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Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Inhibition and Treatment in Adhesion, Migration, Invasion, and Metastasis of Cancer Cells

edited by

Magdalena Izdebska

Marta Hałas-Wiśniewska

and Wioletta Zielińska

submission deadline 13 Dec 2024 | 2 articles | Viewed by 2935 | Submission Open

Keywords: migration; metastasis; invasion; tumor progression; cell adhesion; cancer; epithelial– mesenchymal transition; cancer therapy

(This special issue belongs to the Section Medicinal Chemistry)

Last Trends of Antileishmanial Drug Discovery and Development

edited by

Annamaria Passantino

and

Michela Pugliese

submission deadline 14 Dec 2024 | Viewed by 211 | Submission Open

Keywords: leishmania; drugs; parasitic treatment; visceral leishmaniasis; canine leishmaniasis; drug resistance; drug targets

(This special issue belongs to the Section Medicinal Chemistry)

Anticancer Compounds in Medicinal Plants — In Honour of the 20th Anniversary of Pharmaceuticals

edited by

Paulo Santos

and

Lillian Barros

submission deadline 15 Dec 2024 | 13 articles | Viewed by 24150 | Submission Open

Keywords: natural products; phytochemicals; cancer; secondary metabolites; medicinal plants

(This special issue belongs to the Section Natural Products)

Natural Pharmacons: Biologically Active Plant-Based Pharmaceuticals 2024

edited by

Dejan Stojković

and

Marina Soković

submission deadline 15 Dec 2024 | 9 articles | Viewed by 12771 | Submission Open

(This special issue belongs to the Section Natural Products)

Multidrug Therapies Containing Monoclonal Antibodies for Multiple Myeloma 2024

edited by

Massimo Offidani

submission deadline 15 Dec 2024 | 5 articles | Viewed by 9469 | Submission Open

Keywords: multiple myeloma; monoclonal antibodies; immunotherapy

(This special issue belongs to the Section Pharmacology)

Medicinal Plants: A Natural Approach to Inflammatory Diseases and Conditions Related to Oxidative Stress

edited by

Sandra Barbalho

and

Adriano Araujo

submission deadline 15 Dec 2024 | 4 articles | Viewed by 4587 | Submission Open

Keywords: medicinal plants; phytocompounds; natural products; inflammatory diseases; oxidative stress

(This special issue belongs to the Section Natural Products)

Small Molecules as Antimicrobials 2024

edited by

Poce Giovanna

submission deadline 15 Dec 2024 | 1 articles | Viewed by 598 | Submission Open

Keywords: small molecules; antimicrobials; antivirals; antibacterials; antimycobacterials

(This special issue belongs to the Section Medicinal Chemistry)

Recent Advances in Behavioral Psychopharmacology

edited by

Agnieszka Pałucha-Poniewiera

submission deadline 15 Dec 2024 | Viewed by 239 | Submission Open

Keywords: addiction; behavioral models; behavioral pharmacology; cognition; depression; drug abuse; memory; psychoactive drugs

(This special issue belongs to the Section Pharmacology)

Next-Generation Contrast Agents for Medical Imaging

edited by

Sara Pinto

and

Rafael Aroso

submission deadline 20 Dec 2024 | 9 articles | Viewed by 22653 | Submission Open

Keywords: targeting; contrast agent; medical imaging; radiolabeling; paramagnetic; magnetic resonance imaging; positron emission tomography; optical imaging; SPECT; X-ray

Infectious Disease Epidemiology and Pharmaceutical Development

edited by Victoria Birlutiu,

Simin Aysel Florescu

and Oana Săndulescu

submission deadline 20 Dec 2024 | 8 articles | Viewed by 12612 | Submission Open

Keywords: viral infections; bacterial infections; healthcare-associated infections; tropical diseases; epidemiology of infectious diseases; antibiotic resistance; vaccination; epidemiology of bone and joint infections

(This special issue belongs to the Section Pharmacology)

Rheumatic Diseases: Pathophysiology, Targeted Therapy, Focus on Vascular and Pulmonary Manifestations 2023

edited by

Barbara Ruaro

submission deadline 20 Dec 2024 | 3 articles | Viewed by 8789 | Submission Open

Keywords: rheumatic diseases; pathophysiology; therapy; pulmonary fibrosis; pulmonary arterial hypertension (PAH); imaging techniques

(This special issue belongs to the Section Pharmacology)

