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Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Resveratrol: Pharmacological Mechanisms and Therapeutic Potential as a Natural Product

edited by

Dumitriţa Rugină

and

Roxana Pop

submission deadline 20 Aug 2026 | 1 articles | Viewed by 2551 | Submission Open

Keywords: resveratrol; natural compound pharmacology; therapeutic potential; drug development; biomedical research

(This special issue belongs to the Section Natural Products)

Challenges in the Development of PET and SPECT Radiotracers: Innovative Ideas with Negative Outcomes

edited by Magali Toussaint and Barbara Wenzel

submission deadline 25 Aug 2026 | 8 articles | Viewed by 14186 | Submission Open

Keywords: radiotracer development; positron emission tomography (PET); single-photon emission computed tomography (SPECT); negative results; diagnostic radiotracers; therapeutic radiopharmaceuticals; radiolabeling; automated synthesis and GMP; pre-clinical studies; medicinal chemistry

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Chemotherapeutic and Targeted Drugs in Antitumor Therapy

edited by

Angéla Takács

and

László Kőhidai

submission deadline 25 Aug 2026 | 2 articles | Viewed by 4619 | Submission Open

Keywords: cancer; drug discovery; small-molecule drugs; targeted therapy; combination therapy; synergism; selectivity; immunotherapy; precision medicine

(This special issue belongs to the Section Pharmacology)

Innovative Approaches to GABAergic Drug Discovery: From Molecular Mechanisms to Advanced Therapeutics

edited by

Wojciech Kołodziejczyk

and

Donato Colangelo

submission deadline 25 Aug 2026 | 2 articles | Viewed by 3671 | Submission Open

Keywords: GABAergic signaling; GABA receptors; drug discovery; neurological and psychiatric disorders; ligand design; computational drug development; artificial intelligence in pharmacology; high-throughput screening; targeted drug delivery; controlled release systems

(This special issue belongs to the Section Pharmacology)

Drug Treatment for Epilepsy

edited by Clarissa Fantin Cavarsan

submission deadline 25 Aug 2026 | 1 articles | Viewed by 2975 | Submission Open

Keywords: epilepsy; anticonvulsant; epileptic syndrome; seizure; epileptogenic; small molecule drugs

(This special issue belongs to the Section Pharmacology)

Drug Safety and Real-World Evidence: From Databases to Artificial Intelligence

edited by

Maria Antonietta Barbieri

submission deadline 25 Aug 2026 | 4 articles | Viewed by 2907 | Submission Open

Keywords: drug safety; real-world evidence; patient’s clinical outcomes; pharmacovigilance; pharmacoepidemiology; artificial intelligence; adverse drug reactions; inappropriate prescribing

(This special issue belongs to the Section AI in Drug Development)

Crystal Engineering in the Pharmaceutical Sciences

edited by

Stephen Robert Byrn

submission deadline 25 Aug 2026 | 2 articles | Viewed by 2348 | Submission Open

Keywords: intermolecular interactions; cocrystals; salts; disproportionation; crystal structure prediction; space manufacturing

(This special issue belongs to the Section Medicinal Chemistry)

Innovative Applications and Performance Optimization of Biodegradable Polymers in Drug Delivery

edited by

Nikolaos D. Bikiaris

submission deadline 25 Aug 2026 | 1 articles | Viewed by 1960 | Submission Open

Keywords: biodegradable polymers; drug delivery systems; controlled release; polymeric nanoparticles; targeted drug delivery; in vivo drug delivery; sustained release formulations

(This special issue belongs to the Section Pharmaceutical Technology)

Immunotherapy as a Promising Therapeutic Paradigm for Cancers

edited by

Gheorghița Isvoranu

and

Marioara Chiritoiu-Butnaru

submission deadline 25 Aug 2026 | 1 articles | Viewed by 959 | Submission Open

Keywords: cancer immunotherapy; cell-based therapy in cancer; immune checkpoint and co-stimulator modulators; bispecific antibodies; neoantigen-based vaccines; signal transduction inhibitors; small molecules of cancer drugs; tumor microenvironment; mechanisms of resistance

(This special issue belongs to the Section Pharmacology)

Innovative Tools for Drug Analysis and Therapeutic Drug Monitoring (TDM): 2nd Edition

edited by

Juraj Piestansky

and

Andrej Kovac

submission deadline 25 Aug 2026 | 1 articles | Viewed by 920 | Submission Open

Keywords: therapeutic drug monitoring; biologics; separation analytical methods; bioanalysis; quality control; dosage forms; green analytical chemistry; personalized medicine; clinical bioanalysis; bioanalytical methods

