Special Issues

Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Scientific Evidence-Based Applications of Polyamines in Pharmaceuticals Science
edited by Kuniyasu Soda
submission deadline 5 Aug 2025 | Viewed by 210 | Submission Open
Keywords: polyamine; spermine; spermidine; health; senescence; age-related; disease
(This special issue belongs to the Section Pharmacology)
The Role of Phytochemicals in Aging and Aging-Related Diseases submission deadline 15 Aug 2025 | 7 articles | Viewed by 15142 | Submission Open
Keywords: phytochemicals; plant-based diet; dietary supplementation; pharma-nutrition; aging; aging-related diseases; prevention
(This special issue belongs to the Section Natural Products)
Innovative Tools for Drug Analysis and Therapeutic Drug Monitoring (TDM) submission deadline 15 Aug 2025 | 8 articles | Viewed by 11186 | Submission Open
Keywords: therapeutic drug monitoring; analysis of drugs; separation analytical methods; mass spectrometry; bioanalysis; quality control; dosage forms; green analytical chemistry
(This special issue belongs to the Section Pharmacology)
Interdisciplinary Approaches to Preventing and Treating Inflammatory and Oxidative Diseases with Medicinal Plants and Bioactive Compounds submission deadline 15 Aug 2025 | 1 articles | Viewed by 1907 | Submission Open
Keywords: interdisciplinary studies; inflammation; inflammatory diseases; oxidative stress; oxidative diseases; pro-inflammatory; pro-oxidative; neurodegenerative diseases; cardiovascular diseases; cancer; medicine; rheumatological diseases; endocrinological diseases; gastroenterological diseases; dermatological diseases; pulmonary diseases; dentistry; nutrition; dietetics; therapy; medicinal plants; bioactive compounds; phytochemicals; phytochemistry
(This special issue belongs to the Section Natural Products)
Natural Products in Internal Diseases: From Preclinical Research to Clinical Translation
edited by Roberto Pontarolo, and
submission deadline 15 Aug 2025 | 1 articles | Viewed by 1070 | Submission Open
Keywords: natural products; internal diseases; cardiovascular diseases; diabetes; autoimmune disorders; gastrointestinal conditions; respiratory illnesses
Potential Therapeutic Targets for the Management of Diabetes Mellitus, Obesity and Cancer
edited by Marisa Jádna Silva Frederico and
submission deadline 15 Aug 2025 | Viewed by 268 | Submission Open
Keywords: diabetes; obesity; cancer; pharmacological targets
(This special issue belongs to the Section Pharmacology)
Enzyme Inhibitors: Potential Therapeutic Approaches, 2nd Edition submission deadline 15 Aug 2025 | Viewed by 229 | Submission Open
Keywords: enzymes; inhibitors; competitive; uncompetitive; non-competitive; drug target; pharmaceutical approach; disease treatment
(This special issue belongs to the Section Medicinal Chemistry)
Glial Cells as Drug Targets for Schizophrenia
edited by and Paraskevi Papakyriakopoulou
submission deadline 15 Aug 2025 | Viewed by 177 | Submission Open
Keywords: schizophrenia; astrocytes; oligodendrocytes; microglia
(This special issue belongs to the Section Pharmacology)
Small-Molecule Inhibitors for Novel Therapeutics
edited by and Simone Giovannuzzi
submission deadline 20 Aug 2025 | 4 articles | Viewed by 9320 | Submission Open
Keywords: small molecules; enzyme inhibition/activation; protein modulation; novel therapeutics; high-throughput screening; target proteins; drug delivery
Integrating Machine Learning (ML) into Medicinal Chemistry and Cheminformatics
edited by
submission deadline 20 Aug 2025 | 5 articles | Viewed by 5780 | Submission Open
Keywords: small molecules; molecular descriptors; molecular similarity; structure-based and ligand-based screening; homology modeling; molecular docking; drug– receptor docking; biological activity
