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Pathogens, Volume 15, Issue 3

2026 March - 104 articles

Cover Story: Canine coronavirus (CCoV) continues to evolve, raising concerns about animal health and potential zoonotic transmission. In this work, we present a novel peptide-based strategy to stop the virus at its earliest stage: entry into host cells. Inspired by the spike protein’s fusion machinery, we designed an HRC-derived peptide that effectively disrupts membrane fusion. The peptide exhibits low cytotoxicity and strong antiviral activity, significantly reducing both cell–cell fusion and viral replication in vitro. Supported by computational modelling, our findings reveal a mechanism in which the peptide blocks the formation of the fusion core required for viral entry. This study highlights peptide-based fusion inhibitors as a promising and innovative approach to combat emerging coronaviruses. View this paper
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Articles (104)

  • Article
  • Open Access
1,491 Views
21 Pages

Between 1993 and 2024, a total of 274 hard ticks (Ixodidae) were collected from 138 subterranean localities in Croatia. This study represents the most extensive survey of hard tick fauna in subterranean habitats in Croatia to date. The collected spec...

(This article belongs to the Special Issue Ticks and Tick-Borne Diseases―Pathogens, Parasites, People and Practices)
  • Article
  • Open Access
1 Citations
1,316 Views
14 Pages

HBV and HCV Burden in a Greek Hospital Population (2018–2024): Trends and Correlates of HBsAg and Anti-HCV Positivity

  • Nikolaos Georgiadis,
  • Christina Seitopoulou,
  • Maria Kimouli,
  • Theodoros N. Sergentanis,
  • Apostolos Beloukas and
  • Georgina Tzanakaki

Background: Hepatitis B and C remain a major public health challenge in Greece, particularly amid demographic shifts, migration, and evolving socioeconomic conditions. Updated epidemiological data are essential to guide public health planning and pre...

  • Article
  • Open Access
2 Citations
1,861 Views
20 Pages

Feline immunodeficiency virus (FIV) is a lentivirus that exhibits significant structural and pathological similarities to human immunodeficiency virus (HIV), establishing it as a valuable model for HIV vaccine development. In this study, artificial i...

(This article belongs to the Section Immunological Responses and Immune Defense Mechanisms)
  • Article
  • Open Access
1,183 Views
15 Pages

Diseases Caused by Parasites with Invertebrate Hosts in China: Burden and Trends of Leishmaniasis and Schistosomiasis

  • Cun-Chen Wang,
  • Shu-Jing Wang,
  • Rui Han,
  • Gui-Zhi Xu,
  • Hai-Ting Zhang,
  • Xin-Xue Zhu,
  • Qi-Long Wu,
  • Yi-Xue Zhao,
  • Yu-Jie Zhou and
  • Sheng-Qun Deng
  • + 2 authors

Parasitic diseases involving invertebrate hosts, notably leishmaniasis (transmitted by sandflies) and schistosomiasis (transmitted via aquatic snails), remain public health concerns in China. Based on the Global Burden of Disease 2021 data, the age-s...

(This article belongs to the Section Ticks)
  • Article
  • Open Access
1 Citations
1,560 Views
14 Pages

Identification and Biological Features of Sesame Phyllody-Associated Phytoplasmas in Western Iran

  • Samira Pakbaz,
  • Ehsan Hasanvand,
  • Assunta Bertaccini and
  • Sara Gharouni-Kardani

Sesame is an oilseed crop threatened by a phyllody disease associated with the presence of phytoplasmas, which can reduce yields by up to 80%. The molecular identification of these bacteria in crops located in Western Iran was achieved from samples s...

(This article belongs to the Special Issue Next-Gen Sequencing Advances Pathogen Research in Health, Agriculture & Environment)
  • Article
  • Open Access
1,142 Views
11 Pages

Molecular Epidemiology of Toscana Virus in Northern and Central Italy Using Metagenomic Next-Generation Sequencing

  • Giulia Alessandri,
  • Giada Beligni,
  • Gianni Gori Savellini,
  • Alessandra Mistral De Pascali,
  • Federica Gobbo,
  • Fabrizio Montarsi,
  • Davide Mileto,
  • Letizia Rizzo and
  • Maria Grazia Cusi

Toscana virus (TOSV) is an arthropod-borne virus, transmitted by sandflies, which represents a major cause of aseptic meningitis in Mediterranean countries during summer months. Despite its epidemiological importance, recent genomic data on circulati...