(This special issue belongs to the Section Pharmacology)

Network and Systems Pharmacology of Natural Products for Multi-Target Intervention in Cancer and Metabolic Disease

edited by Aleksandra Golonko

submission deadline 25 Aug 2026 | Viewed by 580 | Submission Open

Keywords: pleiotropy; multi-target; obesity; cancer; diabetes; adverse effect; metabolism; drug synthesis; drug discovery

(This special issue belongs to the Section Natural Products)

Antiparasitic Essential Oils: Mechanisms of Action, Technological Approaches, and Metabolism

edited by

Damião Pergentino de Sousa

submission deadline 25 Aug 2026 | Viewed by 400 | Submission Open

Keywords: volatile; essential oils; aromatic plants; aromas; protozoa; helminths; Trypanosoma; Leishmania

(This special issue belongs to the Section Natural Products)

Perioperative Precision in Modern Anesthesia: Efficacy and Safety of Pharmacotherapy with Risk Modulation

edited by

Michał Jan Stasiowski

submission deadline 25 Aug 2026 | Viewed by 295 | Submission Open

Keywords: perioperative precision anesthesia; anesthesia pharmacotherapy; perioperative drug management; anesthesia efficacy; anesthesia safety; risk modulation; adverse event prevention

(This special issue belongs to the Section Pharmacology)

Vitamin D and Its Derivatives in Pharmacology: Mechanisms and Therapeutic Applications

edited by

Agnieszka Sliwinska

submission deadline 27 Aug 2026 | 5 articles | Viewed by 10631 | Submission Open

Keywords: vitamin D, synthesis and metabolism; vitamin D derivatives; vitamin D deficiency related diseases; clinical trials on vitamin D and/or its derivatives

(This special issue belongs to the Section Pharmacology)

Innovative Drug Strategies in Chronic Disease Management: Addressing Non-Adherence and Improving Therapeutic Outcomes

edited by

Eduardo Gutiérrez-Abejón

and

F. Javier Alvarez

submission deadline 27 Aug 2026 | 4 articles | Viewed by 6809 | Submission Open

Keywords: adherence; persistence; chronic diseases; therapeutic strategies; individualized therapy; personalized medicine; clinical pharmacology; clinical trials; observational studies; real-world data studies

(This special issue belongs to the Section Pharmacology)

Drug Candidates for the Treatment of Oral Cancer and Oral Cancer Pain, 2nd Edition

edited by

Cara B. Gonzales

submission deadline 27 Aug 2026 | Viewed by 516 | Submission Open

Keywords: oral cancer; oral cancer pain; drug discovery; natural compounds; immunotherapy; small molecule inhibitors; biomarkers

(This special issue belongs to the Section Pharmacology)

A Commemorative Special Issue in Honor of Professor Carlos Alberto Manssour Fraga: Medicinal Chemistry’s Efforts to Discover Novel Bioactive Molecules for Complex Diseases

edited by

Luzineide Tinoco

and

Pedro De Sena Murteira Pinheiro

submission deadline 28 Aug 2026 | 7 articles | Viewed by 25681 | Submission Open

Keywords: medicinal chemistry; bioactive molecules; complex diseases; cardiovascular diseases; diabetes; cancer; neurodegenerative disorders; drug discovery; synthetic chemistry; target identification; structure–activity relationship; preclinical evaluation

(This special issue belongs to the Section Medicinal Chemistry)

Multitargeted Compounds: A Promising Approach in Medicinal Chemistry—2nd Edition

edited by

Abdallah Hamze

submission deadline 28 Aug 2026 | 1 articles | Viewed by 1103 | Submission Open

Keywords: multitargeted compounds; medicinal chemistry; rational design; drug discovery; synergistic effects; emerging technologies; therapeutic applications; dual compounds

(This special issue belongs to the Section Medicinal Chemistry)

Natural Compounds and Extracts Loaded into Advanced Delivery Platforms

edited by Judyta Cielecka-Piontek,

Anna Stasiłowicz-Krzemień

and

Nunzio Denora

submission deadline 30 Aug 2026 | Viewed by 406 | Submission Open

Keywords: bioavailability enhancement; biopolymer-based carriers; controlled delivery; nanoencapsulation; nanocarriers; natural bioactive compounds; phytochemical delivery systems; plant extract formulations; sustainable delivery systems; targeted delivery

(This special issue belongs to the Section Natural Products)

