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Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Role of Phytochemicals in Aging and Aging-Related Diseases

edited by

Giovanni Scapagnini

Sergio Davinelli

and

Alessandro Medoro

submission deadline 15 Aug 2025 | 7 articles | Viewed by 15425 | Submission Open

Keywords: phytochemicals; plant-based diet; dietary supplementation; pharma-nutrition; aging; aging-related diseases; prevention

(This special issue belongs to the Section Natural Products)

Innovative Tools for Drug Analysis and Therapeutic Drug Monitoring (TDM)

edited by

Juraj Piestansky

and

Andrej Kovac

submission deadline 15 Aug 2025 | 8 articles | Viewed by 11492 | Submission Open

Keywords: therapeutic drug monitoring; analysis of drugs; separation analytical methods; mass spectrometry; bioanalysis; quality control; dosage forms; green analytical chemistry

(This special issue belongs to the Section Pharmacology)

Natural Products in Internal Diseases: From Preclinical Research to Clinical Translation

edited by Roberto Pontarolo,

Luana Mota Ferreira

and

Raul Edison Luna Lazo

submission deadline 15 Aug 2025 | 1 articles | Viewed by 1141 | Submission Open

Keywords: natural products; internal diseases; cardiovascular diseases; diabetes; autoimmune disorders; gastrointestinal conditions; respiratory illnesses

Potential Therapeutic Targets for the Management of Diabetes Mellitus, Obesity and Cancer

edited by Marisa Jádna Silva Frederico and

Fátima Regina Mena Barreto Silva

submission deadline 15 Aug 2025 | Viewed by 277 | Submission Open

Keywords: diabetes; obesity; cancer; pharmacological targets

(This special issue belongs to the Section Pharmacology)

Glial Cells as Drug Targets for Schizophrenia

edited by

Kumlesh Kumar Dev

and Paraskevi Papakyriakopoulou

submission deadline 15 Aug 2025 | Viewed by 184 | Submission Open

Keywords: schizophrenia; astrocytes; oligodendrocytes; microglia

(This special issue belongs to the Section Pharmacology)

Small-Molecule Inhibitors for Novel Therapeutics

edited by

Gustavo Provensi

and Simone Giovannuzzi

submission deadline 20 Aug 2025 | 4 articles | Viewed by 9971 | Submission Open

Keywords: small molecules; enzyme inhibition/activation; protein modulation; novel therapeutics; high-throughput screening; target proteins; drug delivery

Integrating Machine Learning (ML) into Medicinal Chemistry and Cheminformatics

edited by

Vartika Tomar

submission deadline 20 Aug 2025 | 6 articles | Viewed by 6280 | Submission Open

Keywords: small molecules; molecular descriptors; molecular similarity; structure-based and ligand-based screening; homology modeling; molecular docking; drug– receptor docking; biological activity

(This special issue belongs to the Section Medicinal Chemistry)

Design, Synthesis and Development of Novel Antiviral Agents

edited by

Antonio Lupia

submission deadline 20 Aug 2025 | 3 articles | Viewed by 4883 | Submission Open

Keywords: viruses; emerging viral diseases; infectious diseases; antiviral agents; small molecules; structure− activity relationship (SAR) studies; drug design (DD) and synthesis; computer-aided drug discovery (CADD); medicinal chemistry

(This special issue belongs to the Section Medicinal Chemistry)

Computational (In Silico) Approaches for Drug Target Discovery and Disposition

edited by

Frederico Severino Martins

and

Leonardo Luiz Borges

submission deadline 20 Aug 2025 | 1 articles | Viewed by 1578 | Submission Open

Keywords: computational drug discovery; in silico modeling; drug target identification; pharmacokinetics (pk); physiologically based pharmacokinetics (PBPK); physiologically based biokinetics (PBBK); physiologically based biopharmaceutics (PBBM); ADME/Tox; machine learning in drug development; systems pharmacology

New Approaches to Fighting Infectious Diseases: Overcoming the Antimicrobial Resistance in Current Treatments

edited by

Antonia Efstathiou

and

Dimitra K. Toubanaki

submission deadline 25 Aug 2025 | 12 articles | Viewed by 39219 | Submission Open

Keywords: infectious diseases; antimicrobial resistance; parasites; viruses; bacteria; treatment approaches; therapeutics; chemotherapy; targeted drug design; natural products

(This special issue belongs to the Section Medicinal Chemistry)