(This special issue belongs to the Section Medicinal Chemistry)
Design, Synthesis and Development of Novel Antiviral Agents
edited by
submission deadline 20 Aug 2025 | 3 articles | Viewed by 4743 | Submission Open
Keywords: viruses; emerging viral diseases; infectious diseases; antiviral agents; small molecules; structure− activity relationship (SAR) studies; drug design (DD) and synthesis; computer-aided drug discovery (CADD); medicinal chemistry
(This special issue belongs to the Section Medicinal Chemistry)
Computational (In Silico) Approaches for Drug Target Discovery and Disposition submission deadline 20 Aug 2025 | 1 articles | Viewed by 1484 | Submission Open
Keywords: computational drug discovery; in silico modeling; drug target identification; pharmacokinetics (pk); physiologically based pharmacokinetics (PBPK); physiologically based biokinetics (PBBK); physiologically based biopharmaceutics (PBBM); ADME/Tox; machine learning in drug development; systems pharmacology
Pharmaceutical Process Engineering: Experimental and Computational Innovation
edited by Marcial Gonzalez and Francesco Destro
submission deadline 22 Aug 2025 | Viewed by 149 | Submission Open
Keywords: pharmaceutical process engineering; process development; process analytical technology (PAT); process analytical chemistry (PAC); quality by design (QbD); sustainable manufacturing; drug product quality; biopharmaceuticals
(This special issue belongs to the Section Pharmaceutical Technology)
New Approaches to Fighting Infectious Diseases: Overcoming the Antimicrobial Resistance in Current Treatments submission deadline 25 Aug 2025 | 12 articles | Viewed by 37875 | Submission Open
Keywords: infectious diseases; antimicrobial resistance; parasites; viruses; bacteria; treatment approaches; therapeutics; chemotherapy; targeted drug design; natural products
(This special issue belongs to the Section Medicinal Chemistry)
Natural Products in Health Promotion and Disease Prevention 2025
edited by and
submission deadline 25 Aug 2025 | 9 articles | Viewed by 16272 | Submission Open
Keywords: natural products; nutraceuticals; bioactive compounds; traditional medicine; drug discovery
(This special issue belongs to the Section Natural Products)
Tumor Immunopharmacology submission deadline 25 Aug 2025 | 4 articles | Viewed by 13526 | Submission Open
Keywords: immunotherapy; immunomodulation; drug development; cytokine receptor antagonist; T-cell based therapies; therapeutic antibodies; drug delivery; cancer vaccine
(This special issue belongs to the Section Pharmacology)
Therapeutic Drug Monitoring and Adverse Drug Reactions: 2nd Edition
edited by Engi Abd El Hady Algharably and
submission deadline 25 Aug 2025 | 10 articles | Viewed by 11781 | Submission Open
Keywords: therapeutic drug monitoring; adverse drug reactions; pharmacokinetics; personalized medicine; medication safety; pharmacogenomics; medication review; pharmacokinetic modelling
(This special issue belongs to the Section Pharmacology)
Progress of Hydrogel Applications in Novel Drug Delivery Platforms submission deadline 25 Aug 2025 | 4 articles | Viewed by 9628 | Submission Open
Keywords: hydrogels; targeted drug delivery; drug release; drug delivery; smart hydrogels; stimuli-responsive hydrogels; controlled release; hydrogel-based drug delivery; drug carriers
(This special issue belongs to the Section Pharmaceutical Technology)
Psychiatric Drug Treatment and Drug Addiction submission deadline 25 Aug 2025 | 2 articles | Viewed by 8514 | Submission Open
Keywords: drug addiction; drug abuse; psychiatric disorder; drug dependence
(This special issue belongs to the Section Pharmacology)
Drug Candidates for the Treatment of Obesity, 2nd Edition submission deadline 25 Aug 2025 | 3 articles | Viewed by 6515 | Submission Open