Plant-Based Extracts and the Therapeutic Potential of Bioactive Compounds, 2nd Edition

edited by

Grażyna Zgórka

submission deadline 31 Aug 2026 | 9 articles | Viewed by 21179 | Submission Open

Keywords: plant extracts; herbal medicinal products; standardization; phytochemical profiling; bioactive plant compounds; therapeutic effects

(This special issue belongs to the Section Natural Products)

Bioactive Compounds from Plants and Foods: From Traditional Medicine to Modern Applications in Nutrition and Health

edited by

Sendar Nery-Flores

Filiberto Gutierrez-Gutierrez

, Walter Trujillo-Rangel and

Raúl Rodríguez-Herrera

submission deadline 31 Aug 2026 | 6 articles | Viewed by 8302 | Submission Open

Keywords: herbal extracts; natural compounds; nutraceuticals; bioactive compounds; in vitro and in vivo studies; biological activities; phytochemistry; natural product drug discovery; computational screening of natural products; nanomaterials for natural product extraction

(This special issue belongs to the Section Natural Products)

Applications of Pharmacogenomics in Precision Medicine

edited by

Kariofyllis Karamperis

, Branka Zukic and

Fernanda Rodrigues-Soares

submission deadline 31 Aug 2026 | 2 articles | Viewed by 4430 | Submission Open

Keywords: personalized medicine; pharmacogenomics; drug–gene interactions; adverse drug reactions; pharmacogenomic biomarkers; multi-omics; population pharmacogenomics; precision therapeutics

(This special issue belongs to the Section Pharmacology)

Pyrazole and Its Derivatives: Drug Design, Synthesis, and Biological Evaluation

edited by

Matteo Lusardi

and

Marco Ponassi

submission deadline 31 Aug 2026 | 3 articles | Viewed by 3784 | Submission Open

Keywords: medicinal chemistry; drug design; drug discovery; pyrazole-based compounds; innovative synthesis; structure–activity relationships; biological activities; drug-like properties

(This special issue belongs to the Section Medicinal Chemistry)

Research on Guanidine-Based Drugs: Synthesis, Antiparasitic, Antifungal, Antiviral, and Anticancer Activities

edited by

Eduardo René Pérez González

Eduardo Henrique Zampieri

, Francisco Jaime Bezerra Mendonça-Junior,

Eduardo Maffud Cilli

and

Ana Marisa Fusco Almeida

submission deadline 31 Aug 2026 | 3 articles | Viewed by 2861 | Submission Open

Keywords: guanidine derivatives; medicinal chemistry; SAR analysis; neglected diseases; antiparasitic; antifungal; antiviral; anticancer; drug development

(This special issue belongs to the Section Medicinal Chemistry)

Cancer Therapeutics: Drug Repurposing and Computational Strategies

edited by

Minh Tuan Nguyen

submission deadline 31 Aug 2026 | 3 articles | Viewed by 2627 | Submission Open

Keywords: cancer therapeutics; drug repurposing; computer-aided drug design (CADD); molecular dynamics simulation; virtual screening; targeted therapy; structure-based drug design; molecular docking; pharmacophore modeling

(This special issue belongs to the Section AI in Drug Development)

New Perspective of Antiviral Drugs

edited by

Grigoris Zoidis

submission deadline 31 Aug 2026 | 1 articles | Viewed by 2318 | Submission Open

Keywords: antiviral drugs; antiviral agents; small organic molecules; metal complexes; natural products

(This special issue belongs to the Section Medicinal Chemistry)

Application of Natural Products in Retinal Disorders Therapy

edited by

Francesca Corsi

and

Maria Claudia Gargini

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1895 | Submission Open

Keywords: natural products; retinal disorders; neuroprotection; oxidative stress; retinal inflammation; retinal neurodegeneration; nutraceuticals; in vitro and in vivo retinal models

(This special issue belongs to the Section Natural Products)

Natural Products Drug Discovery and Their Pharmacological Applications

edited by Rosana Crespo

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1888 | Submission Open

Keywords: natural product; pharmaceutical applications; neurodegenerative disorders

(This special issue belongs to the Section Natural Products)

Molecular Systems for the Delivery of Drugs and Contrast Agents, 2nd Edition

edited by

Angelo Maspero

Luca Nardo

and

Marco Lamperti

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1841 | Submission Open

Keywords: biomarker-targeted drugs; contrast media for diagnostic imaging; drug delivery systems; photoactivated drugs and photoswitches; theranostics; liposomes; biomaterials-based drugs and drug shuttles (e.g., DNA origami); biomimetic materials; nanoparticle applications to diagnostics and therapy; in silico drug design