(This article belongs to the Section Viral Pathogens)
  • Article
  • Open Access
1,461 Views
14 Pages

First Detection of Human- and Dog-Associated Demodex Mites (Acari, Arachnida) in Southern European Wolves (Canis lupus)

  • Natalia Sastre,
  • Manena Fayos,
  • Luca Rossi,
  • Olga Francino,
  • Roser Velarde,
  • Sebastian E. Ramos-Onsins and
  • Lluís Ferrer

Demodex mites are common commensals of mammalian skin, but under certain conditions, they can cause severe skin diseases. This study analyzed the presence, diversity, and phylogenetic relationships of Demodex species in two wolf subspecies from south...

(This article belongs to the Special Issue Parasitic Infections in Animals)
  • Article
  • Open Access
3,243 Views
17 Pages

Clinical Features and Outcomes of Treatment for Effusive Feline Infectious Peritonitis with GS-441524 in Seventeen Retrovirus-Positive Cats

  • Marilize Van der Walt,
  • Sarah E. Jones,
  • Julie K. Levy,
  • Emma Hart,
  • Rosa Negash,
  • Wendy M. Novicoff,
  • Nicole Jacque and
  • Samantha J. M. Evans

Background: There is limited information about treatment success and outcomes in retrovirus-positive cats diagnosed with feline infectious peritonitis (FIP). Methods: A survey was distributed to caretakers of cats with feline leukemia virus (FeLV) an...

  • Review
  • Open Access
1 Citations
2,829 Views
31 Pages

Insights into Arcanobacterium haemolyticum: A Narrative Review of an Emerging Pathogen Revisited

  • Alessandra Consonni,
  • Elena Briozzo,
  • Chiara Giubbi,
  • Silvia Tonolo,
  • Francesco Luzzaro and
  • Carola Mauri

Arcanobacterium haemolyticum is a facultative anaerobic, Gram-positive bacillus that has garnered attention due to its role in human infections, particularly among adolescents and young adults. Traditionally associated with pharyngitis, this organism...

(This article belongs to the Section Bacterial Pathogens)
  • Article
  • Open Access
1 Citations
1,065 Views
15 Pages

Green Tea Catechins Significantly Reduce Zika Virus in RBCs Through Viral Inactivation

  • Xipeng Yan,
  • Jinlian Li,
  • Xiaoqiong Duan,
  • Limin Chen,
  • Yujia Li and
  • Chunhui Yang

Background: Despite significant improvements in blood safety, the risk of transfusion-transmitted infections persists, particularly from emerging and re-emerging viruses. For red blood cell (RBC) products, this risk is exacerbated by the fact that th...

(This article belongs to the Special Issue Emerging Arboviruses and Novel Viral Threats: Detection, Surveillance, and Mitigation Strategies)
  • Article
  • Open Access
1,486 Views
28 Pages

Practical Real-Time Quaking-Induced Conversion for Detecting Classical Bovine Spongiform Encephalopathy and Classical and Atypical Scrapie Prions

  • Akio Suzuki,
  • Kazuhei Sawada,
  • Taku Nakashima,
  • Toyotaka Sato,
  • Kohtaro Miyazawa,
  • Yuichi Matsuura,
  • Keigo Ikeda,
  • Yoshifumi Iwamaru and
  • Motohiro Horiuchi

Real-time quaking-induced conversion (RT-QuIC) is highly sensitive for prion detection; however, inhibitory factors present in tissue homogenates readily interfere with the assay. We previously reported that recombinant cervid prion protein (rCerPrP)...

(This article belongs to the Collection Prions and Chronic Wasting Diseases)
  • Article
  • Open Access
1 Citations
1,581 Views
24 Pages

Potential Activity of 6-Pentyl-α-pyrone as an Antiviral for Bovine Coronavirus

  • Luca Del Sorbo,
  • Rosa Giugliano,
  • Clementina Acconcia,
  • Maria Michela Salvatore,
  • Alessia Staropoli,
  • Violetta Iris Vasinioti,
  • Maria Stella Lucente,
  • Paolo Capozza,
  • Francesco Vinale and
  • Filomena Fiorito
  • + 3 authors

During infection in vitro with the strain 438/06 of bovine coronavirus (BCoV), a β-coronavirus similar to severe acute respiratory syndrome (SARS) CoV-2, treatment with 6-pentyl-α-pyrone (6PP), a fungal metabolite obtained from Trichoderma...