Natural Products in Health Promotion and Disease Prevention 2025

edited by

Marco Alves

and

Ariane Zamoner

submission deadline 25 Aug 2025 | 9 articles | Viewed by 16836 | Submission Open

Keywords: natural products; nutraceuticals; bioactive compounds; traditional medicine; drug discovery

(This special issue belongs to the Section Natural Products)

Tumor Immunopharmacology

edited by

Marco A. Velasco-Velázquez

submission deadline 25 Aug 2025 | 4 articles | Viewed by 13923 | Submission Open

Keywords: immunotherapy; immunomodulation; drug development; cytokine receptor antagonist; T-cell based therapies; therapeutic antibodies; drug delivery; cancer vaccine

(This special issue belongs to the Section Pharmacology)

Therapeutic Drug Monitoring and Adverse Drug Reactions: 2nd Edition

edited by Engi Abd El Hady Algharably and

Ursula Gundert-Remy

submission deadline 25 Aug 2025 | 10 articles | Viewed by 13014 | Submission Open

Keywords: therapeutic drug monitoring; adverse drug reactions; pharmacokinetics; personalized medicine; medication safety; pharmacogenomics; medication review; pharmacokinetic modelling

(This special issue belongs to the Section Pharmacology)

Progress of Hydrogel Applications in Novel Drug Delivery Platforms

edited by

Anna Drabczyk

and

Katarzyna Bialik-Wąs

submission deadline 25 Aug 2025 | 4 articles | Viewed by 9970 | Submission Open

Keywords: hydrogels; targeted drug delivery; drug release; drug delivery; smart hydrogels; stimuli-responsive hydrogels; controlled release; hydrogel-based drug delivery; drug carriers

(This special issue belongs to the Section Pharmaceutical Technology)

Psychiatric Drug Treatment and Drug Addiction

edited by

Javier Navarro-Zaragoza

submission deadline 25 Aug 2025 | 2 articles | Viewed by 8597 | Submission Open

Keywords: drug addiction; drug abuse; psychiatric disorder; drug dependence

(This special issue belongs to the Section Pharmacology)

Drug Candidates for the Treatment of Obesity, 2nd Edition

edited by

Maria Isabel Cardoso Alonso-Vale

and

Monica Marques Telles

submission deadline 25 Aug 2025 | 3 articles | Viewed by 6605 | Submission Open

Keywords: obesity; appetite supressors; nutraceuticals; plant extracts; lipid metabolism; high-fat diet; adipogenesis

(This special issue belongs to the Section Medicinal Chemistry)

The 20th Anniversary of Pharmaceuticals—New Insights in Medicinal Chemistry of Nitrogen-Containing Compounds

edited by

María del Carmen Terán Moldes

and Pedro Besada Pereira

submission deadline 25 Aug 2025 | 2 articles | Viewed by 6243 | Submission Open

Keywords: drug design; synthesis; nitrogen heterocycles; nitrogen functional groups; biological activity; structure-activity relationship; molecular modeling

(This special issue belongs to the Section Medicinal Chemistry)

Small Molecule Drug Discovery: Driven by In-Silico Techniques

edited by

Roberta Rocca

submission deadline 25 Aug 2025 | 1 articles | Viewed by 2839 | Submission Open

Keywords: drug discovery; nutraceuticals; virtual screening; docking; molecular dynamics; pharmacophore; lead compound

(This special issue belongs to the Section Medicinal Chemistry)

Drug Treatment of Thyroid Cancer

edited by

Cristina Alina Silaghi

Carmen Emanuela Georgescu

Horaţiu Silaghi

and

Cristina Pop

submission deadline 25 Aug 2025 | 2 articles | Viewed by 2752 | Submission Open

Keywords: differentiated thyroid cancer; medullary thyroid cancer; anaplastic thyroid carcinoma; advanced/metastatic thyroid cancer; refractory thyroid cancer; targeted therapy in thyroid cancer; tyrosine kinase inhibitors; immune checkpoint inhibitors; redifferentiation treatment; drug resistance

Antimalarial Drug Candidates

edited by Djane Baia-da-Silva and Anna Caroline Campos Aguiar

submission deadline 25 Aug 2025 | 1 articles | Viewed by 2043 | Submission Open

Keywords: malaria; antimalarial drug candidates; efficacy; safety; pharmacokinetics; clinical; preclinical and translational; resistance