Wnt Signaling in Cancer: New Advances

edited by

Danilo Predes

submission deadline 20 Dec 2024 | 1 articles | Viewed by 3299 | Submission Open

Keywords: Wnt signaling; cancer; colorectal cancer; cancer stem cells; stem cells; small molecules; oncogenesis

(This special issue belongs to the Section Pharmacology)

Peptide Drug Conjugates and Their Applications

edited by

Stela Georgieva

and

Petar Todorov

submission deadline 20 Dec 2024 | Viewed by 183 | Submission Open

Keywords: peptides; endogenous opioid peptides; peptidomimetics; neuropeptides; peptide– metal complexes; opioid receptors; chemical biology of peptides

(This special issue belongs to the Section Biopharmaceuticals)

The 20th Anniversary of Pharmaceuticals—Emerging Trends in Biopharmaceuticals

edited by

Alfredo Berzal-Herranz

Gill Diamond

Yan-Ru Lou

and

Nuno Xavier

submission deadline 22 Dec 2024 | 19 articles | Viewed by 52028 | Submission Open

Keywords: proteins; nucleic acids; aptamers; Glycans; macromolecules; antibodies; phages; viruses; therapeutic tools; peptidomimetics

(This special issue belongs to the Section Biopharmaceuticals)

Medicinal Plants: Current Insights into Their Biological Activities and Integration with Micro- or Nanotechnologies

edited by

Jorge L. Mejía Méndez

Gildardo Sanchez-Ante

and

Edgar R. López-Mena

submission deadline 22 Dec 2024 | 1 articles | Viewed by 1801 | Submission Open

Keywords: medicinal plants; plant extracts; bioactive nanomaterials; inorganic materials; organic materials; drug delivery systems

Therapeutic Potential of Bee Products

edited by Călin Vasile Andriţoiu,

Marcel Popa

and

Lacramioara Ochiuz

submission deadline 22 Dec 2024 | Viewed by 1068 | Submission Open

Keywords: Apitherapy; bee products; honey; polen; apilarnil; Royal Jelly; polymer delivery system of apitherapy products

(This special issue belongs to the Section Natural Products)

Pharmacotherapy for Schizophrenia: New Advances

edited by Dennis Kätzel and Holger Rosenbrock

submission deadline 22 Dec 2024 | Viewed by 315 | Submission Open

Keywords: schizophrenia; psychosis; pharmaco-resistance; refractory symptoms; cognitive symptoms; negative symptoms; aberrant salience; drug repurposing; target discovery; drug development; translatable biomarkers; endophenotypes; precision medicine; patient stratification; circuit neuroscience; glutamate hypothesis; dopamine hypothesis; oxidative stress

(This special issue belongs to the Section Pharmacology)

New Perspectives in Ocular Pharmacology

edited by

Ioannis Tsinopoulos

Ioanna Mylona

and

Stylianos Kandarakis

submission deadline 23 Dec 2024 | 5 articles | Viewed by 19128 | Submission Open

Keywords: ocular pharmacology; pharmacodynamics; ophthalmology; drug delivery systems

(This special issue belongs to the Section Pharmacology)

Antiviral Compounds in Medicinal Plants 2023

edited by

Daniela De Vita

submission deadline 23 Dec 2024 | 6 articles | Viewed by 18708 | Submission Open

Keywords: antiviral agents; viruses; medicinal plants; phytochemicals; natural compounds

(This special issue belongs to the Section Natural Products)

Targeting Apoptosis as a Strategy for Developing New Drugs

edited by

Magdalena Skonieczna

and

Anna Kasprzycka

submission deadline 24 Dec 2024 | 4 articles | Viewed by 7202 | Submission Open

Keywords: proapoptotic drugs; cellular death; death pathways; cell signaling; apoptosis inductors; intracellular death executors; crosstalk of signaling pathways; regulatory cell death (RCD); regulation of cell death

(This special issue belongs to the Section Pharmacology)

Application of 2D and 3D-QSAR Models in Drug Design

edited by

Jaime Mella Raipan

submission deadline 24 Dec 2024 | 3 articles | Viewed by 5126 | Submission Open

Keywords: 2D-QSAR; 3D-QSAR; Hansch analysis; Free– Wilson; structure-activity relationships; CoMFA; CoMSIA; drug design; molecular docking; molecular dynamics.