(This article belongs to the Special Issue Emerging/Re-Emerging Viruses and Antiviral Drug Design)
  • Article
  • Open Access
1 Citations
2,598 Views
14 Pages

Meningitis Mortality in U.S. Adults Aged ≥25 Years: Demographic and Geographic Insights from the CDC WONDER Database (1999–2024)

  • Hassaan Abid,
  • Muhammad Jawad,
  • Muhammad Vazaym,
  • Gaaitri Lohano,
  • Syed Mohamin Abbas Shah,
  • Naveed Ahmed Khan,
  • Abdullah Afridi and
  • Muhammad Mohid Haroon

Meningitis remains a significant cause of morbidity and mortality in the United States despite advances in vaccination, antimicrobial therapy, and critical care. However, long-term national mortality patterns across demographic and geographic subgrou...

(This article belongs to the Special Issue Epidemiology of Infectious Diseases and Prevention Strategies in Clinical Populations)
  • Article
  • Open Access
1,288 Views
20 Pages

Exploring the Antibacterial Properties of a Newly Isolated Microviridae Phage Against Multidrug-Resistant Escherichia coli

  • Yoana Kizheva,
  • Maria Pandova,
  • Zoltan Urshev,
  • Yoana Gladicheva,
  • Tsvetelina Paunova-Krasteva,
  • Sergei Ivanov and
  • Petya Hristova

In response to the alarming rise in antimicrobial resistance, bacteriophages have re-emerged as a promising alternative to conventional antibiotic therapy. The main objective of this paper was to characterize a newly isolated phage (vB_SEC_3) in the...

(This article belongs to the Special Issue Current Progress on Bacterial Antimicrobial Resistance)
  • Article
  • Open Access
1 Citations
1,469 Views
22 Pages

Profile of Priority Antimicrobial-Resistant Pathogens and the Behavior of Multidrug-Resistant Tuberculosis in the Santiago de Cali District, Colombia

  • Alejandra Mondragón Quiguanas,
  • Jorge Iván Montoya Salazar,
  • Juan Camilo Mosquera-Hernandez,
  • Margareth Zuluaga Aricapa,
  • Carlos Eduardo Pinzón Flórez,
  • German Escobar Morales,
  • Johana Alejandra Moreno-Drada,
  • Bruno Gutiérrez and
  • Lucy Marcela Díaz Rivadeneira

Background: Antimicrobial resistance is a threat that increases morbidity and mortality. This cross-sectional study aimed to describe the profile of priority antimicrobial-resistant pathogens and to analyze the behavior of multidrug-resistant tubercu...

(This article belongs to the Special Issue Advanced Antimicrobial Agents: Combatting Multi-Drug Resistant Bacterial Infections)
  • Article
  • Open Access
1,155 Views
16 Pages

Epidemiological Features and Environmental Factors of Severe Fever with Thrombocytopenia Syndrome Patients in a Highly Endemic Region: A 12-Year Surveillance Study

  • Xin Yang,
  • Cheng-Juan Liu,
  • Hong-Han Ge,
  • Chun-Hui Li,
  • Li-Fen Hu,
  • Xiao-Ai Zhang,
  • Ming Yue,
  • Pei-Jun Guo and
  • Wei Liu

Background: Severe fever with thrombocytopenia syndrome (SFTS) has become an increasing public health threat in China, with Yantai City representing a major endemic focus. A fine-scale, long-term epidemiological analysis integrating human case data w...

(This article belongs to the Section Viral Pathogens)
  • Article
  • Open Access
4 Citations
2,500 Views
22 Pages

Clinical Manifestations of Lyme Borreliosis in Europe: Burden of Lyme Disease Study (BOLD), 2021–2022

  • Kate Halsby,
  • Alexandra Loew-Baselli,
  • Franc Strle,
  • Anna Moniuszko-Malinowska,
  • Johan Sanmartin Berglund,
  • Viliam Cibik,
  • Dagmar Zakova,
  • Ye Tan,
  • Frederick J. Angulo and
  • on behalf of the BOLD Study Group
  • + 5 authors

Lyme borreliosis (LB), the most common European tick-borne disease, can manifest as an erythema migrans (EM) rash or as disseminated LB. The prospective Burden of Lyme Disease (BOLD) study evaluated the frequency of LB clinical manifestations, includ...

