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Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Lithium in Psychiatric Therapy: Celebrating 75th Anniversary

edited by

Janusz K. Rybakowski

and Ewa Ferensztajn-Rochowiak

submission deadline 25 Nov 2025 | 8 articles | Viewed by 51279 | Submission Open

Keywords: lithium; bipolar disorder; mania; depression; the prevention of recurrences; suicide; dementia; immunomodulation; genetics; kidney function

(This special issue belongs to the Section Pharmacology)

Discovery of Novel Antidepressants and Anxiolytics

edited by James Oluwagbamigbe Fajemiroye and Gunnar P. H. Dietz

submission deadline 25 Nov 2025 | 7 articles | Viewed by 25326 | Submission Open

Keywords: biomarkers; depression; anxiety; anxiolytics; antidepressants; preclinical or clinical overview; experimental data; adverse effects; pharmacotherapy options; novel drugs

(This special issue belongs to the Section Pharmacology)

Multitargeted Compounds: A Promising Approach in Medicinal Chemistry

edited by Abdallah Hamze

submission deadline 25 Nov 2025 | 6 articles | Viewed by 19471 | Submission Open

Keywords: multitargeted compounds; medicinal chemistry; rational design; drug discovery; synergistic effects; emerging technologies; therapeutic applications; dual compounds

(This special issue belongs to the Section Medicinal Chemistry)

Pediatric Drug Therapy: Safety, Efficacy, and Personalized Medicine

edited by

Catherine M. T. Sherwin

submission deadline 25 Nov 2025 | 5 articles | Viewed by 18739 | Submission Open

Keywords: pediatric pharmacotherapy; drug safety in children; pediatric drug efficacy; personalized medicine in pediatrics; pediatric pharmacokinetics; pediatric pharmacodynamics; pharmacogenomics in children; pediatric clinical trials; pediatric dosing strategies; pediatric drug formulations

(This special issue belongs to the Section Pharmacology)

Peptide Synthesis and Drug Development: Exploring Progress and Potential

edited by

Othman Al Musaimi

, Da’san M.M. Jaradat and Vera D'Aloisio

submission deadline 25 Nov 2025 | 5 articles | Viewed by 13845 | Submission Open

Keywords: peptides; enzymatic degradation; drug discovery; formulation; draggability

(This special issue belongs to the Section Biopharmaceuticals)

Biosimilars Development Strategies

edited by

Sarfaraz K. Niazi

and Sesselja S. Ómarsdóttir

submission deadline 25 Nov 2025 | 4 articles | Viewed by 10465 | Submission Open

Keywords: biosimilars; generic medicines; drug development; biosimilar development

(This special issue belongs to the Section Medicinal Chemistry)

Molecular Mechanisms and Treatment of Brain Cancer: Recent Advances and Future Trends

edited by

Terezia Kiskova-Simkova

submission deadline 25 Nov 2025 | 4 articles | Viewed by 8813 | Submission Open

Keywords: brain cancer; molecular mechanism; treatment; diagnosis; in vitro; in vivo; models

(This special issue belongs to the Section Pharmacology)

Recent Advances in the Discovery and Development of Drugs for Civilization Diseases, 2nd Edition

edited by

Marcin Gackowski

Karolina Szewczyk-Golec

and

Renata Studzińska

submission deadline 25 Nov 2025 | 5 articles | Viewed by 8144 | Submission Open

Keywords: anticancer drugs; anticancer treatment; anticoagulants; atherosclerosis; cardiovascular disease; civilization diseases; diabetes mellitus; drug development; in silico research; medication form/drug dosage form; molecular descriptors; molecular docking; molecular dynamics; molecular modeling; neoplastic disease; obesity; QSAR; radiopharmaceuticals; synthesis of bioactive compounds; type 2 diabetes

(This special issue belongs to the Section Medicinal Chemistry)

Nanotechnology in Biomedical Applications

edited by

Luciano Paulino Silva

submission deadline 25 Nov 2025 | 7 articles | Viewed by 8052 | Submission Open

Keywords: nanotechnology; nanobiotechnology; biomedical applications; drug delivery; nanobiosensors; targeted therapy; diagnostics; nanomaterials; therapeutics; theranostics

(This special issue belongs to the Section Pharmaceutical Technology)