Keywords: obesity; appetite supressors; nutraceuticals; plant extracts; lipid metabolism; high-fat diet; adipogenesis
(This special issue belongs to the Section Medicinal Chemistry)
The 20th Anniversary of Pharmaceuticals—New Insights in Medicinal Chemistry of Nitrogen-Containing Compounds
edited by and Pedro Besada Pereira
submission deadline 25 Aug 2025 | 2 articles | Viewed by 6180 | Submission Open
Keywords: drug design; synthesis; nitrogen heterocycles; nitrogen functional groups; biological activity; structure-activity relationship; molecular modeling
(This special issue belongs to the Section Medicinal Chemistry)
Small Molecule Drug Discovery: Driven by In-Silico Techniques
edited by
submission deadline 25 Aug 2025 | 1 articles | Viewed by 2812 | Submission Open
Keywords: drug discovery; nutraceuticals; virtual screening; docking; molecular dynamics; pharmacophore; lead compound
(This special issue belongs to the Section Medicinal Chemistry)
Drug Treatment of Thyroid Cancer submission deadline 25 Aug 2025 | 2 articles | Viewed by 2593 | Submission Open
Keywords: differentiated thyroid cancer; medullary thyroid cancer; anaplastic thyroid carcinoma; advanced/metastatic thyroid cancer; refractory thyroid cancer; targeted therapy in thyroid cancer; tyrosine kinase inhibitors; immune checkpoint inhibitors; redifferentiation treatment; drug resistance
Antimalarial Drug Candidates
edited by Djane Baia-da-Silva and Anna Caroline Campos Aguiar
submission deadline 25 Aug 2025 | 1 articles | Viewed by 1963 | Submission Open
Keywords: malaria; antimalarial drug candidates; efficacy; safety; pharmacokinetics; clinical; preclinical and translational; resistance
(This special issue belongs to the Section Medicinal Chemistry)
Recent Advancements in Radiochemistry and PET Radiotracer Development: 2nd Edition
edited by Kenneth Dahl and
submission deadline 25 Aug 2025 | 1 articles | Viewed by 1360 | Submission Open
Keywords: radiochemistry; labeling; automation; GMP; PET; radiotracer; radioligand; radiopharmaceutical; drug discovery
(This special issue belongs to the Section Radiopharmaceutical Sciences)
Natural Pharmaceutical Component Analysis
edited by
submission deadline 25 Aug 2025 | 1 articles | Viewed by 985 | Submission Open
Keywords: natural pharmaceutical component analysis; data acquisition technologies; pretreatment methods; data processing; online activity analysis
(This special issue belongs to the Section Natural Products)
Pharmacology and Mechanism of Action of Peptides in the Brain
edited by
submission deadline 25 Aug 2025 | 1 articles | Viewed by 743 | Submission Open
Keywords: peptide derivatives; neuropeptides; receptors; brain; pain; epilepsy; depression; anxiety
(This special issue belongs to the Section Pharmacology)
Flavonoids in Medicinal Chemistry: Trends and Future Directions
edited by
submission deadline 25 Aug 2025 | Viewed by 541 | Submission Open
Keywords: flavonoids; synthesis; natural products; medicinal chemistry; biological activity
(This special issue belongs to the Section Medicinal Chemistry)
Pharmacological Approaches of Chronic Obstructive Pulmonary Disease (COPD) and Lung Cancer submission deadline 25 Aug 2025 | Viewed by 339 | Submission Open
Keywords: chronic obstructive pulmonary disease (COPD); inflammasomes; lung cancer (LC); chronic bronchitis; cancer prevention and treatment; therapeutic approaches
(This special issue belongs to the Section Pharmacology)
Challenges and Emerging Trends in Photopharmacology
edited by Oleksandra Tiapko and Bernadett Bacsa
submission deadline 25 Aug 2025 | Viewed by 308 | Submission Open
Keywords: photopharmacology; ion channels; receptors; protein– ligand interactions; precision medicine; optogenetics