(This article belongs to the Special Issue Tick-Borne Threats in Europe: From Epidemiology to the Impact of Vaccination)
  • Article
  • Open Access
1 Citations
1,396 Views
12 Pages

The Resurgence of Pertussis in Tuscany (Italy): A Six-Year Retrospective Epidemiological Analysis

  • Sara Boccalini,
  • Manuela Chiavarini,
  • Alice Dell’Acqua,
  • Beatrice Conti,
  • Zhanna Tumanova,
  • Alessandra Picelli,
  • Vanessa Verniani,
  • Daniele Borchi,
  • Lorenzo Latella and
  • Angela Bechini
  • + 6 authors

Pertussis, caused by Bordetella pertussis, remains a public health concern despite long-standing vaccination programs. After a marked decline during the COVID-19 pandemic, a resurgence was observed in Europe and Italy, with a sharp increase in 2024....

  • Review
  • Open Access
1 Citations
1,837 Views
19 Pages

Heavy metal pollution is increasingly recognized, not merely as a source of static toxicity, but also as a driver of dynamic microbial regulation. At sublethal concentrations, these pollutants function as critical environmental cues that reshape micr...

(This article belongs to the Section Bacterial Pathogens)
  • Article
  • Open Access
3 Citations
1,172 Views
17 Pages

Antiviral Activity of Pyrazolopyrimidine and Triazolopyrimidine Derivatives Against SARS-CoV-2 In Vitro: Identifying PZP25 as a Promising Scaffold

  • Saiqa Sardar,
  • Jessica S. C. C. Martins,
  • Thiago C. Sousa,
  • Andreon S. M. Silva,
  • Marcelo A. Pinto,
  • Flávia F. Silveira,
  • Thais B. Silva,
  • Rodolfo R. F. França,
  • Luiz C. S. Pinheiro and
  • Leonardo J. M. Carvalho
  • + 3 authors

Prior molecular docking and dynamics studies indicated a pyrazolopyridine–sulfonamide derivative (L87/PPS2, or simply PPS2) as a potential interactant with SARS-CoV-2 protein targets. The in vitro anti-SARS-CoV-2 activity and cytotoxicity profi...

(This article belongs to the Special Issue Advances in Virus-Host Interactions, Viral Pathogenicity and Antiviral Drug Development)
  • Article
  • Open Access
1,082 Views
18 Pages

Background: Methicillin-resistant Staphylococcus pseudintermedius (MRSP) represents an emerging challenge in veterinary dermatology. Commercially available ozonated oils promise antibacterial activity, but their efficacy under physiologically relevan...

(This article belongs to the Section Bacterial Pathogens)
  • Article
  • Open Access
2,794 Views
24 Pages

Assessment of the Microbiological Quality of Raw Milk Sold Through Vending Machines at the Farm Level in Switzerland

  • Thomas Paravicini,
  • Marc J. A. Stevens,
  • Karen Barmettler,
  • Nicole Cernela and
  • Roger Stephan

The sale of raw milk via vending machines represents a well-established distribution model in many European countries, including Switzerland. As part of this study, data on the microbiological quality of raw milk sold via vending machines in Switzerl...

(This article belongs to the Special Issue Dairy Cattle Health: Mastitis, Milk Quality, and Antimicrobial Resistance from a One Health Perspective)
  • Case Report
  • Open Access
1 Citations
1,736 Views
8 Pages

A Fatal Case of Puumala Virus Infection with Pulmonary and Renal Syndrome in Moscow Region, Russia

  • Ekaterina Blinova,
  • Tamara Dzagurova,
  • Galina Gopatsa,
  • Natalya Pshenichnaya,
  • Evgeny Morozkin and
  • Vasiliy Akimkin

Hemorrhagic fever with renal syndrome (HFRS) is the most common zoonotic disease in Russia, with about a 98% abundance of Puumala virus in all HFRS cases. We report clinical manifestations and genomic characteristics of the Puumala virus strain that...

(This article belongs to the Section Viral Pathogens)
  • Article
  • Open Access
2 Citations
1,945 Views
17 Pages

Whole-Genome Sequencing and Phenotypic Drug Susceptibility Testing of Bedaquilin, Delamanid, Pretomanid, and Linezolid in Drug-Resistant Mycobacterium tuberculosis from a Single Institute in South Korea

  • Hyun-Woo Choi,
  • Yoo-Ree Kang,
  • Eun-Soon Son,
  • Kyungsik Choi,
  • Myungsun Cho,
  • Young Jin Kim,
  • Seo A Lee,
  • Jin Young Lee,
  • Jee Hey Kim and
  • Hee Joo Lee
  • + 3 authors

Multidrug-resistant tuberculosis is a major global health concern. Newer agents, including bedaquiline (BDQ), delamanid (DLM), pretomanid (PMD), and linezolid (LZD), are essential for treatment; however, the resistance mechanisms of these drugs remai...

