia Sokolnikova

18 December 2025

Despite the economic importance of Mizuhopecten yessoensis, little is known about their parasites and immunity. This study, the first to examine the prevalence and intensity of Perkinsus across three age groups of scallops from four locations in the...

  • Review
  • Open Access
377 Views
25 Pages

Detection, Isolation, and Identification of Mycobacteria That Cause Nontuberculous Mycobacterial Disease and Tuberculosis

  • Lyudmila Severova,
  • Dmitrii Giller,
  • Inga Enilenis,
  • Patimat Gadzhieva,
  • Galina Shcherbakova,
  • Oleg Kesaev,
  • Vadim Koroev,
  • Olga Frolova,
  • Anna Popova and
  • Alexandr Ilyukhin
  • + 5 authors

18 December 2025

Pulmonary diseases caused by nontuberculous mycobacteria are increasingly becoming common worldwide and are occurring more frequently alongside pulmonary tuberculosis. Given that pulmonary diseases resulting from nontuberculous mycobacteria and pulmo...

  • Article
  • Open Access
291 Views
21 Pages

Bacterial Contaminants in Ambulances from a Tertiary Care Hospital as Potential Threats to Patients and Medical Staff in Al-Qassim Region, Saudi Arabia—Effect of Decontamination

  • Ahmed E. Taha,
  • Ahmad R. Alharbi,
  • Omar N. Alharbi,
  • Alaaeldin M. Komila,
  • Abdullah Almushawwah,
  • Solaiman Aldeghaim,
  • Ahmed N. Algefary,
  • Majed Allahim,
  • Khalid Alzaben and
  • Faisal M. Alharbi

18 December 2025

Bacterial contaminants in ambulances could have a major impact on morbidities, mortalities, and healthcare resources, especially if these bacteria are antimicrobial-resistant. As far as we know, this is the first study in Al-Qassim region to evaluate...

  • Article
  • Open Access
323 Views
16 Pages

Ceftazidime-Avibactam Regimens for the Treatment of Bacteremic and Non-Bacteremic Episodes of Carbapenemase-Producing Enterobacterales Infections in Immunosuppressed Patients

  • Fabián Herrera,
  • Diego Torres,
  • María Leone,
  • Maximiliano Gabriel Castro,
  • Jorge López Camelo,
  • Elena Temporiti,
  • Natalin Grippo,
  • Silvia Relloso and
  • Pablo Bonvehí

18 December 2025

Ceftazidime-avibactam (CA) and CA plus aztreonam (ATM) are the preferred treatment options for KPC and MBL carbapenemase-producing Enterobacterales infections (CPEis). All episodes of monomicrobial CPEis in immunosuppressed patients (IPs) admitted fr...

  • Article
  • Open Access
260 Views
13 Pages

Pentraxin 3 Levels Reflect Inflammatory and Parasitic Activity in Human Visceral Leishmaniasis

  • Lucyo Flávio Bezerra Diniz,
  • Milena Xavier Silva Barbosa,
  • Samuel Ricarte de Aquino,
  • Anderson da Costa Armstrong,
  • Carlos Dornels Freire de Souza and
  • Rodrigo Feliciano Carmo

18 December 2025

Visceral leishmaniasis (VL) is a severe zoonotic disease characterized by high mortality and a pronounced systemic inflammatory response. Although Pentraxin 3 (PTX3) has been implicated in infectious and inflammatory disorders, its role in human VL r...

  • Article
  • Open Access
321 Views
11 Pages

Development of a Novel Sandwich ELISA Test for the Detection of Antibodies Against Rickettsia

  • Marco Quevedo-Diaz,
  • Semen Kaliukanov,
  • Frantisek Csicsay,
  • Diana Hopkova and
  • Ludovit Skultety

18 December 2025

Diagnosis of rickettsial infections is challenging due to nonspecific clinical symptoms and limitations of current diagnostic methods. Molecular assays allow early detection but are limited by cost and technical demands, whereas conventional serologi...

  • Article
  • Open Access
429 Views
22 Pages

Antimicrobial Resistance in Urinary Tract Infections Among Patients with and Without Renal Comorbidities: A Retrospective Study from Al-Baha, Saudi Arabia

  • Shazia Shaheen Mir,
  • Eman Ali,
  • Samiyah Ahmad Abdullah Alghamdi,
  • Nora Mohamed Alghamdi,
  • Raed A. Alharbi,
  • Abdulmajeed A. A. Sindi and
  • Ali A. Zaeri

17 December 2025

Urinary tract infections are among the most common bacterial infections worldwide, with increasing antimicrobial resistance posing a significant public health challenge. This study aimed to determine the demographic distribution, antimicrobial suscep...

  • Article
  • Open Access
439 Views
13 Pages

Genetic Characterization of Hepatitis C Virus Among People Who Use Crack Cocaine: A Study Conducted on the Brazilian Amazon Coast

  • João Alphonse A. Heymbeeck,
  • Wilker Leite do Nascimento,
  • Marina Cristina S. Freitas,
  • Leticia de Sousa Rocha,
  • Franciane Ferreira Costa,
  • Jocilena Pamela Q. de Queiroz,
  • Diego Simeone,
  • Luísa Caricio Martins,
  • Luiz Fernando A. Machado and
  • Benedikt Fischer
  • + 2 authors

17 December 2025

People who use crack cocaine (PWUCC) constitute a key population due to vulnerability and marginalization, especially in a socio-ecologically diverse, relatively isolated region with limited public health infrastructure. This study aimed to perform a...

  • Review
  • Open Access
414 Views
10 Pages

17 December 2025

Measles, also known as rubeola, is a highly contagious and potentially life-threatening disease caused by the measles virus. It classically presents with fever, cough, coryza, conjunctivitis, and a maculopapular rash. Despite the availability of an e...

  • Article
  • Open Access
332 Views
16 Pages

Immune Responses and Protective Efficacy of Nanoemulsion-Adjuvanted Monkeypox Virus Recombinant Vaccines Against Lethal Challenge in Mice

  • Congcong Zhang,
  • Nuo Liu,
  • Yanqi Zhao,
  • Zhendong Pan,
  • Dawei Wang,
  • Wanda Tang,
  • Yanhua He,
  • Xu Zheng,
  • Zhongtian Qi and
  • Xinxin Zhang
  • + 1 author

16 December 2025

The ongoing global monkeypox outbreak since 2022 has highlighted the urgent need for vaccine development. Current vaccination strategies rely on cross-protective immunity provided by orthopoxvirus-based live-attenuated vaccines. However, these vaccin...

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Pathogens - ISSN 2076-0817