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Pharmaceuticals, Volume 16, Issue 12

December 2023 - 111 articles

Cover Story: Combining in silico and in vitro approaches allowed us to investigate the mechanism of action as CFTR correctors of three hybrid derivatives (2a, 7a and 7m) featuring the thiazole core tethered to the benzodioxole motif of VX809. Molecular modelling suggested that 2a, 7a and 7m interact with the MSD1/NBD1 interface. Biochemical analyses confirmed these data, showing that the three molecules affect the expression and stability of the F508del NBD1. We tested the ability of combinations of 2a, 7a and 7m with correctors already in clinical use to increase the activity of the F508del CFTR channel. We used VX661, a class I corrector binding to MSD1, and VX445, increasing the expression and stability of MSD2. A YFP assay was applied to confirm the additive influence of 2a, 7a and 7m on F508del CFTR function to that of VX661 and VX445. view this paper
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Articles (111)

  • Case Report
  • Open Access
6 Citations
2,655 Views
14 Pages

18 December 2023

The Bacillus and Paenibacillus genera are diverse soil-related bacterial pathogens. In this case report, we describe, to our knowledge, the first report of septic arthritis in a native hip joint in an immunocompetent adult patient caused by Bacillus&...

  • Article
  • Open Access
4 Citations
3,060 Views
19 Pages

In Silico, In Vitro, and In Vivo Evaluation of Caffeine-Coated Nanoparticles as a Promising Therapeutic Avenue for AML through NF-Kappa B and TRAIL Pathways Modulation

  • Muhammad Hamid Siddique,
  • Sidra Bukhari,
  • Inam Ullah Khan,
  • Asiya Essa,
  • Zain Ali,
  • Usama Sabir,
  • Omiya Ayoub,
  • Haleema Saadia,
  • Muhammad Yaseen and
  • Aneesa Sultan
  • + 4 authors

18 December 2023

Background: Advancements in nanoscience have led to a profound paradigm shift in the therapeutic applications of medicinally important natural drugs. The goal of this research is to develop a nano-natural product for efficient cancer treatment. Metho...

  • Article
  • Open Access
2,639 Views
14 Pages

At-Home Foscarnet Administration in Patients with Cytomegalovirus Infection Post-Allogeneic Stem Cell Transplantation: A Unicentric, Safe, and Feasible Program

  • Sonia Ruiz-Boy,
  • Alexandra Pedraza,
  • Marta Prat,
  • Maria Queralt Salas,
  • Esther Carcelero,
  • Gisela Riu-Viladoms,
  • María Suárez-Lledó,
  • Inés Monge-Escartín,
  • Luis Gerardo Rodríguez-Lobato and
  • Alexandra Martínez-Roca
  • + 7 authors

18 December 2023

Cytomegalovirus (CMV) infection is a relevant cause of morbimortality in patients receiving allogeneic stem cell transplantation (allo-HCT). Foscarnet (FCN) is an effective drug against CMV administered intravenously and usually on an inpatient basis...

  • Article
  • Open Access
4 Citations
5,454 Views
12 Pages

Beta Blockers Improve Prognosis When Used Early in Patients with Cardiogenic Shock: An Analysis of the FRENSHOCK Multicenter Prospective Registry

  • Laura Sofia Cardelli,
  • Miloud Cherbi,
  • Fabien Huet,
  • Guillaume Schurtz,
  • Eric Bonnefoy-Cudraz,
  • Edouard Gerbaud,
  • Laurent Bonello,
  • Guillaume Leurent,
  • Etienne Puymirat and
  • Gianni Casella
  • + 2 authors

18 December 2023

Background: Beta blockers (BBs) are a cornerstone for patients with heart failure (HF) and ventricular dysfunction. However, their use in patients recovering from a cardiogenic shock (CS) remains a bone of contention, especially regarding whether and...

  • Article
  • Open Access
6 Citations
3,396 Views
18 Pages

17 December 2023

Tendon injuries, while prevalent, present significant challenges regarding their structural and functional restoration. Utilizing alpha-smooth muscle actin (α-SMA)-Ai9-scleraxis (Scx)-green fluorescent protein (GFP) transgenic mice, which exhib...

  • Article
  • Open Access
5 Citations
3,686 Views
17 Pages

Promising Anti-Wrinkle Applications of Aromatic Extracts of Hedychium coronarium J. Koenig via Antioxidation and Collagenase Inhibition

  • Pattiya Tammasorn,
  • Wannaree Charoensup,
  • Anurak Bunrod,
  • Watchara Kanjanakawinkul and
  • Wantida Chaiyana

17 December 2023

This study aimed to extract aromatic compounds from the rhizomes, leaf sheaths, and leaves of Hedychium coronarium and investigate their chemical compositions, cosmetic/cosmeceutical activities, and irritation potency. The chemical compositions were...

  • Article
  • Open Access
5 Citations
2,458 Views
18 Pages

Biological Potential and Bioaccessibility of Encapsulated Curcumin into Cetyltrimethylammonium Bromide Modified Cellulose Nanocrystals

  • Francisca Casanova,
  • Carla F. Pereira,
  • Alessandra B. Ribeiro,
  • Pedro M. Castro,
  • Ricardo Freixo,
  • Eva Martins,
  • Diana Tavares-Valente,
  • João C. Fernandes,
  • Manuela E. Pintado and
  • Óscar L. Ramos

17 December 2023

Curcumin is a natural phenolic compound with important biological functions. Despite its demonstrated efficacy in vitro, curcumin biological activities in vivo are dependent on its bioaccessibility and bioavailability, which have been highlighted as...

  • Article
  • Open Access
18 Citations
8,787 Views
14 Pages

Validation of an HPLC-DAD Method for Quercetin Quantification in Nanoparticles

  • Daniel Carvalho,
  • Ângelo Jesus,
  • Cláudia Pinho,
  • Rita Ferraz Oliveira,
  • Fernando Moreira and
  • Ana Isabel Oliveira

17 December 2023

The evaluation of the efficacy of incorporation of quercetin in nanoparticles is crucial, both for the development and quality control of pharmaceutical formulations. The validation of analytical methods for the precise quantification of quercetin is...

  • Review
  • Open Access
6 Citations
3,460 Views
24 Pages

16 December 2023

Age-related macular degeneration (AMD), a leading cause of visual loss and dysfunction worldwide, is a disease initiated by genetic polymorphisms that impair the negative regulation of complement. Proteomic investigation points to altered glycosylati...

  • Review
  • Open Access
25 Citations
4,886 Views
17 Pages

15 December 2023

The application of chemotherapy drugs in tumor treatment has a long history, but the lack of selectivity of drugs often leads to serious side effects during chemotherapy. The natural anti-tumor ingredients derived from Chinese herbal medicine are att...

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Pharmaceuticals - ISSN 1424-8247