New Development in Pharmacotherapy of Kidney Diseases

edited by Chihchao Yang

submission deadline 25 Nov 2025 | 4 articles | Viewed by 7977 | Submission Open

Keywords: chronic kidney disease (CKD); acute kidney injury (AKI); pharmacotherapy; cardiovascular protection; kidney protection; bone health; endocrine function; gut health; metabolism; neuromuscular function; nutrition; symptom management; sodium-glucose cotransporter-2 (SGLT-2) inhibitors; glucagon-like peptide-1 (GLP-1) receptor agonists; non-steroidal mineralocorticoid receptor antagonists (MRA); endothelin receptor antagonists; anemia management; electrolyte abnormalities; dialysis; nephrotoxicity; drug interactions; uremic toxin; clinical trials; innovative therapies; protein-energy wasting; chronic kidney disease and bone mineral disease; inflammation; oxidation; diabetes; hypertension; obesity; hyperlipidemia; pruritus; osteoporosis; fracture; sarcopenia; protein-energy wasting

(This special issue belongs to the Section Pharmacology)

Novel Therapeutic Strategies for Alzheimer’s Disease Treatment

edited by

Melvin Hayden

submission deadline 25 Nov 2025 | 1 articles | Viewed by 5189 | Submission Open

Keywords: Sporadic; late-onset Alzheimer’ s disease (LOAD); neurodegenerative diseases

(This special issue belongs to the Section Pharmacology)

Pharmacovigilance Insights: Addressing Drug Misuse and Enhancing Drug Safety

edited by

Cristina Sofia De Jesus Monteiro

and

Samuel Martins Silvestre

submission deadline 25 Nov 2025 | 1 articles | Viewed by 3592 | Submission Open

Keywords: adverse drug reaction; pharmacovigilance; drug safety; signal detection; risk management

(This special issue belongs to the Section Pharmacology)

Cutting-Edge Biotechnologies and Applications of Natural Products in Drug R&D and Disease Treatment

edited by

Sujay Paul

submission deadline 25 Nov 2025 | 2 articles | Viewed by 2577 | Submission Open

Keywords: natural products; bioactive compounds; natural product drug discovery and drug design; natural drug formulation; metabolic engineering for bioactive compounds; natural therapeutic agents; nanoformulations of natural compounds; synthetic biology for natural product biosynthesis; genome editing and creation of novel bioactive compounds

(This special issue belongs to the Section Natural Products)

Pharmacology and Toxicology of Opioids, 2nd Edition

edited by

Juliana Faria

, Joana Barbosa and

Ricardo Dinis-Oliveira

submission deadline 25 Nov 2025 | 1 articles | Viewed by 2026 | Submission Open

Keywords: opioid toxicity; opioid pharmacodynamics; opioid pharmacokinetics; opioid pharmacogenetics; prescription opioids; toxicity assays; in vivo; in vitro; abuse; dependence

(This special issue belongs to the Section Pharmacology)

Pharmaceutical Approaches to Orofacial Pain and Chronic Pain Conditions

edited by

Takahiko Nagamine

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1835 | Submission Open

Keywords: chronic orofacial pain; pharmaceutical approach; myofascial orofacial pain; temporomandibular joint pain; neurovascular orofacial pain; idiopathic orofacial pain; burning mouth syndrome; persistent idiopathic facial pain; persistent idiopathic dentoalveolar pain; tricyclic antidepressants; serotonin reuptake inhibitors; anticonvulsants

(This special issue belongs to the Section Pharmacology)

Antimicrobial Therapies Affect the Microbial Ecosystems Within Our Body: The Urinary Microbiome and Urolithiasis

edited by

Loredana Sabina Cornelia Manolescu

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1552 | Submission Open

Keywords: antibiotics; antimicrobials; resistance; microbiome; urolithiasis; biofilms; infections; pathogens; pharmacotherapy; inflammation

(This special issue belongs to the Section Pharmacology)

Advances in Hydrazone Compounds with Anticancer Activity

edited by

Boryana Nikolova-Mladenova

and

Mariyana Atanasova

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1488 | Submission Open

Keywords: hydrazones; lipophilicity; logP; anticancer activity; selectivity

(This special issue belongs to the Section Medicinal Chemistry)

Dental Medication

edited by

Michelle Franz-Montan

and

Camila Batista Da Silva

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1145 | Submission Open

Keywords: dental medication; local anesthetics; controlled drug delivery; nanotechnology in dentistry; therapeutic biomaterials; smart drug delivery systems; digital health in dental pharmacology; dental materials

(This special issue belongs to the Section Pharmaceutical Technology)

Epithelial Plasticity and Therapy Resistance in Cancer

edited by Naisana Seyedasli

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1079 | Submission Open

Keywords: cancer stem cells; epithelial– mesenchymal transition; epithelial reprogramming; resistance; drug targets; resistance mechanisms; biomarker discovery