(This special issue belongs to the Section Medicinal Chemistry)

Metal Nanoparticles’ Biological Activity and Pharmaceutical Applications

edited by

Elitsa L. Pavlova

and

Debbie Crans

submission deadline 25 Dec 2024 | 8 articles | Viewed by 24808 | Submission Open

Keywords: metal nanoparticles; redox reactions; biological activity; pharmaceuticals; cytotoxicity; antibacterial effect; oxidative stress; disease; safety; in vivo applications

(This special issue belongs to the Section Medicinal Chemistry)

Development of Specific Dosage Form: Wound Dressing

edited by

Mihaela Ghica

Madalina Georgiana Albu Kaya

Lacramioara Popa

and Cristina Elena Dinu-Pirvu

submission deadline 25 Dec 2024 | 8 articles | Viewed by 17421 | Submission Open

Keywords: skin lesion; wound healing; wound dressing; regenerative medicine; biomaterials; smart biopolymers; therapeutic system; controlled delivery system; scaffolds; biocompatibility

(This special issue belongs to the Section Pharmaceutical Technology)

Botanicals: Bioactive Molecules and Therapeutic Properties for Human Health 2023

edited by

Sabesan Yoganathan

and

Leonard Barasa

submission deadline 25 Dec 2024 | 5 articles | Viewed by 16532 | Submission Open

Keywords: isolation/characterization of plant metabolites; biosynthesis of medicinal botanicals; chemical synthesis of botanicals; biological activity screening of botanicals; medicinal chemistry evaluation of botanicals; application of computational methods to study bioactive botanicals; phytochemical-derived drug leads

(This special issue belongs to the Section Natural Products)

Histamine Receptor Ligands in Medicinal Chemistry

edited by

Krzysztof Walczyński

and

Marek Staszewski

submission deadline 25 Dec 2024 | 6 articles | Viewed by 15739 | Submission Open

Keywords: drug discovery; histamine; receptors; biogenic amines; ligands; antagonist/inverse agonist; affinity/potency; intrinsic activity; pharmacological evaluation; pharmacokinetic evaluation; SAR; CNS diseases; anticancer ligands; allergy; neurodegeneration; cognitive functions; multitarget ligands; molecular modeling; in vitro studies; in silico studies; in vivo studies

(This special issue belongs to the Section Medicinal Chemistry)

20th Anniversary of Pharmaceuticals—Advances in Pathophysiology, Pharmacology and Neuroprotection in Glaucoma

edited by Najam A. Sharif

submission deadline 25 Dec 2024 | 11 articles | Viewed by 13519 | Submission Open

Keywords: Genetics & Epigenetics; Enzymes; Ion-channels; miRNAs; Gene and Cell Therapies; Optogenetics; Novel techniques/technologies; Receptors; Ocular hypertension; Intraocular pressure; Retina; Optic Nerve; Brain Visual centers; Animal Models of Glaucoma; Neuroprotection

(This special issue belongs to the Section Pharmacology)

Exploring Natural Products with Antioxidant and Anticancer Properties

edited by

Sikiru Olaitan Balogun

and

Edson Lucas Dos Santos

submission deadline 25 Dec 2024 | 6 articles | Viewed by 13051 | Submission Open

Keywords: antioxidant; anticancer; neoplasms; natural products; cytotoxicity

(This special issue belongs to the Section Natural Products)

The 20th Anniversary of Pharmaceuticals—Advances in Pharmacology

edited by

Gary J. Stephens

submission deadline 25 Dec 2024 | 8 articles | Viewed by 11360 | Submission Open

Keywords: behavioral pharmacology; cancer pharmacology; cardiovascular pharmacology; chronopharmacology; clinical pharmacology; immunopharmacology; molecular and biochemical pharmacology; neuropharmacology; pharmacoepidemiology; pharmacogenetics/pharmacogenomics; pharmacokinetics; systems pharmacology; toxicology; translational pharmacology/medicine; safety pharmacology

(This special issue belongs to the Section Pharmacology)

Kynurenine Pathway: A Novel Therapeutic Opportunity

edited by

Verónica Pérez de la Cruz

Tonali Blanco-Ayala

and

Daniela Ramírez-Ortega

submission deadline 25 Dec 2024 | 4 articles | Viewed by 8882 | Submission Open

(This special issue belongs to the Section Pharmacology)

Recent Advances in Psychopharmacology

edited by Roos Van Westrhenen and

Allan H. Young

submission deadline 25 Dec 2024 | 3 articles | Viewed by 6592 | Submission Open

Keywords: psychopharmaca; pharmacogenomics; pharmacogenetics; psychedelics; dementia drugs

(This special issue belongs to the Section Pharmacology)