(This article belongs to the Section Bacterial Pathogens)
  • Review
  • Open Access
3 Citations
4,006 Views
17 Pages

Herpes simplex virus type 2 (HSV-2) is the primary pathogen responsible for genital herpes. Predominantly transmitted via sexual contact, HSV-2 not only poses significant physical and psychological burdens on infected individuals but also substantial...

  • Article
  • Open Access
1 Citations
1,830 Views
23 Pages

A Compact Closed Genome of Orientia tsutsugamushi from Hainan Island, China Provides a TA763_A Reference and Reveals Repeat-Driven Remodeling

  • Yi Niu,
  • Yijia Guo,
  • Zhao Xu,
  • Siqi Chen,
  • Liyuan Zhang,
  • Xiuji Cui,
  • Dachuan Lin,
  • Kwok-Yung Yuen,
  • Jasper Fuk-Woo Chan and
  • Feifei Yin
  • + 1 author

Scrub typhus, caused by the obligate intracellular bacterium Orientia tsutsugamushi (O. tsutsugamushi), remains a major public-health concern in the Asia–Pacific region. Genome-wide inference is complicated by extensive repetitive DNA and frequ...

(This article belongs to the Special Issue New Insights into Rickettsia and Related Organisms)
  • Article
  • Open Access
2 Citations
1,680 Views
15 Pages

Survey of Antimicrobial-Resistant Bacteria Isolated from Rivers in Japan, Indonesia and Nepal

  • Kayo Osawa,
  • Ryohei Nomoto,
  • Takashi Suzuki,
  • Taishi Maeda,
  • Ganesh Rai,
  • Shouhiro Kinoshita,
  • Noriko Nakanishi,
  • Dadik Raharjo,
  • Masanori Kameoka and
  • Toshiro Shirakawa
  • + 3 authors

The threat of antimicrobial resistance in aquatic environments, particularly riverine systems, is escalating, in part due to effluents discharged from healthcare facilities. This issue has been recognized not only in Japan but also in other Asian cou...

(This article belongs to the Special Issue New Insights into Antibiotic-Resistant Pathogens Within the One Health Framework: Epidemiology, Mechanisms and Strategies for Eradication)
  • Article
  • Open Access
1,191 Views
13 Pages

Different Trends of Immune Activation Markers When Switching to Either Oral or Injectable Dual Antiretroviral Therapy Based on Integrase Inhibitors in People Living with HIV

  • Matteo Vassallo,
  • Jacques Durant,
  • Roxane Fabre,
  • Jacqueline Capeau,
  • Soraya Fellahi,
  • Jean-Philippe Bastard,
  • Pierre Corbeau and
  • Christian Pradier

Background: Despite improvements in life expectancy, people living with HIV (PWH) continue displaying immune activation and high rates of comorbid conditions. No comparative studies concerning activation markers exist between simplification strategie...

  • Article
  • Open Access
1 Citations
1,527 Views
20 Pages

Design and Characterization of an HRC-Derived Peptide Inhibitor of Canine Coronavirus Spike-Mediated Fusion

  • Valentina Iovane,
  • Rosa Giugliano,
  • Antonio Gentile,
  • Roberta Della Marca,
  • Laura Di Clemente,
  • Annalisa Chianese,
  • Serena Montagnaro,
  • Anna De Filippis,
  • Massimiliano Galdiero and
  • Carla Zannella

Canine coronavirus (CCoV), an alphacoronavirus belonging to the Coronaviridae family, is primarily associated with enteric infections in dogs. The ongoing evolution of coronaviruses through genetic recombination and mutation leads to the emergence of...

(This article belongs to the Special Issue Current Challenges in Veterinary Virology)
  • Article
  • Open Access
1 Citations
970 Views
11 Pages

Streptococcus suis is an emerging zoonotic pathogen that typically causes bacteremia or meningitis in humans, whereas vertebral osteomyelitis with epidural abscess is exceedingly rare and may be missed. We describe a 65-year-old farmer with fever and...

(This article belongs to the Section Bacterial Pathogens)
  • Article
  • Open Access
1 Citations
1,726 Views
19 Pages

The rising prevalence of Candidozyma auris and Candida parapsilosis, characterized by high surface persistence and biofilm-forming capabilities, challenges the efficacy of standard laundry and surface disinfection protocols. This study evaluated the...