(This special issue belongs to the Section Pharmacology)

Application of Nanotechnology in Drug Delivery

edited by

Camila Batista Da Silva

and

Michelle Franz-Montan

submission deadline 25 Nov 2025 | 1 articles | Viewed by 610 | Submission Open

Keywords: drug discovery; drug combinations; nanotechnology; drug liberation

(This special issue belongs to the Section Pharmaceutical Technology)

New Findings in Pharmacogenomics of Neuropsychiatric Disorders

edited by

Alireza Tafazoli

and

Mandana Hasanzad

submission deadline 25 Nov 2025 | Viewed by 511 | Submission Open

Keywords: pharmacogenomics; genome informatics; advanced DNA-sequencing technologies; bioinformatics of pharmacogenomics; diagnostic approaches in the pharmacogenomics of neuropsychiatric disorders

(This special issue belongs to the Section Pharmacology)

The Development and Application of Broad-Spectrum Antiviral Drugs

edited by Chieh-Wen Lo

submission deadline 25 Nov 2025 | Viewed by 504 | Submission Open

Keywords: broad-spectrum antiviral; direct-acting antiviral; host-targeted antiviral; emerging viruses; pandemic preparedness

(This special issue belongs to the Section Medicinal Chemistry)

Research on Diagnosis, Treatment and Related Microbiota in Gastrointestinal Diseases

edited by

Edoardo V. Savarino

and Brigida Barberio

submission deadline 25 Nov 2025 | Viewed by 390 | Submission Open

Keywords: gut microbiota; inflammatory bowel disease; eosinophilic esophagitis; primary sclerosing cholangitis; metabolic-associated steatotic liver disease; immune checkpoint inhibitor colitis; dysbiosis; prebiotics; probiotics

(This special issue belongs to the Section Medicinal Chemistry)

Anticancer Compounds in Medicinal Plants—4th Edition

edited by

Paulo Santos

and

Lillian Barros

submission deadline 25 Nov 2025 | Viewed by 343 | Submission Open

Keywords: natural products; phytochemicals; cancer; secondary metabolites; medicinal plants

(This special issue belongs to the Section Natural Products)

Synthesis, In Silico Prediction and Antitumor Activity of Nitrogen Heterocycle-Based Drug Development

edited by Jamerson F. De Oliveira and Paulo André Teixeira de Moraes Gomes

submission deadline 25 Nov 2025 | Viewed by 175 | Submission Open

Keywords: privileged structures; nitrogen heterocycles; ADMET prediction; cancer biological target; molecular dynamic; computational studies; antitumor activity; in vitro and in vivo studies; SAR of lead compounds; molecular hybridization

(This special issue belongs to the Section Medicinal Chemistry)

Small Molecules to Fight Cancer and Neurodegenerative Diseases

edited by

Daniela Catarzi

Vittoria Colotta

and

Flavia Varano

submission deadline 25 Nov 2025 | Viewed by 155 | Submission Open

Keywords: small molecules; cancer; neurodegenerative diseases; receptor ligands; enzyme modulators; targeted drugs; multitarget agents; PROTACs; immunomodulators; natural products; drug design

(This special issue belongs to the Section Medicinal Chemistry)

Targeting Bacterial Metabolism with Natural and Synthetic Inhibitors

edited by

Mihaela Ileana Ionescu

Cristina Nastasă

and

Ovidiu Oniga

submission deadline 25 Nov 2025 | Viewed by 124 | Submission Open

Keywords: bacterial metabolism; protein kinases; therapeutic strategy; clinical studies; natural inhibitors; enzymatic activity; drug design; structural studies

(This special issue belongs to the Section Medicinal Chemistry)

Boron-Containing Compounds: Identification, Synthesis, Biological Actions and Pharmacology

edited by

Marvin Antonio Soriano-Ursúa

and

Andrei Biță

submission deadline 28 Nov 2025 | 7 articles | Viewed by 10695 | Submission Open

Keywords: boron; drug development; drug discovery; bioactive boron compounds; bioinorganic chemistry; inorganic biological chemistry; synthesis; natural boron compounds; chemical characterization

(This special issue belongs to the Section Medicinal Chemistry)

Medicinal Plants: Current Insights into Their Biological Activities and Integration with Micro- or Nanotechnologies

edited by

Jorge L. Mejía Méndez

Gildardo Sanchez-Ante

and

Edgar R. López-Mena

submission deadline 28 Nov 2025 | 2 articles | Viewed by 4352 | Submission Open

Keywords: medicinal plants; plant extracts; bioactive nanomaterials; inorganic materials; organic materials; drug delivery systems