(This special issue belongs to the Section Pharmacology)
Neuropsychiatric Disorders: Pharmacological Aspects submission deadline 25 Aug 2025 | Viewed by 303 | Submission Open
Keywords: neuropsychiatric disorders; DSM-V; pharmacodynamics; innovative therapies; animal models; neuropsychiatric patients; trauma and stress; neurodegeneration; affective disorders; neurodevelopmental disorders; schizophrenia; sleep disorders; comorbidities; cardiovascular; coagulopathies; gastrointestinal; microbiome– gut– brain axis
(This special issue belongs to the Section Pharmacology)
Application of Biosensors in Pharmaceutical Research submission deadline 25 Aug 2025 | Viewed by 291 | Submission Open
Keywords: biosensors; diagnostics; high-throughput screening of pharmaceuticals; pharmaceutical analysis; point-of-care systems; drug discovery; drug analysis
(This special issue belongs to the Section Pharmaceutical Technology)
Application of Neuroimaging Biomarkers in the Diagnosis and Treatment of Mental Diseases, 2nd Edition
edited by Deborah A. Yurgelun-Todd, Douglas Kondo, Nicolas A Nunez, Perry Franklin Renshaw and Dost Öngür
submission deadline 25 Aug 2025 | Viewed by 185 | Submission Open
Keywords: neuroimaging; biomarkers; 1H-MRS; 31P-MRS; brain spectroscopy; mood disorders
(This special issue belongs to the Section Pharmaceutical Technology)
Application of MRI in Drug Metabolism and Pharmacokinetics
edited by and
submission deadline 25 Aug 2025 | Viewed by 182 | Submission Open
Keywords: MRI; drug metabolism; pharmacokinetics; chemical exchange saturation transfer (CEST); magnetic resonance spectroscopy (MRS); advanced imaging techniques; molecular imaging; preclinical imaging; quantitative imaging biomarkers; ADME (absorption; distribution; metabolism; excretion)
(This special issue belongs to the Section Pharmacology)
Treatment and Molecular Mechanisms of Depression
edited by Zuleide Maria Ignácio and Ricieri Mocelin
submission deadline 25 Aug 2025 | Viewed by 147 | Submission Open
Keywords: major depressive disorder; molecular mechanisms; neurotransmitters; epigenetic; genetic polymorphisms; inflammation; neuroinflammation; pharmacological strategies; drugs; intracellular signaling
(This special issue belongs to the Section Medicinal Chemistry)
Lithium in Psychiatric Therapy: Celebrating 75th Anniversary
edited by and Ewa Ferensztajn-Rochowiak
submission deadline 28 Aug 2025 | 5 articles | Viewed by 19112 | Submission Open
Keywords: lithium; bipolar disorder; mania; depression; the prevention of recurrences; suicide; dementia; immunomodulation; genetics; kidney function
(This special issue belongs to the Section Pharmacology)
Natural Products for Therapeutic Potential submission deadline 29 Aug 2025 | 4 articles | Viewed by 4945 | Submission Open
Keywords: natural products chemistry; therapeutic potential; medicinal plants; marine organisms; microorganisms; bioactive compounds; natural products inspired compounds; biological activities; computational chemistry
(This special issue belongs to the Section Natural Products)
Unveiling Nature's Pharmacy: Exploring Drug Discovery Through Medicinal Plants
edited by
submission deadline 29 Aug 2025 | 2 articles | Viewed by 4867 | Submission Open
Keywords: plant-derived drugs; secondary metabolites; advanced glycation end-products (AGEs); reactive oxygen species (ROS); molecular targets; pharmacokinetics; ADMET; bioavailability
(This special issue belongs to the Section Natural Products)
Advanced Nanosystems and Emerging Therapies: Innovations in Tuberculosis Treatment and Drug Resistance submission deadline 29 Aug 2025 | 1 articles | Viewed by 1214 | Submission Open
Keywords: nanosystems; tuberculosis therapy; drug delivery; multidrug-resistant Mycobacterium tuberculosis (MDR-TB); nanotechnology-based therapeutics