(This special issue belongs to the Section Medicinal Chemistry)

Recent Advancements in Radiochemistry and PET Radiotracer Development: 2nd Edition

edited by Kenneth Dahl and

Sangram Nag

submission deadline 25 Aug 2025 | 1 articles | Viewed by 1376 | Submission Open

Keywords: radiochemistry; labeling; automation; GMP; PET; radiotracer; radioligand; radiopharmaceutical; drug discovery

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Natural Pharmaceutical Component Analysis

edited by

Tingting Zhou

submission deadline 25 Aug 2025 | 1 articles | Viewed by 1026 | Submission Open

Keywords: natural pharmaceutical component analysis; data acquisition technologies; pretreatment methods; data processing; online activity analysis

(This special issue belongs to the Section Natural Products)

Pharmacology and Mechanism of Action of Peptides in the Brain

edited by

Jana Tchekalarova

submission deadline 25 Aug 2025 | 1 articles | Viewed by 776 | Submission Open

Keywords: peptide derivatives; neuropeptides; receptors; brain; pain; epilepsy; depression; anxiety

(This special issue belongs to the Section Pharmacology)

Flavonoids in Medicinal Chemistry: Trends and Future Directions

edited by

Honorina Cidade

submission deadline 25 Aug 2025 | Viewed by 546 | Submission Open

Keywords: flavonoids; synthesis; natural products; medicinal chemistry; biological activity

(This special issue belongs to the Section Medicinal Chemistry)

Pharmacological Approaches of Chronic Obstructive Pulmonary Disease (COPD) and Lung Cancer

edited by

Karolina H. Czarnecka-Chrebelska

and

Jinxiang Xi

submission deadline 25 Aug 2025 | Viewed by 344 | Submission Open

Keywords: chronic obstructive pulmonary disease (COPD); inflammasomes; lung cancer (LC); chronic bronchitis; cancer prevention and treatment; therapeutic approaches

(This special issue belongs to the Section Pharmacology)

Challenges and Emerging Trends in Photopharmacology

edited by Oleksandra Tiapko and Bernadett Bacsa

submission deadline 25 Aug 2025 | Viewed by 310 | Submission Open

Keywords: photopharmacology; ion channels; receptors; protein– ligand interactions; precision medicine; optogenetics

(This special issue belongs to the Section Pharmacology)

Neuropsychiatric Disorders: Pharmacological Aspects

edited by

Ioana-Miruna Balmus

submission deadline 25 Aug 2025 | Viewed by 308 | Submission Open

Keywords: neuropsychiatric disorders; DSM-V; pharmacodynamics; innovative therapies; animal models; neuropsychiatric patients; trauma and stress; neurodegeneration; affective disorders; neurodevelopmental disorders; schizophrenia; sleep disorders; comorbidities; cardiovascular; coagulopathies; gastrointestinal; microbiome– gut– brain axis

(This special issue belongs to the Section Pharmacology)

Application of Biosensors in Pharmaceutical Research

edited by

Vasileios Tsekouras

and

Sofia Mavrikou

submission deadline 25 Aug 2025 | Viewed by 297 | Submission Open

Keywords: biosensors; diagnostics; high-throughput screening of pharmaceuticals; pharmaceutical analysis; point-of-care systems; drug discovery; drug analysis

(This special issue belongs to the Section Pharmaceutical Technology)

Application of Neuroimaging Biomarkers in the Diagnosis and Treatment of Mental Diseases, 2nd Edition

edited by Deborah A. Yurgelun-Todd, Douglas Kondo, Nicolas A Nunez, Perry Franklin Renshaw and Dost Öngür

submission deadline 25 Aug 2025 | Viewed by 193 | Submission Open

Keywords: neuroimaging; biomarkers; 1H-MRS; 31P-MRS; brain spectroscopy; mood disorders

(This special issue belongs to the Section Pharmaceutical Technology)

Application of MRI in Drug Metabolism and Pharmacokinetics

edited by

Do-Wan Lee

and

Donghoon Lee

submission deadline 25 Aug 2025 | Viewed by 182 | Submission Open

Keywords: MRI; drug metabolism; pharmacokinetics; chemical exchange saturation transfer (CEST); magnetic resonance spectroscopy (MRS); advanced imaging techniques; molecular imaging; preclinical imaging; quantitative imaging biomarkers; ADME (absorption; distribution; metabolism; excretion)