(This article belongs to the Section Fungal Pathogens)
  • Article
  • Open Access
1,357 Views
12 Pages

Development and Evaluation of a Dual-Target One-Step Nested PCR for the Detection of Spotted Fever Group Rickettsia spp. in Ticks

  • Phiaw Chong Foo,
  • Canedy Jacob,
  • Christina Injan Mawang,
  • Ernieenor Faraliana Che Lah and
  • Mariana Ahamad

Spotted fever group (SFG) rickettsioses are tick-borne infectious diseases caused by more than 30 Rickettsia species. As ticks may harbor and transmit multiple pathogens during a single blood meal, sensitive and specific molecular detection methods a...

(This article belongs to the Special Issue Ticks and Tick-Borne Diseases in Southeast Asia)
  • Article
  • Open Access
1,508 Views
19 Pages

Molecular Profiles and Antimicrobial Resistance Genes in Bacterial Isolates from Chronic Rhinosinusitis Patients

  • Andrei Osman,
  • Alice Elena Ghenea,
  • Carmen Aurelia Mogoanta,
  • Irina Enache,
  • Alexandra Bucătaru,
  • Ramona Cioboată,
  • Mădălina Georgescu,
  • Andrei Theodor Bălășoiu and
  • Ovidiu Mircea Zlatian

(1) Background: Chronic rhinosinusitis (CRS) with recurrent symptoms despite therapy raises concern for underlying antimicrobial resistance. While inflammation is central to disease pathophysiology, increasing evidence suggests that resistant bacteri...

(This article belongs to the Special Issue Antimicrobial Resistance in the Post-COVID Era: A Silent Pandemic)
  • Article
  • Open Access
1 Citations
1,655 Views
16 Pages

Improving Molecular Detection of Tick-Borne Pathogens in Citizen-Collected Ticks

  • Andrea Matucci,
  • Salvatore Scarso,
  • Graziana Da Rold,
  • Federica Obber,
  • Filippo Marzoli,
  • Andrea Ragusa,
  • Fabio Formenti,
  • Davide Treggiari,
  • Antonio Mori and
  • Chiara Piubelli
  • + 10 authors

This study aimed primarily to evaluate the performance of two Conformité Européenne—In Vitro Diagnostic (CE-IVD) multiplex real-time PCR (rt-PCR) assays for the molecular identification of tick-borne pathogens (TBPs) of human inte...

(This article belongs to the Special Issue Ticks and Tick-Borne Diseases―Pathogens, Parasites, People and Practices)
  • Review
  • Open Access
1,515 Views
10 Pages

Theileria haneyi, a recently discovered tick-borne hemoparasite infecting equids globally, has significant implications for equine health. Although it is closely related to T. equi (sharing 23% genomic divergence), it establishes an asymptomatic carr...

(This article belongs to the Special Issue Piroplasms and Tick-Borne Pathogens: Transmission, Surveillance, and One Health Perspectives)
  • Article
  • Open Access
1,549 Views
17 Pages

Molecular Evidence of Zoonotic Pathogens in Free-Living Wild Birds: A Greek Surveillance Study

  • Sokratis Perdikaris,
  • Maria Evangelidou,
  • George Diamantopoulos,
  • Evangelia Kofidou,
  • Grigorios Markakis,
  • Dimitrios Vourvidis,
  • Emmanouil Papadogiannakis,
  • Anastasia Komnenou and
  • Emmanouil Angelakis

Wild birds are increasingly recognized as contributors to the circulation and environmental dissemination of zoonotic pathogens, yet data from Greece remain limited, particularly for raptors, corvids, and water birds. This study investigated selected...

(This article belongs to the Special Issue Emerging and Neglected Pathogens in the Balkans)
  • Review
  • Open Access
1 Citations
1,608 Views
25 Pages

Circular RNAs (circRNAs) are a special category of non-coding RNAs. The latter are known for their pivotal regulatory functions over many cellular processes. In biology, circRNAs exert regulatory functions on many physiological events, most likely th...

(This article belongs to the Special Issue Molecular Aspects of Host-Parasite Interactions)
  • Article
  • Open Access
1 Citations
1,258 Views
14 Pages

Molecular Detection and Identification of Bacterial Pathogens in Qinghai Province, China

  • Didi Zhang,
  • Yihong Ma,
  • Xinyuan Zhao,
  • Huaixing Yang,
  • Xiuping Li,
  • Guanghua Wang,
  • Yong Hu,
  • Shenghua Tang,
  • Rong Li and
  • Liqing Ma
  • + 2 authors

As a core pastoral region of the Qinghai–Tibet Plateau, Qinghai Province faces substantial threats to livestock production from tick-borne diseases. This study aimed to investigate the prevalence of six bacterial pathogens in dominant tick spec...