(This special issue belongs to the Section Pharmaceutical Technology)
Antibiotic Resistance and Misuse submission deadline 31 Aug 2025 | 2 articles | Viewed by 4121 | Submission Open
Keywords: antibiotic resistance; antibiotic misuse; antimicrobial stewardship; infection control; resistance mechanisms; diagnostic innovations; therapeutic strategies; policy reforms; clinical outcomes
(This special issue belongs to the Section Pharmacology)
A Commemorative Special Issue in Honor of Professor Eliezer J. Barreiro: Early Drug Discovery: From Target Identification and Validation to Lead Optimization submission deadline 31 Aug 2025 | 2 articles | Viewed by 3001 | Submission Open
Keywords: target validation; LBDD; FBDD; SBDD; QSAR; artificial intelligence; organic synthesis; natural product; drug discovery; medicinal chemistry
(This special issue belongs to the Section Medicinal Chemistry)
Advances in the Synthesis and Application of Heterocyclic Compounds submission deadline 31 Aug 2025 | 1 articles | Viewed by 2267 | Submission Open
Keywords: organic synthesis; heterocyclic compounds; biological activity; medicine; therapeutics
(This special issue belongs to the Section Medicinal Chemistry)
Advances in Antiparasitic Drug Research submission deadline 31 Aug 2025 | 2 articles | Viewed by 1474 | Submission Open
Keywords: antiparasitic drug; novel drug targets; parasite resistance; drug efficacy; parasite genetics
(This special issue belongs to the Section Pharmacology)
P2X Receptors and Their Pharmacology submission deadline 31 Aug 2025 | 1 articles | Viewed by 1171 | Submission Open
Keywords: compounds; substances; synthetic; natural product; inhibitor; purinergic receptor; ATP; antagonista
(This special issue belongs to the Section Pharmacology)
Advances in Cancer Treatment and Toxicity
edited by
submission deadline 31 Aug 2025 | Viewed by 377 | Submission Open
Keywords: oxidative stress; cell signaling; cell death; tissue remodeling; inflammation; molecular mechanisms; heart; muscle; antioxidants; cell therapy; exosomes
(This special issue belongs to the Section Pharmacology)
Synthesis and Biological Activity of Metal Complexes
edited by
submission deadline 31 Aug 2025 | Viewed by 268 | Submission Open
Keywords: metal complexes; biological activity; synthesis; pharmacology; cancer; pathogens; medicine; chemistry; stability; target
(This special issue belongs to the Section Medicinal Chemistry)
Pharmacotherapeutics of Sarcoidosis
edited by , and Giorgio Monteleone
submission deadline 31 Aug 2025 | Viewed by 169 | Submission Open
Keywords: sarcoidosis; drug combinations; interstitial lung disease; biological therapy; target therapy; biomarkers
(This special issue belongs to the Section Pharmacology)
Advances in Radionuclide Production and Their Applications in Therapeutic Radiopharmaceuticals
edited by Svetlana Selivanova
submission deadline 31 Aug 2025 | Viewed by 126 | Submission Open
Keywords: radiopharmaceutical sciences; radiochemistry; radiopharmacology; radionuclide production; molecular imaging
(This special issue belongs to the Section Radiopharmaceutical Sciences)
Stem Cells in Oncology: Emerging Targets for Therapy
edited by and
submission deadline 31 Aug 2025 | Viewed by 96 | Submission Open
Keywords: cancer stem cells (CSCs); tumor microenvironment (TME); targeted therapy; treatment resistance; biomarkers
(This special issue belongs to the Section Biopharmaceuticals)
Design, Synthesis and Biological Assessment of Amphiphiles submission deadline 1 Sep 2025 | Viewed by 285 | Submission Open
Keywords: amphiphilic compounds; structure– activity relationship; biological potential
(This special issue belongs to the Section Medicinal Chemistry)
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