(This special issue belongs to the Section Pharmacology)

Treatment and Molecular Mechanisms of Depression

edited by Zuleide Maria Ignácio and Ricieri Mocelin

submission deadline 25 Aug 2025 | Viewed by 154 | Submission Open

Keywords: major depressive disorder; molecular mechanisms; neurotransmitters; epigenetic; genetic polymorphisms; inflammation; neuroinflammation; pharmacological strategies; drugs; intracellular signaling

(This special issue belongs to the Section Medicinal Chemistry)

Lithium in Psychiatric Therapy: Celebrating 75th Anniversary

edited by

Janusz K. Rybakowski

and Ewa Ferensztajn-Rochowiak

submission deadline 28 Aug 2025 | 5 articles | Viewed by 21198 | Submission Open

Keywords: lithium; bipolar disorder; mania; depression; the prevention of recurrences; suicide; dementia; immunomodulation; genetics; kidney function

(This special issue belongs to the Section Pharmacology)

Natural Products for Therapeutic Potential

edited by

Xavier Siwe Noundou

submission deadline 29 Aug 2025 | 4 articles | Viewed by 5129 | Submission Open

Keywords: natural products chemistry; therapeutic potential; medicinal plants; marine organisms; microorganisms; bioactive compounds; natural products inspired compounds; biological activities; computational chemistry

(This special issue belongs to the Section Natural Products)

Unveiling Nature's Pharmacy: Exploring Drug Discovery Through Medicinal Plants

edited by

Guglielmina Froldi

submission deadline 29 Aug 2025 | 3 articles | Viewed by 5114 | Submission Open

Keywords: plant-derived drugs; secondary metabolites; advanced glycation end-products (AGEs); reactive oxygen species (ROS); molecular targets; pharmacokinetics; ADMET; bioavailability

(This special issue belongs to the Section Natural Products)

Advanced Nanosystems and Emerging Therapies: Innovations in Tuberculosis Treatment and Drug Resistance

edited by

Fernando Rogério Pavan

submission deadline 29 Aug 2025 | 1 articles | Viewed by 1261 | Submission Open

Keywords: nanosystems; tuberculosis therapy; drug delivery; multidrug-resistant Mycobacterium tuberculosis (MDR-TB); nanotechnology-based therapeutics

(This special issue belongs to the Section Pharmaceutical Technology)

Antibiotic Resistance and Misuse

edited by

Bogdan Vintila

Claudiu Morgovan

and

Anca-Maria Arseniu

submission deadline 31 Aug 2025 | 2 articles | Viewed by 4494 | Submission Open

Keywords: antibiotic resistance; antibiotic misuse; antimicrobial stewardship; infection control; resistance mechanisms; diagnostic innovations; therapeutic strategies; policy reforms; clinical outcomes

(This special issue belongs to the Section Pharmacology)

A Commemorative Special Issue in Honor of Professor Eliezer J. Barreiro: Early Drug Discovery: From Target Identification and Validation to Lead Optimization

edited by

Luzineide Tinoco

and

Lídia Lima

submission deadline 31 Aug 2025 | 2 articles | Viewed by 3123 | Submission Open

Keywords: target validation; LBDD; FBDD; SBDD; QSAR; artificial intelligence; organic synthesis; natural product; drug discovery; medicinal chemistry

(This special issue belongs to the Section Medicinal Chemistry)

Advances in the Synthesis and Application of Heterocyclic Compounds

edited by

Monika Olesiejuk

and

Agnieszka Kudelko

submission deadline 31 Aug 2025 | 1 articles | Viewed by 2432 | Submission Open

Keywords: organic synthesis; heterocyclic compounds; biological activity; medicine; therapeutics

(This special issue belongs to the Section Medicinal Chemistry)

Advances in Antiparasitic Drug Research

edited by

Andre Aires

and

Maria Cristiano

submission deadline 31 Aug 2025 | 2 articles | Viewed by 1536 | Submission Open

Keywords: antiparasitic drug; novel drug targets; parasite resistance; drug efficacy; parasite genetics

(This special issue belongs to the Section Pharmacology)

P2X Receptors and Their Pharmacology

edited by

Robson Xavier Faria

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1231 | Submission Open

Keywords: compounds; substances; synthetic; natural product; inhibitor; purinergic receptor; ATP; antagonista

(This special issue belongs to the Section Pharmacology)