(This article belongs to the Special Issue Epidemiology of Vector-Borne Pathogens)
  • Article
  • Open Access
4 Citations
1,550 Views
21 Pages

Microbiological Characteristics and Clinical Outcomes of Periprosthetic Infections Following Oncologic Megaprosthetic Reconstruction: A Retrospective Cohort Study

  • Vasileios Karampikas,
  • Stavros Goumenos,
  • Andreas G. Tsantes,
  • Ioannis G. Trikoupis,
  • Panayiotis Gavriil,
  • Anastasios G. Roustemis,
  • Alexandros Zikopoulos,
  • Vasileios Petrakis,
  • Dimitrios V. Papadopoulos and
  • Panayiotis J. Papagelopoulos
  • + 3 authors

Background: Periprosthetic joint infection (PJI) is a severe complication following megaprosthetic reconstruction in musculoskeletal oncology. This study aimed to evaluate outcomes of different surgical strategies for PJI in lower-limb megaprostheses...

  • Article
  • Open Access
1,241 Views
13 Pages

Epidemiology and Molecular Characterization of Mycoplasmosis in Northeastern Part of Italy, 2023

  • Caterina Signoretto,
  • Luca Caiazzo,
  • Gelinda De Grandi,
  • Donato Zipeto and
  • Paolo Gaibani

Mycoplasma genitalium (MG) is a cell wall–deficient bacterial pathogen associated with several sexually transmitted infections (STIs), including nongonococcal urethritis, cervicitis, and pelvic inflammatory disease. In the context of increasing...

(This article belongs to the Special Issue Surveillance, Prevention and Control of Sexually Transmitted Infections)
  • Article
  • Open Access
1 Citations
1,250 Views
13 Pages

Nationwide Serological Survey of Equine Trypanosomosis in Kazakhstan

  • Ainur Nurpeisova,
  • Zhadra Kudaibergenova,
  • Roza Aitlessova,
  • Bolat Shalabayev,
  • Maksat Serikov,
  • Altynai Arysbekova,
  • Makay Zheney,
  • Nuray Ibraim,
  • Kobeikhan Begassyl and
  • Zhandos Abay
  • + 10 authors

Equine trypanosomosis remains an important veterinary concern in regions where horses play a significant economic and cultural role. In Kazakhstan, comprehensive nationwide data on the seroepidemiological status of equine trypanosomes are limited. Th...

(This article belongs to the Section Parasitic Pathogens)
  • Article
  • Open Access
1,289 Views
14 Pages

Laboratory Diagnostics of Botulism Cases in Livestock in Poland in 2022–2024

  • Aleksandra Jarosz,
  • Magdalena Sapała and
  • Tomasz Grenda

Botulism is a neuroparalytic disease caused by exposure to botulinum neurotoxins produced by anaerobic spore-forming bacteria of the genus Clostridium. This disease occurs in both humans and wild and domestic animals, and is currently becoming an inc...

(This article belongs to the Section Epidemiology of Infectious Diseases)
  • Article
  • Open Access
1,056 Views
14 Pages

Genetic Diversity and Novel Lineages of Anaplasma, Ehrlichia, and Coxiella-like Endosymbionts in Ticks from a Forest Ecosystem in Northeastern China

  • Qingzhu Huang,
  • Zhongqiu Teng,
  • Miao Lu,
  • Yuqing Cheng,
  • Xincheng Qin,
  • Lupeng Dai,
  • Junrong Liang,
  • Tian Qin and
  • Jianguo Xu

Ticks are important vectors of bacterial pathogens with veterinary and public health significance. However, information on the diversity of tick-associated bacteria in forest ecosystems of northeastern China remains limited. In this study, 821 questi...

  • Article
  • Open Access
1,658 Views
12 Pages

The Blowfly Chrysomya megacephala as a Vector of Pathogens Associated with Infectious Diseases

  • César Valverde-Castro,
  • Alba Luz Peralta-Botello and
  • Maria Teresa Mojica

Chrysomya megacephala is a synanthropic fly with a high potential to act as a mechanical vector of pathogenic bacteria, surpassing Musca domestica in both bacterial load and diversity. Native to Asia and Africa, it has become a cosmopolitan species,...