Next-Generation Targeted Therapy: vNARs as Drug Carriers and Intracellular Neutralizing Agents

edited by

Tanya Camacho-Villegas

and

Mirna Burciaga-Flores

submission deadline 28 Nov 2025 | Viewed by 154 | Submission Open

Keywords: vNAR; drug delivery; intrabodies; payload; nanotechnology; immunotoxins; phage display; biopanning; single-domain antibody

(This special issue belongs to the Section Pharmacology)

New Insights of Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors in Biomedical Applications

edited by

Afif Nakhleh

, Bshara Mansour and Naim Shehadeh

submission deadline 30 Nov 2025 | 3 articles | Viewed by 12855 | Submission Open

Keywords: SGLT2 Inhibitors; cardiovascular protection; renal health; metabolic benefits

(This special issue belongs to the Section Pharmacology)

Pharmacological Strategies to Modulate Symptoms in Autism Spectrum Disorders (ASD)

edited by

Jaime Mella Raipan

submission deadline 30 Nov 2025 | 3 articles | Viewed by 3193 | Submission Open

Keywords: pharmacological treatment of ASD; neurodevelopmental disorders; molecular modeling and ASD; drug discovery for autism; repurposing drugs for ASD; 5-HT receptors; GABAergic system; TRPC6; mGluR5

(This special issue belongs to the Section Pharmacology)

Comprehensive Strategies in Cancer Immunotherapy

edited by Yee Peng Phoon

submission deadline 30 Nov 2025 | 3 articles | Viewed by 1627 | Submission Open

Keywords: immunotherapy; CAR-T; TIL therapy; predictive biomarker; neoadjuvant; cytokine therapy; bispecific antibodies; personalized treatment; combination therapies; tumor microenvironment; immune modulation; interaction and mechanism

(This special issue belongs to the Section Pharmacology)

Therapeutic Potential of Natural Extracts in Cancer Prevention and Treatment

edited by

Zlatina Gospodinova

and

Michael Danilenko

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1282 | Submission Open

Keywords: natural products; anticancer therapeutic potential; cancer chemoprevention; mechanism of action and molecular targets; preclinical and clinical studies

(This special issue belongs to the Section Natural Products)

Medicinal Plants: Exploring Plant-Based Bioactive Compounds for Metabolic Diseases Prevention and Intervention

edited by

Nceba Gqaleni

and

Suresh Babu Naidu Krishna

submission deadline 30 Nov 2025 | 1 articles | Viewed by 817 | Submission Open

Keywords: metabolic diseases; diabetes; medicinal plants; bioactives; metabolic disorders

(This special issue belongs to the Section Natural Products)

Advancements in Radiopharmaceutical Theranostics

edited by

Aiko Yamaguchi

, Shilpa Sharma and

Ryan Patrick Coll

submission deadline 30 Nov 2025 | Viewed by 355 | Submission Open

Keywords: radiopharmaceuticals; radiotheranostics; emerging radionuclides; radiometals; image-guided dosimetry; alpha-emitters; PET; SPECT; radioligand therapy; targeted radionuclide therapy

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Emerging Computational Approaches in Drug Discovery and Design

edited by

Cleber C. Melo-Filho

submission deadline 30 Nov 2025 | Viewed by 336 | Submission Open

Keywords: computer-aided drug design (CADD); quantitative structure-activity/property relationship (QSAR/QSPR); cheminformatics; virtual screening; data curation; in silico; molecular docking; machine learning; deep learning

(This special issue belongs to the Section Medicinal Chemistry)

Green Synthesis and Biological Applications of Metal Nanoparticles Influenced by Different Seasonal Periods

edited by

Alan Kelbis Oliveira Lima

, Paulo Sérgio Taube and

Gerson Nakazato

submission deadline 30 Nov 2025 | Viewed by 251 | Submission Open

Keywords: nanobiotechnology; metal nanoparticles; green chemistry; biodiversity; seasonality

(This special issue belongs to the Section Pharmacology)

Advances in Antibody–Drug Conjugates

edited by

Aiko Yamaguchi

submission deadline 30 Nov 2025 | Viewed by 194 | Submission Open

Keywords: antibody– drug conjugates; linker technology; bispecific antibodies; conditionally activated antibodies; degrader– antibody conjugates; antibody– immunotoxin conjugates; antibody– radionuclide conjugates; oncology; autoimmune disease; infectious disease

(This special issue belongs to the Section Pharmacology)