Advances in Cancer Treatment and Toxicity

edited by

Dinender K. Singla

submission deadline 31 Aug 2025 | Viewed by 379 | Submission Open

Keywords: oxidative stress; cell signaling; cell death; tissue remodeling; inflammation; molecular mechanisms; heart; muscle; antioxidants; cell therapy; exosomes

(This special issue belongs to the Section Pharmacology)

Synthesis and Biological Activity of Metal Complexes

edited by

Francois Dufrasne

submission deadline 31 Aug 2025 | Viewed by 269 | Submission Open

Keywords: metal complexes; biological activity; synthesis; pharmacology; cancer; pathogens; medicine; chemistry; stability; target

(This special issue belongs to the Section Medicinal Chemistry)

Pharmacotherapeutics of Sarcoidosis

edited by

Lucrezia Mondini

Barbara Ruaro

and Giorgio Monteleone

submission deadline 31 Aug 2025 | Viewed by 176 | Submission Open

Keywords: sarcoidosis; drug combinations; interstitial lung disease; biological therapy; target therapy; biomarkers

(This special issue belongs to the Section Pharmacology)

Advances in Radionuclide Production and Their Applications in Therapeutic Radiopharmaceuticals

edited by Svetlana Selivanova

submission deadline 31 Aug 2025 | Viewed by 137 | Submission Open

Keywords: radiopharmaceutical sciences; radiochemistry; radiopharmacology; radionuclide production; molecular imaging

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Stem Cells in Oncology: Emerging Targets for Therapy

edited by

Ling Li

and

Umesh P Yadav

submission deadline 31 Aug 2025 | Viewed by 101 | Submission Open

Keywords: cancer stem cells (CSCs); tumor microenvironment (TME); targeted therapy; treatment resistance; biomarkers

(This special issue belongs to the Section Biopharmaceuticals)

Design, Synthesis and Biological Assessment of Amphiphiles

edited by

Renata Odžak

and

Matilda Šprung

submission deadline 1 Sep 2025 | Viewed by 304 | Submission Open

Keywords: amphiphilic compounds; structure– activity relationship; biological potential

(This special issue belongs to the Section Medicinal Chemistry)

Bioactive Compounds Derived from Plants and Their Medicinal Potential, 2nd Edition

edited by

Maria de Lourdes Pereira

Veeranoot Nissapatorn

, Ana Paula Girol and

Sónia M. R. Oliveira

submission deadline 5 Sep 2025 | 3 articles | Viewed by 2113 | Submission Open

Keywords: phytopharmaceutical drugs; activity screening (antimicrobial; antioxidant; anticancer; and immunomodulatory activity); experimental models (in vitro; ex vivo; in vivo; etc.); microfluidic systems

(This special issue belongs to the Section Natural Products)

Emerging Freeze Drying and Spray Drying Techniques

edited by

Lauryna Pudžiuvelytė

and

Jurga Bernatoniene

submission deadline 10 Sep 2025 | 1 articles | Viewed by 4763 | Submission Open

Keywords: freeze drying; spray drying; microencapsulation; emulsions; herbal extracts; essential oil; natural ingredients; active ingredients; wall materials; polysaccharides; powders; physicochemical characteristics; microparticles; encapsulation efficiency; biological activity; pharmaceutical forms (tablets; capsules; solutions; gels; etc.); study of stability; study of release in vitro; active compound(s) and wall material interaction; morphology of microparticles

(This special issue belongs to the Section Pharmaceutical Technology)

New Targets and Experimental Therapeutic Approaches for Cancers

edited by

Saurabh Agarwal

and Rohit K. Srivastava

submission deadline 10 Sep 2025 | 2 articles | Viewed by 3302 | Submission Open

Keywords: cancer; pharmaceutical therapy; therapeutic targets; drug delivery; immunotherapy; precision medicine; emerging pharmaceutical technologies; combination therapy

(This special issue belongs to the Section Pharmacology)

Recent Advances in Nanocarriers for Drug Delivery

edited by

Liliana Mititelu-Tartau

submission deadline 15 Sep 2025 | 2 articles | Viewed by 3151 | Submission Open

Keywords: nanocarriers; drug delivery; targeted therapy; controlled release; biocompatibility; liposomal delivery; polymeric nanoparticles; gene therapy; smart drug systems; biomedical applications

(This special issue belongs to the Section Pharmaceutical Technology)

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