(This special issue belongs to the Section Medicinal Chemistry)

Current Advances, Applications and Future Development of Transition Metal Complexes, 2nd Edition

edited by

Domenico Iacopetta

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1814 | Submission Open

Keywords: transition metal complexes; synthesis; catalysis; ligands; biological activity; applications; enzyme inhibition

(This special issue belongs to the Section Medicinal Chemistry)

Advances in Neuropharmacology and Brain Injury Therapeutics

edited by

Bruce X.W. Wong

and

Kaelyn Tan

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1596 | Submission Open

Keywords: neurodegenerative diseases; brain injuries; nanomedicine and targeted delivery; stem cell and regenerative therapies; precision medicine and diagnostic biomarkers

(This special issue belongs to the Section Pharmacology)

Active Molecule Design Based on Conformational Pharmacology: Synthesis, NMR Spectroscopy, and Computational Modeling

edited by

Nikitas Georgiou

and

Demeter Tzeli

submission deadline 31 Aug 2026 | 1 articles | Viewed by 781 | Submission Open

Keywords: DFT; molecular docking; NMR; molecular dynamics

(This special issue belongs to the Section Pharmacology)

Contemporary Challenges and Solutions in Antimicrobial Use

edited by

Anca-Maria Arseniu

Alina Bereanu

and

Bogdan Vintila

submission deadline 31 Aug 2026 | Viewed by 624 | Submission Open

Keywords: antimicrobial use; novel drug delivery systems; biological barriers

(This special issue belongs to the Section Pharmacology)

From Prion Molecular Mechanisms to Targeted Therapeutics: Informing the Broader Proteinopathy Paradigm

edited by Patricia Aguilar-Calvo

submission deadline 31 Aug 2026 | Viewed by 454 | Submission Open

Keywords: prion diseases; prion-like; protein aggregation; proteinopathies; neurodegeneration; neurotoxicity; diagnostics; therapeutic strategies

(This special issue belongs to the Section Pharmacology)

Hybrid Molecules in Medicinal Chemistry: Design, Synthesis and Biological Evaluation

edited by

Tao Zhang

and John J. Walsh

submission deadline 31 Aug 2026 | Viewed by 439 | Submission Open

Keywords: hybrid molecules; medicinal chemistry; drug discovery; drug development; structure–activity relationships (SAR); multitarget-directed ligands; natural products; synthetic chemistry; biological evaluation; therapeutic innovation

(This special issue belongs to the Section Medicinal Chemistry)

Innovations in Integrin-Targeted Drug Delivery: From Peptide Conjugates to Dual-Action Therapeutics

edited by

Kelly Bugatti

Lucia Battistini

and

Andrea Sartori

submission deadline 31 Aug 2026 | Viewed by 367 | Submission Open

Keywords: integrins; peptide-drug conjugates (PDCs); drug delivery; peptide synthesis; dual conjugates

(This special issue belongs to the Section Biopharmaceuticals)

Bio-Based Materials from Food Sources: Advanced Platforms for Drug Delivery and Regenerative Therapeutics

edited by

Chengliang Li

, Min Wu and

Ruoyang Zhao

submission deadline 31 Aug 2026 | Viewed by 330 | Submission Open

Keywords: food biomacromolecules; natural proteins and peptides; formulation science; controlled release; targeted delivery; bone regeneration; wound healing; drug delivery

(This special issue belongs to the Section Pharmaceutical Technology)

Protein Silencing in Pharmaceutical Applications

edited by

Hamidreza Montazeri Aliabadi

submission deadline 31 Aug 2026 | Viewed by 324 | Submission Open

Keywords: siRNA; CRISPR/Cas9; protein silencing; cancer; in vivo; clinical applications

(This special issue belongs to the Section Biopharmaceuticals)

Antioxidant Therapeutics: From Discovery to Clinical Practice

edited by

Alain R. Rodríguez-Orozco

and

Christian Cortés-Rojo

submission deadline 31 Aug 2026 | Viewed by 317 | Submission Open

Keywords: antioxidants; ethnobotany; natural products; biopharmaceuticals; bioactive antioxidants

(This special issue belongs to the Section Natural Products)

Pharmacological Innovations for Healthy Ageing Throughout Life

edited by

Luca Soraci

submission deadline 31 Aug 2026 | Viewed by 279 | Submission Open

Keywords: age-related diseases; pharmacological innovations; adverse drug events

(This special issue belongs to the Section Medicinal Chemistry)