Recent Advancements in the Development of Antiprotozoal Agents

edited by Francesco Saccoliti and Alessandro Giraudo

submission deadline 25 Dec 2024 | 2 articles | Viewed by 3655 | Submission Open

Keywords: antiprotozoal; drug discovery; chemotherapy; parasite; protozoa; mechanism of action of antiprotozoal agents

(This special issue belongs to the Section Medicinal Chemistry)

Purinergic Signaling: A New Pharmacological Target

edited by

Margarete Dulce Bagatini

submission deadline 25 Dec 2024 | 1 articles | Viewed by 2054 | Submission Open

Keywords: purinergic receptors; ectonucleotidases; nucleotides; nucleoside

(This special issue belongs to the Section Pharmacology)

Chirality: The Important Factor for Drug Discovery and Development

edited by

Li Li

Xuqin Li

and

Tao Ma

submission deadline 25 Dec 2024 | 1 articles | Viewed by 1893 | Submission Open

Keywords: chiral drugs; chiral natural products; chiral resolution; asymmetric synthesis; chiral spectroscopy; chiral impurities; atropisomerism; chiral analysis

(This special issue belongs to the Section Medicinal Chemistry)

20th Anniversary of Pharmaceuticals—Recent Advances in Metallodrug Design and Application

edited by Andrew Knight

submission deadline 25 Dec 2024 | 1 articles | Viewed by 1190 | Submission Open

Keywords: metallodrugs; metal complexes; transition metals; anti-viral; antibacterial; gold; silver; ruthenium; platinum; organometallic; drug discovery

(This special issue belongs to the Section Medicinal Chemistry)

Mitochondrial Protease ClpP in Antitumor-Drug Development: Recent Advances and Challenges

edited by

Maria Grazia Perrone

and

Morena Miciaccia

submission deadline 25 Dec 2024 | Viewed by 446 | Submission Open

Keywords: caseinolytic peptidase P (ClpP); mitochondrial protein quality control; small molecules as targeted drugs; cancer therapy; high-grade glioma; breast cancer; prostate adenocarcinoma; hematological malignancies; bladder cancer; ovarian cancer

(This special issue belongs to the Section Medicinal Chemistry)

The Pharmacology of Bisphosphonates: New Advances

edited by

Ewa Chmielewska

and

Paweł Kafarski

submission deadline 25 Dec 2024 | Viewed by 319 | Submission Open

Keywords: bisphosphonates; bisphosphonic acids; pharmacology of bisphosphonates; pharmacokinetics; pharmacodynamics; hypocalcemia; osteonecrosis; gastrointestinal disturbances; delivery systems of bisphosphonates; bisphosphonate prodrugs; osteoporosis; breast cancer; prostate cancer; hypercalcemia; antiresorptive properties; antibacterial properties; anti-cancer properties; antiparasitic activity; antiprotozoal properties; antiviral properties; effects of drugs on the metabolism and biomechanical properties of bone tissue; properties and effects of bisphosphonates in in vitro and/or in vivo experimental models of bone disorders; different bisphosphonates in an in vitro experimental model of bone disease

(This special issue belongs to the Section Pharmacology)

Recent Advances in Ocular Pharmacology

edited by

Lampros Lamprogiannis

and

Ioannis Tsinopoulos

submission deadline 25 Dec 2024 | Viewed by 211 | Submission Open

Keywords: ophthalmology; ocular diseases; drug delivery; drug targeting; controlled drug release; eye drops; biopolymers; nanomedicine; clinical applications; clinical trials

(This special issue belongs to the Section Pharmacology)

Discovering Novel Drugs from Plants

edited by

Yung-Chia Chen

submission deadline 25 Dec 2024 | Viewed by 169 | Submission Open

Keywords: natural products; drug discovery; bioactive compound; extraction; ethnopharmacology; preclinical test

(This special issue belongs to the Section Natural Products)

In Vivo Nuclear Molecular Imaging in Drug Development and Pharmacological Research, 2nd Edition

edited by

Xuyi Yue

and

Kiran Kumar Solingapuram Sai

submission deadline 30 Dec 2024 | 6 articles | Viewed by 12086 | Submission Open

Keywords: nuclear molecular imaging; drug development; in vivo application; biomarkers; nuclear precision medicine

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Biological Treatment for Rheumatic Diseases

edited by

Kornelia Kuźnik-Trocha

submission deadline 30 Dec 2024 | 1 articles | Viewed by 1332 | Submission Open

Keywords: biological drugs; new treatment strategies; antirheumatic agents; arthritis; rheumatic diseases

(This special issue belongs to the Section Biopharmaceuticals)