Population Pharmacokinetics and Pharmacogenetics

edited by

Seung-Hyun Jeong

submission deadline 10 Dec 2025 | 7 articles | Viewed by 11379 | Submission Open

Keywords: pharmacokinetics; pharmacogenetics; precision medicine; population pharmacometrics model; mathematical modeling; dosage regimen; inter-subject variability

(This special issue belongs to the Section Pharmacology)

Orodispersible and Innovative Dosage Forms: Advances in Preparation Technologies, Direct Compression, and Co-Processed Excipients

edited by

Witold Brniak

and

Aleksander Mendyk

submission deadline 10 Dec 2025 | 2 articles | Viewed by 5949 | Submission Open

Keywords: orodispersible films; buccal films; chewable tablets; orodispersible granules; buccal dosage forms; mucoadhesive dosage forms; tabletability; modified release tablets; minitablets

(This special issue belongs to the Section Pharmaceutical Technology)

Natural Products for Anticancer, Anti-Inflammatory and Antimicrobial Therapies

edited by Heriberto Torres-Moreno,

Julio César López-Romero

Elena Y. Enioutina

and

Max Vidal Gutiérrez

submission deadline 10 Dec 2025 | 2 articles | Viewed by 4227 | Submission Open

Keywords: natural products; anticancer; anti-inflammatory; antimicrobial; pharmacy; pharmacology

(This special issue belongs to the Section Natural Products)

New Platforms for Cancer Treatment—Emerging Advances

edited by Fernanda Karoline Vieira da Silva Torchelsen, Maria Alice de Oliveira, Renata Tupinambá Branquinho and

Vanessa Carla Furtado Mosqueira

submission deadline 10 Dec 2025 | 2 articles | Viewed by 2576 | Submission Open

Keywords: cancer treatment; emerging advances; nanotechnology; nanotheranostics; novel drugs; nanostructures; pre-clinical studies

(This special issue belongs to the Section Pharmaceutical Technology)

Metal–Organic Frameworks (MOFs) in Drug Delivery

edited by

Vânia André

submission deadline 12 Dec 2025 | Viewed by 176 | Submission Open

Keywords: MOFs; drug delivery; drugs; drug delivery systems

(This special issue belongs to the Section Pharmaceutical Technology)

New Advances in Antiarrhythmic Drugs

edited by

Norbert Szentandrássy

submission deadline 15 Dec 2025 | 7 articles | Viewed by 18954 | Submission Open

Keywords: antiarrhythmic drugs; ion channel blockers; cardiac action potential; sudden cardiac death; cardiac arrhythmia; proarrhythmic action

(This special issue belongs to the Section Pharmacology)

QSAR and Chemoinformatics in Drug Design and Discovery

edited by

Elena Cichero

and

Naomi Scarano

submission deadline 15 Dec 2025 | 2 articles | Viewed by 1783 | Submission Open

Keywords: QSAR modeling; machine learning; ligand-based virtual screening and design; computer-aided drug repurposing; computational methods; molecular modeling; molecular dynamics; drug design

(This special issue belongs to the Section Medicinal Chemistry)

Antifungal Therapy Strategies: A Focus on Novel Compounds and Inhibitors

edited by

Lucimar Ferreira Kneipp

and

André Luis Souza dos Santos

submission deadline 15 Dec 2025 | Viewed by 183 | Submission Open

Keywords: medicinal chemistry; combined therapy; antivirulence action; anti-resistance strategies; drug repositioning; drug delivery; multi-omics technologies

(This special issue belongs to the Section Medicinal Chemistry)

Structural and Computationally Driven Molecule Design in Drug Discovery: 2nd Edition

edited by

Halil İbrahim Ciftci

Belgin Sever

and

Hasan Demirci

submission deadline 20 Dec 2025 | 13 articles | Viewed by 32078 | Submission Open

Keywords: structural dynamics studies; computer-aided drug design; molecular dynamics simulations; molecular docking; virtual screening; QSAR; in silico ADMET; artificial intelligence (AI) techniques

(This special issue belongs to the Section Medicinal Chemistry)

Natural Products as an Alternative for Treatment of Human Diseases

edited by Eduardo Lira,

Jackson Guedes

and Raimundo Gonçalves De Oliveira Junior

submission deadline 20 Dec 2025 | 7 articles | Viewed by 17505 | Submission Open

Keywords: medicinal plants; herbal remedies; natural products; traditional medicine

(This special issue belongs to the Section Natural Products)

Pharmaceutical Applications and Therapeutic Mechanisms of Substances from Plant Origin

edited by Iliya Zhelev Slavov,