Endocannabinoid-Like Mediators and Their Derivatives

edited by Irene Palenca and

Martina Vincenzi

submission deadline 31 Aug 2026 | Viewed by 278 | Submission Open

Keywords: bioactive lipids; lipid mediators; cell signaling; inflammation; neuroimmune interaction; molecular pharmacology; therapeutic targets; translational research; metabolic disorders; precision medicine

(This special issue belongs to the Section Medicinal Chemistry)

Advances in Drug Treatment of Systemic Amyloidosis

edited by Juan González-Moreno

submission deadline 31 Aug 2026 | Viewed by 241 | Submission Open

Keywords: amyloid protein misfolding; disease-modifying therapies; gene-silencing strategies; protein stabilizers; translational pharmacology

(This special issue belongs to the Section Pharmacology)

Medicinal Chemistry of Thiazine and Oxazine Derivatives: Trends and Future Directions as Therapeutic Drugs

edited by

Berenika M. Szczȩśniak-Siȩga

and

Żaneta Czyżnikowska

submission deadline 10 Sep 2026 | 1 articles | Viewed by 2839 | Submission Open

Keywords: thiazine; oxazine; morpholine; thiomorpholine; benzothiazine; phenothiazine; synthesis; drug; anti-inflammatory; anticancer

(This special issue belongs to the Section Medicinal Chemistry)

Pharmacogenomics and Pediatric Pharmacotherapy

edited by

Chakradhara Rao Satyanarayana Uppugunduri

submission deadline 10 Sep 2026 | 1 articles | Viewed by 974 | Submission Open

Keywords: pharmacokinetics; pediatric formulations; pharmacodynamics; drug metabolism; pharmacogenetics; drug transport; ontogeny developmental pattern; modeling; drug safety; simulation; off-label drug use

(This special issue belongs to the Section Pharmacology)

Biomarkers in the Treatment of Cardiovascular Diseases

edited by

Luca Marino

submission deadline 10 Sep 2026 | Viewed by 319 | Submission Open

Keywords: biomarkers; precision medicine; pharmacogenomics; heart failure phenotyping; molecular cardiology

(This special issue belongs to the Section Medicinal Chemistry)

Pharmaceutical Formulation Characterization Design, 2nd Edition

edited by

Katalin Kristó

and

Tamás Sovány

submission deadline 15 Sep 2026 | 3 articles | Viewed by 3020 | Submission Open

Keywords: Quality by Design; factorial design; design space; solid dosage forms; risk assessment; critical process parameters; quality target product profile

(This special issue belongs to the Section Pharmaceutical Technology)

Structural Insights into Protein Kinases-Targeted Therapies: Overcoming Resistance and Advancing Precision Oncology

edited by David Hecht

submission deadline 20 Sep 2026 | 4 articles | Viewed by 7093 | Submission Open

Keywords: protein kinases inhibitor resistance; structural biology of of protein kinases; computational modeling; drug design; preclinical and clinical studies; precision oncology; ALK resistance for personalized medicine

(This special issue belongs to the Section Medicinal Chemistry)

Natural Antioxidants from Medicinal Plants: Extraction and Bioactivity

edited by

Julio Escalona-Arranz

and

Jesús García-Díaz

submission deadline 20 Sep 2026 | 2 articles | Viewed by 1831 | Submission Open

Keywords: natural antioxidants; medicinal plants; extraction methods; bioactivity; phenolic compounds; free radical scavenging; pharmacological potential; in silico and in vitro correlation; molecular modeling

(This special issue belongs to the Section Natural Products)

Computation-Driven Discovery of Modern Small-Molecule Therapeutics: From Enzyme Inhibition to Targeted Protein Degradation

edited by

Yudibeth Sixto-López

submission deadline 20 Sep 2026 | 1 articles | Viewed by 712 | Submission Open

Keywords: computer-aided drug design; small-molecule drugs; enzyme inhibition; PROTACs; molecular docking; molecular dynamics simulation; artificial intelligence in drug design; virtual screening

(This special issue belongs to the Section AI in Drug Development)

Multiomics Perspective in Pharmacogenomics

edited by

Alireza Tafazoli

submission deadline 20 Sep 2026 | Viewed by 311 | Submission Open

Keywords: clinical pharmacogenomics; epigenomics in pharmacogenomics; transcriptomics in pharmacogenomics; proteomics and metabolomics in pharmacogenomics; microbiome in pharmacogenomics; multiomics in pharmacogenomics; AI and computational tools in pharmacogenomics; genome profiling in pharmacogenomics; metadata in pharmacogenomics

(This special issue belongs to the Section Pharmacology)

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