Computational Predictions of Molecules with Potential Therapeutic Effects

edited by

Whelton Miller

submission deadline 30 Dec 2024 | 1 articles | Viewed by 1294 | Submission Open

Keywords: biophysics; medicinal chemistry; drug discovery; molecular docking; molecular dynamics; structure-activity relationships; computer-aided drug design (CADD)

(This special issue belongs to the Section Medicinal Chemistry)

Recent Update of Gastroretentive and Intestinal Drug Delivery Systems

edited by Marival Bermejo,

Paloma Marina De la Torre-Iglesias

and Covadonga Álvarez-Álvarez

submission deadline 30 Dec 2024 | Viewed by 589 | Submission Open

Keywords: drug formulation; controlled release systems; colon-targeted release systems; biodegradable systems; gastroretentive drug delivery systems; intestinal drug delivery systems; chemical– physical characterization; in vitro/ex vivo/in vivo evaluation; drug gastroretention; pharmaceutical development

(This special issue belongs to the Section Pharmaceutical Technology)

Sex Differences in Pharmaceutical Practice

edited by

Silvia De Francia

and

Sarah Allegra

submission deadline 31 Dec 2024 | 6 articles | Viewed by 15301 | Submission Open

Keywords: sex; differences; drugs; kinetics; dynamics; preclinical; clinical; research

(This special issue belongs to the Section Medicinal Chemistry)

The 20th Anniversary of Pharmaceuticals—Advances in Natural Products

edited by

Daniela De Vita

and

Marianna Carbone

submission deadline 31 Dec 2024 | 7 articles | Viewed by 14730 | Submission Open

(This special issue belongs to the Section Natural Products)

Plant-Based Extracts and the Therapeutic Potential of Bioactive Compounds

edited by

Grażyna Zgórka

submission deadline 31 Dec 2024 | 7 articles | Viewed by 14570 | Submission Open

Keywords: plant extracts; herbal medicinal products; standardization; phytochemical profiling; bioactive plant compounds; therapeutic effects

(This special issue belongs to the Section Natural Products)

Structural and Computationally Driven Molecule Design in Drug Discovery: 2nd Edition

edited by

Halil İbrahim Ciftci

Belgin Sever

and

Hasan Demirci

submission deadline 31 Dec 2024 | 3 articles | Viewed by 2696 | Submission Open

Keywords: structural dynamics studies; computer-aided drug design; molecular dynamics simulations; molecular docking; virtual screening; QSAR; in silico ADMET; artificial intelligence (AI) techniques

(This special issue belongs to the Section Medicinal Chemistry)

Recent Advances in Psychiatric Medications

edited by

Przemyslaw Waszak

and Paweł Zagożdżon

submission deadline 31 Dec 2024 | 1 articles | Viewed by 2166 | Submission Open

Keywords: mental health treatment; psychopharmacology; antidepressants; antipsychotics; side effects; safety profiles; treatment resistance; adherence issues

(This special issue belongs to the Section Medicinal Chemistry)

Natural Compounds as Potential Anticancer, Anti-inflammatory and Antioxidant Agents in Medicine

edited by

Justyna Stefanowicz-Hajduk

submission deadline 31 Dec 2024 | 1 articles | Viewed by 2028 | Submission Open

Keywords: phytochemistry of plant extracts; plant secondary metabolites; clinical applications; in vitro; in vivo; ex vivo studies; cell and tissue cultures

(This special issue belongs to the Section Natural Products)

Calcium Channels as Therapeutic Targets

edited by

Gary J. Stephens

David Adams

and

Hussein N. Rubaiy

submission deadline 31 Dec 2024 | 2 articles | Viewed by 1729 | Submission Open

Keywords: voltage-gated Ca2+ channels; TRP channels; Ca2+-permeable TRP and ASIC channels; STIM/orai channels; Ca2+ channel structure and function; Ca2+ channel toxins; Ca2+ channelopathies; neuropharmacology; pain; epilepsy; neurodegenerative and neuropsychiatric disorders

(This special issue belongs to the Section Pharmacology)

Drug Discovery of Antiprotozoal Agents 2024

edited by

Francisco Jaime Bezerra Mendonça Júnior

and

Pascal Marchand

submission deadline 31 Dec 2024 | 1 articles | Viewed by 1462 | Submission Open

Keywords: antiprotozoal agents; drug discovery; medicinal chemistry; natural products; in vitro and in vivo studies; ADMET; computer-aided drug design; chemoinformatics; molecular docking; virtual screening

(This special issue belongs to the Section Medicinal Chemistry)

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