(This article belongs to the Topic Vector-Borne Disease Spatial Epidemiology, Disease Ecology, and Zoonoses)
  • Article
  • Open Access
710 Views
12 Pages

Occurrence and Multi-Locus Genotyping of Enterocytozoon bieneusi in Black Goats from Fujian Province, China

  • Kai Hu,
  • Zhong-Yang Chen,
  • Yanlong Gu,
  • Sheng-Jie Tang,
  • Peng-Fei Fu and
  • Dong-Hui Zhou

Enterocytozoon bieneusi is an important zoonotic intestinal protozoon causing diarrhea in humans and animals, threatening public health and livestock farming. This study aimed to investigate the infection and genotype distribution of E. bieneusi in b...

(This article belongs to the Topic Advances in Infectious and Parasitic Diseases of Animals)
  • Review
  • Open Access
3 Citations
2,406 Views
20 Pages

West Nile Virus in Europe: Epidemiology, Vector Ecology, Environmental Drivers, and the Role of Equine Sentinel Surveillance in a One Health Framework

  • Paula Nistor,
  • Livia Stanga,
  • Vlad Iorgoni,
  • Razvan Grigore Cojocaru,
  • Alexandru Gligor,
  • Alexandru Ciresan,
  • Bogdan Florea,
  • Vlad Cocioba,
  • Ionica Iancu and
  • Viorel Herman
  • + 3 authors

West Nile virus (WNV) is a mosquito-borne flavivirus that remains an important public and veterinary health concern across Europe. Periodic outbreaks affecting humans, horses, and wildlife highlight the complex ecological interactions underlying vira...

(This article belongs to the Section Ticks)
  • Article
  • Open Access
5 Citations
1,989 Views
30 Pages

Immunoinformatic Design and Evaluation of a Multi-Epitope mRNA Vaccine RP14914P Targeting Latent Tuberculosis Infection

  • Yuan Tian,
  • Mingming Zhang,
  • Syed Luqman Ali,
  • Aigul Abduldayeva,
  • Shuang Zhou,
  • Yajing An,
  • Yufeng Li,
  • Ruizi Ni,
  • Lingxia Zhang and
  • Wenping Gong
  • + 2 authors

Background: Latent tuberculosis infection (LTBI) is the principal reservoir for active tuberculosis, with >85% of cases attributable to reactivation. Bacillus Calmette-Guérin fails to block this transition, leaving a critical gap in prevent...

(This article belongs to the Section Vaccines and Therapeutic Developments)
  • Article
  • Open Access
1,175 Views
14 Pages

Background: Scarlet fever has seen a sharp increase in its reported incidence in China since 2011, and this study focuses on Shanghai as a representative setting to systematically investigate its transmission dynamics by analyzing age structure. It f...

(This article belongs to the Section Epidemiology of Infectious Diseases)
  • Article
  • Open Access
2,207 Views
19 Pages

Long-Term Trends and Determinants of Tuberculosis Burden in China, 1990–2023: Insights from the Global Burden of Disease Study 2023

  • Yingxing Wang,
  • Guozhong He,
  • Hoiman Ng,
  • Chaoxi Niu,
  • Rong Li,
  • Furong Zhang,
  • Ruimei Shi,
  • Xingyue Dian,
  • Qingping Ma and
  • Zhong Sun

Tuberculosis (TB) remains a major public health challenge in China despite substantial long-term progress. Using data from the Global Burden of Disease Study 2023, this study reassessed trends and determinants of TB burden in China from 1990 to 2023....

(This article belongs to the Section Emerging Pathogens)
  • Review
  • Open Access
2 Citations
2,786 Views
41 Pages

Promising Drug Repurposing Candidates Targeting Free-Living Amoebae: A Systematic and Critical Review of Laboratory-Based Evidence

  • Beni Jequicene Mussengue Chaúque,
  • Luiza Bernardes Chagas,
  • Thaisla Cristiane Borella da Silva,
  • Denise Leal dos Santos,
  • Luciano Palmeiro Rodrigues,
  • Lucile da Silva Lins Baía,
  • Manoella Kessler Gomes Rodrigues,
  • Guilherme Brittes Benitez,
  • Thais Lemos Mendes and
  • José Roberto Goldim
  • + 5 authors

Devastating or nearly invariably fatal infections caused by free-living amoebae (FLA), including Acanthamoeba keratitis (AK), granulomatous amoebic encephalitis (GAE), and primary amoebic meningoencephalitis (PAM), remain a significant public health...

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Pathogens - ISSN 2076-0817